JP2019532644A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019532644A5 JP2019532644A5 JP2019517305A JP2019517305A JP2019532644A5 JP 2019532644 A5 JP2019532644 A5 JP 2019532644A5 JP 2019517305 A JP2019517305 A JP 2019517305A JP 2019517305 A JP2019517305 A JP 2019517305A JP 2019532644 A5 JP2019532644 A5 JP 2019532644A5
- Authority
- JP
- Japan
- Prior art keywords
- casx
- seq
- nucleic acid
- polypeptide
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022199477A JP2023027277A (ja) | 2016-09-30 | 2022-12-14 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
| JP2025133612A JP2025166123A (ja) | 2016-09-30 | 2025-08-08 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662402846P | 2016-09-30 | 2016-09-30 | |
| US62/402,846 | 2016-09-30 | ||
| PCT/US2017/054081 WO2018064371A1 (en) | 2016-09-30 | 2017-09-28 | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022199477A Division JP2023027277A (ja) | 2016-09-30 | 2022-12-14 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019532644A JP2019532644A (ja) | 2019-11-14 |
| JP2019532644A5 true JP2019532644A5 (cg-RX-API-DMAC7.html) | 2020-11-12 |
Family
ID=61760962
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019517305A Pending JP2019532644A (ja) | 2016-09-30 | 2017-09-28 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
| JP2022199477A Pending JP2023027277A (ja) | 2016-09-30 | 2022-12-14 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
| JP2025133612A Pending JP2025166123A (ja) | 2016-09-30 | 2025-08-08 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022199477A Pending JP2023027277A (ja) | 2016-09-30 | 2022-12-14 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
| JP2025133612A Pending JP2025166123A (ja) | 2016-09-30 | 2025-08-08 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US11873504B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3523426A4 (cg-RX-API-DMAC7.html) |
| JP (3) | JP2019532644A (cg-RX-API-DMAC7.html) |
| KR (2) | KR20230170126A (cg-RX-API-DMAC7.html) |
| CN (1) | CN110023494A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017335890B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112019006384A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3038960A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA201990861A1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB2569733B (cg-RX-API-DMAC7.html) |
| IL (1) | IL265598A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2019003674A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ751946A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018064371A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US20150166982A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting pi3k point mutations |
| EP3177718B1 (en) | 2014-07-30 | 2022-03-16 | President and Fellows of Harvard College | Cas9 proteins including ligand-dependent inteins |
| EP3204496A1 (en) | 2014-10-10 | 2017-08-16 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| WO2016073990A2 (en) | 2014-11-07 | 2016-05-12 | Editas Medicine, Inc. | Methods for improving crispr/cas-mediated genome-editing |
| JP7030522B2 (ja) | 2015-05-11 | 2022-03-07 | エディタス・メディシン、インコーポレイテッド | 幹細胞における遺伝子編集のための最適化ｃｒｉｓｐｒ／ｃａｓ９システムおよび方法 |
| KR20230110368A (ko) | 2015-06-01 | 2023-07-21 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | Hiv 감염의 rna-가이드된 치료를 위한 방법 및 조성물 |
| KR102796744B1 (ko) | 2015-06-09 | 2025-04-15 | 에디타스 메디신, 인코포레이티드 | 이식의 개선을 위한 crispr/cas-관련 방법 및 조성물 |
| US11667911B2 (en) | 2015-09-24 | 2023-06-06 | Editas Medicine, Inc. | Use of exonucleases to improve CRISPR/CAS-mediated genome editing |
| SG11201803173VA (en) | 2015-10-23 | 2018-05-30 | Harvard College | Nucleobase editors and uses thereof |
| WO2017165826A1 (en) | 2016-03-25 | 2017-09-28 | Editas Medicine, Inc. | Genome editing systems comprising repair-modulating enzyme molecules and methods of their use |
| EP4047092B1 (en) | 2016-04-13 | 2025-07-30 | Editas Medicine, Inc. | Cas9 fusion molecules, gene editing systems, and methods of use thereof |
| US10337051B2 (en) | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
