JP2020096630A5 - - Google Patents
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- Publication number
- JP2020096630A5 JP2020096630A5 JP2020025935A JP2020025935A JP2020096630A5 JP 2020096630 A5 JP2020096630 A5 JP 2020096630A5 JP 2020025935 A JP2020025935 A JP 2020025935A JP 2020025935 A JP2020025935 A JP 2020025935A JP 2020096630 A5 JP2020096630 A5 JP 2020096630A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- cldn6
- recombinant nucleic
- cell
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000003859 Claudin-6 Human genes 0.000 claims description 38
- 108090000229 Claudin-6 Proteins 0.000 claims description 38
- 108020004707 nucleic acids Proteins 0.000 claims description 34
- 102000039446 nucleic acids Human genes 0.000 claims description 34
- 150000007523 nucleic acids Chemical class 0.000 claims description 34
- 108091007741 Chimeric antigen receptor T cells Proteins 0.000 claims description 30
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 24
- 210000004027 cell Anatomy 0.000 claims description 22
- 239000012634 fragment Substances 0.000 claims description 22
- 230000027455 binding Effects 0.000 claims description 21
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 11
- 230000005754 cellular signaling Effects 0.000 claims description 7
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 108060003951 Immunoglobulin Proteins 0.000 claims description 4
- 102000018358 immunoglobulin Human genes 0.000 claims description 4
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 3
- 230000028993 immune response Effects 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 238000010276 construction Methods 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 210000002472 endoplasmic reticulum Anatomy 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 230000037452 priming Effects 0.000 claims description 2
- 230000004936 stimulating effect Effects 0.000 claims description 2
- 230000002463 transducing effect Effects 0.000 claims description 2
- 239000013598 vector Substances 0.000 claims 13
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 241000710929 Alphavirus Species 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 108020005202 Viral DNA Proteins 0.000 claims 1
- 108020000999 Viral RNA Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 210000004507 artificial chromosome Anatomy 0.000 claims 1
- 239000013601 cosmid vector Substances 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000013600 plasmid vector Substances 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
- 102000006707 alpha-beta T-Cell Antigen Receptors Human genes 0.000 description 25
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 19
- 108010087408 alpha-beta T-Cell Antigen Receptors Proteins 0.000 description 19
- 108091008874 T cell receptors Proteins 0.000 description 16
- 108090000765 processed proteins & peptides Proteins 0.000 description 16
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 description 4
- 239000002773 nucleotide Substances 0.000 description 4
- 125000003729 nucleotide group Chemical group 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021190855A JP7451858B2 (ja) | 2014-04-01 | 2021-11-25 | クローディン６特異的免疫受容体およびｔ細胞エピトープ |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2014000868 | 2014-04-01 | ||
| EPPCT/EP2014/000868 | 2014-04-01 | ||
| EP2014072864 | 2014-10-24 | ||
| EPPCT/EP2014/072864 | 2014-10-24 | ||
