JP2019534863A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019534863A5 JP2019534863A5 JP2019515630A JP2019515630A JP2019534863A5 JP 2019534863 A5 JP2019534863 A5 JP 2019534863A5 JP 2019515630 A JP2019515630 A JP 2019515630A JP 2019515630 A JP2019515630 A JP 2019515630A JP 2019534863 A5 JP2019534863 A5 JP 2019534863A5
- Authority
- JP
- Japan
- Prior art keywords
- liquid pharmaceutical
- pharmaceutical composition
- composition according
- delivery device
- drug delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 238000012377 drug delivery Methods 0.000 claims 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229920005862 polyol Polymers 0.000 claims 3
- 150000003077 polyols Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- 229930195725 Mannitol Natural products 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000000594 mannitol Substances 0.000 claims 2
- 235000010355 mannitol Nutrition 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 229920000136 polysorbate Polymers 0.000 claims 2
- 229950008882 polysorbate Drugs 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 229940068968 polysorbate 80 Drugs 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 208000007465 Giant cell arteritis Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 206010043207 temporal arteritis Diseases 0.000 claims 1
- 229960003989 tocilizumab Drugs 0.000 claims 1
- 239000008215 water for injection Substances 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022146770A JP2022188075A (ja) | 2016-09-27 | 2022-09-15 | 液体医薬組成物 |
| JP2024148123A JP2024178197A (ja) | 2016-09-27 | 2024-08-30 | 液体医薬組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16190957 | 2016-09-27 | ||
| EP16190957.7 | 2016-09-27 | ||
| PCT/EP2017/074413 WO2018060210A1 (en) | 2016-09-27 | 2017-09-26 | Liquid pharmaceutical composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022146770A Division JP2022188075A (ja) | 2016-09-27 | 2022-09-15 | 液体医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019534863A JP2019534863A (ja) | 2019-12-05 |
| JP2019534863A5 true JP2019534863A5 (enExample) | 2020-08-20 |
Family
ID=57047015
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019515630A Pending JP2019534863A (ja) | 2016-09-27 | 2017-09-26 | 液体医薬組成物 |
| JP2022146770A Pending JP2022188075A (ja) | 2016-09-27 | 2022-09-15 | 液体医薬組成物 |
| JP2024148123A Pending JP2024178197A (ja) | 2016-09-27 | 2024-08-30 | 液体医薬組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022146770A Pending JP2022188075A (ja) | 2016-09-27 | 2022-09-15 | 液体医薬組成物 |
| JP2024148123A Pending JP2024178197A (ja) | 2016-09-27 | 2024-08-30 | 液体医薬組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10961314B2 (enExample) |
| EP (1) | EP3518891A1 (enExample) |
| JP (3) | JP2019534863A (enExample) |
| KR (1) | KR102546471B1 (enExample) |
| CN (1) | CN109862880A (enExample) |
| AU (1) | AU2017333367A1 (enExample) |
| BR (1) | BR112019005328A2 (enExample) |
| CA (1) | CA3037440A1 (enExample) |
| MA (1) | MA46334A (enExample) |
| RU (1) | RU2019112680A (enExample) |
| WO (1) | WO2018060210A1 (enExample) |
| ZA (1) | ZA201901590B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| KR101933197B1 (ko) | 2010-11-08 | 2018-12-27 | 제넨테크, 인크. | 피하 투여용 항―ｉｌ―6 수용체 항체 |
| BR112019005328A2 (pt) * | 2016-09-27 | 2019-06-18 | Fresenius Kabi Deutschland Gmbh | composição farmacêutica líquida |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| MX2020005630A (es) * | 2017-11-30 | 2020-08-20 | Bio Thera Solutions Ltd | Formulacion liquida de anticuerpos humanizados para el tratamiento de enfermedades relacionadas con il-6. |
