JP2020073504A5 - - Google Patents
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- JP2020073504A5 JP2020073504A5 JP2019229640A JP2019229640A JP2020073504A5 JP 2020073504 A5 JP2020073504 A5 JP 2020073504A5 JP 2019229640 A JP2019229640 A JP 2019229640A JP 2019229640 A JP2019229640 A JP 2019229640A JP 2020073504 A5 JP2020073504 A5 JP 2020073504A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- antibody
- seq
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022019186A JP7492981B2 (ja) | 2013-08-01 | 2022-02-10 | 抗ｇａｒｐタンパク質及びその使用 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361861008P | 2013-08-01 | 2013-08-01 | |
| US61/861,008 | 2013-08-01 | ||
| EP13178958.8 | 2013-08-01 | ||
| EP13178958.8A EP2832747A1 (en) | 2013-08-01 | 2013-08-01 | Anti-GARP protein and uses thereof |
| EP14167425 | 2014-05-07 | ||
| EP14167425.9 | 2014-05-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016530550A Division JP2016529892A (ja) | 2013-08-01 | 2014-08-01 | 抗ｇａｒｐタンパク質及びその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022019186A Division JP7492981B2 (ja) | 2013-08-01 | 2022-02-10 | 抗ｇａｒｐタンパク質及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020073504A JP2020073504A (ja) | 2020-05-14 |
| JP2020073504A5 true JP2020073504A5 (enExample) | 2020-10-01 |
Family
ID=52431038
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016530550A Withdrawn JP2016529892A (ja) | 2013-08-01 | 2014-08-01 | 抗ｇａｒｐタンパク質及びその使用 |
| JP2019229640A Pending JP2020073504A (ja) | 2013-08-01 | 2019-12-19 | 抗ｇａｒｐタンパク質及びその使用 |
| JP2022019186A Active JP7492981B2 (ja) | 2013-08-01 | 2022-02-10 | 抗ｇａｒｐタンパク質及びその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016530550A Withdrawn JP2016529892A (ja) | 2013-08-01 | 2014-08-01 | 抗ｇａｒｐタンパク質及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022019186A Active JP7492981B2 (ja) | 2013-08-01 | 2022-02-10 | 抗ｇａｒｐタンパク質及びその使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US10000572B2 (enExample) |
| EP (2) | EP3786187A1 (enExample) |
| JP (3) | JP2016529892A (enExample) |
| KR (2) | KR102362609B1 (enExample) |
| CN (2) | CN113583128A (enExample) |
| AU (3) | AU2014298373B2 (enExample) |
| BR (1) | BR112016002199B8 (enExample) |
| CA (1) | CA2919765C (enExample) |
| EA (1) | EA035550B1 (enExample) |
| ES (1) | ES2860952T3 (enExample) |
| IL (2) | IL243899B (enExample) |
| MX (2) | MX377091B (enExample) |
| NZ (1) | NZ717476A (enExample) |
| SG (2) | SG11201600741SA (enExample) |
| WO (1) | WO2015015003A1 (enExample) |
| ZA (1) | ZA201601085B (enExample) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20201914T1 (hr) | 2013-05-06 | 2021-01-22 | Scholar Rock, Inc. | Sastavi i postupci za modulaciju faktora rasta |
| AU2014298373B2 (en) | 2013-08-01 | 2019-12-05 | Ludwig Institute For Cancer Research Ltd | Anti-GARP protein and uses thereof |
| WO2016125017A1 (en) * | 2015-02-03 | 2016-08-11 | Universite Catholique De Louvain | Anti-garp protein and uses thereof |
| EP3297672B1 (en) | 2015-05-21 | 2021-09-01 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| EP3326624A1 (en) * | 2015-07-22 | 2018-05-30 | Hospital Sant Joan de Deu | Immunotherapy for casr-expressing cancer (e.g. neuroblastoma) |
| CN110922481A (zh) | 2015-09-24 | 2020-03-27 | 第一三共株式会社 | 抗garp抗体 |
| KR102803158B1 (ko) * | 2015-12-02 | 2025-05-08 | 주식회사 에스티큐브앤컴퍼니 | Btn1a1에 면역특이적으로 결합하는 항체와 분자 및 그의 치료 용도 |
| ES2951648T3 (es) | 2016-03-11 | 2023-10-24 | Scholar Rock Inc | Inmunoglobulinas de unión a Tgfbeta1 y uso de las mismas |
| WO2017173091A1 (en) * | 2016-03-30 | 2017-10-05 | Musc Foundation For Research Development | Methods for treatment and diagnosis of cancer by targeting glycoprotein a repetitions predominant (garp) and for providing effective immunotherapy alone or in combination |
