JP2019533714A5 - - Google Patents
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- JP2019533714A5 JP2019533714A5 JP2019524943A JP2019524943A JP2019533714A5 JP 2019533714 A5 JP2019533714 A5 JP 2019533714A5 JP 2019524943 A JP2019524943 A JP 2019524943A JP 2019524943 A JP2019524943 A JP 2019524943A JP 2019533714 A5 JP2019533714 A5 JP 2019533714A5
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- JP
- Japan
- Prior art keywords
- alkyl
- halogen
- cycloalkyl
- case
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 Cc1cc(*)c(*)c(*)c1 Chemical compound Cc1cc(*)c(*)c(*)c1 0.000 description 3
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023000165A JP2023033259A (ja) | 2016-11-11 | 2023-01-04 | 脂質合成の複素環式モジュレーター |
| JP2024229040A JP2025036565A (ja) | 2016-11-11 | 2024-12-25 | 脂質合成の複素環式モジュレーター |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/349,960 | 2016-11-11 | ||
| US15/349,960 US20170119786A1 (en) | 2011-03-08 | 2016-11-11 | Heterocyclic modulators of lipid synthesis |
| US201762574497P | 2017-10-19 | 2017-10-19 | |
| US62/574,497 | 2017-10-19 | ||
| PCT/US2017/061330 WO2018089904A1 (en) | 2016-11-11 | 2017-11-13 | Heterocyclic modulators of lipid synthesis |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023000165A Division JP2023033259A (ja) | 2016-11-11 | 2023-01-04 | 脂質合成の複素環式モジュレーター |
| JP2024229040A Division JP2025036565A (ja) | 2016-11-11 | 2024-12-25 | 脂質合成の複素環式モジュレーター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019533714A JP2019533714A (ja) | 2019-11-21 |
| JP2019533714A5 true JP2019533714A5 (https=) | 2020-12-10 |
| JP7668509B2 JP7668509B2 (ja) | 2025-04-25 |
Family
ID=60473676
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019524943A Active JP7668509B2 (ja) | 2016-11-11 | 2017-11-13 | 脂質合成の複素環式モジュレーター |
| JP2023000165A Pending JP2023033259A (ja) | 2016-11-11 | 2023-01-04 | 脂質合成の複素環式モジュレーター |
| JP2024229040A Withdrawn JP2025036565A (ja) | 2016-11-11 | 2024-12-25 | 脂質合成の複素環式モジュレーター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023000165A Pending JP2023033259A (ja) | 2016-11-11 | 2023-01-04 | 脂質合成の複素環式モジュレーター |
| JP2024229040A Withdrawn JP2025036565A (ja) | 2016-11-11 | 2024-12-25 | 脂質合成の複素環式モジュレーター |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11034690B2 (https=) |
| EP (1) | EP3538088A1 (https=) |
| JP (3) | JP7668509B2 (https=) |
| KR (3) | KR102890891B1 (https=) |
| CN (3) | CN121774967A (https=) |
| AU (2) | AU2017356214B2 (https=) |
| CA (1) | CA3043308A1 (https=) |
| IL (1) | IL266505B2 (https=) |
| NZ (1) | NZ754372A (https=) |
| WO (1) | WO2018089904A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170119786A1 (en) | 2011-03-08 | 2017-05-04 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| CN110078613B (zh) * | 2019-05-31 | 2022-04-22 | 杭州科耀医药科技有限公司 | 一种2-卤-5-碘苯甲酸的合成方法 |
| UY38911A (es) | 2019-10-09 | 2021-05-31 | Bayer Ag | Compuestos de heteroarilo-triazol como pesticidas, formulaciones, usos y métodos de uso de los mismos |
| CN114469945A (zh) * | 2020-10-28 | 2022-05-13 | 歌礼生物科技（杭州）有限公司 | 脂肪酸合酶抑制剂的用途和药物组合物 |
| US20250166821A1 (en) * | 2021-11-11 | 2025-05-22 | Sagimet Biosciences Inc. | Methods for prediction of treatment response in non-alcoholic fatty liver disease |
| CN114436979B (zh) * | 2022-02-22 | 2024-03-26 | 成都化润药业有限公司 | 一种合成1,2,4-三氮唑-3-羧酸甲酯的方法 |
| JPWO2024172156A1 (https=) * | 2023-02-16 | 2024-08-22 | ||
| CN119080742A (zh) * | 2023-06-05 | 2024-12-06 | 甘莱制药有限公司 | 脂质合成的杂环调节剂的工业化制备 |
| WO2025086054A1 (zh) * | 2023-10-23 | 2025-05-01 | 歌礼生物科技（杭州）有限公司 | 一种包含苯甲腈衍生物的药物组合物 |
| CN119868349A (zh) * | 2023-10-23 | 2025-04-25 | 歌礼生物科技（杭州）有限公司 | 一种包含苯甲腈衍生物的药物组合物 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
| WO2007052843A1 (ja) | 2005-11-04 | 2007-05-10 | Takeda Pharmaceutical Company Limited | 複素環アミド化合物およびその用途 |
