JP2020138960A5 - - Google Patents
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- Publication number
- JP2020138960A5 JP2020138960A5 JP2020021119A JP2020021119A JP2020138960A5 JP 2020138960 A5 JP2020138960 A5 JP 2020138960A5 JP 2020021119 A JP2020021119 A JP 2020021119A JP 2020021119 A JP2020021119 A JP 2020021119A JP 2020138960 A5 JP2020138960 A5 JP 2020138960A5
- Authority
- JP
- Japan
- Prior art keywords
- crystal form
- form according
- group
- ppm
- difluorocyclopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013078 crystal Substances 0.000 claims 14
- -1 octane-8-yl Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 238000000634 powder X-ray diffraction Methods 0.000 claims 5
- 201000004384 Alopecia Diseases 0.000 claims 4
- 206010012438 Dermatitis atopic Diseases 0.000 claims 4
- 201000004681 Psoriasis Diseases 0.000 claims 4
- 231100000360 alopecia Toxicity 0.000 claims 4
- 201000008937 atopic dermatitis Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 claims 4
- 208000011231 Crohn disease Diseases 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- 238000005481 NMR spectroscopy Methods 0.000 claims 3
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 3
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 3
- 238000001069 Raman spectroscopy Methods 0.000 claims 3
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 239000012049 topical pharmaceutical composition Substances 0.000 claims 3
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 206010047642 Vitiligo Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000002741 leukoplakia Diseases 0.000 claims 2
- 206010025135 lupus erythematosus Diseases 0.000 claims 2
- 208000025865 Ulcer Diseases 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 229940012356 eye drops Drugs 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962806180P | 2019-02-15 | 2019-02-15 | |
| US62/806180 | 2019-02-15 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020138960A JP2020138960A (ja) | 2020-09-03 |
| JP2020138960A5 true JP2020138960A5 (enExample) | 2021-01-07 |
| JP7561497B2 JP7561497B2 (ja) | 2024-10-04 |
Family
ID=69726639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020021119A Active JP7561497B2 (ja) | 2019-02-15 | 2020-02-12 | 結晶性ピリミジニル－３，８－ジアザビシクロ［３．２．１］オクタニルメタノン化合物およびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US12312358B2 (enExample) |
| EP (1) | EP3924355B1 (enExample) |
| JP (1) | JP7561497B2 (enExample) |
| KR (2) | KR102820235B1 (enExample) |
| CN (1) | CN113646310A (enExample) |
| AR (1) | AR118099A1 (enExample) |
| AU (1) | AU2020222083B2 (enExample) |
| BR (1) | BR112021015951A2 (enExample) |
| CA (1) | CA3130034C (enExample) |
| MX (1) | MX2021009761A (enExample) |
| SG (1) | SG11202108863WA (enExample) |
| TW (1) | TWI820301B (enExample) |
| WO (1) | WO2020165788A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI820301B (zh) * | 2019-02-15 | 2023-11-01 | 美商輝瑞股份有限公司 | 結晶型嘧啶基－３，８－二氮雜雙環〔３．２．１〕辛烷基甲酮化合物及其用途 |
| WO2021249367A1 (zh) * | 2020-06-09 | 2021-12-16 | 苏州晶云药物科技股份有限公司 | 二氮杂双环类化合物的对甲苯磺酸盐新晶型及其制备方法 |
| CN114835717A (zh) * | 2021-02-01 | 2022-08-02 | 杭州领业医药科技有限公司 | Brepocitinib甲苯磺酸盐的晶型及其制备方法和用途 |
| CN113461687B (zh) * | 2021-08-10 | 2022-04-19 | 四川大学华西医院 | 2,8-氮杂-[4,5]十螺环酮衍生物及其制备方法和用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5023556A (en) | 1990-02-02 | 1991-06-11 | Conax Florida Corporation | Sensor circuit response to different fluid conductivities and having time delay feature |
| SI3290421T1 (sl) | 2013-02-22 | 2019-03-29 | Pfizer Inc. | Kombinacija derivatov pirolo (2,3-D)pirimidina z enim ali več dodatnimi sredstvi za zaviranje z janusom povezane kinaze (JAK) |
| NO2721710T3 (enExample) * | 2014-08-21 | 2018-03-31 | ||
| HUE067471T2 (hu) * | 2018-03-30 | 2024-10-28 | Incyte Corp | Gennyes verejtékmirigy-gyulladás kezelése jak inhibitorok alkalmazásával |
| TWI820301B (zh) * | 2019-02-15 | 2023-11-01 | 美商輝瑞股份有限公司 | 結晶型嘧啶基－３，８－二氮雜雙環〔３．２．１〕辛烷基甲酮化合物及其用途 |
-
2020
- 2020-02-12 TW TW109104358A patent/TWI820301B/zh active
- 2020-02-12 CN CN202080028910.4A patent/CN113646310A/zh active Pending
- 2020-02-12 AU AU2020222083A patent/AU2020222083B2/en active Active
- 2020-02-12 KR KR1020247024393A patent/KR102820235B1/ko active Active
- 2020-02-12 MX MX2021009761A patent/MX2021009761A/es unknown
- 2020-02-12 US US17/430,373 patent/US12312358B2/en active Active
- 2020-02-12 SG SG11202108863WA patent/SG11202108863WA/en unknown
- 2020-02-12 EP EP20708183.7A patent/EP3924355B1/en active Active
- 2020-02-12 WO PCT/IB2020/051128 patent/WO2020165788A1/en not_active Ceased
- 2020-02-12 CA CA3130034A patent/CA3130034C/en active Active
- 2020-02-12 BR BR112021015951-7A patent/BR112021015951A2/pt unknown
- 2020-02-12 JP JP2020021119A patent/JP7561497B2/ja active Active
- 2020-02-12 KR KR1020217025620A patent/KR20210114470A/ko not_active Abandoned
- 2020-02-14 AR ARP200100415A patent/AR118099A1/es unknown
-
2025
- 2025-04-25 US US19/189,349 patent/US20250282789A1/en active Pending
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