JP2020502111A5 - - Google Patents
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- Publication number
- JP2020502111A5 JP2020502111A5 JP2019531649A JP2019531649A JP2020502111A5 JP 2020502111 A5 JP2020502111 A5 JP 2020502111A5 JP 2019531649 A JP2019531649 A JP 2019531649A JP 2019531649 A JP2019531649 A JP 2019531649A JP 2020502111 A5 JP2020502111 A5 JP 2020502111A5
- Authority
- JP
- Japan
- Prior art keywords
- oxy
- hydrogen
- indene
- hex
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 36
- 239000001257 hydrogen Substances 0.000 claims 36
- -1 cyano, hydroxy Chemical group 0.000 claims 32
- 239000002253 acid Substances 0.000 claims 27
- 150000002431 hydrogen Chemical class 0.000 claims 26
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000003545 alkoxy group Chemical group 0.000 claims 16
- 239000000126 substance Substances 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 229910052760 oxygen Inorganic materials 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 208000016097 disease of metabolism Diseases 0.000 claims 4
- 208000030159 metabolic disease Diseases 0.000 claims 4
- 125000004970 halomethyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 102100026148 Free fatty acid receptor 1 Human genes 0.000 claims 2
- 101710142060 Free fatty acid receptor 1 Proteins 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 239000008196 pharmacological composition Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20160171541 | 2016-12-15 | ||
| KR10-2016-0171541 | 2016-12-15 | ||
| KR1020170171228A KR102007633B1 (ko) | 2016-12-15 | 2017-12-13 | 신규 페닐 프로피온 산 유도체 및 이의 용도 |
| KR10-2017-0171228 | 2017-12-13 | ||
| PCT/KR2017/014757 WO2018111012A1 (en) | 2016-12-15 | 2017-12-14 | Novel phenyl propionic acid derivatives and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020502111A JP2020502111A (ja) | 2020-01-23 |
| JP2020502111A5 true JP2020502111A5 (OSRAM) | 2020-11-12 |
| JP6892922B2 JP6892922B2 (ja) | 2021-06-23 |
Family
ID=62559593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531649A Active JP6892922B2 (ja) | 2016-12-15 | 2017-12-14 | 新規フェニルプロピオン酸誘導体及びその用途 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US11225472B2 (OSRAM) |
| EP (1) | EP3555076B1 (OSRAM) |
| JP (1) | JP6892922B2 (OSRAM) |
| KR (1) | KR102007633B1 (OSRAM) |
| CN (1) | CN110049984B (OSRAM) |
| AU (1) | AU2017374460B2 (OSRAM) |
| BR (1) | BR112019012433A2 (OSRAM) |
| CA (1) | CA3042528C (OSRAM) |
| DK (1) | DK3555076T3 (OSRAM) |
| ES (1) | ES2948485T3 (OSRAM) |
| FI (1) | FI3555076T3 (OSRAM) |
| HU (1) | HUE062468T2 (OSRAM) |
| IL (1) | IL267239B (OSRAM) |
| MX (1) | MX2019007071A (OSRAM) |
| MY (1) | MY198292A (OSRAM) |
| PH (1) | PH12019501251A1 (OSRAM) |
| PL (1) | PL3555076T3 (OSRAM) |
| PT (1) | PT3555076T (OSRAM) |
| RS (1) | RS64259B1 (OSRAM) |
| RU (1) | RU2760266C2 (OSRAM) |
| SI (1) | SI3555076T1 (OSRAM) |
| WO (1) | WO2018111012A1 (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220112185A1 (en) * | 2016-12-15 | 2022-04-14 | Ildong Pharmaceutical Co., Ltd. | Novel phenyl propionic acid derivatives and uses thereof |
| KR102007633B1 (ko) * | 2016-12-15 | 2019-08-06 | 일동제약(주) | 신규 페닐 프로피온 산 유도체 및 이의 용도 |
| JP7062792B2 (ja) | 2018-02-13 | 2022-05-06 | ギリアード サイエンシーズ， インコーポレイテッド | Ｐｄ－１／ｐｄ－ｌ１阻害剤 |
| CA3093851A1 (en) | 2018-03-29 | 2019-10-03 | Arbutus Biopharma Corporation | Substituted 1,1'-biphenyl compounds, analogues thereof, and methods using same |
| EP3781556B1 (en) | 2018-04-19 | 2025-06-18 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| CN118221646A (zh) | 2018-07-13 | 2024-06-21 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
| KR102635333B1 (ko) | 2018-10-24 | 2024-02-15 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| JP2022552655A (ja) | 2019-10-07 | 2022-12-19 | キャリーオペ，インク． | Ｇｐｒ１１９アゴニスト |
| PH12022552277A1 (en) | 2020-02-28 | 2024-03-04 | Kallyope Inc | Gpr40 agonists |
| CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
| JP2023531726A (ja) | 2020-06-26 | 2023-07-25 | キャリーオペ，インク． | Ａｍｐｋアクチベーター |
