JP2019535265A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019535265A5 JP2019535265A5 JP2019524951A JP2019524951A JP2019535265A5 JP 2019535265 A5 JP2019535265 A5 JP 2019535265A5 JP 2019524951 A JP2019524951 A JP 2019524951A JP 2019524951 A JP2019524951 A JP 2019524951A JP 2019535265 A5 JP2019535265 A5 JP 2019535265A5
- Authority
- JP
- Japan
- Prior art keywords
- population
- cells
- days
- item
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims description 297
- 210000004116 schwann cell Anatomy 0.000 claims description 172
- 238000000034 method Methods 0.000 claims description 171
- 239000012190 activator Substances 0.000 claims description 166
- 230000004069 differentiation Effects 0.000 claims description 124
- 210000000130 stem cell Anatomy 0.000 claims description 115
- 239000002243 precursor Substances 0.000 claims description 102
- 239000000411 inducer Substances 0.000 claims description 88
- 239000003112 inhibitor Substances 0.000 claims description 84
- 102000013814 Wnt Human genes 0.000 claims description 82
- 108050003627 Wnt Proteins 0.000 claims description 82
- 230000011664 signaling Effects 0.000 claims description 82
- 239000000203 mixture Substances 0.000 claims description 76
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 71
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 71
- -1 HNK1 Proteins 0.000 claims description 49
- 239000003623 enhancer Substances 0.000 claims description 44
- 210000000933 neural crest Anatomy 0.000 claims description 40
- 239000003550 marker Substances 0.000 claims description 39
- 238000000338 in vitro Methods 0.000 claims description 38
- OHCQJHSOBUTRHG-KGGHGJDLSA-N FORSKOLIN Chemical compound O=C([C@@]12O)C[C@](C)(C=C)O[C@]1(C)[C@@H](OC(=O)C)[C@@H](O)[C@@H]1[C@]2(C)[C@@H](O)CCC1(C)C OHCQJHSOBUTRHG-KGGHGJDLSA-N 0.000 claims description 32
- 230000024245 cell differentiation Effects 0.000 claims description 32
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical group C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 claims description 21
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 claims description 21
- 102100032818 Integrin alpha-4 Human genes 0.000 claims description 21
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims description 21
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims description 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 21
- 230000001939 inductive effect Effects 0.000 claims description 21
- 101000664703 Homo sapiens Transcription factor SOX-10 Proteins 0.000 claims description 20
- 102100038808 Transcription factor SOX-10 Human genes 0.000 claims description 20
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 20
- 150000003384 small molecules Chemical class 0.000 claims description 19
- 102100032912 CD44 antigen Human genes 0.000 claims description 17
- 102100022529 Cadherin-19 Human genes 0.000 claims description 17
- 241000483002 Euproctis similis Species 0.000 claims description 17
- 102100037733 Fatty acid-binding protein, brain Human genes 0.000 claims description 17
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 17
- 101000899410 Homo sapiens Cadherin-19 Proteins 0.000 claims description 17
- 102100025311 Monocarboxylate transporter 7 Human genes 0.000 claims description 17
- 108091006603 SLC16A6 Proteins 0.000 claims description 17
- 230000035800 maturation Effects 0.000 claims description 17
- AQGNHMOJWBZFQQ-UHFFFAOYSA-N CT 99021 Chemical group CC1=CNC(C=2C(=NC(NCCNC=3N=CC(=CC=3)C#N)=NC=2)C=2C(=CC(Cl)=CC=2)Cl)=N1 AQGNHMOJWBZFQQ-UHFFFAOYSA-N 0.000 claims description 16
- 108010005939 Ciliary Neurotrophic Factor Proteins 0.000 claims description 16
- 102100031614 Ciliary neurotrophic factor Human genes 0.000 claims description 16
