JP2020500220A5 - - Google Patents
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- JP2020500220A5 JP2020500220A5 JP2019547182A JP2019547182A JP2020500220A5 JP 2020500220 A5 JP2020500220 A5 JP 2020500220A5 JP 2019547182 A JP2019547182 A JP 2019547182A JP 2019547182 A JP2019547182 A JP 2019547182A JP 2020500220 A5 JP2020500220 A5 JP 2020500220A5
- Authority
- JP
- Japan
- Prior art keywords
- film
- weight
- alginate
- monovalent cation
- film according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000010443 alginic acid Nutrition 0.000 claims 14
- 229920000615 alginic acid Polymers 0.000 claims 14
- 229940072056 alginate Drugs 0.000 claims 12
- -1 cation alginate Chemical class 0.000 claims 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 9
- ZISSAWUMDACLOM-UHFFFAOYSA-N triptane Chemical compound CC(C)C(C)(C)C ZISSAWUMDACLOM-UHFFFAOYSA-N 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000000600 sorbitol Substances 0.000 claims 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 239000008186 active pharmaceutical agent Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000000214 mouth Anatomy 0.000 claims 2
- 239000004014 plasticizer Substances 0.000 claims 2
- 235000010413 sodium alginate Nutrition 0.000 claims 2
- 239000000661 sodium alginate Substances 0.000 claims 2
- 229940005550 sodium alginate Drugs 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 229960003708 sumatriptan Drugs 0.000 claims 2
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 claims 2
- KRQUFUKTQHISJB-YYADALCUSA-N 2-[(E)-N-[2-(4-chlorophenoxy)propoxy]-C-propylcarbonimidoyl]-3-hydroxy-5-(thian-3-yl)cyclohex-2-en-1-one Chemical compound CCC\C(=N/OCC(C)OC1=CC=C(Cl)C=C1)C1=C(O)CC(CC1=O)C1CCCSC1 KRQUFUKTQHISJB-YYADALCUSA-N 0.000 claims 1
- 208000006561 Cluster Headache Diseases 0.000 claims 1
- 208000019505 Deglutition disease Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000002535 acidifier Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 239000000728 ammonium alginate Substances 0.000 claims 1
- 235000010407 ammonium alginate Nutrition 0.000 claims 1
- KPGABFJTMYCRHJ-YZOKENDUSA-N ammonium alginate Chemical compound [NH4+].[NH4+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O KPGABFJTMYCRHJ-YZOKENDUSA-N 0.000 claims 1
- 239000011260 aqueous acid Substances 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 208000018912 cluster headache syndrome Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 1
- 229910000397 disodium phosphate Inorganic materials 0.000 claims 1
- 235000019800 disodium phosphate Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims 1
- 235000019799 monosodium phosphate Nutrition 0.000 claims 1
- 229960005254 naratriptan Drugs 0.000 claims 1
- UNHGSHHVDNGCFN-UHFFFAOYSA-N naratriptan Chemical compound C=12[CH]C(CCS(=O)(=O)NC)=CC=C2N=CC=1C1CCN(C)CC1 UNHGSHHVDNGCFN-UHFFFAOYSA-N 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 235000010408 potassium alginate Nutrition 0.000 claims 1
- 239000000737 potassium alginate Substances 0.000 claims 1
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 claims 1
- 238000007789 sealing Methods 0.000 claims 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical group [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims 1
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 1
- 229960001360 zolmitriptan Drugs 0.000 claims 1
- UTAZCRNOSWWEFR-ZDUSSCGKSA-N zolmitriptan Chemical compound C=1[C]2C(CCN(C)C)=CN=C2C=CC=1C[C@H]1COC(=O)N1 UTAZCRNOSWWEFR-ZDUSSCGKSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022153002A JP2023002545A (ja) | 2016-11-15 | 2022-09-26 | 医薬製剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201619324 | 2016-11-15 | ||
| GB1619324.5 | 2016-11-15 | ||
| PCT/EP2017/079217 WO2018091473A1 (en) | 2016-11-15 | 2017-11-14 | Pharmaceutical formulation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022153002A Division JP2023002545A (ja) | 2016-11-15 | 2022-09-26 | 医薬製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020500220A JP2020500220A (ja) | 2020-01-09 |
| JP2020500220A5 true JP2020500220A5 (cg-RX-API-DMAC7.html) | 2020-12-24 |
Family
ID=60452618
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019547182A Pending JP2020500220A (ja) | 2016-11-15 | 2017-11-14 | 医薬製剤 |
| JP2022153002A Pending JP2023002545A (ja) | 2016-11-15 | 2022-09-26 | 医薬製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022153002A Pending JP2023002545A (ja) | 2016-11-15 | 2022-09-26 | 医薬製剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US11007144B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP4631569A3 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2020500220A (cg-RX-API-DMAC7.html) |
