CN110691601A - 源自干细胞的施旺细胞 - Google Patents

源自干细胞的施旺细胞 Download PDF

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CN110691601A
CN110691601A CN201780082987.8A CN201780082987A CN110691601A CN 110691601 A CN110691601 A CN 110691601A CN 201780082987 A CN201780082987 A CN 201780082987A CN 110691601 A CN110691601 A CN 110691601A
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cells
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L·施图德
F·法塔希
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Memorial Of Sloan Catherine Cancer Center
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CN201780082987.8A 2016-11-14 2017-11-14 源自干细胞的施旺细胞 Pending CN110691601A (zh)

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US201662421816P 2016-11-14 2016-11-14
US62/421,816 2016-11-14
PCT/US2017/061541 WO2018090002A1 (en) 2016-11-14 2017-11-14 Stem cell derived schwann cells

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CN201780083272.4A Pending CN110249047A (zh) 2016-11-14 2017-11-14 使用源自干细胞的施旺细胞的药物发现方法

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US (2) US20190331666A1 (enExample)
EP (2) EP3538115A4 (enExample)
JP (4) JP2019535265A (enExample)
KR (1) KR20190077095A (enExample)
CN (2) CN110691601A (enExample)
AU (2) AU2017357072A1 (enExample)
CA (2) CA3043223A1 (enExample)
IL (2) IL266524A (enExample)
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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL272246B1 (en) 2017-07-28 2025-09-01 Applied Therapeutics Inc Derivatives of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as aldose reductase inhibitors in treating galactosemia or preventing complications associated with galactosemia
CN111655336A (zh) * 2017-11-17 2020-09-11 纽约州立大学研究基金会 使用x射线微束辐射治疗受损周围神经的方法
AU2018379993A1 (en) * 2017-12-04 2020-07-02 Axosim, Inc. Cell systems using spheroids and methods of making and using the same
AU2020210630B2 (en) 2019-01-23 2025-10-23 Regeneron Pharmaceuticals, Inc. Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors
US11845989B2 (en) 2019-01-23 2023-12-19 Regeneron Pharmaceuticals, Inc. Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors
CN113966396A (zh) 2019-05-07 2022-01-21 迈阿密大学 遗传性神经病和相关障碍的治疗和检测
CN110157660A (zh) * 2019-06-10 2019-08-23 西安飞如生物科技有限公司 诱导成纤维细胞分泌抗菌肽的诱导培养基和方法、成纤维细胞及应用
JPWO2021166984A1 (enExample) * 2020-02-20 2021-08-26
EP3929281A1 (en) 2020-06-24 2021-12-29 Fachhochschule Technikum Wien Cell construct comprising schwann cells or schwann cell-like cells and a biocompatible matrix
EP4298219A1 (en) 2021-02-26 2024-01-03 Regeneron Pharmaceuticals, Inc. Treatment of inflammation with glucocorticoids and angiopoietin-like 7 (angptl7) inhibitors
AU2022291933A1 (en) * 2021-06-18 2024-01-18 Memorial Hospital For Cancer And Allied Diseases Methods of generating sacral neural crest lineages and uses thereof
EP4573186A1 (en) * 2022-08-16 2025-06-25 The Regents Of The University Of California Cell compositions and methods of using the same
WO2025170529A1 (en) 2024-02-09 2025-08-14 Hedlund Eva A method for deriving a multipotent neuromesodermal progenitor cell and/or daughter lineages, and related compositions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101066472A (zh) * 2007-04-18 2007-11-07 中国人民解放军第二军医大学 组织工程化周围神经移植体及其制备方法
US20150010515A1 (en) * 2012-01-11 2015-01-08 Max- Planck-Gesellschaft zur Förderung der Wissenschaften E.V. Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons
CN105392881A (zh) * 2013-07-23 2016-03-09 豪夫迈·罗氏有限公司 体细胞基于小分子转化为神经嵴细胞