- SUZLHDUTVMZSEV-UHFFFAOYSA-N Deoxycoleonol Natural products C12C(=O)CC(C)(C=C)OC2(C)C(OC(=O)C)C(O)C2C1(C)C(O)CCC2(C)C SUZLHDUTVMZSEV-UHFFFAOYSA-N 0.000 claims description 16
- 102100035290 Fibroblast growth factor 13 Human genes 0.000 claims description 16
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims description 16
- 101000572981 Homo sapiens POU domain, class 3, transcription factor 1 Proteins 0.000 claims description 16
- 102100026458 POU domain, class 3, transcription factor 1 Human genes 0.000 claims description 16
- OHCQJHSOBUTRHG-UHFFFAOYSA-N colforsin Natural products OC12C(=O)CC(C)(C=C)OC1(C)C(OC(=O)C)C(O)C1C2(C)C(O)CCC1(C)C OHCQJHSOBUTRHG-UHFFFAOYSA-N 0.000 claims description 16
- 102100039289 Glial fibrillary acidic protein Human genes 0.000 claims description 15
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 claims description 15
- 101000635944 Homo sapiens Myelin protein P0 Proteins 0.000 claims description 15
- 102100030741 Myelin protein P0 Human genes 0.000 claims description 15
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 claims description 15
- 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 claims description 14
- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 claims description 14
- 101000979249 Homo sapiens Neuromodulin Proteins 0.000 claims description 14
- 101000757378 Homo sapiens Transcription factor AP-2-alpha Proteins 0.000 claims description 14
- 102100023206 Neuromodulin Human genes 0.000 claims description 14
- 102100022972 Transcription factor AP-2-alpha Human genes 0.000 claims description 14
- CDOVNWNANFFLFJ-UHFFFAOYSA-N 4-[6-[4-(1-piperazinyl)phenyl]-3-pyrazolo[1,5-a]pyrimidinyl]quinoline Chemical compound C1CNCCN1C1=CC=C(C2=CN3N=CC(=C3N=C2)C=2C3=CC=CC=C3N=CC=2)C=C1 CDOVNWNANFFLFJ-UHFFFAOYSA-N 0.000 claims description 12
- 102100022464 5'-nucleotidase Human genes 0.000 claims description 12
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims description 12
- 239000002771 cell marker Substances 0.000 claims description 12
- 102100038521 Calcitonin gene-related peptide 2 Human genes 0.000 claims description 10
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims description 10
- 101710098548 Fatty acid-binding protein, brain Proteins 0.000 claims description 10
- 101000741431 Homo sapiens Calcitonin gene-related peptide 2 Proteins 0.000 claims description 10
- 101000852596 Homo sapiens Inositol-trisphosphate 3-kinase A Proteins 0.000 claims description 10
- 101000695536 Homo sapiens Synaptophysin-like protein 2 Proteins 0.000 claims description 10
- 101000658628 Homo sapiens Testis-specific Y-encoded-like protein 5 Proteins 0.000 claims description 10
- 101000744915 Homo sapiens Zinc finger protein 502 Proteins 0.000 claims description 10
- 102100036405 Inositol-trisphosphate 3-kinase A Human genes 0.000 claims description 10
- 108010013563 Lipoprotein Lipase Proteins 0.000 claims description 10
- 102100022119 Lipoprotein lipase Human genes 0.000 claims description 10
- 108010083674 Myelin Proteins Proteins 0.000 claims description 10
- 102000006386 Myelin Proteins Human genes 0.000 claims description 10
- 108091006616 SLC10A4 Proteins 0.000 claims description 10
- 108091006162 SLC17A6 Proteins 0.000 claims description 10
- 108091006561 SLC30A2 Proteins 0.000 claims description 10
- 102100021730 Sodium/bile acid cotransporter 4 Human genes 0.000 claims description 10
- 102100028522 Synaptophysin-like protein 2 Human genes 0.000 claims description 10
- 102100034914 Testis-specific Y-encoded-like protein 5 Human genes 0.000 claims description 10
- 102100038036 Vesicular glutamate transporter 2 Human genes 0.000 claims description 10
- 102100039965 Zinc finger protein 502 Human genes 0.000 claims description 10
