JP2019535003A5 - - Google Patents
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- Publication number
- JP2019535003A5 JP2019535003A5 JP2019514077A JP2019514077A JP2019535003A5 JP 2019535003 A5 JP2019535003 A5 JP 2019535003A5 JP 2019514077 A JP2019514077 A JP 2019514077A JP 2019514077 A JP2019514077 A JP 2019514077A JP 2019535003 A5 JP2019535003 A5 JP 2019535003A5
- Authority
- JP
- Japan
- Prior art keywords
- beads
- polymer layer
- transparent polymer
- bead
- analyte
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000011324 bead Substances 0.000 claims 40
- 229920000642 polymer Polymers 0.000 claims 26
- 239000010410 layer Substances 0.000 claims 25
- 239000012491 analyte Substances 0.000 claims 13
- 238000000034 method Methods 0.000 claims 13
- 239000003795 chemical substances by application Substances 0.000 claims 11
- 238000003384 imaging method Methods 0.000 claims 9
- 238000003556 assay Methods 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 5
- 108020004414 DNA Proteins 0.000 claims 4
- 238000007837 multiplex assay Methods 0.000 claims 4
- 230000011664 signaling Effects 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 239000007801 affinity label Substances 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 150000001720 carbohydrates Chemical group 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- 239000013047 polymeric layer Substances 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- 239000004593 Epoxy Substances 0.000 claims 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 claims 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 1
- 108010004729 Phycoerythrin Proteins 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 claims 1
- 239000013642 negative control Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000013641 positive control Substances 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662396056P | 2016-09-16 | 2016-09-16 | |
| US62/396,056 | 2016-09-16 | ||
| PCT/US2016/063202 WO2018052464A1 (en) | 2016-09-16 | 2016-11-21 | Methods and systems for multiplex assays |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019535003A JP2019535003A (ja) | 2019-12-05 |
| JP2019535003A5 true JP2019535003A5 (enExample) | 2020-01-23 |
| JP7062002B2 JP7062002B2 (ja) | 2022-05-02 |
Family
ID=61620090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019514077A Active JP7062002B2 (ja) | 2016-09-16 | 2016-11-21 | マルチプレックスアッセイの方法及びシステム |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11796535B2 (enExample) |
| EP (1) | EP3513186A4 (enExample) |
| JP (1) | JP7062002B2 (enExample) |
| CN (1) | CN110073212B (enExample) |
| AU (1) | AU2016423082B2 (enExample) |
| WO (1) | WO2018052464A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI737614B (zh) | 2015-06-11 | 2021-09-01 | 博錸生技股份有限公司 | 已編碼微載體及其製造方法以及用以進行多工分析之包含該等已編碼微載體之套件 |
| US10894975B2 (en) | 2016-12-09 | 2021-01-19 | Plexbio Co., Ltd. | Image differentiated multiplex assays for multiplex detection of DNA mutations |
| SG11201911961RA (en) | 2018-04-20 | 2020-01-30 | Illumina Inc | Methods of encapsulating single cells, the encapsulated cells and uses thereof |
| WO2020086843A1 (en) * | 2018-10-26 | 2020-04-30 | Illumina, Inc. | Modulating polymer beads for dna processing |
| US11366109B2 (en) * | 2018-12-06 | 2022-06-21 | Winmems Technologies Co., Ltd. | Encoded microflakes |
| EP4293568B1 (en) * | 2019-01-23 | 2025-08-27 | BGI Shenzhen | Microbead |
| GB202004469D0 (en) | 2020-03-27 | 2020-05-13 | Olink Proteomics Ab | Controls for proximity detection assays |
| JP7719767B2 (ja) | 2020-03-31 | 2025-08-06 | デンカ株式会社 | スタフィロコッカス・アルジェンテウスの検出のためのプライマーセット及びプローブ |
| EP4130272A4 (en) | 2020-03-31 | 2024-05-22 | Denka Company Limited | PRIMER SET AND PROBE FOR DETECTION OF KLEBSIELLA BACTERIA |
| GB202006800D0 (en) * | 2020-05-07 | 2020-06-24 | Cambridge Entpr Ltd | Carrier system and method |
| CA3211971A1 (en) * | 2021-03-02 | 2022-09-09 | Idexx Laboratories, Inc. | Biochemical probes attached to epoxy-based resins |
| JP7645989B2 (ja) | 2021-03-24 | 2025-03-14 | デンカ株式会社 | 特定のｇｃ含量を有する標的遺伝子の増幅方法 |