| BR112023022114A2 (pt) * | 2021-04-29 | 2024-01-30 | Ildong Pharmaceutical Co Ltd | Composto farmacêutico compreendendo agonista de gpr40 e inibidor de sglt-2 |
| EP4358958A1 (en) * | 2021-06-21 | 2024-05-01 | Yunovia, Co., Ltd. | Method of controlling blood sugar level and treatment of diabetes and related conditions |
| WO2023080299A1 (ko) * | 2021-11-08 | 2023-05-11 | 일동제약(주) | 페닐 프로피온 산 유도체의 신규 염, 이의 제조 방법 및 이를 포함하는 약학 조성물 |
| KR20240084229A (ko) * | 2022-12-06 | 2024-06-13 | 유노비아 주식회사 | 안정성이 향상된 gpr40 효현제를 유효성분으로 포함하는 약제학적 조성물 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4594611B2 (ja) * | 2002-11-08 | 2010-12-08 | 武田薬品工業株式会社 | 受容体機能調節剤 |
| KR20070004769A (ko) * | 2004-02-27 | 2007-01-09 | 암젠 인코포레이션 | 대사 장애의 치료에 사용되는 화합물, 약제학적 조성물 및그 사용방법 |
| EP1726580A4 (en) * | 2004-03-15 | 2008-02-13 | Takeda Pharmaceutical | AMINOPHNYLPROPANO ACID DERIVATIVE |
| EP1890690A4 (en) | 2005-06-02 | 2010-06-02 | Jenrin Discovery | MAO-B INHIBITORS FOR TREATING OBESITY |
| AU2006291234A1 (en) * | 2005-09-14 | 2007-03-22 | Amgen Inc. | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
| JP5055852B2 (ja) | 2006-06-21 | 2012-10-24 | 住友大阪セメント株式会社 | 鉄資源の回収方法 |
| AR084050A1 (es) * | 2010-12-01 | 2013-04-17 | Boehringer Ingelheim Int | Acidos indaniloxidihidrobenzofuranilaceticos |
| JP2013147443A (ja) * | 2012-01-18 | 2013-08-01 | Daiichi Sankyo Co Ltd | β置換カルボン酸誘導体 |
| US8633182B2 (en) * | 2012-05-30 | 2014-01-21 | Boehringer Ingelheim International Gmbh | Indanyloxyphenylcyclopropanecarboxylic acids |
| JP6533778B2 (ja) * | 2013-09-26 | 2019-06-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｇｐｒ４０アゴニストとしてのインダニルオキシジヒドロベンゾフラニル酢酸誘導体を調製するための方法および中間体 |
| US10195178B2 (en) | 2016-04-11 | 2019-02-05 | Janssen Pharmaceutica Nv | GPR40 agonists in anti-diabetic drug combinations |
| US20220112185A1 (en) * | 2016-12-15 | 2022-04-14 | Ildong Pharmaceutical Co., Ltd. | Novel phenyl propionic acid derivatives and uses thereof |
| KR102007633B1 (ko) * | 2016-12-15 | 2019-08-06 | 일동제약(주) | 신규 페닐 프로피온 산 유도체 및 이의 용도 |
| BR112023022114A2 (pt) * | 2021-04-29 | 2024-01-30 | Ildong Pharmaceutical Co Ltd | Composto farmacêutico compreendendo agonista de gpr40 e inibidor de sglt-2 |
| EP4358958A1 (en) * | 2021-06-21 | 2024-05-01 | Yunovia, Co., Ltd. | Method of controlling blood sugar level and treatment of diabetes and related conditions |
| US20230022803A1 (en) * | 2021-06-25 | 2023-01-26 | Ildong Pharmaceutical Co., Ltd. | Novel crystalline form of gpr40 agonist |
-
2017
- 2017-12-13 KR KR1020170171228A patent/KR102007633B1/ko active Active
- 2017-12-14 WO PCT/KR2017/014757 patent/WO2018111012A1/en not_active Ceased
- 2017-12-14 PT PT178808721T patent/PT3555076T/pt unknown
- 2017-12-14 ES ES17880872T patent/ES2948485T3/es active Active
- 2017-12-14 CN CN201780074801.4A patent/CN110049984B/zh not_active Expired - Fee Related
- 2017-12-14 IL IL267239A patent/IL267239B/en unknown
- 2017-12-14 JP JP2019531649A patent/JP6892922B2/ja active Active
- 2017-12-14 DK DK17880872.1T patent/DK3555076T3/da active
- 2017-12-14 FI FIEP17880872.1T patent/FI3555076T3/fi active
- 2017-12-14 RS RS20230456A patent/RS64259B1/sr unknown
- 2017-12-14 PL PL17880872.1T patent/PL3555076T3/pl unknown
- 2017-12-14 EP EP17880872.1A patent/EP3555076B1/en active Active
- 2017-12-14 BR BR112019012433A patent/BR112019012433A2/pt not_active Application Discontinuation
- 2017-12-14 HU HUE17880872A patent/HUE062468T2/hu unknown
- 2017-12-14 CA CA3042528A patent/CA3042528C/en active Active
- 2017-12-14 AU AU2017374460A patent/AU2017374460B2/en not_active Ceased
- 2017-12-14 US US16/467,654 patent/US11225472B2/en active Active
- 2017-12-14 MY MYPI2019003388A patent/MY198292A/en unknown
- 2017-12-14 MX MX2019007071A patent/MX2019007071A/es unknown
- 2017-12-14 RU RU2019121871A patent/RU2760266C2/ru active
- 2017-12-14 SI SI201731367T patent/SI3555076T1/sl unknown
-
2019
- 2019-06-06 PH PH12019501251A patent/PH12019501251A1/en unknown
-
2021
- 2021-11-10 US US17/523,652 patent/US11731961B2/en active Active
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