- 102100034994 Zinc transporter 2 Human genes 0.000 claims description 10
- 230000006378 damage Effects 0.000 claims description 10
- 210000005012 myelin Anatomy 0.000 claims description 10
- 102100034598 Angiopoietin-related protein 7 Human genes 0.000 claims description 9
- 101100017049 Drosophila melanogaster Hira gene Proteins 0.000 claims description 9
- 101000924546 Homo sapiens Angiopoietin-related protein 7 Proteins 0.000 claims description 9
- 102100032352 Leukemia inhibitory factor Human genes 0.000 claims description 9
- 108090000581 Leukemia inhibitory factor Proteins 0.000 claims description 9
- 102000014413 Neuregulin Human genes 0.000 claims description 9
- 108050003475 Neuregulin Proteins 0.000 claims description 9
- 102000048238 Neuregulin-1 Human genes 0.000 claims description 9
- 108090000556 Neuregulin-1 Proteins 0.000 claims description 9
- 208000027418 Wounds and injury Diseases 0.000 claims description 9
- 101150042351 dhh gene Proteins 0.000 claims description 9
- 208000014674 injury Diseases 0.000 claims description 9
- 101100156752 Caenorhabditis elegans cwn-1 gene Proteins 0.000 claims description 8
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 claims description 8
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims description 8
- 102100028412 Fibroblast growth factor 10 Human genes 0.000 claims description 8
- 102100035323 Fibroblast growth factor 18 Human genes 0.000 claims description 8
- 102100028043 Fibroblast growth factor 3 Human genes 0.000 claims description 8
- 102100028072 Fibroblast growth factor 4 Human genes 0.000 claims description 8
- 102100028071 Fibroblast growth factor 7 Human genes 0.000 claims description 8
- 102100037680 Fibroblast growth factor 8 Human genes 0.000 claims description 8
- 101000917237 Homo sapiens Fibroblast growth factor 10 Proteins 0.000 claims description 8
- 101000878128 Homo sapiens Fibroblast growth factor 18 Proteins 0.000 claims description 8
- 101001060280 Homo sapiens Fibroblast growth factor 3 Proteins 0.000 claims description 8
- 101001060274 Homo sapiens Fibroblast growth factor 4 Proteins 0.000 claims description 8
- 101001060261 Homo sapiens Fibroblast growth factor 7 Proteins 0.000 claims description 8
- 101001027382 Homo sapiens Fibroblast growth factor 8 Proteins 0.000 claims description 8
- 101150010310 WNT-4 gene Proteins 0.000 claims description 8
- 101150109862 WNT-5A gene Proteins 0.000 claims description 8
- 108700020987 Wnt-1 Proteins 0.000 claims description 8
- 102000052547 Wnt-1 Human genes 0.000 claims description 8
- 102000052548 Wnt-4 Human genes 0.000 claims description 8
- 108700020984 Wnt-4 Proteins 0.000 claims description 8
- 108700020483 Wnt-5a Proteins 0.000 claims description 8
- 102000043366 Wnt-5a Human genes 0.000 claims description 8
- 102000044880 Wnt3A Human genes 0.000 claims description 8
- 108700013515 Wnt3A Proteins 0.000 claims description 8
- 101150068520 wnt3a gene Proteins 0.000 claims description 8
- 102100033400 4F2 cell-surface antigen heavy chain Human genes 0.000 claims description 7
- 102100030310 5,6-dihydroxyindole-2-carboxylic acid oxidase Human genes 0.000 claims description 7
- 102100024956 5-hydroxytryptamine receptor 2B Human genes 0.000 claims description 7
- 102100021546 60S ribosomal protein L10 Human genes 0.000 claims description 7
- 102100021176 ATP-sensitive inward rectifier potassium channel 10 Human genes 0.000 claims description 7
- 108010036280 Aquaporin 4 Proteins 0.000 claims description 7
- 102100037276 Aquaporin-4 Human genes 0.000 claims description 7
- 102100029406 Aquaporin-7 Human genes 0.000 claims description 7
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims description 7
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims description 7
