JP2020500006A5 - - Google Patents
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- JP2020500006A5 JP2020500006A5 JP2019520053A JP2019520053A JP2020500006A5 JP 2020500006 A5 JP2020500006 A5 JP 2020500006A5 JP 2019520053 A JP2019520053 A JP 2019520053A JP 2019520053 A JP2019520053 A JP 2019520053A JP 2020500006 A5 JP2020500006 A5 JP 2020500006A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 30
- 239000000427 antigen Substances 0.000 claims 14
- 102000036639 antigens Human genes 0.000 claims 14
- 108091007433 antigens Proteins 0.000 claims 14
- 125000000539 amino acid group Chemical group 0.000 claims 10
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 7
- 102000017578 LAG3 Human genes 0.000 claims 6
- 101150030213 Lag3 gene Proteins 0.000 claims 6
- 238000000684 flow cytometry Methods 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 102000043131 MHC class II family Human genes 0.000 claims 3
- 108091054438 MHC class II family Proteins 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 238000012875 competitive assay Methods 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 239000013642 negative control Substances 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 239000004175 ponceau 4R Substances 0.000 claims 2
- 230000004614 tumor growth Effects 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 101000867232 Escherichia coli Heat-stable enterotoxin II Proteins 0.000 claims 1
- 201000008808 Fibrosarcoma Diseases 0.000 claims 1
- 241000282567 Macaca fascicularis Species 0.000 claims 1
- 101001137986 Mus musculus Lymphocyte activation gene 3 protein Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000009089 cytolysis Effects 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 231100000655 enterotoxin Toxicity 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000004073 interleukin-2 production Effects 0.000 claims 1
- 230000037041 intracellular level Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022195869A JP7488323B2 (ja) | 2016-10-13 | 2022-12-07 | 抗ｌａｇ－３抗体および組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662407678P | 2016-10-13 | 2016-10-13 | |
| US62/407,678 | 2016-10-13 | ||
| PCT/EP2017/076188 WO2018069500A2 (en) | 2016-10-13 | 2017-10-13 | Anti-lag-3 antibodies and compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022195869A Division JP7488323B2 (ja) | 2016-10-13 | 2022-12-07 | 抗ｌａｇ－３抗体および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020500006A JP2020500006A (ja) | 2020-01-09 |
| JP2020500006A5 true JP2020500006A5 (enExample) | 2020-11-19 |
| JP7212821B2 JP7212821B2 (ja) | 2023-01-26 |
Family
ID=60201531
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019520053A Active JP7212821B2 (ja) | 2016-10-13 | 2017-10-13 | 抗ｌａｇ－３抗体および組成物 |
| JP2022195869A Active JP7488323B2 (ja) | 2016-10-13 | 2022-12-07 | 抗ｌａｇ－３抗体および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022195869A Active JP7488323B2 (ja) | 2016-10-13 | 2022-12-07 | 抗ｌａｇ－３抗体および組成物 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US11390676B2 (enExample) |
| EP (1) | EP3526255A2 (enExample) |
| JP (2) | JP7212821B2 (enExample) |
| KR (2) | KR102583190B1 (enExample) |
| CN (4) | CN117567622A (enExample) |
| AU (1) | AU2017342071B2 (enExample) |
| BR (1) | BR112019006876A2 (enExample) |
| CA (1) | CA3039140A1 (enExample) |
| CL (1) | CL2019000979A1 (enExample) |
| CO (1) | CO2019004003A2 (enExample) |
| EA (1) | EA201990912A1 (enExample) |
| IL (1) | IL265844B2 (enExample) |
| MA (1) | MA46525A (enExample) |
| MX (1) | MX2019004241A (enExample) |
| MY (1) | MY203971A (enExample) |
| NZ (2) | NZ752044A (enExample) |
| PE (1) | PE20190911A1 (enExample) |
| PH (1) | PH12019500668B1 (enExample) |
| RU (1) | RU2755503C2 (enExample) |
| SA (1) | SA519401522B1 (enExample) |
| SG (1) | SG10201912940WA (enExample) |
| TN (1) | TN2019000099A1 (enExample) |
| TW (1) | TWI784976B (enExample) |
| UA (1) | UA127050C2 (enExample) |
| WO (1) | WO2018069500A2 (enExample) |
| ZA (1) | ZA201901924B (enExample) |
Families Citing this family (83)
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|---|---|---|---|---|
| TW202436356A (zh) | 2016-10-11 | 2024-09-16 | 美商艾吉納斯公司 | 抗ｌａｇ－３抗體及其使用方法 |
| PE20190911A1 (es) * | 2016-10-13 | 2019-06-26 | Symphogen As | Composiciones y anticuerpos anti-lag-3 |
| CA3185303A1 (en) | 2017-04-05 | 2018-10-11 | Symphogen A/S | Combination therapies targeting pd-a, tim-3, and lag-3 |
| US20210340250A1 (en) | 2017-05-30 | 2021-11-04 | Bristol-Myers Squibb Company | Compositions comprising a combination of an anti-lag-3 antibody, a pd-1 pathway inhibitor, and an immunotherapeutic agent |
| KR102713203B1 (ko) | 2017-05-30 | 2024-10-10 | 브리스톨-마이어스 스큅 컴퍼니 | Lag-3 양성 종양의 치료 |
| KR20240155979A (ko) | 2017-05-30 | 2024-10-29 | 브리스톨-마이어스 스큅 컴퍼니 | 항-lag-3 항체 또는 항-lag-3 항체 및 항-pd-1 또는 항-pd-l1 항체를 포함하는 조성물 |
| WO2019165982A1 (en) | 2018-02-28 | 2019-09-06 | WuXi Biologics Ireland Limited | Monoclonal antibody against human lag-3, method for preparing same, and use thereof |
| CN115057931B (zh) * | 2018-02-28 | 2025-08-22 | 广州誉衡生物科技有限公司 | 抗人lag-3抗体及其用途 |
| MX2020011588A (es) * | 2018-05-03 | 2020-12-07 | Shanghai Epimab Biotherapeutics Co Ltd | Anticuerpos de alta afinidad a pd-1 y lag-3 y proteinas de union bispecificas preparadas a partir de las mismas. |
| CN110615840A (zh) * | 2018-06-19 | 2019-12-27 | 信达生物制药(苏州)有限公司 | 全人源的抗lag-3抗体及其应用 |
| SG11202100693UA (en) | 2018-07-26 | 2021-02-25 | Bristol Myers Squibb Co | Lag-3 combination therapy for the treatment of cancer |
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| CN111620949A (zh) * | 2019-02-28 | 2020-09-04 | 三生国健药业（上海）股份有限公司 | 结合人lag-3的抗体、其制备方法和用途 |
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| CN115942973A (zh) | 2019-11-08 | 2023-04-07 | 百时美施贵宝公司 | 用于黑色素瘤的lag-3拮抗剂疗法 |
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