JP2020176111A5 - - Google Patents
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- Publication number
- JP2020176111A5 JP2020176111A5 JP2020068069A JP2020068069A JP2020176111A5 JP 2020176111 A5 JP2020176111 A5 JP 2020176111A5 JP 2020068069 A JP2020068069 A JP 2020068069A JP 2020068069 A JP2020068069 A JP 2020068069A JP 2020176111 A5 JP2020176111 A5 JP 2020176111A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- alzheimer
- disease
- tyrosol
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 32
- YCCILVSKPBXVIP-UHFFFAOYSA-N 2-(4-hydroxyphenyl)ethanol Chemical compound OCCC1=CC=C(O)C=C1 YCCILVSKPBXVIP-UHFFFAOYSA-N 0.000 claims description 24
- 208000024827 Alzheimer disease Diseases 0.000 claims description 16
- 206010029350 Neurotoxicity Diseases 0.000 claims description 14
- 206010044221 Toxic encephalopathy Diseases 0.000 claims description 14
- 230000007135 neurotoxicity Effects 0.000 claims description 14
- 231100000228 neurotoxicity Toxicity 0.000 claims description 14
- 208000010877 cognitive disease Diseases 0.000 claims description 13
- 208000027061 mild cognitive impairment Diseases 0.000 claims description 13
- DBLDQZASZZMNSL-QMMMGPOBSA-N L-tyrosinol Natural products OC[C@@H](N)CC1=CC=C(O)C=C1 DBLDQZASZZMNSL-QMMMGPOBSA-N 0.000 claims description 12
- 230000001603 reducing effect Effects 0.000 claims description 12
- 235000004330 tyrosol Nutrition 0.000 claims description 12
- 239000004480 active ingredient Substances 0.000 claims description 9
- 235000013305 food Nutrition 0.000 claims description 8
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims description 7
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims description 7
- 230000002265 prevention Effects 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 239000013589 supplement Substances 0.000 claims description 3
- 239000000419 plant extract Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 230000003449 preventive effect Effects 0.000 description 3
- 230000007082 Aβ accumulation Effects 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000037259 Amyloid Plaque Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 239000004278 EU approved seasoning Substances 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 240000008415 Lactuca sativa Species 0.000 description 1
- 102000029749 Microtubule Human genes 0.000 description 1
- 108091022875 Microtubule Proteins 0.000 description 1
- 244000294411 Mirabilis expansa Species 0.000 description 1
- 235000015429 Mirabilis expansa Nutrition 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000042430 Rhodiola rosea Species 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000007278 cognition impairment Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940000406 drug candidate Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000021107 fermented food Nutrition 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 210000002891 metencephalon Anatomy 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013536 miso Nutrition 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 235000013557 nattō Nutrition 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 235000012015 potatoes Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 235000021067 refined food Nutrition 0.000 description 1
- 235000012045 salad Nutrition 0.000 description 1
- 235000014102 seafood Nutrition 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 235000013555 soy sauce Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000000946 synaptic effect Effects 0.000 description 1
- 230000007617 synaptic impairment Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2020/016483 WO2020213616A1 (en) | 2019-04-15 | 2020-04-14 | A composition for prevention and/or treatment for alzheimer's disease and/or alzheimer dementia, and a composition for reducing amyloid-beta oligomer neurotoxicity |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019077107 | 2019-04-15 | ||
| JP2019077107 | 2019-04-15 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020176111A JP2020176111A (ja) | 2020-10-29 |
| JP2020176111A5 true JP2020176111A5 (enExample) | 2022-03-08 |
| JP7333626B2 JP7333626B2 (ja) | 2023-08-25 |
Family
ID=72936985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020068069A Active JP7333626B2 (ja) | 2019-04-15 | 2020-04-06 | アルツハイマー型認知症予防・治療用組成物、アミロイドβオリゴマー神経毒性低減用組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP7333626B2 (enExample) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003082259A1 (en) | 2002-04-03 | 2003-10-09 | Puleva Biotech, S.A. | Natural phenolic products and derivatives thereof for protection against neurodegenerative diseases |
-
2020
- 2020-04-06 JP JP2020068069A patent/JP7333626B2/ja active Active
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