JP2020122012A5 - - Google Patents
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- JP2020122012A5 JP2020122012A5 JP2020082487A JP2020082487A JP2020122012A5 JP 2020122012 A5 JP2020122012 A5 JP 2020122012A5 JP 2020082487 A JP2020082487 A JP 2020082487A JP 2020082487 A JP2020082487 A JP 2020082487A JP 2020122012 A5 JP2020122012 A5 JP 2020122012A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- drug
- concentration
- benzodiazepine
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229940079593 drug Drugs 0.000 claims 44
- 239000003814 drug Substances 0.000 claims 44
- 238000000034 method Methods 0.000 claims 30
- 239000000611 antibody drug conjugate Substances 0.000 claims 28
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 28
- 229940049706 benzodiazepine Drugs 0.000 claims 24
- 239000000203 mixture Substances 0.000 claims 24
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims 21
- 239000000562 conjugate Substances 0.000 claims 6
- -1 benzodiazepine compound Chemical class 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 3
- JWDFQMWEFLOOED-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCSSC1=CC=CC=N1 JWDFQMWEFLOOED-UHFFFAOYSA-N 0.000 claims 2
- JSHOVKSMJRQOGY-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-(pyridin-2-yldisulfanyl)butanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCSSC1=CC=CC=N1 JSHOVKSMJRQOGY-UHFFFAOYSA-N 0.000 claims 2
- GTBCXYYVWHFQRS-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-(pyridin-2-yldisulfanyl)pentanoate Chemical compound C=1C=CC=NC=1SSC(C)CCC(=O)ON1C(=O)CCC1=O GTBCXYYVWHFQRS-UHFFFAOYSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- DOKWDOLZCMETIJ-ZAQUEYBZSA-N (12as)-9-[[3-[[(12as)-8-methoxy-6-oxo-11,12,12a,13-tetrahydroindolo[2,1-c][1,4]benzodiazepin-9-yl]oxymethyl]-5-[2-[2-(2-methoxyethoxy)ethoxy]ethyl-(2-methyl-2-sulfanylpropyl)amino]phenyl]methoxy]-8-methoxy-12a,13-dihydroindolo[2,1-c][1,4]benzodiazepin-6-o Chemical compound N1=C[C@@H]2CC3=CC=CC=C3N2C(=O)C(C=C2OC)=C1C=C2OCC1=CC(N(CC(C)(C)S)CCOCCOCCOC)=CC(COC=2C(=CC=3C(=O)N4C5=CC=CC=C5C[C@H]4CNC=3C=2)OC)=C1 DOKWDOLZCMETIJ-ZAQUEYBZSA-N 0.000 claims 1
- FUHCFUVCWLZEDQ-UHFFFAOYSA-N 1-(2,5-dioxopyrrolidin-1-yl)oxy-1-oxo-4-(pyridin-2-yldisulfanyl)butane-2-sulfonic acid Chemical compound O=C1CCC(=O)N1OC(=O)C(S(=O)(=O)O)CCSSC1=CC=CC=N1 FUHCFUVCWLZEDQ-UHFFFAOYSA-N 0.000 claims 1
- FYKCKCYYMXDNHZ-UHFFFAOYSA-N 2-sulfobutanoic acid Chemical compound CCC(C(O)=O)S(O)(=O)=O FYKCKCYYMXDNHZ-UHFFFAOYSA-N 0.000 claims 1
- 229940126161 DNA alkylating agent Drugs 0.000 claims 1
- 239000012624 DNA alkylating agent Substances 0.000 claims 1
- 230000000970 DNA cross-linking effect Effects 0.000 claims 1
- 239000012623 DNA damaging agent Substances 0.000 claims 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
- 229940122429 Tubulin inhibitor Drugs 0.000 claims 1
- 150000001557 benzodiazepines Chemical class 0.000 claims 1
- 230000022131 cell cycle Effects 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- CNHYKKNIIGEXAY-UHFFFAOYSA-N thiolan-2-imine Chemical group N=C1CCCS1 CNHYKKNIIGEXAY-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462044592P | 2014-09-02 | 2014-09-02 | |
| US62/044,592 | 2014-09-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017511615A Division JP2017526682A (ja) | 2014-09-02 | 2015-09-02 | 抗体薬物複合体組成物の製剤化方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020122719A Division JP2020172541A (ja) | 2014-09-02 | 2020-07-17 | 抗体薬物複合体組成物の製剤化方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020122012A JP2020122012A (ja) | 2020-08-13 |
| JP2020122012A5 true JP2020122012A5 (https=) | 2020-09-24 |
Family
ID=55401285
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017511615A Withdrawn JP2017526682A (ja) | 2014-09-02 | 2015-09-02 | 抗体薬物複合体組成物の製剤化方法 |
| JP2020082487A Pending JP2020122012A (ja) | 2014-09-02 | 2020-05-08 | 抗体薬物複合体組成物の製剤化方法 |
