JP2019512224A5 - - Google Patents
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- Publication number
- JP2019512224A5 JP2019512224A5 JP2018546669A JP2018546669A JP2019512224A5 JP 2019512224 A5 JP2019512224 A5 JP 2019512224A5 JP 2018546669 A JP2018546669 A JP 2018546669A JP 2018546669 A JP2018546669 A JP 2018546669A JP 2019512224 A5 JP2019512224 A5 JP 2019512224A5
- Authority
- JP
- Japan
- Prior art keywords
- epitope tag
- antibody
- epitope
- seq
- construct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 8
- 238000001514 detection method Methods 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- 125000006850 spacer group Chemical group 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 229940127121 immunoconjugate Drugs 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 239000003593 chromogenic compound Substances 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021156935A JP7174126B2 (ja) | 2016-03-08 | 2021-09-27 | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
| JP2022177332A JP2023024990A (ja) | 2016-03-08 | 2022-11-04 | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662305440P | 2016-03-08 | 2016-03-08 | |
| US62/305,440 | 2016-03-08 | ||
| US201662418667P | 2016-11-07 | 2016-11-07 | |
| US62/418,667 | 2016-11-07 | ||
| US201762461651P | 2017-02-21 | 2017-02-21 | |
| US62/461,651 | 2017-02-21 | ||
| PCT/US2017/021157 WO2017155996A1 (en) | 2016-03-08 | 2017-03-07 | Multiplexed immunohistochemistry using recombinant antibodies with epitope tags |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021156935A Division JP7174126B2 (ja) | 2016-03-08 | 2021-09-27 | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019512224A JP2019512224A (ja) | 2019-05-16 |
| JP2019512224A5 true JP2019512224A5 (enExample) | 2020-04-16 |
| JP6952706B2 JP6952706B2 (ja) | 2021-10-20 |
Family
ID=58361148
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546669A Active JP6952706B2 (ja) | 2016-03-08 | 2017-03-07 | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
| JP2021156935A Active JP7174126B2 (ja) | 2016-03-08 | 2021-09-27 | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
| JP2022177332A Pending JP2023024990A (ja) | 2016-03-08 | 2022-11-04 | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021156935A Active JP7174126B2 (ja) | 2016-03-08 | 2021-09-27 | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
| JP2022177332A Pending JP2023024990A (ja) | 2016-03-08 | 2022-11-04 | エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11112413B2 (enExample) |
| EP (1) | EP3426684B1 (enExample) |
| JP (3) | JP6952706B2 (enExample) |
| AU (1) | AU2017229370B2 (enExample) |
| CA (1) | CA3016555A1 (enExample) |
| WO (1) | WO2017155996A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3002674A1 (en) | 2015-10-30 | 2017-05-04 | Aleta Biotherapeutics Inc. | Compositions and methods for treatment of cancer |
| MX2018005348A (es) | 2015-10-30 | 2018-08-14 | Aleta Biotherapeutics Inc | Composiciones y metodos para transduccion de tumores. |
| AU2017229370B2 (en) * | 2016-03-08 | 2021-03-11 | Ventana Medical Systems, Inc. | Multiplexed immunohistochemistry using recombinant antibodies with epitope tags |
| WO2019094095A1 (en) * | 2017-11-07 | 2019-05-16 | Trustees Of Tufts College | Heteromultimeric binding molecules for toxin neutralization, compositions and methods thereof |
| CN113710365B (zh) * | 2019-04-03 | 2023-12-19 | 万迈医疗仪器有限公司 | 用于在免疫测定中重复使用半抗原涂覆的探针的方法 |
| CN110850094A (zh) * | 2019-11-22 | 2020-02-28 | 西安交通大学 | 一种免疫组化双标单染试剂盒及其使用方法和应用 |
| CN114113616B (zh) * | 2021-12-07 | 2022-08-23 | 深圳裕策生物科技有限公司 | 一种试剂盒及其染色方法 |
| WO2023162042A1 (ja) | 2022-02-22 | 2023-08-31 | 日本電信電話株式会社 | センサー付きハイドロゲル流路型デバイス |