| EP1959951B1 (en) | 2005-12-01 | 2009-12-23 | F. Hoffmann-la Roche AG | Heteroaryl substituted piperidine derivatives as l-cpt1 inhibitors |
| CN101534836B (zh) | 2006-09-05 | 2011-09-28 | 彼帕科学公司 | Parp抑制剂在制备治疗肥胖症的药物中的用途 |
| WO2008059214A1 (en) * | 2006-11-13 | 2008-05-22 | Astrazeneca Ab | Bisamlde derivatives and use thereof as fatty acid synthase inhibitors |
| TW200831092A (en) * | 2006-12-21 | 2008-08-01 | Astrazeneca Ab | Therapeutic agents |
| WO2008075077A1 (en) | 2006-12-21 | 2008-06-26 | Astrazeneca Ab | Piperidine derivatives for the treatment of obesity |
| TW200833663A (en) | 2006-12-21 | 2008-08-16 | Astrazeneca Ab | Therapeutic agents |
| CA2774476A1 (en) | 2009-10-07 | 2011-04-14 | Francis Barany | Coferons and methods of making and using them |
| JP2013520502A (ja) * | 2010-02-25 | 2013-06-06 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体 |
| US9624173B2 (en) | 2011-03-08 | 2017-04-18 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| EP3190108B1 (en) * | 2011-03-08 | 2021-05-19 | Sagimet Biosciences Inc. | Heterocyclic modulators of lipid synthesis |
| US20170119786A1 (en) | 2011-03-08 | 2017-05-04 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| TWI522348B (zh) | 2011-03-08 | 2016-02-21 | ３ Ｖ生物科技公司 | 脂質合成之雜環調節劑 |
| BR112015000106B1 (pt) * | 2012-07-03 | 2022-02-22 | Sagimet Biosciences Inc | Moduladores heterocíclicos de síntese de lipídio, composição farmacêutica e uso dos referidos moduladores |
| JP6285442B2 (ja) | 2012-09-07 | 2018-02-28 | ヤンセン ファーマシューティカ エヌ．ベー． | がん治療用の脂肪酸合成酵素（ｆａｓｎ）阻害剤として有用なイミダゾリン−５−オン誘導体 |
| US9562035B2 (en) * | 2013-12-03 | 2017-02-07 | Janssen Pharmaceutica Nv | Benzamide derivative useful as FASN inhibitors for the treatment of cancer |
| WO2015095011A1 (en) * | 2013-12-17 | 2015-06-25 | Janssen Pharmaceutica Nv | Imidazolin-5-one derivative useful as fasn inhibitors for the treatment of cancer |
| JP6820097B2 (ja) | 2013-12-20 | 2021-01-27 | サギメット バイオサイエンシーズ インコーポレイテッド | 脂質合成の複素環式モジュレータ及びその組み合わせ |
| EP3092232B1 (en) * | 2014-01-07 | 2022-03-09 | Sagimet Biosciences Inc. | Heterocyclic modulators of lipid synthesis for use against cancer and viral infections |
| LT3119757T (lt) * | 2014-03-17 | 2018-07-10 | Pfizer Inc. | Diacilglicerolio aciltransferazės 2 inhibitoriai, skirti panaudoti metabolinių ir susijusių ligų gydyme |
| KR102504168B1 (ko) | 2014-08-15 | 2023-02-27 | 새지메트 바이오사이언시스, 인코포레이티드 | 약물 내성 암의 치료에서 사용하기 위한 지방산 신타제 억제제 |
| KR20170129151A (ko) | 2015-03-19 | 2017-11-24 | 3-브이 바이오사이언시스, 인코포레이티드 | 지질 합성의 복소환식 조절제 |
-
2017
- 2017-11-13 JP JP2019524943A patent/JP7668509B2/ja active Active
- 2017-11-13 CN CN202512049345.7A patent/CN121774967A/zh active Pending
- 2017-11-13 KR KR1020247007294A patent/KR102890891B1/ko active Active
- 2017-11-13 AU AU2017356214A patent/AU2017356214B2/en active Active
- 2017-11-13 WO PCT/US2017/061330 patent/WO2018089904A1/en not_active Ceased
- 2017-11-13 CN CN202310077929.3A patent/CN116139138A/zh active Pending
- 2017-11-13 NZ NZ754372A patent/NZ754372A/en unknown
- 2017-11-13 CN CN201780083446.7A patent/CN110177551B/zh active Active
- 2017-11-13 KR KR1020257039033A patent/KR20250169632A/ko active Pending
- 2017-11-13 CA CA3043308A patent/CA3043308A1/en active Pending
- 2017-11-13 US US16/348,138 patent/US11034690B2/en active Active
- 2017-11-13 KR KR1020197016754A patent/KR102644934B1/ko active Active
- 2017-11-13 EP EP17804772.6A patent/EP3538088A1/en active Pending
-
2019
- 2019-05-07 IL IL266505A patent/IL266505B2/en unknown
-
2023
- 2023-01-04 JP JP2023000165A patent/JP2023033259A/ja active Pending
-
2024
- 2024-02-19 AU AU2024201067A patent/AU2024201067A1/en active Pending
- 2024-12-25 JP JP2024229040A patent/JP2025036565A/ja not_active Withdrawn
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