JP2019532974A5 - - Google Patents
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- JP2019532974A5 JP2019532974A5 JP2019522663A JP2019522663A JP2019532974A5 JP 2019532974 A5 JP2019532974 A5 JP 2019532974A5 JP 2019522663 A JP2019522663 A JP 2019522663A JP 2019522663 A JP2019522663 A JP 2019522663A JP 2019532974 A5 JP2019532974 A5 JP 2019532974A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halo
- cycloalkyl
- oxo
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662416550P | 2016-11-02 | 2016-11-02 | |
| US62/416,550 | 2016-11-02 | ||
| US201662417893P | 2016-11-04 | 2016-11-04 | |
| US62/417,893 | 2016-11-04 | ||
| PCT/EP2017/077886 WO2018083085A1 (en) | 2016-11-02 | 2017-10-31 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019532974A JP2019532974A (ja) | 2019-11-14 |
| JP2019532974A5 true JP2019532974A5 (enExample) | 2020-12-03 |
| JP7059268B2 JP7059268B2 (ja) | 2022-04-25 |
Family
ID=60201582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522663A Expired - Fee Related JP7059268B2 (ja) | 2016-11-02 | 2017-10-31 | ＩＲＡＫ４モデュレーターとしてのピラゾロ［１，５ａ］ピリミジン誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11434250B2 (enExample) |
| EP (1) | EP3535273A1 (enExample) |
| JP (1) | JP7059268B2 (enExample) |
| CN (1) | CN109890829B (enExample) |
| WO (1) | WO2018083085A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI733982B (zh) | 2017-02-16 | 2021-07-21 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒衍生物 |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| TWI721483B (zh) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| JP7164705B2 (ja) * | 2018-08-13 | 2022-11-01 | ギリアード サイエンシーズ， インコーポレイテッド | ＩＲＡＫ４阻害剤としてのピロロ［１，２－ｂ］ピリダジン誘導体 |
| GB201904373D0 (en) * | 2019-03-29 | 2019-05-15 | Galapagos Nv | Novel compounds and pharamaceutical compositions thereof for the treatment of inflammatory disorders |
| CN113402499B (zh) | 2021-06-21 | 2022-05-13 | 上海勋和医药科技有限公司 | 一种亚磺酰亚胺取代的吲唑类irak4激酶抑制剂、制备方法及用途 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0329214D0 (en) | 2003-12-17 | 2004-01-21 | Glaxo Group Ltd | Novel compounds |
| US8642660B2 (en) | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| KR20110033223A (ko) | 2008-06-20 | 2011-03-30 | 제넨테크, 인크. | 트리아졸로피리딘 ｊａｋ 억제제 화합물 및 방법 |
| CN102985426B (zh) * | 2010-07-13 | 2015-10-07 | 弗·哈夫曼-拉罗切有限公司 | 作为irak4调节剂的吡唑并[1,5a]嘧啶和噻吩并[3,2b]嘧啶衍生物 |
| ES2846821T3 (es) | 2010-07-14 | 2021-07-29 | Ecole Polytechnique Fed Lausanne Epfl | Sistema y método para la evaluación de la marcha en 3D |
| CA2820362C (en) * | 2010-12-08 | 2020-03-24 | The United States Of America, As Represented By The Secretary, Departmt Of Health And Human Services | Substituted pyrazolopyrimidines as glucocerebrosidase activators |
| SMT202000713T1 (it) * | 2012-12-07 | 2021-03-15 | Vertex Pharma | Pirazolo [1,5-a] pirimidine utili come inibitori dell'atr chinasi per il trattamento di malattie del cancro |
| EP2943485B1 (en) * | 2013-01-14 | 2017-09-20 | Incyte Holdings Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
| KR20170016500A (ko) | 2014-06-20 | 2017-02-13 | 오리진 디스커버리 테크놀로지스 리미티드 | Irak4 저해제로서의 치환된 인다졸 화합물 |
| CN107001379B (zh) | 2014-11-06 | 2022-11-01 | Bial研发投资股份有限公司 | 取代的吡唑并[1,5-a]嘧啶以及它们在治疗医学障碍中的用途 |
| US10155765B2 (en) * | 2015-03-12 | 2018-12-18 | Merck Sharp & Dohme Corp. | Carboxamide inhibitors of IRAK4 activity |
| WO2016144846A1 (en) | 2015-03-12 | 2016-09-15 | Merck Sharp & Dohme Corp. | Pyrazolopyrimidine inhibitors of irak4 activity |
| WO2016144848A1 (en) | 2015-03-12 | 2016-09-15 | Merck Sharp & Dohme Corp. | Pyrrolotriazine inhibitors of irak4 activity |
| EP3268003B1 (en) | 2015-03-12 | 2020-07-29 | Merck Sharp & Dohme Corp. | Thienopyrazine inhibitors of irak4 activity |
| CN108024971A (zh) * | 2015-07-15 | 2018-05-11 | 奥列基因发现技术有限公司 | 作为irak-4抑制剂的取代的氮杂化合物 |
| AU2016293441A1 (en) | 2015-07-15 | 2018-02-01 | Aurigene Discovery Technologies Limited | Indazole and azaindazole compounds as IRAK-4 inhibitors |
| CN108473498B (zh) * | 2015-12-22 | 2021-11-02 | 豪夫迈·罗氏有限公司 | 作为IRAK4调节剂的吡唑并[1,5a]嘧啶衍生物 |
-
2017
- 2017-10-31 WO PCT/EP2017/077886 patent/WO2018083085A1/en not_active Ceased
- 2017-10-31 EP EP17792062.6A patent/EP3535273A1/en not_active Ceased
- 2017-10-31 JP JP2019522663A patent/JP7059268B2/ja not_active Expired - Fee Related
- 2017-10-31 CN CN201780065283.XA patent/CN109890829B/zh not_active Expired - Fee Related
-
2020
- 2020-04-30 US US16/863,741 patent/US11434250B2/en active Active
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