| JP7231935B2 (ja) | 2016-08-03 | 2023-03-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | アデノシン核酸塩基編集因子およびそれらの使用 |
| CA3033327A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR20230170126A (ko) | 2016-09-30 | 2023-12-18 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Rna-가이드된 핵산 변형 효소 및 이의 사용 방법 |
| EA201990860A1 (ru) | 2016-09-30 | 2019-10-31 | Рнк-направляемые модифицирующие нуклеиновые кислоты ферменты и способы их применения | |
| WO2018071868A1 (en) | 2016-10-14 | 2018-04-19 | President And Fellows Of Harvard College | Aav delivery of nucleobase editors |
| EP3555297A1 (en) | 2016-12-19 | 2019-10-23 | Editas Medicine, Inc. | Assessing nuclease cleavage |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| JP7229923B2 (ja) | 2017-01-06 | 2023-02-28 | エディタス・メディシン、インコーポレイテッド | ヌクレアーゼ切断を評価する方法 |
| US20180201921A1 (en) * | 2017-01-18 | 2018-07-19 | Excision Biotherapeutics, Inc. | CRISPRs |
| US20190367924A1 (en) * | 2017-02-17 | 2019-12-05 | Temple University - Of The Commonwealth System Of Higher Education | Gene editing therapy for hiv infection via dual targeting of hiv genome and ccr5 |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| EP3615672A1 (en) | 2017-04-28 | 2020-03-04 | Editas Medicine, Inc. | Methods and systems for analyzing guide rna molecules |
| CN110832074A (zh) * | 2017-05-03 | 2020-02-21 | 科沃施种子欧洲股份两合公司 | CRISPR-Cas核酸内切酶在植物基因组工程中的应用 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| US10428319B2 (en) | 2017-06-09 | 2019-10-01 | Editas Medicine, Inc. | Engineered Cas9 nucleases |
| US11866726B2 (en) | 2017-07-14 | 2024-01-09 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
| AU2018352592C1 (en) | 2017-10-16 | 2025-09-25 | Beam Therapeutics, Inc. | Uses of adenosine base editors |
| WO2019084148A1 (en) * | 2017-10-25 | 2019-05-02 | Monsanto Technology Llc | TARGETED RNA GUIDED ENDONUCLEASE ENDONUCLEASE ACTIVITY IN EUKARYOTES |
| MX2020004578A (es) | 2017-11-01 | 2020-12-03 | Univ California | Composiciones de casz y metodos de uso. |
| US12227753B2 (en) | 2017-11-01 | 2025-02-18 | The Regents Of The University Of California | CasY compositions and methods of use |
| US11970719B2 (en) | 2017-11-01 | 2024-04-30 | The Regents Of The University Of California | Class 2 CRISPR/Cas compositions and methods of use |
| US11661599B1 (en) | 2017-12-14 | 2023-05-30 | National Technology & Engineering Solutions Of Sandia, Llc | CRISPR-Cas based system for targeting single-stranded sequences |
| EP3724214A4 (en) | 2017-12-15 | 2021-09-01 | The Broad Institute Inc. | SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING |
| CN112020554B (zh) | 2018-02-23 | 2024-10-22 | 先锋国际良种公司 | 新颖cas9直系同源物 |
| US11807877B1 (en) | 2018-03-22 | 2023-11-07 | National Technology & Engineering Solutions Of Sandia, Llc | CRISPR/Cas activity assays and compositions thereof |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| CA3101648A1 (en) | 2018-06-07 | 2019-12-12 | Arc Bio, Llc | Compositions and methods for making guide nucleic acids |
| US20190390193A1 (en) * | 2018-06-23 | 2019-12-26 | John Lawrence Mee | Reversible method for sustainable human cognitive enhancement |
| CA3104856A1 (en) | 2018-06-29 | 2020-01-02 | Editas Medicine, Inc. | Synthetic guide molecules, compositions and methods relating thereto |
| US20210284981A1 (en) * | 2018-07-24 | 2021-09-16 | The Regents Of The University Of California | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
| EP3830301B1 (en) | 2018-08-01 | 2024-05-22 | Mammoth Biosciences, Inc. | Programmable nuclease compositions and methods of use thereof |
| WO2020041456A1 (en) | 2018-08-22 | 2020-02-27 | The Regents Of The University Of California | Variant type v crispr/cas effector polypeptides and methods of use thereof |
| US12281338B2 (en) | 2018-10-29 | 2025-04-22 | The Broad Institute, Inc. | Nucleobase editors comprising GeoCas9 and uses thereof |
| CA3117228A1 (en) | 2018-12-14 | 2020-06-18 | Pioneer Hi-Bred International, Inc. | Novel crispr-cas systems for genome editing |
| WO2020142754A2 (en) | 2019-01-04 | 2020-07-09 | Mammoth Biosciences, Inc. | Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection |
