JP2019536860A5 - - Google Patents
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- JP2019536860A5 JP2019536860A5 JP2019524042A JP2019524042A JP2019536860A5 JP 2019536860 A5 JP2019536860 A5 JP 2019536860A5 JP 2019524042 A JP2019524042 A JP 2019524042A JP 2019524042 A JP2019524042 A JP 2019524042A JP 2019536860 A5 JP2019536860 A5 JP 2019536860A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heteroalkyl
- amino
- substituted
- amide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000000217 alkyl group Chemical group 0.000 claims description 66
- 150000003839 salts Chemical class 0.000 claims description 50
- 125000003277 amino group Chemical group 0.000 claims description 37
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 29
- 229910052739 hydrogen Inorganic materials 0.000 claims description 27
- 239000001257 hydrogen Substances 0.000 claims description 27
- 150000002431 hydrogen Chemical class 0.000 claims description 24
- 239000007790 solid phase Substances 0.000 claims description 21
- 125000003118 aryl group Chemical group 0.000 claims description 20
- 229910052799 carbon Inorganic materials 0.000 claims description 20
- 125000003342 alkenyl group Chemical group 0.000 claims description 18
- 125000005018 aryl alkenyl group Chemical group 0.000 claims description 18
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 18
- 125000001188 haloalkyl group Chemical group 0.000 claims description 18
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 17
- 125000002252 acyl group Chemical group 0.000 claims description 12
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 11
- 125000001475 halogen functional group Chemical group 0.000 claims description 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 10
- 125000000304 alkynyl group Chemical group 0.000 claims description 9
- 125000001072 heteroaryl group Chemical group 0.000 claims description 9
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 8
- 150000005215 alkyl ethers Chemical class 0.000 claims description 8
- 125000005012 alkyl thioether group Chemical group 0.000 claims description 8
- 239000002773 nucleotide Substances 0.000 claims description 8
- 125000003729 nucleotide group Chemical group 0.000 claims description 8
- 229910052710 silicon Inorganic materials 0.000 claims description 8
- 108091023037 Aptamer Proteins 0.000 claims description 6
- 108010043958 Peptoids Proteins 0.000 claims description 6
- 150000001720 carbohydrates Chemical class 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 6
- 239000002777 nucleoside Substances 0.000 claims description 6
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 6
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 5
- 229910021399 diatomic carbon Inorganic materials 0.000 claims description 5
- 230000005484 gravity Effects 0.000 claims description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 108091033319 polynucleotide Proteins 0.000 claims description 4
- 239000002157 polynucleotide Substances 0.000 claims description 4
- 102000040430 polynucleotide Human genes 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 150000003573 thiols Chemical class 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 239000000412 dendrimer Substances 0.000 claims description 3
- 229920000736 dendritic polymer Polymers 0.000 claims description 3
- 125000004469 siloxy group Chemical group [SiH3]O* 0.000 claims description 3
- 239000004952 Polyamide Substances 0.000 claims description 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 2
- 229920002647 polyamide Polymers 0.000 claims description 2
- 125000005864 sulfonamidyl group Chemical group 0.000 claims description 2
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 claims 3
- 238000000034 method Methods 0.000 description 24
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 6
- -1 sulfone amidyl Chemical group 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 5
- 229920000083 poly(allylamine) Polymers 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 238000000151 deposition Methods 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 150000002118 epoxides Chemical class 0.000 description 3
- 239000012948 isocyanate Substances 0.000 description 3
