KR102820235B1 - 결정질 피리미디닐-3,8-다이아자바이사이클로[3.2.1]옥타닐메타논 화합물 및 이의 용도 - Google Patents

결정질 피리미디닐-3,8-다이아자바이사이클로[3.2.1]옥타닐메타논 화합물 및 이의 용도 Download PDF

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KR102820235B1
KR102820235B1 KR1020247024393A KR20247024393A KR102820235B1 KR 102820235 B1 KR102820235 B1 KR 102820235B1 KR 1020247024393 A KR1020247024393 A KR 1020247024393A KR 20247024393 A KR20247024393 A KR 20247024393A KR 102820235 B1 KR102820235 B1 KR 102820235B1
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diazabicyclo
methyl
difluorocyclopropyl
pyrazol
pyrimidin
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KR20240116855A (ko
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시아오징 양
아만다 패드리스 수라지에 사무엘
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화이자 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
KR1020247024393A 2019-02-15 2020-02-12 결정질 피리미디닐-3,8-다이아자바이사이클로[3.2.1]옥타닐메타논 화합물 및 이의 용도 Active KR102820235B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962806180P 2019-02-15 2019-02-15
US62/806,180 2019-02-15
PCT/IB2020/051128 WO2020165788A1 (en) 2019-02-15 2020-02-12 Crystalline pyrimidinyl-3,8-diazabicyclo[3.2.1]octanylmethanone compound and use thereof
KR1020217025620A KR20210114470A (ko) 2019-02-15 2020-02-12 결정질 피리미디닐-3,8-다이아자바이사이클로[3.2.1]옥타닐메타논 화합물 및 이의 용도

Related Parent Applications (1)

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KR1020217025620A Division KR20210114470A (ko) 2019-02-15 2020-02-12 결정질 피리미디닐-3,8-다이아자바이사이클로[3.2.1]옥타닐메타논 화합물 및 이의 용도

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KR20240116855A KR20240116855A (ko) 2024-07-30
KR102820235B1 true KR102820235B1 (ko) 2025-06-16

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KR1020247024393A Active KR102820235B1 (ko) 2019-02-15 2020-02-12 결정질 피리미디닐-3,8-다이아자바이사이클로[3.2.1]옥타닐메타논 화합물 및 이의 용도
KR1020217025620A Abandoned KR20210114470A (ko) 2019-02-15 2020-02-12 결정질 피리미디닐-3,8-다이아자바이사이클로[3.2.1]옥타닐메타논 화합물 및 이의 용도

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KR1020217025620A Abandoned KR20210114470A (ko) 2019-02-15 2020-02-12 결정질 피리미디닐-3,8-다이아자바이사이클로[3.2.1]옥타닐메타논 화합물 및 이의 용도

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US (2) US12312358B2 (enExample)
EP (1) EP3924355B1 (enExample)
JP (1) JP7561497B2 (enExample)
KR (2) KR102820235B1 (enExample)
CN (1) CN113646310A (enExample)
AR (1) AR118099A1 (enExample)
AU (1) AU2020222083B2 (enExample)
BR (1) BR112021015951A2 (enExample)
CA (1) CA3130034C (enExample)
MX (1) MX2021009761A (enExample)
SG (1) SG11202108863WA (enExample)
TW (1) TWI820301B (enExample)
WO (1) WO2020165788A1 (enExample)

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TWI820301B (zh) * 2019-02-15 2023-11-01 美商輝瑞股份有限公司 結晶型嘧啶基－３，８－二氮雜雙環〔３．２．１〕辛烷基甲酮化合物及其用途
WO2021249367A1 (zh) * 2020-06-09 2021-12-16 苏州晶云药物科技股份有限公司 二氮杂双环类化合物的对甲苯磺酸盐新晶型及其制备方法
CN114835717A (zh) * 2021-02-01 2022-08-02 杭州领业医药科技有限公司 Brepocitinib甲苯磺酸盐的晶型及其制备方法和用途
CN113461687B (zh) * 2021-08-10 2022-04-19 四川大学华西医院 2,8-氮杂-[4,5]十螺环酮衍生物及其制备方法和用途

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US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5023556A (en) 1990-02-02 1991-06-11 Conax Florida Corporation Sensor circuit response to different fluid conductivities and having time delay feature
SI3290421T1 (sl) 2013-02-22 2019-03-29 Pfizer Inc. Kombinacija derivatov pirolo (2,3-D)pirimidina z enim ali več dodatnimi sredstvi za zaviranje z janusom povezane kinaze (JAK)
NO2721710T3 (enExample) * 2014-08-21 2018-03-31
HUE067471T2 (hu) * 2018-03-30 2024-10-28 Incyte Corp Gennyes verejtékmirigy-gyulladás kezelése jak inhibitorok alkalmazásával
TWI820301B (zh) * 2019-02-15 2023-11-01 美商輝瑞股份有限公司 結晶型嘧啶基－３，８－二氮雜雙環〔３．２．１〕辛烷基甲酮化合物及其用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Andrew Fensome 등, Journal of Medicinal Chemistry, 2018, 제61권, 페이지 8597-8612(2018.08.16.)

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Publication number Publication date
JP7561497B2 (ja) 2024-10-04
CN113646310A (zh) 2021-11-12
TWI820301B (zh) 2023-11-01
TW202045511A (zh) 2020-12-16
US20220144846A1 (en) 2022-05-12
AU2020222083A1 (en) 2021-09-02
US12312358B2 (en) 2025-05-27
CA3130034A1 (en) 2020-08-20
WO2020165788A1 (en) 2020-08-20
EP3924355A1 (en) 2021-12-22
SG11202108863WA (en) 2021-09-29
AU2020222083B2 (en) 2022-11-17
CA3130034C (en) 2023-12-19
KR20240116855A (ko) 2024-07-30
KR20210114470A (ko) 2021-09-23
MX2021009761A (es) 2021-12-15
JP2020138960A (ja) 2020-09-03
US20250282789A1 (en) 2025-09-11
AR118099A1 (es) 2021-09-15
EP3924355B1 (en) 2025-12-31
BR112021015951A2 (pt) 2021-10-05

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