| US12598675B2 (en) * | 2021-03-25 | 2026-04-07 | Uniheat Inc. | Infrared heating and heat transfer and radiation element including nanocomposite |
| EP4341378A4 (en) * | 2021-05-21 | 2024-09-18 | Timo Rapakko | HIGH CAPACITY CLINICAL TESTING |
| TW202440944A (zh) * | 2023-03-30 | 2024-10-16 | 日商電化股份有限公司 | 訊號放大方法 |
| EP4692778A1 (en) | 2023-03-31 | 2026-02-11 | Denka Company Limited | Method for detecting pyrophosphoric acid |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4677045A (en) | 1984-07-27 | 1987-06-30 | International Business Machines Corporation | Squarylium charge generating dye and electrophotographic photoconductor |
| US5237498A (en) | 1988-07-08 | 1993-08-17 | Hitachi, Ltd. | System and method for computing profits for individual entities of an entity group via use of means to retrieve and process data for specific entities |
| US5354873A (en) | 1991-11-20 | 1994-10-11 | Polaroid Corporation | Squarylium dyes, and processes and intermediates for the preparation thereof |
| GB9521943D0 (en) | 1995-10-26 | 1996-01-03 | Univ Hertfordshire | Coded particles for process sequence tracking in combinatorial compound library preparation |
| US5641634A (en) | 1995-11-30 | 1997-06-24 | Mandecki; Wlodek | Electronically-indexed solid-phase assay for biomolecules |
| US20020150909A1 (en) | 1999-02-09 | 2002-10-17 | Stuelpnagel John R. | Automated information processing in randomly ordered arrays |
| US20030134330A1 (en) | 1999-04-15 | 2003-07-17 | Ilya Ravkin | Chemical-library composition and method |
| WO2000063695A1 (en) | 1999-04-16 | 2000-10-26 | Tibotec N.V. | Encoding of microcarriers |
| EP1204869B1 (en) | 1999-08-17 | 2008-10-22 | Luminex Corporation | Method for analyzing a number of samples from a variety of sources for a single analyte |
| US6934408B2 (en) | 2000-08-25 | 2005-08-23 | Amnis Corporation | Method and apparatus for reading reporter labeled beads |
| JP4404547B2 (ja) | 2000-10-19 | 2010-01-27 | バイオカルテイス・エス・エイ | マイクロキャリアの識別用操作のための方法及び装置 |
| US20020155618A1 (en) | 2001-01-17 | 2002-10-24 | O'hagan David | Methods of analyzing and sorting one or more analytes |
| US7811768B2 (en) | 2001-01-26 | 2010-10-12 | Aviva Biosciences Corporation | Microdevice containing photorecognizable coding patterns and methods of using and producing the same |
| US7872804B2 (en) | 2002-08-20 | 2011-01-18 | Illumina, Inc. | Encoded particle having a grating with variations in the refractive index |
| US7960184B2 (en) * | 2002-09-20 | 2011-06-14 | George Mason Intellectual Properties, Inc. | Methods and devices for active bioassay |
| WO2004027378A2 (en) | 2002-09-20 | 2004-04-01 | Promega Corporation | Luminescence-based methods and probes for measuring cytochrome p450 activity |
| DE10345021A1 (de) | 2003-09-23 | 2005-05-04 | Univ Potsdam | Verfahren zur nichtinvasiven Früherkennung von Dickdarmkrebs und/oder Darmkrebsvorläuferzellen |
| US7456506B2 (en) | 2005-03-14 | 2008-11-25 | Rcd Technology Inc. | Radio frequency identification (RFID) tag lamination process using liner |
| US7858307B2 (en) | 2005-08-09 | 2010-12-28 | Maxwell Sensors, Inc. | Light transmitted assay beads |
| US8232092B2 (en) * | 2005-08-09 | 2012-07-31 | Maxwell Sensors, Inc. | Apparatus and method for digital magnetic beads analysis |
| US7871770B2 (en) | 2005-08-09 | 2011-01-18 | Maxwell Sensors, Inc. | Light transmitted assay beads |
| US20090201504A1 (en) | 2005-08-09 | 2009-08-13 | Maxwell Sensors, Inc. | Hydrodynamic focusing for analyzing rectangular microbeads |
| US20100227770A1 (en) * | 2005-09-13 | 2010-09-09 | Randall True | Brownian microbarcodes for bioassays |
| US8697334B2 (en) | 2005-09-13 | 2014-04-15 | Affymetrix, Inc. | Miniaturized microparticles |
| US8586389B2 (en) | 2005-09-28 | 2013-11-19 | Kent State University | Ligand concentrating, liquid crystal biosensor system |
| EP2384811A1 (en) | 2006-01-11 | 2011-11-09 | Novo Nordisk A/S | A spherical encoded bead with an ultrasonic identification chip |
| US20070238140A1 (en) | 2006-04-07 | 2007-10-11 | Pentoney Stephen L Jr | Method For Multiplex Bead-Based Assays Using Chemiluminescence and Fluorescence |