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023568A2 (en) * 1998-10-06 2000-04-27 Albert Einstein College Of Medicine Of Yeshiva University Methods and compositions for decreasing mitochondrial overproduction of reactive oxygen species in cells
JP5751548B2 (ja) * 2009-08-07 2015-07-22 国立大学法人京都大学 イヌｉＰＳ細胞及びその製造方法
WO2011046189A1 (ja) * 2009-10-15 2011-04-21 国立大学法人京都大学 神経変性疾患のモデル細胞、その製造方法及びその用途
CN102191217A (zh) * 2010-03-12 2011-09-21 上海市第一人民医院 一种诱导脐带间充质干细胞分化为类神经细胞的方法
DK2577318T3 (da) * 2010-05-25 2019-10-07 Memorial Sloan Kettering Cancer Center Fremgangsmåde til nociceptor-differentiering af humane embryoniske stamceller og anvendelser deraf
BR112013008957A2 (pt) * 2010-10-15 2019-09-24 Univ Cornell composições e métodos para tratamento de doenças endócrinas, gastrointestinais ou autoimunes
WO2012112933A1 (en) * 2011-02-18 2012-08-23 The Scripps Research Institute Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate
WO2015017523A1 (en) * 2013-07-30 2015-02-05 Waters Technologies Corporation Check valve having polymeric seat and poppet
GB201318126D0 (en) * 2013-10-14 2013-11-27 Univ Cardiff Neuronal Stem Cell Differentiation
CA2931334A1 (en) 2013-11-21 2015-05-28 Memorial Sloan-Kettering Cancer Center Specification of functional cranial placode derivatives from human pluripotent stem cells
US10675382B2 (en) * 2014-09-12 2020-06-09 Kyoto Prefectural Public University Corporation Schwann cells and method for preparing same
US20180140637A1 (en) * 2015-05-19 2018-05-24 Maya Sieber-Blum Epidermal neural crest stem cells as a source of schwann cells
KR101903458B1 (ko) * 2017-01-20 2018-10-02 한국생명공학연구원 슈반 세포 전구체 (Schwann cell precursor) 및 이로부터 분화된 슈반 세포 (Schwann cell)의 제조 방법

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101066472A (zh) * 2007-04-18 2007-11-07 中国人民解放军第二军医大学 组织工程化周围神经移植体及其制备方法
US20150010515A1 (en) * 2012-01-11 2015-01-08 Max- Planck-Gesellschaft zur Förderung der Wissenschaften E.V. Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons
CN105392881A (zh) * 2013-07-23 2016-03-09 豪夫迈·罗氏有限公司 体细胞基于小分子转化为神经嵴细胞

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MING-SAN MA ET AL.: "Pluripotent Stem Cells for Schawnn Cell Engineering", 《STEM CELL REV AND REP》 *
MOTOHARU SAKAUE ET AL.: "Human epidermal neural crest stem cells as a source of Schwann cells", 《DEVELOPMENT》 *
QIUYUE LIU ET AL.: "Human Neural Crest Stem Cells Derived from Human ESCs and Induced Pluripotent Stem Cells: Induction, Maintenance, and Differentiation into Functional Schwann Cells", 《STEM CELLS TRANSLATIONAL MEDICINE》 *
YVONNE MICA ET AL.: "Modeling neural crest induction, melanocyte specification and disease-related pigmentation defects in hESCs and patient specific iPSCs", 《CELL REP.》 *

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AU2017357076A1 (en) 2019-05-30
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CA3043226A1 (en) 2018-05-17
EP3538115A4 (en) 2020-04-22
JP2019535265A (ja) 2019-12-12
US20190331666A1 (en) 2019-10-31
EP3538110A1 (en) 2019-09-18
WO2018090006A1 (en) 2018-05-17
EP3538110A4 (en) 2020-04-22
IL266524A (en) 2019-07-31
AU2017357072A1 (en) 2019-05-30
EP3538115A1 (en) 2019-09-18
KR20190077095A (ko) 2019-07-02
JP2022059056A (ja) 2022-04-12
CA3043223A1 (en) 2018-05-17
WO2018090002A1 (en) 2018-05-17
IL266554A (en) 2019-07-31
JP2022090133A (ja) 2022-06-16
US20190264173A1 (en) 2019-08-29

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Application publication date: 20200114