| JP2017503063A JP6726656B2 (ja) | 2014-04-01 | 2015-03-30 | クローディン６特異的免疫受容体およびｔ細胞エピトープ |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017503063A Division JP6726656B2 (ja) | 2014-04-01 | 2015-03-30 | クローディン６特異的免疫受容体およびｔ細胞エピトープ |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021190855A Division JP7451858B2 (ja) | 2014-04-01 | 2021-11-25 | クローディン６特異的免疫受容体およびｔ細胞エピトープ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020096630A JP2020096630A (ja) | 2020-06-25 |
| JP2020096630A5 true JP2020096630A5 (https=) | 2020-08-06 |
| JP6985440B2 JP6985440B2 (ja) | 2021-12-22 |
Family
ID=52745896
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017503063A Active JP6726656B2 (ja) | 2014-04-01 | 2015-03-30 | クローディン６特異的免疫受容体およびｔ細胞エピトープ |
| JP2020025935A Active JP6985440B2 (ja) | 2014-04-01 | 2020-02-19 | クローディン６特異的免疫受容体およびｔ細胞エピトープ |
| JP2021190855A Active JP7451858B2 (ja) | 2014-04-01 | 2021-11-25 | クローディン６特異的免疫受容体およびｔ細胞エピトープ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017503063A Active JP6726656B2 (ja) | 2014-04-01 | 2015-03-30 | クローディン６特異的免疫受容体およびｔ細胞エピトープ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021190855A Active JP7451858B2 (ja) | 2014-04-01 | 2021-11-25 | クローディン６特異的免疫受容体およびｔ細胞エピトープ |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US10370423B2 (https=) |
| EP (3) | EP3708579B1 (https=) |
| JP (3) | JP6726656B2 (https=) |
| CN (3) | CN113150109A (https=) |
| AU (3) | AU2015239683B2 (https=) |
| CA (1) | CA2942459C (https=) |
| CY (1) | CY1121539T1 (https=) |
| DK (3) | DK3708579T3 (https=) |
| ES (3) | ES2784537T3 (https=) |
| FI (1) | FI3708579T3 (https=) |
| HR (2) | HRP20240926T1 (https=) |
| HU (3) | HUE050355T2 (https=) |
| LT (2) | LT3708579T (https=) |
| ME (1) | ME03407B (https=) |
| MX (1) | MX376026B (https=) |
| PL (3) | PL3514172T3 (https=) |
| PT (3) | PT3514172T (https=) |
| RS (2) | RS58627B2 (https=) |
| SI (3) | SI3126381T2 (https=) |
| SM (1) | SMT201900262T1 (https=) |
| WO (1) | WO2015150327A1 (https=) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ716587A (en) | 2009-11-11 | 2017-10-27 | Ganymed Pharmaceuticals Ag | Antibodies specific for claudin 6 (cldn6) |
| PL3489261T3 (pl) | 2012-08-24 | 2021-08-16 | The Regents Of The University Of California | Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu |
| PE20160870A1 (es) | 2013-11-06 | 2016-09-09 | Abbvie Stemcentrx Llc | Anticuerpos anti-claudina novedosos y metodos de uso |
| MA40921A (fr) * | 2014-11-05 | 2017-09-12 | Abbvie Stemcentrx Llc | Récepteurs antigéniques chimériques anti-cldn et procédés d'utilisation |
| CA2967778C (en) | 2014-11-14 | 2024-04-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-thyroglobulin t cell receptors |
| CN106146666B (zh) * | 2015-03-26 | 2019-09-06 | 科济生物医药（上海）有限公司 | 靶向cldn6的免疫效应细胞及其制备方法和应用 |
| WO2016180467A1 (en) * | 2015-05-11 | 2016-11-17 | Biontech Cell & Gene Therapies Gmbh | Enhancing the effect of car-engineered t cells by means of nucleic acid vaccination |
| WO2016180468A1 (en) | 2015-05-11 | 2016-11-17 | Biontech Cell & Gene Therapies Gmbh | Claudin-18.2-specific immunoreceptors and t cell epitopes |
| CN107995913B (zh) | 2015-05-18 | 2022-02-11 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
| EA201792573A1 (ru) | 2015-05-21 | 2018-04-30 | Харпун Терапьютикс, Инк. | Триспецифические связанные белки и способы их применения |
| GB201520568D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd | Peptides |