| KR102530742B1 (ko) | 2016-05-20 | 2023-05-09 | 하푼 테라퓨틱스, 인크. | 단일 도메인 혈청 알부민 결합 단백질 |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| KR102379464B1 (ko) | 2016-06-20 | 2022-03-29 | 키맵 리미티드 | 항-pd-l1 항체 |
| EP3484499A4 (en) * | 2016-07-14 | 2020-05-13 | Scholar Rock, Inc. | TGFB ANTIBODIES, METHODS AND USE |
| WO2018132427A1 (en) | 2017-01-10 | 2018-07-19 | The General Hospital Corporation | Targeted t cells with cytotoxicity toward immunosuppressive cells |
| EP4759318A2 (en) * | 2017-04-14 | 2026-06-17 | The General Hospital Corporation | Chimeric antigen receptor t cells targeting the tumor microenvironment |
| GB201707561D0 (en) | 2017-05-11 | 2017-06-28 | Argenx Bvba | GARP-TGF-beta antibodies |
| SG10202107880XA (en) | 2017-05-12 | 2021-09-29 | Harpoon Therapeutics Inc | Mesothelin binding proteins |
| CA3078969A1 (en) | 2017-10-13 | 2019-04-18 | Harpoon Therapeutics, Inc. | Trispecific proteins and methods of use |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| MX2020006213A (es) | 2017-12-12 | 2020-09-14 | Pionyr Immunotherapeutics Inc | Anticuerpos anti-trem2 y metodos relacionados. |
| ES3068176T3 (en) * | 2018-02-12 | 2026-05-28 | Massachusetts Gen Hospital | Chimeric antigen receptor t cells targeting the tumor microenvironment |
| CN113164570B (zh) | 2018-08-08 | 2024-05-14 | 蜻蜓疗法股份有限公司 | 结合nkg2d、cd16和肿瘤相关抗原的蛋白质 |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| CN119306844A (zh) | 2018-09-25 | 2025-01-14 | 哈普恩治疗公司 | Dll3结合蛋白及使用方法 |
| KR102648762B1 (ko) * | 2018-10-16 | 2024-03-19 | 주식회사 뉴라클사이언스 | 항-fam19a5 항체의 용도 |
| WO2020136566A1 (en) | 2018-12-24 | 2020-07-02 | Sanofi | Multispecific binding proteins with mutant fab domains |
| WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
| AR119594A1 (es) | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
| CN114630679A (zh) | 2019-10-25 | 2022-06-14 | 第一三共株式会社 | 抗garp抗体和免疫调节剂的组合 |
| CN114728168B (zh) | 2019-11-15 | 2024-04-09 | 吉利德科学公司 | 三唑氨基甲酸酯吡啶基磺酰胺作为lpa受体拮抗剂及其用途 |
| CA3166328A1 (en) | 2020-01-11 | 2021-07-15 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| JP7511377B2 (ja) * | 2020-04-16 | 2024-07-05 | デンカ株式会社 | アデノウイルスの免疫測定方法及び免疫測定器具 |
| US20230192867A1 (en) | 2020-05-15 | 2023-06-22 | Bristol-Myers Squibb Company | Antibodies to garp |
| TWI843503B (zh) | 2020-06-03 | 2024-05-21 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
| US11702407B2 (en) | 2020-06-03 | 2023-07-18 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
| CN116234568A (zh) | 2020-07-07 | 2023-06-06 | 生物技术公司 | 用于hpv阳性癌症的治疗性rna |
| CN116723861A (zh) * | 2020-12-02 | 2023-09-08 | 上海复宏汉霖生物技术股份有限公司 | 抗GARP/TGFβ抗体及使用方法 |
| WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
| TW202245808A (zh) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | 用於治療癌症之治療性ｒｎａ |
| WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
| KR20230169936A (ko) * | 2021-01-18 | 2023-12-18 | 상하이 제민케어 파마슈티칼 컴퍼니 리미티드 | Garp 단백질 항체 및 이의 적용 |
| WO2022204581A2 (en) | 2021-03-26 | 2022-09-29 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| AU2022273631B2 (en) | 2021-05-11 | 2025-04-17 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
| KR20240007233A (ko) | 2021-05-13 | 2024-01-16 | 길리애드 사이언시즈, 인코포레이티드 | Lpa 수용체 길항제 및 이의 용도 |
| EP4348260A2 (en) | 2021-06-03 | 2024-04-10 | Scholar Rock, Inc. | Tgf-beta inhibitors and therapeutic use thereof |
| WO2023285552A1 (en) | 2021-07-13 | 2023-01-19 | BioNTech SE | Multispecific binding agents against cd40 and cd137 in combination therapy for cancer |
| US20240425571A1 (en) * | 2021-10-11 | 2024-12-26 | Ohio State Innovation Foundation | Glycoprotein a repetitions predominant (garp)-binding antibodies and uses thereof |
