JP2019533695A5 - - Google Patents

Info

Publication number

JP2019533695A5

JP2019533695A5 JP2019522925A JP2019522925A JP2019533695A5 JP 2019533695 A5 JP2019533695 A5 JP 2019533695A5 JP 2019522925 A JP2019522925 A JP 2019522925A JP 2019522925 A JP2019522925 A JP 2019522925A JP 2019533695 A5 JP2019533695 A5 JP 2019533695A5

Authority

JP

Japan

Prior art keywords

subject

pharmaceutical composition

composition according

identified

acute kidney

Prior art date

2017-10-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 14
• DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 4
• 230000006378 damage Effects 0.000 claims 4
• 208000009304 Acute Kidney Injury Diseases 0.000 claims 3
• 208000007342 Diabetic Nephropathies Diseases 0.000 claims 3
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
• 208000033626 Renal failure acute Diseases 0.000 claims 3
• 201000011040 acute kidney failure Diseases 0.000 claims 3
• 208000020832 chronic kidney disease Diseases 0.000 claims 3
• 208000033679 diabetic kidney disease Diseases 0.000 claims 3
• 230000003907 kidney function Effects 0.000 claims 3
• 102100029228 Insulin-like growth factor-binding protein 7 Human genes 0.000 claims 2
• 102100026262 Metalloproteinase inhibitor 2 Human genes 0.000 claims 2
• 230000001154 acute effect Effects 0.000 claims 2
• 239000000090 biomarker Substances 0.000 claims 2
• 229940109239 creatinine Drugs 0.000 claims 2
• 230000024924 glomerular filtration Effects 0.000 claims 2
• 108010008598 insulin-like growth factor binding protein-related protein 1 Proteins 0.000 claims 2
• 210000003734 kidney Anatomy 0.000 claims 2
• 210000002966 serum Anatomy 0.000 claims 2
• 208000024891 symptom Diseases 0.000 claims 2
• 230000002485 urinary effect Effects 0.000 claims 2
• 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
• 108010036949 Cyclosporine Proteins 0.000 claims 1
• 206010016654 Fibrosis Diseases 0.000 claims 1
• 206010019280 Heart failures Diseases 0.000 claims 1
• 102000001554 Hemoglobins Human genes 0.000 claims 1
• 108010054147 Hemoglobins Proteins 0.000 claims 1
• 206010020772 Hypertension Diseases 0.000 claims 1
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
• 102000019210 Metalloproteinase inhibitor 2 Human genes 0.000 claims 1
• 108050006602 Metalloproteinase inhibitor 2 Proteins 0.000 claims 1
• 102000036675 Myoglobin Human genes 0.000 claims 1
• 108010062374 Myoglobin Proteins 0.000 claims 1
• 208000001647 Renal Insufficiency Diseases 0.000 claims 1
• 206010040047 Sepsis Diseases 0.000 claims 1
• ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 claims 1
• QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
• 229940126575 aminoglycoside Drugs 0.000 claims 1
• 238000007675 cardiac surgery Methods 0.000 claims 1
• 229960001265 ciclosporin Drugs 0.000 claims 1
• 230000007882 cirrhosis Effects 0.000 claims 1
• 208000019425 cirrhosis of liver Diseases 0.000 claims 1
• 208000029078 coronary artery disease Diseases 0.000 claims 1
• 210000004351 coronary vessel Anatomy 0.000 claims 1
• 229930182912 cyclosporin Natural products 0.000 claims 1
• 230000003247 decreasing effect Effects 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 208000002296 eclampsia Diseases 0.000 claims 1
• 229910001385 heavy metal Inorganic materials 0.000 claims 1
• HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims 1
• 229960001101 ifosfamide Drugs 0.000 claims 1
• 201000006370 kidney failure Diseases 0.000 claims 1
• 229960000485 methotrexate Drugs 0.000 claims 1
• 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
• 201000011461 pre-eclampsia Diseases 0.000 claims 1
• 201000001474 proteinuria Diseases 0.000 claims 1
• 230000005855 radiation Effects 0.000 claims 1
• 210000005084 renal tissue Anatomy 0.000 claims 1
• ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 claims 1
• 229960001052 streptozocin Drugs 0.000 claims 1
• 229960001967 tacrolimus Drugs 0.000 claims 1
• QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 238000007631 vascular surgery Methods 0.000 claims 1