- 102100027221 CD81 antigen Human genes 0.000 claims description 7
- 102100037904 CD9 antigen Human genes 0.000 claims description 7
- 102100025805 Cadherin-1 Human genes 0.000 claims description 7
- 108091007854 Cdh1/Fizzy-related Proteins 0.000 claims description 7
- 102100038887 ENTH domain-containing protein 1 Human genes 0.000 claims description 7
- 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 claims description 7
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 claims description 7
- 101000800023 Homo sapiens 4F2 cell-surface antigen heavy chain Proteins 0.000 claims description 7
- 101000773083 Homo sapiens 5,6-dihydroxyindole-2-carboxylic acid oxidase Proteins 0.000 claims description 7
- 101000761319 Homo sapiens 5-hydroxytryptamine receptor 2B Proteins 0.000 claims description 7
- 101001108634 Homo sapiens 60S ribosomal protein L10 Proteins 0.000 claims description 7
- 101000614696 Homo sapiens ATP-sensitive inward rectifier potassium channel 10 Proteins 0.000 claims description 7
- 101000771402 Homo sapiens Aquaporin-7 Proteins 0.000 claims description 7
- 101000771413 Homo sapiens Aquaporin-9 Proteins 0.000 claims description 7
- 101000777555 Homo sapiens CCN family member 3 Proteins 0.000 claims description 7
- 101000914479 Homo sapiens CD81 antigen Proteins 0.000 claims description 7
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims description 7
- 101000882393 Homo sapiens ENTH domain-containing protein 1 Proteins 0.000 claims description 7
- 101001027674 Homo sapiens Fatty acid-binding protein, brain Proteins 0.000 claims description 7
- 101000599940 Homo sapiens Interferon gamma Proteins 0.000 claims description 7
- 101000605020 Homo sapiens Large neutral amino acids transporter small subunit 1 Proteins 0.000 claims description 7
- 101001115699 Homo sapiens Myelin-oligodendrocyte glycoprotein Proteins 0.000 claims description 7
- 101000634196 Homo sapiens Neurotrophin-3 Proteins 0.000 claims description 7
- 101001120753 Homo sapiens Oligodendrocyte transcription factor 1 Proteins 0.000 claims description 7
- 101001000631 Homo sapiens Peripheral myelin protein 22 Proteins 0.000 claims description 7
- 101001082860 Homo sapiens Peroxisomal membrane protein 2 Proteins 0.000 claims description 7
- 101001067189 Homo sapiens Plexin-A1 Proteins 0.000 claims description 7
- 101000825071 Homo sapiens Sclerostin domain-containing protein 1 Proteins 0.000 claims description 7
- 101000801481 Homo sapiens Tissue-type plasminogen activator Proteins 0.000 claims description 7
- 108091058560 IL8 Proteins 0.000 claims description 7
- 102100037850 Interferon gamma Human genes 0.000 claims description 7
- 102000004890 Interleukin-8 Human genes 0.000 claims description 7
- 108090001007 Interleukin-8 Proteins 0.000 claims description 7
- 102100023302 Myelin-oligodendrocyte glycoprotein Human genes 0.000 claims description 7
- 102000002673 NFATC Transcription Factors Human genes 0.000 claims description 7
- 108010018525 NFATC Transcription Factors Proteins 0.000 claims description 7
- 108010032605 Nerve Growth Factor Receptors Proteins 0.000 claims description 7
- 108010074223 Netrin-1 Proteins 0.000 claims description 7
- 102000009065 Netrin-1 Human genes 0.000 claims description 7
- 102100029268 Neurotrophin-3 Human genes 0.000 claims description 7
- 102100026073 Oligodendrocyte transcription factor 1 Human genes 0.000 claims description 7
- 102100030564 Peroxisomal membrane protein 2 Human genes 0.000 claims description 7
- 102100022432 Sclerostin domain-containing protein 1 Human genes 0.000 claims description 7
- 102100021796 Sonic hedgehog protein Human genes 0.000 claims description 7
- 101710113849 Sonic hedgehog protein Proteins 0.000 claims description 7
- 102100033571 Tissue-type plasminogen activator Human genes 0.000 claims description 7
