JP2020141669A5 - - Google Patents
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- JP2020141669A5 JP2020141669A5 JP2020047903A JP2020047903A JP2020141669A5 JP 2020141669 A5 JP2020141669 A5 JP 2020141669A5 JP 2020047903 A JP2020047903 A JP 2020047903A JP 2020047903 A JP2020047903 A JP 2020047903A JP 2020141669 A5 JP2020141669 A5 JP 2020141669A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- tau
- antibody
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 24
- 102100040243 Microtubule-associated protein tau Human genes 0.000 claims 12
- 239000012634 fragment Substances 0.000 claims 9
- 239000003112 inhibitor Substances 0.000 claims 7
- 230000037396 body weight Effects 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- LZXHHNKULPHARO-UHFFFAOYSA-M (3,4-dichlorophenyl)methyl-triphenylphosphanium;chloride Chemical compound [Cl-].C1=C(Cl)C(Cl)=CC=C1C[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 LZXHHNKULPHARO-UHFFFAOYSA-M 0.000 claims 4
- SNKZJIOFVMKAOJ-UHFFFAOYSA-N 3-Amino-1-propanesulfonic acid Natural products NCCCS(O)(=O)=O SNKZJIOFVMKAOJ-UHFFFAOYSA-N 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 150000001413 amino acids Chemical group 0.000 claims 4
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims 4
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 230000006866 deterioration Effects 0.000 claims 3
- 238000011156 evaluation Methods 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 3
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 3
- -1 tramipro Cate Substances 0.000 claims 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 claims 2
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 claims 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 2
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 claims 2
- 230000006933 amyloid-beta aggregation Effects 0.000 claims 2
- 239000002738 chelating agent Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229960003530 donepezil Drugs 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 229960003980 galantamine Drugs 0.000 claims 2
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims 2
- 229950002508 gantenerumab Drugs 0.000 claims 2
- 239000002955 immunomodulating agent Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 claims 1
- 229940122578 Acetylcholine receptor agonist Drugs 0.000 claims 1
- 229940100578 Acetylcholinesterase inhibitor Drugs 0.000 claims 1
- 102100033367 Appetite-regulating hormone Human genes 0.000 claims 1
- 101710111255 Appetite-regulating hormone Proteins 0.000 claims 1
- 229940126077 BACE inhibitor Drugs 0.000 claims 1
- 102000009132 CB1 Cannabinoid Receptor Human genes 0.000 claims 1
- 108010073366 CB1 Cannabinoid Receptor Proteins 0.000 claims 1
- 229940123158 Cannabinoid CB1 receptor antagonist Drugs 0.000 claims 1
- 229940122502 Cholesterol absorption inhibitor Drugs 0.000 claims 1
- 230000033616 DNA repair Effects 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 1
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 1
- 101000854943 Enterobacteria phage T4 Valyl-tRNA ligase modifier Proteins 0.000 claims 1
- 229940122601 Esterase inhibitor Drugs 0.000 claims 1
- 108091007911 GSKs Proteins 0.000 claims 1
- 229940125373 Gamma-Secretase Inhibitor Drugs 0.000 claims 1
- 102000004103 Glycogen Synthase Kinases Human genes 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims 1
- 102000004895 Lipoproteins Human genes 0.000 claims 1
- 108090001030 Lipoproteins Proteins 0.000 claims 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 1
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 1
- 102000007072 Nerve Growth Factors Human genes 0.000 claims 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 claims 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims 1
- 208000034799 Tauopathies Diseases 0.000 claims 1
- 229930003427 Vitamin E Natural products 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims 1
- 230000002424 anti-apoptotic effect Effects 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 230000001621 anti-mitogenic effect Effects 0.000 claims 1
- 239000003524 antilipemic agent Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 235000006708 antioxidants Nutrition 0.000 claims 1
- 239000002439 beta secretase inhibitor Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 239000003555 cannabinoid 1 receptor antagonist Substances 0.000 claims 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960001231 choline Drugs 0.000 claims 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 1