| US11427639B2 (en) * | 2018-04-02 | 2022-08-30 | Richter Gedeon Nyrt. | Antibody-containing aqueous formulation and use thereof |
| WO2020088346A1 (en) | 2018-10-31 | 2020-05-07 | Mycenax Biotech Inc. | Aqueous pharmaceutical formulations |
| KR20210124308A (ko) | 2019-01-30 | 2021-10-14 | 트루바인딩 아이엔씨. | 항-gal3 항체 및 이의 용도 |
| CN110179746A (zh) | 2019-05-17 | 2019-08-30 | 通化东宝生物科技有限公司 | 一种稳定的苏金单抗注射剂及其制备方法 |
| EP3714902B1 (en) * | 2020-03-13 | 2024-08-28 | LEK Pharmaceuticals d.d. | Stabilization of pharmaceutical compositions comprising polysorbate |
| CN113456582B (zh) * | 2020-03-30 | 2024-06-14 | 鲁南制药集团股份有限公司 | 重组人源化抗pd-1单克隆抗体的液体制剂 |
| CN115605184A (zh) * | 2020-05-15 | 2023-01-13 | 豪夫迈·罗氏有限公司（Ch） | 防止胃肠外蛋白质溶液中的可见颗粒形成 |
| MX2022014786A (es) | 2020-05-26 | 2023-01-16 | Truebinding Inc | Metodos para tratar enfermedades inflamatorias mediante el bloqueo de galectina-3. |
| RU2745814C1 (ru) * | 2020-06-05 | 2021-04-01 | Закрытое Акционерное Общество "Биокад" | Водная фармацевтическая композиция левилимаба и ее применение |
| WO2022006051A1 (en) * | 2020-06-29 | 2022-01-06 | Anovent Pharmaceutical (U.S.), Llc | Formulation of tocilizumab and method for treating covid-19 by inhalation |
| WO2022037606A1 (en) * | 2020-08-19 | 2022-02-24 | Bio-Thera Solutions, Ltd. | Liquid formulations comprising high concentrations humanized antibodies for treating il-6 related diseases |
| KR20220028972A (ko) * | 2020-08-31 | 2022-03-08 | (주)셀트리온 | 안정한 약제학적 제제 |
| WO2022139457A1 (ko) * | 2020-12-24 | 2022-06-30 | 이니스트에스티 주식회사 | 봉독 추출물로부터 bvPLA2를 50~99% 함량으로 포함하는 봉독 주사제 조성물 및 이의 제조방법 |
| WO2024245170A1 (en) * | 2023-05-26 | 2024-12-05 | Bio-Thera Solutions, Ltd. | Liquid formulations comprising high concentrations humanized antibodies for treating il-6 related diseases |
| WO2026117626A1 (en) * | 2024-11-27 | 2026-06-04 | Disc Medicine, Inc. | Antibody compositions and uses thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU668349B2 (en) | 1991-04-25 | 1996-05-02 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human interleukin 6 receptor |
| US8632778B2 (en) | 2000-08-11 | 2014-01-21 | Chugai Seiyaku Kabushiki Kaisha | Stabilized anti-interleukin-6 antibody-containing preparations |
| WO2003068260A1 (fr) | 2002-02-14 | 2003-08-21 | Chugai Seiyaku Kabushiki Kaisha | Produits pharmaceutiques en solution contenant des anticorps |
| PE20091174A1 (es) * | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| MX2011005672A (es) * | 2008-11-28 | 2011-06-20 | Abbott Lab | Composiciones de anticuerpo estables y metodos para estabilizar a las mismas. |
| EP2196476A1 (en) * | 2008-12-10 | 2010-06-16 | Novartis Ag | Antibody formulation |
| CN102387814A (zh) * | 2009-01-29 | 2012-03-21 | 米迪缪尼有限公司 | 延长体内半衰期的人抗il-6抗体及其在治疗肿瘤、自身免疫性疾病和炎症性疾病中的应用 |
| RU2565809C2 (ru) * | 2009-03-19 | 2015-10-20 | Чугаи Сейяку Кабусики Кайся | Фармацевтический состав, содержащий молекулы антител с улучшенными свойствами |
| PL3721904T3 (pl) * | 2009-11-20 | 2022-01-31 | Biocon Limited | Formulacje przeciwciała t1h |
| US20110158987A1 (en) * | 2009-12-29 | 2011-06-30 | F. Hoffmann-Laroche Ag | Novel antibody formulation |
| JO3417B1 (ar) * | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
| KR101933197B1 (ko) * | 2010-11-08 | 2018-12-27 | 제넨테크, 인크. | 피하 투여용 항―ｉｌ―6 수용체 항체 |
| UY34105A (es) * | 2011-06-03 | 2012-07-31 | Lg Life Sciences Ltd | Formulación líquida estable de etanercept |
| AU2012328524B2 (en) | 2011-10-28 | 2017-05-18 | Excelse Bio, Inc. | Protein formulations containing amino acids |
| US20150239970A1 (en) * | 2012-10-25 | 2015-08-27 | Medimmune, Llc | Stable, Low Viscosity Antibody Formulation |