- 102100032120 Toll/interleukin-1 receptor domain-containing adapter protein Human genes 0.000 claims description 7
- 102100033725 Tumor necrosis factor receptor superfamily member 16 Human genes 0.000 claims description 7
- 108010065059 methylaspartate ammonia-lyase Proteins 0.000 claims description 7
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 7
- 108010009392 Cyclin-Dependent Kinase Inhibitor p16 Proteins 0.000 claims description 6
- 102100024458 Cyclin-dependent kinase inhibitor 2A Human genes 0.000 claims description 6
- 101000635938 Homo sapiens Transforming growth factor beta-1 proprotein Proteins 0.000 claims description 6
- 101100312878 Rattus norvegicus Tm4sf4 gene Proteins 0.000 claims description 6
- 102100030742 Transforming growth factor beta-1 proprotein Human genes 0.000 claims description 6
- 230000004913 activation Effects 0.000 claims description 6
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 6
- 210000002569 neuron Anatomy 0.000 claims description 5
- 102100022142 Achaete-scute homolog 1 Human genes 0.000 claims description 4
- 102100035080 BDNF/NT-3 growth factors receptor Human genes 0.000 claims description 4
- 101150054987 ChAT gene Proteins 0.000 claims description 4
- 102100023460 Choline O-acetyltransferase Human genes 0.000 claims description 4
- 241000237858 Gastropoda Species 0.000 claims description 4
- 102100035108 High affinity nerve growth factor receptor Human genes 0.000 claims description 4
- 101000901099 Homo sapiens Achaete-scute homolog 1 Proteins 0.000 claims description 4
- 101000596896 Homo sapiens BDNF/NT-3 growth factors receptor Proteins 0.000 claims description 4
- 101000596894 Homo sapiens High affinity nerve growth factor receptor Proteins 0.000 claims description 4
- 101001053263 Homo sapiens Insulin gene enhancer protein ISL-1 Proteins 0.000 claims description 4
- 101000979001 Homo sapiens Methionine aminopeptidase 2 Proteins 0.000 claims description 4
- 101000969087 Homo sapiens Microtubule-associated protein 2 Proteins 0.000 claims description 4
- 101001111338 Homo sapiens Neurofilament heavy polypeptide Proteins 0.000 claims description 4
- 101001094741 Homo sapiens POU domain, class 4, transcription factor 1 Proteins 0.000 claims description 4
- 101001129803 Homo sapiens Paired mesoderm homeobox protein 2A Proteins 0.000 claims description 4
- 101000692768 Homo sapiens Paired mesoderm homeobox protein 2B Proteins 0.000 claims description 4
- 101000652332 Homo sapiens Transcription factor SOX-1 Proteins 0.000 claims description 4
- 102100024392 Insulin gene enhancer protein ISL-1 Human genes 0.000 claims description 4
- 102100023174 Methionine aminopeptidase 2 Human genes 0.000 claims description 4
- 102100029166 NT-3 growth factor receptor Human genes 0.000 claims description 4
- 101150117329 NTRK3 gene Proteins 0.000 claims description 4
- 102000008730 Nestin Human genes 0.000 claims description 4
- 108010088225 Nestin Proteins 0.000 claims description 4
- 102100024007 Neurofilament heavy polypeptide Human genes 0.000 claims description 4
- 108010032788 PAX6 Transcription Factor Proteins 0.000 claims description 4
- 102100035395 POU domain, class 4, transcription factor 1 Human genes 0.000 claims description 4
- 102100037506 Paired box protein Pax-6 Human genes 0.000 claims description 4
- 102100031686 Paired mesoderm homeobox protein 2A Human genes 0.000 claims description 4
- 102100026354 Paired mesoderm homeobox protein 2B Human genes 0.000 claims description 4
- 102100030248 Transcription factor SOX-1 Human genes 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 210000005055 nestin Anatomy 0.000 claims description 4
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 3