- 230000019771 cognition Effects 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 239000002329 esterase inhibitor Substances 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 1
- 239000003540 gamma secretase inhibitor Substances 0.000 claims 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000003324 growth hormone secretagogue Substances 0.000 claims 1
- 239000003395 histamine H3 receptor antagonist Substances 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 229940125425 inverse agonist Drugs 0.000 claims 1
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 claims 1
- 229960004640 memantine Drugs 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000003149 muscarinic antagonist Substances 0.000 claims 1
- 239000002858 neurotransmitter agent Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000008055 phosphate buffer solution Substances 0.000 claims 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- MGNVWUDMMXZUDI-UHFFFAOYSA-N propane-1,3-disulfonic acid Chemical compound OS(=O)(=O)CCCS(O)(=O)=O MGNVWUDMMXZUDI-UHFFFAOYSA-N 0.000 claims 1
- 229940121649 protein inhibitor Drugs 0.000 claims 1
- 239000012268 protein inhibitor Substances 0.000 claims 1
- 108060006633 protein kinase Proteins 0.000 claims 1
- 229940044551 receptor antagonist Drugs 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 239000002469 receptor inverse agonist Substances 0.000 claims 1
- 230000009467 reduction Effects 0.000 claims 1
- 229960004136 rivastigmine Drugs 0.000 claims 1
- 229950007874 solanezumab Drugs 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 229960001685 tacrine Drugs 0.000 claims 1
- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 claims 1
- 229910052723 transition metal Inorganic materials 0.000 claims 1
- 150000003624 transition metals Chemical class 0.000 claims 1
- 235000019165 vitamin E Nutrition 0.000 claims 1
- 229940046009 vitamin E Drugs 0.000 claims 1
- 239000011709 vitamin E Substances 0.000 claims 1
- 229940124648 γ-Secretase Modulator Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021063583A JP2021119774A (ja) | 2014-11-19 | 2021-04-02 | アルツハイマー病におけるヒト化タウ抗体 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462081809P | 2014-11-19 | 2014-11-19 | |
| US62/081,809 | 2014-11-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017526550A Division JP6830061B2 (ja) | 2014-11-19 | 2015-11-18 | アルツハイマー病におけるヒト化タウ抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021063583A Division JP2021119774A (ja) | 2014-11-19 | 2021-04-02 | アルツハイマー病におけるヒト化タウ抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020141669A JP2020141669A (ja) | 2020-09-10 |
| JP2020141669A5 true JP2020141669A5 (enExample) | 2021-03-25 |
| JP6864763B2 JP6864763B2 (ja) | 2021-04-28 |
Family
ID=55411706
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017526550A Active JP6830061B2 (ja) | 2014-11-19 | 2015-11-18 | アルツハイマー病におけるヒト化タウ抗体 |
| JP2020047903A Active JP6864763B2 (ja) | 2014-11-19 | 2020-03-18 | アルツハイマー病におけるヒト化タウ抗体 |
| JP2021063583A Pending JP2021119774A (ja) | 2014-11-19 | 2021-04-02 | アルツハイマー病におけるヒト化タウ抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017526550A Active JP6830061B2 (ja) | 2014-11-19 | 2015-11-18 | アルツハイマー病におけるヒト化タウ抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021063583A Pending JP2021119774A (ja) | 2014-11-19 | 2021-04-02 | アルツハイマー病におけるヒト化タウ抗体 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US10160799B2 (enExample) |
| EP (2) | EP3221349B1 (enExample) |
| JP (3) | JP6830061B2 (enExample) |
| KR (1) | KR20170126855A (enExample) |
| CN (1) | CN107428820B (enExample) |
| AU (2) | AU2015348012B2 (enExample) |
| BR (1) | BR112017010498A2 (enExample) |
| CA (1) | CA2966964A1 (enExample) |
| CY (1) | CY1123746T1 (enExample) |
| DK (1) | DK3221349T3 (enExample) |
| ES (1) | ES2848376T3 (enExample) |
| HR (1) | HRP20210124T1 (enExample) |
| HU (1) | HUE053239T2 (enExample) |
| IL (2) | IL251921B (enExample) |
| LT (1) | LT3221349T (enExample) |
| MX (2) | MX388142B (enExample) |
| PL (1) | PL3221349T3 (enExample) |
| PT (1) | PT3221349T (enExample) |
| RS (1) | RS61431B1 (enExample) |
| RU (2) | RU2730668C2 (enExample) |
| SG (1) | SG11201703237VA (enExample) |
| SI (1) | SI3221349T1 (enExample) |
| SM (1) | SMT202100055T1 (enExample) |
| WO (1) | WO2016079597A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX375354B (es) | 2013-03-13 | 2025-03-06 | Prothena Biosciences Ltd | Anticuerpos que se unen a tau y usos de los mismos. |
| CN107106689A (zh) | 2014-11-05 | 2017-08-29 | 沃雅戈治疗公司 | 用于治疗帕金森病的aadc多核苷酸 |