| US20080129455A1 (en) | 2006-05-24 | 2008-06-05 | Rcd Technology Inc. | Method for forming rfid tags |
| EP1903337B1 (en) | 2006-09-20 | 2015-07-22 | Mycartis N.V. | Coating for microcarriers |
| US7884719B2 (en) | 2006-11-21 | 2011-02-08 | Rcd Technology Inc. | Radio frequency identification (RFID) tag lamination process |
| WO2008116093A2 (en) | 2007-03-20 | 2008-09-25 | Becton, Dickinson And Company | Assays using surface-enhanced raman spectroscopy (sers)-active particles |
| EP3620465B1 (en) | 2007-07-03 | 2025-02-19 | Dako Denmark A/S | Improved methods for generation, labeling and use of mhc multimers |
| JP2010536029A (ja) * | 2007-08-08 | 2010-11-25 | マックスウェル センサーズ インコーポレイテッド | デジタル磁気ビーズ分析のための装置および方法 |
| EP3136103B1 (en) * | 2007-10-05 | 2018-08-29 | Affymetrix, Inc. | Highly multiplexed assays |
| EP2342561B1 (en) | 2008-10-08 | 2019-06-26 | Applied Biocode Inc. | Biocompatible and photocurable polymers |
| EP2367633B1 (en) | 2008-12-23 | 2019-03-27 | MyCartis N.V. | Assay device and method for performing biological assays |
| US20110007955A1 (en) * | 2009-07-08 | 2011-01-13 | Applied Biocode Inc. | Apparatus and Method for Barcoded Magnetic Beads Analysis |
| AU2010278710A1 (en) | 2009-07-31 | 2012-03-15 | Prognosys Biosciences, Inc. | Assay tools and methods of use |
| EP2312393A1 (en) | 2009-10-14 | 2011-04-20 | Biocartis SA | Method for producing microparticles |
| KR101932628B1 (ko) * | 2010-06-07 | 2018-12-27 | 파이어플라이 바이오웍스, 인코포레이티드 | 후혼성 표지화 및 범용 코드화에 의한 핵산 검출 및 정량화 |
| US20120088691A1 (en) | 2010-10-08 | 2012-04-12 | Gao Chen | Highly multiplexed real-time pcr using encoded microbeads |
| EP2484447A1 (en) | 2011-02-07 | 2012-08-08 | Biocartis SA | Improved encoded microcarriers, assay system using them and method for performing an assay |
| KR101827849B1 (ko) | 2011-02-09 | 2018-02-12 | 삼성디스플레이 주식회사 | 블랙 매트릭스 레지스트 조성물, 블랙 매트릭스 레지스트 제조 방법, 컬러 필터 표시판 및 그 제조 방법 |
| EP2776833B1 (en) * | 2011-11-11 | 2018-09-05 | Eli N. Glezer | Co-binder assisted assay methods |
| EP2690057A1 (en) | 2012-07-24 | 2014-01-29 | Biocartis SA | Method for producing structured microcarriers |
| EP4148118A1 (en) * | 2012-08-24 | 2023-03-15 | Yale University | System, device and method for high-throughput multi-plexed detection |
| US9063044B2 (en) | 2013-02-27 | 2015-06-23 | Plexbio Co. Ltd. | Magnetic aggregating and washing device for in vitro assays and methods of use thereof |
| EP2774997A1 (en) | 2013-03-05 | 2014-09-10 | Bayer Pharma Aktiengesellschaft | Detection of Androgen Receptor (AR) mutations in circulating tumor DNA from plasma samples of castration-resistant prostate cancer patients using locked nucleic acid-clamp PCR |
| US10436778B2 (en) | 2013-03-15 | 2019-10-08 | Plexbio Co., Ltd. | Methods and systems for multiplex assays |
| US10119964B2 (en) | 2014-12-22 | 2018-11-06 | Digital Biotech, LLC | Multiplex assay strip, beads, device and method |
| TWI737614B (zh) * | 2015-06-11 | 2021-09-01 | 博錸生技股份有限公司 | 已編碼微載體及其製造方法以及用以進行多工分析之包含該等已編碼微載體之套件 |
| US10436776B2 (en) | 2015-11-20 | 2019-10-08 | Plexbio Co., Ltd. | Methods and systems for selection of detection area |
| US10019815B2 (en) | 2016-03-17 | 2018-07-10 | Plexbio Co., Ltd. | Methods and systems for image differentiated multiplex assays |
| US20180195113A1 (en) | 2016-12-09 | 2018-07-12 | Plexbio Co., Ltd. | Image differentiated multiplex assays for multiplex detection of dna mutations |
| US10894975B2 (en) | 2016-12-09 | 2021-01-19 | Plexbio Co., Ltd. | Image differentiated multiplex assays for multiplex detection of DNA mutations |
-
2016
- 2016-11-21 EP EP16916388.8A patent/EP3513186A4/en active Pending
- 2016-11-21 US US16/332,271 patent/US11796535B2/en active Active
- 2016-11-21 CN CN201680089213.3A patent/CN110073212B/zh active Active
- 2016-11-21 JP JP2019514077A patent/JP7062002B2/ja active Active
- 2016-11-21 WO PCT/US2016/063202 patent/WO2018052464A1/en not_active Ceased
- 2016-11-21 AU AU2016423082A patent/AU2016423082B2/en active Active
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