| TW202333802A (zh) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | 用於肺癌之治療性rna(二) |
| US11939318B2 (en) | 2021-12-08 | 2024-03-26 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
| US20240124412A1 (en) | 2021-12-22 | 2024-04-18 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| CN118488948A (zh) | 2021-12-22 | 2024-08-13 | 吉利德科学公司 | Ikaros锌指家族降解剂及其用途 |
| GB202203269D0 (en) | 2022-03-09 | 2022-04-20 | Argenx Iip Bv | TGF-Beta antibodies |
| PL4245756T3 (pl) | 2022-03-17 | 2025-02-17 | Gilead Sciences, Inc. | Środki degradujące palec cynkowy z rodziny ikaros i ich zastosowania |
| US20260029402A1 (en) | 2022-07-22 | 2026-01-29 | Institut National de la Santé et de la Recherche Médicale | Garp as a biomarker and biotarget in t-cell malignancies |
| US20240042020A1 (en) | 2022-07-29 | 2024-02-08 | Abbvie Biotherapeutics Inc. | Anti-garp-tgf-beta1/pd-1 combination therapy |
| JP2026501506A (ja) | 2022-12-14 | 2026-01-16 | アステラス・ファーマ・ヨーロッパ・ベスローデン・フェンノートシャップ | Ｃｌｄｎ１８．２及びｃｄ３に結合する二重特異性結合剤並びに免疫チェックポイント阻害剤を含む併用療法 |
| EP4638436A1 (en) | 2022-12-22 | 2025-10-29 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| EP4676954A1 (en) | 2023-03-07 | 2026-01-14 | Scholar Rock, Inc. | Tgf-beta inhibitors for use for treating resistant or unresponsive cancer in patients |
| PE20260121A1 (es) | 2023-04-21 | 2026-01-16 | Gilead Sciences Inc | Inhibidores de prmt5 y usos de los mismos |
| JP2026520908A (ja) * | 2023-06-05 | 2026-06-25 | ピュア バイオロジクス スプウカ アクツィイナ | 抗ｇａｒｐ抗体及び使用方法 |
| WO2025096589A1 (en) | 2023-11-03 | 2025-05-08 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| AR134560A1 (es) | 2023-12-08 | 2026-01-28 | Astellas Pharma Inc | Terapia de combinación que implica agentes de unión biespecíficos que se unen a cldn18.2 y cd3 y agentes que estabilizan o aumentan la expresión de cldn18.2 |
| WO2026033885A1 (en) | 2024-08-08 | 2026-02-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| WO2025120866A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| WO2025120867A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and anti-vegfr2 antibodies |
| US20250230168A1 (en) | 2023-12-22 | 2025-07-17 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2025240343A1 (en) | 2024-05-13 | 2025-11-20 | Scholar Rock, Inc. | Tgf-beta inhibitors for treating cancer |
| WO2025245003A1 (en) | 2024-05-21 | 2025-11-27 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| US20260130893A1 (en) | 2024-10-21 | 2026-05-14 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| DE69233528T2 (de) | 1991-11-25 | 2006-03-16 | Enzon, Inc. | Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen |
| NZ298145A (en) * | 1994-12-29 | 1998-08-26 | Yamanouchi Pharma Co Ltd | Monoclonal antibodies having inhibitory effect on type ii phospholipase a2, proteins forming part thereof, cells producing them, dna encoding them, recombinant vector comprising the dna and medicament |
| CN1333274A (zh) * | 2000-07-07 | 2002-01-30 | 上海博德基因开发有限公司 | 一种新的多肽——人garp蛋白12.98和编码这种多肽的多核苷酸 |
| US7709610B2 (en) * | 2003-05-08 | 2010-05-04 | Facet Biotech Corporation | Therapeutic use of anti-CS1 antibodies |
| US20070048785A1 (en) * | 2004-06-09 | 2007-03-01 | Lin Laura L | Anti-IL-13 antibodies and complexes |
| WO2006103639A2 (en) | 2005-03-31 | 2006-10-05 | Case Western Reserve University | Methods and reagents for identifying/isolating t regulatory (treg) cells and for treating individuals |
| WO2007113301A1 (en) | 2006-04-03 | 2007-10-11 | Medizinische Hochschule Hannover | Pharmaceuticals for influencing the reaction of the human immune system |
| US20100291677A1 (en) * | 2007-08-24 | 2010-11-18 | Keio University | Reducer of immunosuppression by tumor cell and antitumor agent using the same |