| KR (1) | KR102499414B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN110381921A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017359973B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112019009775A2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK3541362T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES3060767T3 (cg-RX-API-DMAC7.html) |
| FI (1) | FI3541362T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL266537B2 (cg-RX-API-DMAC7.html) |
| MX (1) | MX389336B (cg-RX-API-DMAC7.html) |
| PT (1) | PT3541362T (cg-RX-API-DMAC7.html) |
| RU (1) | RU2767436C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018091473A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI3541362T3 (fi) | 2016-11-15 | 2026-02-05 | Klaria Pharma Holding Ab | Triptaania käsittävä alginaattikalvo |
| GB201709141D0 (en) | 2017-06-08 | 2017-07-26 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| GB201808462D0 (en) | 2018-05-23 | 2018-07-11 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| EP3912622A1 (en) | 2020-05-19 | 2021-11-24 | tesa Labtec GmbH | Oral film for safe administration of api |
| DE102020122557A1 (de) * | 2020-08-28 | 2022-03-03 | Lts Lohmann Therapie-Systeme Ag | Mucosa-Perforierung |
| KR102413426B1 (ko) * | 2020-12-21 | 2022-06-29 | 주식회사 씨엠지제약 | 나라트립탄을 포함하는 구강용해 필름 제형 |
| DE102021105268A1 (de) * | 2021-03-04 | 2022-09-08 | Lts Lohmann Therapie-Systeme Ag. | Oraler Dünnfilm |
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| MX393613B (es) | 2016-01-07 | 2025-03-24 | Viramal Ltd | Composiciones de gel para administracion transdermica para maximizar las concentraciones de farmaco en el estrato corneo y suero, y metodos de uso de las mismas. |
| CN108883308A (zh) | 2016-01-26 | 2018-11-23 | 利维申制药有限公司 | α-肾上腺素能药剂的组合物和用途 |
| JPWO2017135195A1 (ja) | 2016-02-03 | 2018-11-22 | 社会医療法人蘇西厚生会 まつなみリサーチパーク | アレルギー症状の予防又は治療剤 |
| WO2017180707A1 (en) | 2016-04-12 | 2017-10-19 | Schaneville Scott | Ingestible films having substances from hemp or cannabis |
| US12427121B2 (en) | 2016-05-05 | 2025-09-30 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
| BR112018072467A2 (pt) | 2016-05-05 | 2019-02-19 | Aquestive Therapeutics, Inc. | composições farmacêuticas com permeação aumentada |
| WO2017192921A1 (en) | 2016-05-05 | 2017-11-09 | Monosol Rx, Llc | Enhanced delivery epinephrine compositions |
| US20180125977A1 (en) | 2016-05-05 | 2018-05-10 | Monosol Rx, Llc | Enhanced delivery epinephrine compositions |
| WO2017218918A1 (en) | 2016-06-17 | 2017-12-21 | Ys Pharmtech | Stabilization of epinephrine formulations |
| FI3541362T3 (fi) | 2016-11-15 | 2026-02-05 | Klaria Pharma Holding Ab | Triptaania käsittävä alginaattikalvo |
| GB201709141D0 (en) | 2017-06-08 | 2017-07-26 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| GB201807942D0 (en) | 2018-05-16 | 2018-06-27 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| GB201808462D0 (en) | 2018-05-23 | 2018-07-11 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| GB201911715D0 (en) | 2019-08-15 | 2019-10-02 | Klaria Pharma Holding Ab | Film formulation comprising carriers |
| GB201912505D0 (en) | 2019-08-30 | 2019-10-16 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| JP7664916B2 (ja) | 2019-11-04 | 2025-04-18 | ビオタ リミテッド | 難水溶性の有効成分を含有する経口投与可能なフィルム及びその調製 |
-
2017
- 2017-11-14 FI FIEP17804124.0T patent/FI3541362T3/fi active
- 2017-11-14 JP JP2019547182A patent/JP2020500220A/ja active Pending
- 2017-11-14 WO PCT/EP2017/079217 patent/WO2018091473A1/en not_active Ceased
- 2017-11-14 MX MX2019005160A patent/MX389336B/es unknown
- 2017-11-14 KR KR1020197016962A patent/KR102499414B1/ko active Active
- 2017-11-14 RU RU2019115816A patent/RU2767436C2/ru active
- 2017-11-14 IL IL266537A patent/IL266537B2/en unknown
- 2017-11-14 DK DK17804124.0T patent/DK3541362T3/da active
- 2017-11-14 PT PT178041240T patent/PT3541362T/pt unknown
- 2017-11-14 CN CN201780070255.7A patent/CN110381921A/zh active Pending
- 2017-11-14 AU AU2017359973A patent/AU2017359973B2/en active Active
- 2017-11-14 BR BR112019009775A patent/BR112019009775A2/pt active Search and Examination
- 2017-11-14 ES ES17804124T patent/ES3060767T3/es active Active
- 2017-11-14 EP EP25199761.5A patent/EP4631569A3/en active Pending
- 2017-11-14 EP EP17804124.0A patent/EP3541362B1/en active Active
- 2017-11-14 US US16/349,840 patent/US11007144B2/en active Active
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2021
- 2021-03-29 US US17/215,963 patent/US20210283047A1/en not_active Abandoned
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2022
- 2022-07-12 US US17/811,970 patent/US12285521B2/en active Active
- 2022-09-26 JP JP2022153002A patent/JP2023002545A/ja active Pending
-
2025
- 2025-03-24 US US19/088,128 patent/US20250281400A1/en active Pending
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