| BR112019005328A2 (pt) * | 2016-09-27 | 2019-06-18 | Fresenius Kabi Deutschland Gmbh | composição farmacêutica líquida |
| MX2020005630A (es) * | 2017-11-30 | 2020-08-20 | Bio Thera Solutions Ltd | Formulacion liquida de anticuerpos humanizados para el tratamiento de enfermedades relacionadas con il-6. |
| WO2022037606A1 (en) * | 2020-08-19 | 2022-02-24 | Bio-Thera Solutions, Ltd. | Liquid formulations comprising high concentrations humanized antibodies for treating il-6 related diseases |
| WO2023020563A1 (en) * | 2021-08-18 | 2023-02-23 | Bio-Thera Solutions, Ltd. | Liquid formulations comprising high concentrations humanized antibodies for treating il-6 related diseases |
-
2017
- 2017-09-26 BR BR112019005328A patent/BR112019005328A2/pt not_active Application Discontinuation
- 2017-09-26 AU AU2017333367A patent/AU2017333367A1/en not_active Abandoned
- 2017-09-26 RU RU2019112680A patent/RU2019112680A/ru unknown
- 2017-09-26 US US16/334,310 patent/US10961314B2/en active Active
- 2017-09-26 KR KR1020197010731A patent/KR102546471B1/ko active Active
- 2017-09-26 JP JP2019515630A patent/JP2019534863A/ja active Pending
- 2017-09-26 EP EP17780054.7A patent/EP3518891A1/en active Pending
- 2017-09-26 CA CA3037440A patent/CA3037440A1/en active Pending
- 2017-09-26 WO PCT/EP2017/074413 patent/WO2018060210A1/en not_active Ceased
- 2017-09-26 MA MA046334A patent/MA46334A/fr unknown
- 2017-09-26 CN CN201780059493.8A patent/CN109862880A/zh active Pending
-
2019
- 2019-03-14 ZA ZA2019/01590A patent/ZA201901590B/en unknown
-
2021
- 2021-02-22 US US17/181,829 patent/US20210261673A1/en not_active Abandoned
-
2022
- 2022-09-15 JP JP2022146770A patent/JP2022188075A/ja active Pending
-
2023
- 2023-10-25 US US18/494,630 patent/US20240150479A1/en active Pending
-
2024
- 2024-08-30 JP JP2024148123A patent/JP2024178197A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019536761A5 (enExample) | ||
| RU2019112680A (ru) | Жидкая фармацевтическая композиция | |
| Lambros et al. | Citric acid: A multifunctional pharmaceutical excipient | |
| JP2021523162A5 (enExample) | ||
| JP2022166006A5 (enExample) | ||
| RU2019116756A (ru) | Жидкая фармацевтическая композиция | |
| ES2540204T3 (es) | Formulaciones farmacéuticas de inhibidores de la HDAC | |
| US20230338546A1 (en) | Oral formulations of kappa opioid receptor agonists | |
| US9060930B2 (en) | Process for making gastroretentive dosage forms | |
| KR20190107712A (ko) | 특정 위장 부위에서의 제어 방출의 투여 형태 | |
| CN108366956B (zh) | 物理和化学稳定的吉维诺司他口服混悬液 | |
| KR20150111358A (ko) | 증가된 안정성의 신규한 액체 조성물 | |
| NZ730821A (en) | Stable protein solution formulation containing high concentration of an anti-vegf antibody | |
| BR0213143A (pt) | Composições lìquidas para administração oral contendo guaifenesina e um copolìmero de bloco polioxialquileno | |
| BRPI0513904B8 (pt) | forma farmacêutica de multipartícula para substâncias ativas de baixa solubilidade e um processo para preparar a forma farmacêutica | |
| JP2019504086A5 (enExample) | ||
| JP2015512374A5 (enExample) | ||
| JP2010500360A5 (enExample) | ||
| RU2005136983A (ru) | Способ затвердевания с применением антирастворителя | |
| ZA202102986B (en) | Protein solution formulation containing high concentration of an anti-vegf antibody | |
| ES2335622T3 (es) | Suspension acuosa estable con buen gusto. | |
| Morici et al. | Recent advances in nanocrystals for arthritis drug delivery | |
| RU2016119565A (ru) | Полипептиды длительного действия и способы их получения и введения | |
| JP2016535015A5 (enExample) | ||
| JP2005507408A (ja) | 新規製剤 |