| AU2008317331B2 (en) * | 2007-10-25 | 2013-08-29 | The Scripps Research Institute | Antibody-mediated disruption of quorum sensing in bacteria |
| WO2009073163A1 (en) * | 2007-12-03 | 2009-06-11 | American Type Culture Collection (Atcc) | Avian influenza antibodies, compositions, and methods thereof |
| EP3153526B1 (en) * | 2008-01-31 | 2020-09-23 | INSERM - Institut National de la Santé et de la Recherche Médicale | Antibodies against human cd39 and use thereof for inhibiting t regulatory cells activity |
| GB2461546B (en) * | 2008-07-02 | 2010-07-07 | Argen X Bv | Antigen binding polypeptides |
| WO2010022341A1 (en) | 2008-08-21 | 2010-02-25 | The United State Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of enriching and using regulatory t cells |
| AU2013310924B2 (en) | 2012-08-31 | 2017-08-03 | Argenx Bvba | Method for producing antibody molecules having inter-species, intra-target cross-reactivity |
| HRP20201914T1 (hr) | 2013-05-06 | 2021-01-22 | Scholar Rock, Inc. | Sastavi i postupci za modulaciju faktora rasta |
| EP2832747A1 (en) | 2013-08-01 | 2015-02-04 | Université Catholique de Louvain | Anti-GARP protein and uses thereof |
| AU2014298373B2 (en) * | 2013-08-01 | 2019-12-05 | Ludwig Institute For Cancer Research Ltd | Anti-GARP protein and uses thereof |
| WO2016125017A1 (en) | 2015-02-03 | 2016-08-11 | Universite Catholique De Louvain | Anti-garp protein and uses thereof |
| CN110922481A (zh) | 2015-09-24 | 2020-03-27 | 第一三共株式会社 | 抗garp抗体 |
| EP3484499A4 (en) | 2016-07-14 | 2020-05-13 | Scholar Rock, Inc. | TGFB ANTIBODIES, METHODS AND USE |
-
2014
- 2014-08-01 AU AU2014298373A patent/AU2014298373B2/en active Active
- 2014-08-01 EP EP20201515.2A patent/EP3786187A1/en not_active Withdrawn
- 2014-08-01 ES ES14748185T patent/ES2860952T3/es active Active
- 2014-08-01 JP JP2016530550A patent/JP2016529892A/ja not_active Withdrawn
- 2014-08-01 US US14/908,368 patent/US10000572B2/en active Active
- 2014-08-01 EA EA201690314A patent/EA035550B1/ru not_active IP Right Cessation
- 2014-08-01 CA CA2919765A patent/CA2919765C/en active Active
- 2014-08-01 BR BR112016002199A patent/BR112016002199B8/pt active IP Right Grant
- 2014-08-01 NZ NZ717476A patent/NZ717476A/en unknown
- 2014-08-01 KR KR1020167005677A patent/KR102362609B1/ko active Active
- 2014-08-01 MX MX2016001356A patent/MX377091B/es active IP Right Grant
- 2014-08-01 SG SG11201600741SA patent/SG11201600741SA/en unknown
- 2014-08-01 WO PCT/EP2014/066650 patent/WO2015015003A1/en not_active Ceased
- 2014-08-01 CN CN202110765205.9A patent/CN113583128A/zh active Pending
- 2014-08-01 CN CN201480043607.6A patent/CN105658666B/zh active Active
- 2014-08-01 KR KR1020227004383A patent/KR20220025174A/ko not_active Ceased
- 2014-08-01 SG SG10201800889SA patent/SG10201800889SA/en unknown
- 2014-08-01 EP EP14748185.7A patent/EP3027650B1/en active Active
-
2016
- 2016-01-29 MX MX2019011952A patent/MX2019011952A/es unknown
- 2016-02-01 IL IL243899A patent/IL243899B/en active IP Right Grant
- 2016-02-02 US US15/013,706 patent/US20160251438A1/en not_active Abandoned
- 2016-02-17 ZA ZA2016/01085A patent/ZA201601085B/en unknown
-
2018
- 2018-05-09 US US15/975,493 patent/US10604579B2/en active Active
-
2019
- 2019-03-29 US US16/370,822 patent/US10822424B2/en active Active
- 2019-11-18 AU AU2019268046A patent/AU2019268046A1/en not_active Abandoned
- 2019-12-19 JP JP2019229640A patent/JP2020073504A/ja active Pending
-
2020
- 2020-02-14 US US16/791,937 patent/US11230603B2/en active Active
- 2020-07-16 IL IL276106A patent/IL276106A/en unknown
-
2021
- 2021-12-03 AU AU2021277761A patent/AU2021277761A1/en not_active Abandoned
-
2022
- 2022-02-10 JP JP2022019186A patent/JP7492981B2/ja active Active
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