| HRP20210124T1 (hr) * | 2014-11-19 | 2021-03-19 | Axon Neuroscience Se | Humanizirana tau antitijela u alzheimerovoj bolesti |
| CA3022515A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Antibodies recognizing tau |
| CA3022673A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Tau immunotherapy |
| EA201892412A1 (ru) * | 2016-05-02 | 2019-05-31 | Протена Биосайенсис Лимитед | Антитела, распознающие тау |
| SG11201907422RA (en) | 2017-02-17 | 2019-09-27 | Denali Therapeutics Inc | Anti-tau antibodies and methods of use thereof |
| KR20190133191A (ko) * | 2017-03-28 | 2019-12-02 | 얀센 백신스 앤드 프리벤션 비.브이. | 타우에 특이적으로 결합하는 결합 분자 |
| KR102784294B1 (ko) | 2017-05-02 | 2025-03-19 | 프로테나 바이오사이언시즈 리미티드 | 타우 인식 항체 |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| EP3658172A4 (en) | 2017-07-25 | 2021-05-05 | TrueBinding, Inc. | TREATING CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND HIS LIGAND |
| WO2019048017A1 (en) * | 2017-09-07 | 2019-03-14 | Danmarks Tekniske Universitet | METHODS FOR REMOVING NOX FROM A GAS STREAM CONTAINING MORE THAN ONE GAS COMPOUND |
| NZ762251A (en) | 2017-10-16 | 2025-12-19 | Eisai R&D Man Co Ltd | Anti-tau antibodies and uses thereof |
| AU2019215034C1 (en) | 2018-02-01 | 2022-01-06 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| WO2019161384A1 (en) * | 2018-02-19 | 2019-08-22 | New York University | Tau single domain antibodies |
| WO2019186276A2 (en) | 2018-03-28 | 2019-10-03 | Axon Neuroscience Se | Antibody-based methods of detecting and treating alzheimer's disease |
| CN112166117A (zh) * | 2018-05-03 | 2021-01-01 | 华盛顿大学 | 基于位点特异性tau磷酸化的诊断和治疗方法 |
| EP3794126A1 (en) | 2018-05-15 | 2021-03-24 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of parkinson's disease |
| AU2018446059A1 (en) * | 2018-10-17 | 2021-05-20 | The University Of Queensland | Methods and compositions for treating tauopathies |
| EP3877410A4 (en) * | 2018-11-08 | 2022-08-10 | Prothena Biosciences Limited | ANTIBODIES RECOGNIZING TAU PROTEIN |
| CN113711036B (zh) | 2019-01-30 | 2025-03-18 | 真和制药有限公司 | 抗gal3抗体及其用途 |
| CN119371527A (zh) | 2019-03-03 | 2025-01-28 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
| TWI877179B (zh) * | 2019-06-27 | 2025-03-21 | 德商百靈佳殷格翰國際股份有限公司 | 抗-angpt2抗體 |
| MX2022001817A (es) * | 2019-08-13 | 2022-03-11 | Washington University St Louis | Metodos para detectar isoformas de la region de union a microtubulos (mtbr) tau y uso de las mismas. |
| MX2022002852A (es) | 2019-09-09 | 2022-03-25 | Axon Neuroscience Se | Biomarcadores y tratamientos de la enfermedad de alzheimer y deterioro cognitivo leve. |
| CA3150369A1 (en) | 2019-09-10 | 2021-03-18 | Randall Bateman | Blood-based assay for diagnosing and treating based on site-specific tau phosphorylation |
| EP4073119A1 (en) * | 2019-12-12 | 2022-10-19 | Alector LLC | Methods of use of anti-cd33 antibodies |
| WO2021173962A1 (en) * | 2020-02-28 | 2021-09-02 | Genemo, Inc. | Methods and materials for diagnosis and treatment of neuronal disorder |
| CN116157151A (zh) | 2020-05-26 | 2023-05-23 | 真和制药有限公司 | 通过阻断半乳凝素-3治疗炎性疾病的方法 |
| MX2023003334A (es) * | 2020-09-22 | 2023-05-30 | Kathleen E Clarence Smith | Combinacion farmaceutica para el tratamiento de trastornos hipocolinergicos humanos. |
| CN114773466B (zh) * | 2020-11-26 | 2023-08-29 | 江苏荃信生物医药股份有限公司 | 一种抗人白介素23及包含其的试剂盒及其检测方法 |
| US20250034559A1 (en) | 2021-11-17 | 2025-01-30 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
| JP7847834B2 (ja) * | 2022-04-28 | 2026-04-20 | 国立大学法人鳥取大学 | 進行性核上性麻痺の診断マーカー |
| US20260048083A1 (en) * | 2022-08-10 | 2026-02-19 | Nkmax Co., Ltd. | Method of treating alzheimer's disease with expanded natural killer cells |
| CN120019071A (zh) | 2022-09-15 | 2025-05-16 | 沃雅戈治疗公司 | Tau结合化合物 |
| CA3237624A1 (en) * | 2023-07-28 | 2025-04-24 | Genentech, Inc. | NEW USES FOR OMALIZUMAB |
| WO2025122634A1 (en) | 2023-12-05 | 2025-06-12 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
| WO2026005695A1 (en) * | 2024-06-25 | 2026-01-02 | Islam Tohidul | Detection of oligomeric tau and soluble tau aggregates |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| HU196394B (en) | 1986-06-27 | 1988-11-28 | Richter Gedeon Vegyeszet | Process for preparing 2-halogenated ergoline derivatives |
| US4880935A (en) | 1986-07-11 | 1989-11-14 | Icrf (Patents) Limited | Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
| US5004697A (en) | 1987-08-17 | 1991-04-02 | Univ. Of Ca | Cationized antibodies for delivery through the blood-brain barrier |
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