- 210000001654 germ layer Anatomy 0.000 claims description 3
- 230000001537 neural effect Effects 0.000 claims description 3
- 230000003213 activating effect Effects 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 claims description 2
- 230000001070 adhesive effect Effects 0.000 claims description 2
- 230000004931 aggregating effect Effects 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 108091000080 Phosphotransferase Proteins 0.000 claims 2
- 102000020233 phosphotransferase Human genes 0.000 claims 2
- 101001065754 Homo sapiens Leucine-rich repeat transmembrane neuronal protein 4 Proteins 0.000 claims 1
- 101001126414 Homo sapiens Proteolipid protein 2 Proteins 0.000 claims 1
- 102100032046 Leucine-rich repeat transmembrane neuronal protein 4 Human genes 0.000 claims 1
- 101001129122 Mannheimia haemolytica Outer membrane lipoprotein 2 Proteins 0.000 claims 1
- 101000642171 Odontomachus monticola U-poneritoxin(01)-Om2a Proteins 0.000 claims 1
- 102100032421 Protein S100-A6 Human genes 0.000 claims 1
- 102100030486 Proteolipid protein 2 Human genes 0.000 claims 1
- 108010005260 S100 Calcium Binding Protein A6 Proteins 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 12
- 230000001172 regenerating effect Effects 0.000 description 9
- 230000000694 effects Effects 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 101000606895 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Pectin lyase 2 Proteins 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022072292A JP2022090133A (ja) | 2016-11-14 | 2022-04-26 | 幹細胞由来シュワン細胞 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662421816P | 2016-11-14 | 2016-11-14 | |
| US62/421,816 | 2016-11-14 | ||
| PCT/US2017/061541 WO2018090002A1 (en) | 2016-11-14 | 2017-11-14 | Stem cell derived schwann cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022072292A Division JP2022090133A (ja) | 2016-11-14 | 2022-04-26 | 幹細胞由来シュワン細胞 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019535265A JP2019535265A (ja) | 2019-12-12 |
| JP2019535265A5 true JP2019535265A5 (enExample) | 2021-04-08 |
Family
ID=62110088
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019524951A Pending JP2019535265A (ja) | 2016-11-14 | 2017-11-14 | 幹細胞由来シュワン細胞 |
| JP2019524940A Pending JP2019535263A (ja) | 2016-11-14 | 2017-11-14 | 幹細胞由来シュワン細胞を使用する薬物発見のための方法 |
| JP2022022796A Pending JP2022059056A (ja) | 2016-11-14 | 2022-02-17 | 幹細胞由来シュワン細胞を使用する薬物発見のための方法 |
| JP2022072292A Pending JP2022090133A (ja) | 2016-11-14 | 2022-04-26 | 幹細胞由来シュワン細胞 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019524940A Pending JP2019535263A (ja) | 2016-11-14 | 2017-11-14 | 幹細胞由来シュワン細胞を使用する薬物発見のための方法 |
| JP2022022796A Pending JP2022059056A (ja) | 2016-11-14 | 2022-02-17 | 幹細胞由来シュワン細胞を使用する薬物発見のための方法 |
| JP2022072292A Pending JP2022090133A (ja) | 2016-11-14 | 2022-04-26 | 幹細胞由来シュワン細胞 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20190331666A1 (enExample) |
| EP (2) | EP3538115A4 (enExample) |
| JP (4) | JP2019535265A (enExample) |
| KR (1) | KR20190077095A (enExample) |
| CN (2) | CN110691601A (enExample) |
| AU (2) | AU2017357072A1 (enExample) |
| CA (2) | CA3043223A1 (enExample) |
| IL (2) | IL266524A (enExample) |
| WO (2) | WO2018090002A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL272246B1 (en) | 2017-07-28 | 2025-09-01 | Applied Therapeutics Inc | Derivatives of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as aldose reductase inhibitors in treating galactosemia or preventing complications associated with galactosemia |
| CN111655336A (zh) * | 2017-11-17 | 2020-09-11 | 纽约州立大学研究基金会 | 使用x射线微束辐射治疗受损周围神经的方法 |
| AU2018379993A1 (en) * | 2017-12-04 | 2020-07-02 | Axosim, Inc. | Cell systems using spheroids and methods of making and using the same |