| JP2020122719A Withdrawn JP2020172541A (ja) | 2014-09-02 | 2020-07-17 | 抗体薬物複合体組成物の製剤化方法 |
| JP2022010024A Withdrawn JP2022050688A (ja) | 2014-09-02 | 2022-01-26 | 抗体薬物複合体組成物の製剤化方法 |
| JP2024058979A Active JP7789826B2 (ja) | 2014-09-02 | 2024-04-01 | 抗体薬物複合体組成物の製剤化方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017511615A Withdrawn JP2017526682A (ja) | 2014-09-02 | 2015-09-02 | 抗体薬物複合体組成物の製剤化方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020122719A Withdrawn JP2020172541A (ja) | 2014-09-02 | 2020-07-17 | 抗体薬物複合体組成物の製剤化方法 |
| JP2022010024A Withdrawn JP2022050688A (ja) | 2014-09-02 | 2022-01-26 | 抗体薬物複合体組成物の製剤化方法 |
| JP2024058979A Active JP7789826B2 (ja) | 2014-09-02 | 2024-04-01 | 抗体薬物複合体組成物の製剤化方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US20160058884A1 (https=) |
| EP (2) | EP3311846A1 (https=) |
| JP (5) | JP2017526682A (https=) |
| KR (2) | KR20240011258A (https=) |
| CN (3) | CN106999604B (https=) |
| AU (2) | AU2015311951B2 (https=) |
| CA (1) | CA2958882A1 (https=) |
| HK (1) | HK1254612A1 (https=) |
| IL (2) | IL250768B (https=) |
| MA (2) | MA40539A (https=) |
| RU (1) | RU2741470C9 (https=) |
| SG (1) | SG11201701328XA (https=) |
| WO (1) | WO2016036861A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL281714B2 (en) | 2011-04-01 | 2023-11-01 | Immunogen Inc | Methods for increasing the effectiveness of FOLR1 cancer therapy |
| AU2014312086B2 (en) | 2013-08-30 | 2020-03-12 | Immunogen, Inc. | Antibodies and assays for detection of folate receptor 1 |
| CN106999604B (zh) * | 2014-09-02 | 2021-08-03 | 伊缪诺金公司 | 用于配制抗体药物缀合物组合物的方法 |
| EP3769787A1 (en) * | 2015-06-29 | 2021-01-27 | ImmunoGen, Inc. | Conjugates of cysteine engineered antibodies |
| JP7074749B2 (ja) | 2016-06-07 | 2022-05-24 | ナノファーマシューティカルズ エルエルシー | αｖβ３インテグリン甲状腺アンタゴニストにコンジュゲートした非開裂性ポリマー |
| AU2017355402A1 (en) * | 2016-11-02 | 2019-05-30 | Health Research, Inc. | Combination treatment with antibody-drug conjugates and PARP inhibitors |
| TWI845890B (zh) | 2016-11-23 | 2024-06-21 | 美商伊繆諾金公司 | 苯二氮平衍生物之選擇性磺化 |
| MA51629A (fr) * | 2018-01-12 | 2020-11-18 | Immunogen Inc | Procédés de production, purification et formulation de conjugués anticorps-médicaments |
| US11351137B2 (en) | 2018-04-11 | 2022-06-07 | Nanopharmaceuticals Llc | Composition and method for dual targeting in treatment of neuroendocrine tumors |
| US10328043B1 (en) | 2018-04-11 | 2019-06-25 | Nanopharmaceuticals, Llc. | Composition and method for dual targeting in treatment of neuroendocrine tumors |
| US12109273B2 (en) | 2019-02-15 | 2024-10-08 | Wuxi Xdc Singapore Private Limited | Process for preparing antibody-drug conjugates with improved homogeneity |
| JP7232925B2 (ja) | 2019-02-15 | 2023-03-03 | ウーシー バイオロジクス アイルランド リミテッド | 改善された均一性を有する抗体薬物コンジュゲートの調製するプロセス |
| WO2020223221A1 (en) | 2019-04-29 | 2020-11-05 | Immunogen, Inc. | Biparatopic fr-alpha antibodies and immunoconjugates |
| WO2021055894A1 (en) * | 2019-09-19 | 2021-03-25 | Janssen Biotech, Inc. | Materials and methods for differential characterization of molecular conjugates and conjugation |
| US10961204B1 (en) | 2020-04-29 | 2021-03-30 | Nanopharmaceuticals Llc | Composition of scalable thyrointegrin antagonists with improved blood brain barrier penetration and retention into brain tumors |
| US11723888B2 (en) | 2021-12-09 | 2023-08-15 | Nanopharmaceuticals Llc | Polymer conjugated thyrointegrin antagonists |
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-
2015
- 2015-09-02 CN CN201580047269.8A patent/CN106999604B/zh active Active
- 2015-09-02 SG SG11201701328XA patent/SG11201701328XA/en unknown
- 2015-09-02 RU RU2017107873A patent/RU2741470C9/ru active
- 2015-09-02 WO PCT/US2015/048152 patent/WO2016036861A1/en not_active Ceased
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