| JP2025532064A (ja) | 2022-09-22 | 2025-09-29 | アジレント・テクノロジーズ・インク | 免疫組織化学（ｉｈｃ）プロトコールにおける使用のためおよびがんを診断するための抗ヒトｉｃｏｓ抗体 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1564604A (en) | 1925-06-12 | 1925-12-08 | Chas S Hodges | Water wheel |
| US5595707A (en) | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
| US20030211630A1 (en) | 1998-02-27 | 2003-11-13 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| AU763354B2 (en) | 1998-02-27 | 2003-07-17 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US6582962B1 (en) | 1998-02-27 | 2003-06-24 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US6670113B2 (en) | 2001-03-30 | 2003-12-30 | Nanoprobes | Enzymatic deposition and alteration of metals |
| US7632652B2 (en) | 2003-06-24 | 2009-12-15 | Ventana Medical Systems, Inc. | Enzyme-catalyzed metal deposition for the enhanced in situ detection of immunohistochemical epitopes and nucleic acid sequences |
| AU2006239315B2 (en) | 2005-04-28 | 2012-03-01 | Ventana Medical Systems, Inc. | Enzymes conjugated to antiobodies via a PEG heterobifuctional linker |
| EP3095467B1 (en) | 2005-11-23 | 2020-05-06 | Ventana Medical Systems, Inc. | Antibody-enzyme conjugate |
| DK2078197T3 (en) | 2006-11-01 | 2016-05-23 | Ventana Med Syst Inc | Haptenes, hapten conjugates, compositions thereof and processes for their preparation and use |
| EP3561513A1 (en) | 2007-05-23 | 2019-10-30 | Ventana Medical Systems, Inc. | Polymeric carriers for immunohistochemistry and in situ hybridization |
| US20080299555A1 (en) * | 2007-05-30 | 2008-12-04 | Hiroaki Nitta | Multicolor chromogenic detection of biomarkers |
| WO2009111729A1 (en) * | 2008-03-06 | 2009-09-11 | Ventana Medical Systems, Inc. | Anti-dnp antibodies and methods of use |
| CA2734783C (en) | 2008-08-22 | 2016-04-19 | Ventana Medical Systems, Inc. | Method for chromogenic detection of two or more target molecules in a single sample |
| US20120034223A1 (en) * | 2008-11-06 | 2012-02-09 | Hall Christopher J | Methods of improving the therapeutic efficacy and utility of antibody fragments |
| EP2993478B1 (en) | 2009-10-19 | 2022-08-24 | Ventana Medical Systems, Inc. | Device and method for slide caching |
| WO2011139978A1 (en) | 2010-05-04 | 2011-11-10 | Ventana Medical Systems, Inc. | Moving meniscus rinsing and mixing in cell staining |
| AU2011274369A1 (en) | 2010-07-02 | 2012-12-06 | Ventana Medical Systems, Inc. | Hapten conjugates for target detection |
| CA3062786C (en) * | 2010-07-09 | 2022-04-19 | Janssen Vaccines & Prevention B.V. | Anti-human respiratory syncytial virus (rsv) antibodies and methods of use |
| CA2940439C (en) | 2014-02-24 | 2024-03-19 | Ventana Medical Systems, Inc. | Quinone methide analog signal amplification |
| EP4215898A1 (en) | 2015-04-20 | 2023-07-26 | Ventana Medical Systems, Inc. | Inkjet deposition of reagents for histological samples |
| AU2017229370B2 (en) * | 2016-03-08 | 2021-03-11 | Ventana Medical Systems, Inc. | Multiplexed immunohistochemistry using recombinant antibodies with epitope tags |
-
2017
- 2017-03-07 AU AU2017229370A patent/AU2017229370B2/en active Active
- 2017-03-07 EP EP17712344.5A patent/EP3426684B1/en active Active
- 2017-03-07 CA CA3016555A patent/CA3016555A1/en active Pending
- 2017-03-07 WO PCT/US2017/021157 patent/WO2017155996A1/en not_active Ceased
- 2017-03-07 JP JP2018546669A patent/JP6952706B2/ja active Active
-
2018
- 2018-09-06 US US16/123,750 patent/US11112413B2/en active Active
-
2021
- 2021-07-30 US US17/389,757 patent/US11988673B2/en active Active
- 2021-09-27 JP JP2021156935A patent/JP7174126B2/ja active Active
-
2022
- 2022-11-04 JP JP2022177332A patent/JP2023024990A/ja active Pending
-
2024
- 2024-03-26 US US18/617,474 patent/US20240230667A1/en active Pending
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