| AU2020210630B2 (en) | 2019-01-23 | 2025-10-23 | Regeneron Pharmaceuticals, Inc. | Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors |
| US11845989B2 (en) | 2019-01-23 | 2023-12-19 | Regeneron Pharmaceuticals, Inc. | Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors |
| CN113966396A (zh) | 2019-05-07 | 2022-01-21 | 迈阿密大学 | 遗传性神经病和相关障碍的治疗和检测 |
| CN110157660A (zh) * | 2019-06-10 | 2019-08-23 | 西安飞如生物科技有限公司 | 诱导成纤维细胞分泌抗菌肽的诱导培养基和方法、成纤维细胞及应用 |
| JPWO2021166984A1 (enExample) * | 2020-02-20 | 2021-08-26 | ||
| EP3929281A1 (en) | 2020-06-24 | 2021-12-29 | Fachhochschule Technikum Wien | Cell construct comprising schwann cells or schwann cell-like cells and a biocompatible matrix |
| EP4298219A1 (en) | 2021-02-26 | 2024-01-03 | Regeneron Pharmaceuticals, Inc. | Treatment of inflammation with glucocorticoids and angiopoietin-like 7 (angptl7) inhibitors |
| AU2022291933A1 (en) * | 2021-06-18 | 2024-01-18 | Memorial Hospital For Cancer And Allied Diseases | Methods of generating sacral neural crest lineages and uses thereof |
| EP4573186A1 (en) * | 2022-08-16 | 2025-06-25 | The Regents Of The University Of California | Cell compositions and methods of using the same |
| WO2025170529A1 (en) | 2024-02-09 | 2025-08-14 | Hedlund Eva | A method for deriving a multipotent neuromesodermal progenitor cell and/or daughter lineages, and related compositions |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000023568A2 (en) * | 1998-10-06 | 2000-04-27 | Albert Einstein College Of Medicine Of Yeshiva University | Methods and compositions for decreasing mitochondrial overproduction of reactive oxygen species in cells |
| CN101066472B (zh) * | 2007-04-18 | 2010-05-19 | 中国人民解放军第二军医大学 | 组织工程化周围神经移植体及其制备方法 |
| JP5751548B2 (ja) * | 2009-08-07 | 2015-07-22 | 国立大学法人京都大学 | イヌiPS細胞及びその製造方法 |
| WO2011046189A1 (ja) * | 2009-10-15 | 2011-04-21 | 国立大学法人京都大学 | 神経変性疾患のモデル細胞、その製造方法及びその用途 |
| CN102191217A (zh) * | 2010-03-12 | 2011-09-21 | 上海市第一人民医院 | 一种诱导脐带间充质干细胞分化为类神经细胞的方法 |
| DK2577318T3 (da) * | 2010-05-25 | 2019-10-07 | Memorial Sloan Kettering Cancer Center | Fremgangsmåde til nociceptor-differentiering af humane embryoniske stamceller og anvendelser deraf |
| BR112013008957A2 (pt) * | 2010-10-15 | 2019-09-24 | Univ Cornell | composições e métodos para tratamento de doenças endócrinas, gastrointestinais ou autoimunes |
| WO2012112933A1 (en) * | 2011-02-18 | 2012-08-23 | The Scripps Research Institute | Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate |
| EP2614829A1 (en) * | 2012-01-11 | 2013-07-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons |
| KR20160033703A (ko) * | 2013-07-23 | 2016-03-28 | 에프. 호프만-라 로슈 아게 | 체세포로부터 신경 능선 세포로의 소분자 기반 전환 |
| WO2015017523A1 (en) * | 2013-07-30 | 2015-02-05 | Waters Technologies Corporation | Check valve having polymeric seat and poppet |
| GB201318126D0 (en) * | 2013-10-14 | 2013-11-27 | Univ Cardiff | Neuronal Stem Cell Differentiation |
| CA2931334A1 (en) | 2013-11-21 | 2015-05-28 | Memorial Sloan-Kettering Cancer Center | Specification of functional cranial placode derivatives from human pluripotent stem cells |
| US10675382B2 (en) * | 2014-09-12 | 2020-06-09 | Kyoto Prefectural Public University Corporation | Schwann cells and method for preparing same |
| US20180140637A1 (en) * | 2015-05-19 | 2018-05-24 | Maya Sieber-Blum | Epidermal neural crest stem cells as a source of schwann cells |
| KR101903458B1 (ko) * | 2017-01-20 | 2018-10-02 | 한국생명공학연구원 | 슈반 세포 전구체 (Schwann cell precursor) 및 이로부터 분화된 슈반 세포 (Schwann cell)의 제조 방법 |
-
2017
- 2017-11-14 EP EP17870215.5A patent/EP3538115A4/en not_active Withdrawn
- 2017-11-14 AU AU2017357072A patent/AU2017357072A1/en not_active Abandoned
- 2017-11-14 EP EP17870058.9A patent/EP3538110A4/en not_active Withdrawn
- 2017-11-14 JP JP2019524951A patent/JP2019535265A/ja active Pending