| GB201607534D0 (en) | 2016-04-29 | 2016-06-15 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201520550D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201602918D0 (en) | 2016-02-19 | 2016-04-06 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against NHL and other cancers |
| CN114028549A (zh) | 2016-02-19 | 2022-02-11 | 伊玛提克斯生物技术有限公司 | 用于nhl和其他癌症免疫治疗的新型肽和肽组合物 |
| SG10202012157QA (en) | 2016-06-07 | 2021-01-28 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Chimeric antigen receptor and car-t cells that bind bcma |
| IL299099B2 (en) | 2016-06-27 | 2025-07-01 | Univ California | Cancer treatment combinations |
| SG11201811431VA (en) | 2016-07-14 | 2019-01-30 | Genmab As | Multispecific antibodies against cd40 and cd137 |
| CA3036745A1 (en) * | 2016-10-07 | 2018-04-12 | TCR2 Therapeutics Inc. | Compositions and methods for t-cell receptors reprogramming using fusion proteins |
| CN110352068A (zh) | 2016-12-02 | 2019-10-18 | 南加利福尼亚大学 | 合成的免疫受体及其使用方法 |
| MX2019010972A (es) * | 2017-03-15 | 2019-12-02 | Hutchinson Fred Cancer Res | Receptores de linfocito t (tcr) específicos del antígeno asociado a melanoma 1 (mage-a1) de alta afinidad y usos de estos. |
| US20210122831A1 (en) * | 2017-03-27 | 2021-04-29 | Noile-Immune Biotech, Inc. | Chimeric antigen receptor |
| SG11202000198QA (en) | 2017-08-04 | 2020-02-27 | Genmab As | Binding agents binding to pd-l1 and cd137 and use thereof |
| IL273196B2 (en) * | 2017-09-18 | 2024-11-01 | Univ California | Claudin6 antibodies and methods of treating cancer |
| IL301637B2 (en) | 2017-09-29 | 2024-10-01 | Daiichi Sankyo Co Ltd | Antibody-pyrrolobenzodiazepine derivative conjugate |
| WO2020061482A1 (en) | 2018-09-21 | 2020-03-26 | Harpoon Therapeutics, Inc. | Egfr binding proteins and methods of use |
| US20210369842A1 (en) | 2018-11-06 | 2021-12-02 | Genmab A/S | Antibody formulation |
| KR20210102231A (ko) * | 2018-11-09 | 2021-08-19 | 프레드 헛친슨 켄서 리서치 센터 | 메소텔린에 특이적인 t 세포 수용체 및 면역요법에서의 그의 용도 |
| WO2020117952A2 (en) * | 2018-12-05 | 2020-06-11 | Genentech, Inc. | Diagnostic methods and compositions for cancer immunotherapy |
| HUE070174T2 (hu) * | 2019-02-08 | 2025-05-28 | Biontech Cell & Gene Therapies Gmbh | Kiméra antigénreceptorral módosított sejtek a CLDN6-ot expresszáló rákos megbetegedések kezelésére |
| JP2022522802A (ja) | 2019-03-01 | 2022-04-20 | グリットストーン バイオ， インコーポレイテッド | Ｔ細胞受容体の選択 |
| AU2020241896A1 (en) | 2019-03-20 | 2021-09-23 | The Regents Of The University Of California | Claudin-6 antibodies and drug conjugates |
| WO2021129927A1 (en) * | 2019-12-23 | 2021-07-01 | Biontech Cell & Gene Therapies Gmbh | Treatment with immune effector cells engineered to express an antigen receptor |
| IL294967A (en) | 2020-02-04 | 2022-09-01 | Genmab As | Antibodies for use in therapy |
| EP4243868A1 (en) | 2020-11-11 | 2023-09-20 | BioNTech SE | Monoclonal antibodies directed against programmed death-1 protein and their use in medicine |
| US20240216427A1 (en) * | 2020-12-30 | 2024-07-04 | St. Jude Children's Research Hospital, Inc. | Chimeric antigen receptors targeting splice variants of the extracellular matrix proteins tenascin c (tnc) and procollagen 11a1 (col11a1) |
| JP2024523438A (ja) | 2021-06-21 | 2024-06-28 | ジェンマブ エー／エス | Ｃｄ１３７結合物質とｐｄ－ｌ１結合物質の組合せ投薬レジメン |
| JP2024525758A (ja) | 2021-07-13 | 2024-07-12 | ビオンテック・ソシエタス・エウロパエア | がんのための併用療法におけるｃｄ４０およびｃｄ１３７に対する多重特異性結合剤 |