- 150000002513 isocyanates Chemical class 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- OBNDGIHQAIXEAO-UHFFFAOYSA-N [O].[Si] Chemical compound [O].[Si] OBNDGIHQAIXEAO-UHFFFAOYSA-N 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 238000005229 chemical vapour deposition Methods 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- NONOKGVFTBWRLD-UHFFFAOYSA-N isocyanatosulfanylimino(oxo)methane Chemical compound O=C=NSN=C=O NONOKGVFTBWRLD-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- BPSIOYPQMFLKFR-UHFFFAOYSA-N trimethoxy-[3-(oxiran-2-ylmethoxy)propyl]silane Chemical group CO[Si](OC)(OC)CCCOCC1CO1 BPSIOYPQMFLKFR-UHFFFAOYSA-N 0.000 description 2
- MBYLVOKEDDQJDY-UHFFFAOYSA-N tris(2-aminoethyl)amine Chemical compound NCCN(CCN)CCN MBYLVOKEDDQJDY-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical group [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 125000003435 aroyl group Chemical group 0.000 description 1
- 125000004350 aryl cycloalkyl group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 125000003916 ethylene diamine group Chemical group 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 150000002540 isothiocyanates Chemical class 0.000 description 1
- BTWRPQHFJAFXJR-UHFFFAOYSA-N n-[2-(ethylaminooxy)ethoxy]ethanamine Chemical compound CCNOCCONCC BTWRPQHFJAFXJR-UHFFFAOYSA-N 0.000 description 1
- XBXCNNQPRYLIDE-UHFFFAOYSA-M n-tert-butylcarbamate Chemical compound CC(C)(C)NC([O-])=O XBXCNNQPRYLIDE-UHFFFAOYSA-M 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Chemical group 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229910052711 selenium Chemical group 0.000 description 1
- 239000011669 selenium Chemical group 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Chemical group 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662419864P | 2016-11-09 | 2016-11-09 | |
| US62/419,864 | 2016-11-09 | ||
| PCT/US2017/060724 WO2018089556A1 (en) | 2016-11-09 | 2017-11-08 | Coatings with tunable amine density |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019536860A JP2019536860A (ja) | 2019-12-19 |
| JP2019536860A5 true JP2019536860A5 (enExample) | 2020-12-17 |
Family
ID=62109395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019524042A Withdrawn JP2019536860A (ja) | 2016-11-09 | 2017-11-08 | 調整可能なアミン比重を有するコーティング |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11359112B2 (enExample) |
| EP (1) | EP3538591A4 (enExample) |
| JP (1) | JP2019536860A (enExample) |
| KR (1) | KR20190082275A (enExample) |
| CN (1) | CN110036058A (enExample) |
| AU (1) | AU2017359450A1 (enExample) |
| CA (1) | CA3043329A1 (enExample) |
| WO (1) | WO2018089556A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019528428A (ja) | 2016-06-20 | 2019-10-10 | ヘルステル・インコーポレイテッドＨｅａｌｔｈｔｅｌｌ Ｉｎｃ． | 自己免疫疾患の鑑別診断方法 |
| US11774446B2 (en) | 2016-06-20 | 2023-10-03 | Cowper Sciences Inc. | Methods for diagnosis and treatment of autoimmune diseases |
| US12037311B2 (en) | 2016-11-09 | 2024-07-16 | Cowper Sciences Inc. | Pre-assembled, protected, chemically stable, chemoselective linkers |
| US11359112B2 (en) | 2016-11-09 | 2022-06-14 | Cowper Sciences Inc. | Coatings with tunable amine density |
| WO2018089858A1 (en) | 2016-11-11 | 2018-05-17 | Healthtell Inc. | Methods for identifying candidate biomarkers |
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| US12037311B2 (en) | 2016-11-09 | 2024-07-16 | Cowper Sciences Inc. | Pre-assembled, protected, chemically stable, chemoselective linkers |
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-
2017
- 2017-11-08 US US16/348,485 patent/US11359112B2/en active Active
- 2017-11-08 CN CN201780073240.6A patent/CN110036058A/zh active Pending
- 2017-11-08 CA CA3043329A patent/CA3043329A1/en not_active Abandoned
- 2017-11-08 EP EP17870436.7A patent/EP3538591A4/en not_active Withdrawn
- 2017-11-08 WO PCT/US2017/060724 patent/WO2018089556A1/en not_active Ceased
- 2017-11-08 KR KR1020197016059A patent/KR20190082275A/ko not_active Withdrawn
- 2017-11-08 JP JP2019524042A patent/JP2019536860A/ja not_active Withdrawn
- 2017-11-08 AU AU2017359450A patent/AU2017359450A1/en not_active Abandoned
-
2022
- 2022-05-25 US US17/824,528 patent/US20220290005A1/en not_active Abandoned
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