- 2017-11-14 CN CN201780082987.8A patent/CN110691601A/zh active Pending
- 2017-11-14 AU AU2017357076A patent/AU2017357076A1/en not_active Abandoned
- 2017-11-14 CA CA3043223A patent/CA3043223A1/en active Pending
- 2017-11-14 WO PCT/US2017/061541 patent/WO2018090002A1/en not_active Ceased
- 2017-11-14 WO PCT/US2017/061549 patent/WO2018090006A1/en not_active Ceased
- 2017-11-14 CA CA3043226A patent/CA3043226A1/en active Pending
- 2017-11-14 KR KR1020197017089A patent/KR20190077095A/ko not_active Ceased
- 2017-11-14 CN CN201780083272.4A patent/CN110249047A/zh active Pending
- 2017-11-14 JP JP2019524940A patent/JP2019535263A/ja active Pending
-
2019
- 2019-05-08 IL IL266524A patent/IL266524A/en unknown
- 2019-05-12 IL IL266554A patent/IL266554A/en unknown
- 2019-05-13 US US16/410,763 patent/US20190331666A1/en not_active Abandoned
- 2019-05-13 US US16/410,686 patent/US20190264173A1/en active Pending
-
2022
- 2022-02-17 JP JP2022022796A patent/JP2022059056A/ja active Pending
- 2022-04-26 JP JP2022072292A patent/JP2022090133A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019535265A5 (enExample) | ||
| Ebert et al. | EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs | |
| Galiakberova et al. | Neural stem cells and methods for their generation from induced pluripotent stem cells in vitro | |
| Chang et al. | Neurogenic differentiation of dental pulp stem cells to neuron-like cells in dopaminergic and motor neuronal inductive media | |
| Lang et al. | Differentiation of embryonic stem cells to a neural fate: a route to re‐building the nervous system? | |
| Gorris et al. | Pluripotent stem cell‐derived radial glia‐like cells as stable intermediate for efficient generation of human oligodendrocytes | |
| Itsykson et al. | Derivation of neural precursors from human embryonic stem cells in the presence of noggin | |
| Pollard et al. | Adherent neural stem (NS) cells from fetal and adult forebrain | |
| Elkabetz et al. | Human ESC-derived neural rosettes and neural stem cell progression | |
| Erceg et al. | Differentiation of human embryonic stem cells to regional specific neural precursors in chemically defined medium conditions | |
| Dhara et al. | Human neural progenitor cells derived from embryonic stem cells in feeder-free cultures | |
| Yang et al. | Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats | |
| Yamanaka et al. | Pluripotency of embryonic stem cells | |
| US8426200B2 (en) | Neuronal differentiation of stem cells | |
| Gil et al. | Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells | |
| US20190017020A1 (en) | Differentiation of human pluripotent stem cells to multipotent neural crest cells | |
| CN102307990A (zh) | 从干细胞衍生分化细胞的方法 | |
| Sundberg et al. | Production and isolation of NG2+ oligodendrocyte precursors from human embryonic stem cells in defined serum-free medium | |
| Lukovic et al. | Highly efficient neural conversion of human pluripotent stem cells in adherent and animal-free conditions | |
| Noisa et al. | Neural progenitor cells derived from human embryonic stem cells as an origin of dopaminergic neurons | |
| Świerczek et al. | From pluripotency to myogenesis: a multistep process in the dish | |
| Vergaño-Vera et al. | Fibroblast growth factor-2 increases the expression of neurogenic genes and promotes the migration and differentiation of neurons derived from transplanted neural stem/progenitor cells | |
| Shimada et al. | Differentiation of dopaminergic neurons from human embryonic stem cells: modulation of differentiation by FGF-20 | |
| Axell et al. | A method for rapid derivation and propagation of neural progenitors from human embryonic stem cells | |
| Shiraki et al. | Differentiation and characterization of embryonic stem cells into three germ layers |