| CA3230426A1 (en) * | 2021-09-03 | 2023-03-09 | Novarock Biotherapeutics, Ltd. | Bispecific binding proteins that bind cd137 and a tumor associated antigen |
| US20250002600A1 (en) | 2021-10-06 | 2025-01-02 | Genmab A/S | Multispecific binding agents against pd-l1 and cd137 in combination therapy |
| EP4412714A1 (en) | 2021-10-06 | 2024-08-14 | Genmab A/S | Multispecific binding agents against pd-l1 and cd137 in combination with anti pd-1 antibodies for treating cancers |
| US20250057881A1 (en) * | 2021-10-14 | 2025-02-20 | Roswell Park Cancer Institute Corporation | Compositions and methods for use of recombinant t cell receptors against claudin 6 |
| TW202413412A (zh) | 2022-05-12 | 2024-04-01 | 丹麥商珍美寶股份有限公司 | 在組合療法中能夠結合到ｃｄ２７之結合劑 |
| US11932693B2 (en) | 2022-05-12 | 2024-03-19 | BioNTech SE | Monoclonal antibodies directed against programmed death-1 protein and their use in medicine |
| WO2023218051A1 (en) | 2022-05-12 | 2023-11-16 | Genmab A/S | Binding agents capable of binding to cd27 in combination therapy |
| CN115232207B (zh) * | 2022-05-19 | 2023-06-13 | 河南大学 | 抗体-溶菌素（SM-ScFv-Fc-Ly）在治疗变形链球菌感染中的应用 |
| WO2024165057A1 (en) * | 2023-02-07 | 2024-08-15 | LaNova Medicines Limited | Antibodies and antibody-drug conjugates targeting claudin 6 |
| CN121620391A (zh) | 2023-04-06 | 2026-03-06 | 金麦安博股份有限公司 | 用于治疗癌症的针对pd-l1和cd137的多特异性结合剂 |
| US12403202B2 (en) | 2023-05-25 | 2025-09-02 | The Regents Of The University Of California | Dosage of claudin-6 conjugates for cancer treatment |
| TW202540189A (zh) | 2023-11-30 | 2025-10-16 | 德商生物新技術公司 | 在組合療法中能夠結合ｏｘ４０之抗體 |
| WO2025184170A1 (en) | 2024-02-27 | 2025-09-04 | Overt Bio, Inc. | Methods and compositions for improving t cell function in an immunosuppressive environment |
| CN118812714B (zh) * | 2024-08-21 | 2025-05-27 | 广州百吉生物制药有限公司 | 一种紧密连接蛋白抗体b3及其应用 |
| CN119320451B (zh) * | 2024-08-21 | 2025-05-16 | 百吉生物医药(广州)股份有限公司 | 一种紧密连接蛋白抗体d03及其应用 |
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| US5677139A (en) | 1995-04-21 | 1997-10-14 | President And Fellows Of Harvard College | In vitro differentiation of CD34+ progenitor cells into T lymphocytes |
| JP2002515734A (ja) | 1996-01-02 | 2002-05-28 | カイロン コーポレイション | 遺伝子改変された樹状細胞により媒介される免疫刺激 |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7435596B2 (en) * | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
| CN101316610A (zh) * | 2005-09-22 | 2008-12-03 | 艾润·R·科恩 | T细胞受体恒定区的免疫原性片段及其衍生的肽 |
| JP5632582B2 (ja) | 2006-12-14 | 2014-11-26 | 中外製薬株式会社 | 抗Ｃｌａｕｄｉｎ３モノクローナル抗体およびそれを用いる癌の治療および診断 |
| WO2008114733A1 (ja) * | 2007-03-16 | 2008-09-25 | Kyowa Hakko Kirin Co., Ltd. | 抗Claudin-4抗体 |
| CN101918450A (zh) * | 2008-01-11 | 2010-12-15 | 国立大学法人东京大学 | 抗cldn6抗体 |
| LT2398902T (lt) * | 2009-02-20 | 2023-12-27 | Astellas Pharma Inc. | Vėžio diagnostikos ir gydymo būdai bei kompozicijos |
| EP2322555A1 (en) * | 2009-11-11 | 2011-05-18 | Ganymed Pharmaceuticals AG | Antibodies specific for claudin 6 (CLDN6) |
| NZ716587A (en) * | 2009-11-11 | 2017-10-27 | Ganymed Pharmaceuticals Ag | Antibodies specific for claudin 6 (cldn6) |
| EP2547695B1 (en) * | 2010-03-16 | 2018-05-09 | Biontech Protein Therapeutics GmbH | Tumor vaccination involving a humoral immune response against self-protein cldn18.2 |
| EP2558575B1 (en) * | 2010-04-13 | 2015-12-16 | Sigma-Aldrich Co. LLC | Methods for generating endogenously tagged protein |
| EP2404936A1 (en) | 2010-07-06 | 2012-01-11 | Ganymed Pharmaceuticals AG | Cancer therapy using CLDN6 target-directed antibodies in vivo |
