JP2019532974A5 - - Google Patents
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- JP2019532974A5 JP2019532974A5 JP2019522663A JP2019522663A JP2019532974A5 JP 2019532974 A5 JP2019532974 A5 JP 2019532974A5 JP 2019522663 A JP2019522663 A JP 2019522663A JP 2019522663 A JP2019522663 A JP 2019522663A JP 2019532974 A5 JP2019532974 A5 JP 2019532974A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halo
- cycloalkyl
- oxo
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662416550P | 2016-11-02 | 2016-11-02 | |
| US62/416,550 | 2016-11-02 | ||
| US201662417893P | 2016-11-04 | 2016-11-04 | |
| US62/417,893 | 2016-11-04 | ||
| PCT/EP2017/077886 WO2018083085A1 (en) | 2016-11-02 | 2017-10-31 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019532974A JP2019532974A (ja) | 2019-11-14 |
| JP2019532974A5 true JP2019532974A5 (enExample) | 2020-12-03 |
| JP7059268B2 JP7059268B2 (ja) | 2022-04-25 |
Family
ID=60201582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522663A Expired - Fee Related JP7059268B2 (ja) | 2016-11-02 | 2017-10-31 | ＩＲＡＫ４モデュレーターとしてのピラゾロ［１，５ａ］ピリミジン誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11434250B2 (enExample) |
| EP (1) | EP3535273A1 (enExample) |
| JP (1) | JP7059268B2 (enExample) |
| CN (1) | CN109890829B (enExample) |
| WO (1) | WO2018083085A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202340194A (zh) | 2017-02-16 | 2023-10-16 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| TWI721483B (zh) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| WO2020036830A1 (en) * | 2018-08-13 | 2020-02-20 | Gilead Sciences, Inc. | Pyrrolo[1,2-b]pyridazine derivatives as irak4 inhibitors |
| GB201904373D0 (en) * | 2019-03-29 | 2019-05-15 | Galapagos Nv | Novel compounds and pharamaceutical compositions thereof for the treatment of inflammatory disorders |
| CN113402499B (zh) | 2021-06-21 | 2022-05-13 | 上海勋和医药科技有限公司 | 一种亚磺酰亚胺取代的吲唑类irak4激酶抑制剂、制备方法及用途 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0329214D0 (en) | 2003-12-17 | 2004-01-21 | Glaxo Group Ltd | Novel compounds |
| AU2008345225A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| AU2009259853A1 (en) | 2008-06-20 | 2009-12-23 | Genentech, Inc. | Triazolopyridine JAK inhibitor compounds and methods |
| JP5985473B2 (ja) | 2010-07-13 | 2016-09-06 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ＩＲＡＫ４モジュレーターとしてのピラゾロ［１，５ａ］ピリミジン及びチエノ［３，２ｂ］ピリミジン誘導体 |
| ES2846821T3 (es) | 2010-07-14 | 2021-07-29 | Ecole Polytechnique Fed Lausanne Epfl | Sistema y método para la evaluación de la marcha en 3D |
| PL3366688T3 (pl) * | 2010-12-08 | 2022-05-23 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Podstawione pirazolopirymidyny jako aktywatory glukocerebrozydazy |
| LT3418281T (lt) * | 2012-12-07 | 2021-01-11 | Vertex Pharmaceuticals Inc. | Pirazolo[1,5-a]pirimidinai, naudotini kaip atr kinazės inhibitoriai, skirti vėžinių ligų gydymui |
| EP2943485B1 (en) * | 2013-01-14 | 2017-09-20 | Incyte Holdings Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
| CA2952188A1 (en) | 2014-06-20 | 2015-12-23 | Aurigene Discovery Technologies Limited | Substituted indazole compounds as irak4 inhibitors |
| EP3215511B1 (en) | 2014-11-06 | 2024-04-17 | Bial-R&D Investments, S.A. | Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders |
| US10329295B2 (en) | 2015-03-12 | 2019-06-25 | Merck Sharp & Dohme Corp. | Pyrrolotriazine inhibitors of IRAK4 activity |
| US10155765B2 (en) | 2015-03-12 | 2018-12-18 | Merck Sharp & Dohme Corp. | Carboxamide inhibitors of IRAK4 activity |
| US10040802B2 (en) | 2015-03-12 | 2018-08-07 | Merck Sharp & Dohme Corp. | Thienopyrazine inhibitors of IRAK4 activity |
| US10329294B2 (en) | 2015-03-12 | 2019-06-25 | Merck Sharp & Dohme Corp. | Pyrazolopyrimidine inhibitors of IRAK4 activity |
| CA2992406A1 (en) | 2015-07-15 | 2017-01-19 | Aurigene Discovery Technologies Limited | Indazole and azaindazole compounds as irak-4 inhibitors |
| EP3322409A4 (en) | 2015-07-15 | 2019-07-24 | Aurigene Discovery Technologies Limited | SUBSTITUTED AZA COMPOUNDS AS IRAQ-4 INHIBITORS |
| EP3394066A2 (en) | 2015-12-22 | 2018-10-31 | H. Hoffnabb-La Roche Ag | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS |
-
2017
- 2017-10-31 WO PCT/EP2017/077886 patent/WO2018083085A1/en not_active Ceased
- 2017-10-31 JP JP2019522663A patent/JP7059268B2/ja not_active Expired - Fee Related
- 2017-10-31 CN CN201780065283.XA patent/CN109890829B/zh not_active Expired - Fee Related
- 2017-10-31 EP EP17792062.6A patent/EP3535273A1/en not_active Ceased
-
2020
- 2020-04-30 US US16/863,741 patent/US11434250B2/en active Active
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