| ES2754394T3 (es) * | 2010-09-08 | 2020-04-17 | Chemotherapeutisches Forschungsinstitut Georg Speyer Haus | Receptores de antígenos quiméricos con una región bisagra optimizada |
| FR2970083B1 (fr) | 2011-01-05 | 2013-02-15 | Leosphere | Procede et dispositif de determination des mouvements d'un fluide a partir de mesures a distance de vitesses radiales. |
| US9321842B2 (en) * | 2011-05-13 | 2016-04-26 | Ganymed Pharmaceuticals Ag | Antibodies for treatment of cancer |
| WO2013126712A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer |
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2015
- 2015-03-30 SI SI201530629T patent/SI3126381T2/sl unknown
- 2015-03-30 PT PT191512383T patent/PT3514172T/pt unknown
- 2015-03-30 AU AU2015239683A patent/AU2015239683B2/en active Active
- 2015-03-30 RS RS20190361A patent/RS58627B2/sr unknown
- 2015-03-30 CA CA2942459A patent/CA2942459C/en active Active
- 2015-03-30 WO PCT/EP2015/056899 patent/WO2015150327A1/en not_active Ceased
- 2015-03-30 DK DK20160141.6T patent/DK3708579T3/da active
- 2015-03-30 RS RS20240864A patent/RS65784B1/sr unknown
- 2015-03-30 CN CN202110278993.9A patent/CN113150109A/zh active Pending
- 2015-03-30 PL PL19151238T patent/PL3514172T3/pl unknown
- 2015-03-30 SI SI201531143T patent/SI3514172T1/sl unknown
- 2015-03-30 LT LTEP20160141.6T patent/LT3708579T/lt unknown
- 2015-03-30 PT PT15712657T patent/PT3126381T/pt unknown
- 2015-03-30 PL PL20160141.6T patent/PL3708579T3/pl unknown
- 2015-03-30 DK DK19151238.3T patent/DK3514172T3/da active
- 2015-03-30 ME MEP-2019-67A patent/ME03407B/me unknown
- 2015-03-30 CN CN202110279207.7A patent/CN113150110A/zh active Pending
- 2015-03-30 EP EP20160141.6A patent/EP3708579B1/en active Active
- 2015-03-30 CN CN201580017607.3A patent/CN106459165B/zh active Active
- 2015-03-30 ES ES19151238T patent/ES2784537T3/es active Active
- 2015-03-30 HU HUE19151238A patent/HUE050355T2/hu unknown
- 2015-03-30 ES ES20160141T patent/ES2982838T3/es active Active
- 2015-03-30 PT PT201601416T patent/PT3708579T/pt unknown
- 2015-03-30 HR HRP20240926TT patent/HRP20240926T1/hr unknown
- 2015-03-30 HR HRP20190472TT patent/HRP20190472T4/hr unknown
- 2015-03-30 FI FIEP20160141.6T patent/FI3708579T3/fi active
- 2015-03-30 MX MX2016012713A patent/MX376026B/es active IP Right Grant
- 2015-03-30 SI SI201532019T patent/SI3708579T1/sl unknown
- 2015-03-30 LT LTEP15712657.4T patent/LT3126381T/lt unknown
- 2015-03-30 HU HUE20160141A patent/HUE067504T2/hu unknown
- 2015-03-30 ES ES15712657T patent/ES2717530T5/es active Active
- 2015-03-30 DK DK15712657.4T patent/DK3126381T4/da active
- 2015-03-30 SM SM20190262T patent/SMT201900262T1/it unknown
- 2015-03-30 EP EP19151238.3A patent/EP3514172B1/en active Active
- 2015-03-30 JP JP2017503063A patent/JP6726656B2/ja active Active
- 2015-03-30 EP EP15712657.4A patent/EP3126381B2/en active Active
- 2015-03-30 HU HUE15712657 patent/HUE044515T2/hu unknown
- 2015-03-30 US US15/124,640 patent/US10370423B2/en active Active - Reinstated
- 2015-03-30 PL PL15712657T patent/PL3126381T5/pl unknown
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2019
- 2019-04-02 CY CY20191100366T patent/CY1121539T1/el unknown
- 2019-06-18 US US16/444,510 patent/US11345731B2/en active Active
- 2019-07-31 AU AU2019210582A patent/AU2019210582B2/en active Active
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