| MX2021008487A (es) * | 2019-01-14 | 2021-11-12 | Univ Rochester | Escisión y poliadenilación del arn nuclear dirigido con crispr-cas. |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020181101A1 (en) | 2019-03-07 | 2020-09-10 | The Regents Of The University Of California | Crispr-cas effector polypeptides and methods of use thereof |
| KR20210149734A (ko) | 2019-03-11 | 2021-12-09 | 소렌토 쎄라퓨틱스, 인코포레이티드 | Rna-가이드된 엔도뉴클레아제를 사용한 dna 작제물의 통합을 위한 개선된 방법 |
| GB2601617B (en) | 2019-03-19 | 2024-02-21 | Broad Inst Inc | Methods and compositions for editing nucleotide sequences |
| EP3945801A4 (en) * | 2019-04-03 | 2023-06-07 | University of Georgia Research Foundation, Inc. | CRISPR/MCAS9 ADMINISTRATION THROUGH EXTRACELLULAR VESICLES FOR GENOME EDITING |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| JP7744011B2 (ja) * | 2019-06-07 | 2025-09-25 | スクライブ・セラピューティクス・インコーポレイテッド | 操作されたｃａｓｘシステム |
| JP2022536474A (ja) * | 2019-06-10 | 2022-08-17 | アクセス ツー アドバンスト ヘルス インスティチュート | アストロウイルスレプリコンの方法および組成物 |
| CN114206376A (zh) * | 2019-07-11 | 2022-03-18 | 阿伯生物技术公司 | 新型crispr dna靶向酶及系统 |
| JP7630904B2 (ja) * | 2019-07-23 | 2025-02-18 | 株式会社東芝 | 核酸導入キャリア、核酸導入キャリアセット、核酸導入組成物及び核酸導入方法 |
| CA3153700A1 (en) * | 2019-09-09 | 2021-03-18 | Scribe Therapeutics Inc. | Compositions and methods for use in immunotherapy |
| US20220348925A1 (en) | 2019-09-09 | 2022-11-03 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of sod1 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| KR20220097408A (ko) * | 2019-10-17 | 2022-07-07 | 페어와이즈 플랜츠 서비시즈, 인크. | Cas12a 뉴클레아제의 변이체 및 그의 제조 방법 및 용도 |
| CN110669795A (zh) * | 2019-10-18 | 2020-01-10 | 福州大学 | 一种在鱼类胚胎中实现精确定点rna剪切的技术 |
| CA3159316A1 (en) * | 2019-12-06 | 2021-06-10 | Benjamin OAKES | Compositions and methods for the targeting of rhodopsin |
| AU2020398658A1 (en) * | 2019-12-06 | 2022-07-07 | Scribe Therapeutics Inc. | Particle delivery systems |
| EP4069846A1 (en) | 2019-12-07 | 2022-10-12 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of htt |
| IL292896A (en) * | 2019-12-23 | 2022-07-01 | Univ California | Crispr-cas effector polypeptides and methods of use thereof |
| JP2023507891A (ja) * | 2019-12-30 | 2023-02-28 | ディーエスエム アイピー アセッツ ビー．ブイ． | リパーゼ改変株 |
| WO2021142342A1 (en) | 2020-01-10 | 2021-07-15 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of pcsk9 |
| CA3167684A1 (en) * | 2020-01-29 | 2021-08-05 | Jenthera Therapeutics Inc. | Nuclease-scaffold composition delivery platform |
| CA3168986A1 (en) | 2020-02-26 | 2021-09-02 | Sorrento Therapeutics, Inc. | Activatable antigen binding proteins with universal masking moieties |
| JP2023516052A (ja) * | 2020-03-04 | 2023-04-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｂ４ｇａｌｔ１媒介性機能の齧歯類モデル |
| WO2021182474A1 (ja) * | 2020-03-12 | 2021-09-16 | 株式会社Ｆｒｅｓｔ | オリゴヌクレオチド及び標的ｒｎａの部位特異的編集方法 |
| AU2021237633A1 (en) * | 2020-03-18 | 2022-10-06 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of C9orf72 |
| US20230167191A1 (en) | 2020-04-24 | 2023-06-01 | Sorrento Therapeutics, Inc. | Memory Dimeric Antigen Receptors (mDARs) |
| DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
| AU2021315812A1 (en) * | 2020-07-30 | 2023-03-02 | ADARx Pharmaceuticals, Inc | ADAR dependent editing compositions and methods of use thereof |
| WO2022103878A1 (en) * | 2020-11-11 | 2022-05-19 | Monsanto Technology Llc | Methods to improve site-directed integration frequency |
| WO2022119957A1 (en) * | 2020-12-02 | 2022-06-09 | The Regents Of The University Of California | Crispr-cas effector polypeptides and methods of use thereof |
| GB2616584A (en) * | 2020-12-03 | 2023-09-13 | Scribe Therapeutics Inc | Engineered class 2 type V CRISPR systems |
| CA3200815A1 (en) * | 2020-12-03 | 2022-06-09 | Benjamin OAKES | Compositions and methods for the targeting of bcl11a |
| US20240100185A1 (en) * | 2020-12-03 | 2024-03-28 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of ptbp1 |
| CA3201392A1 (en) * | 2020-12-09 | 2022-06-16 | Scribe Therapeutics Inc. | Aav vectors for gene editing |
| EP4267743A4 (en) | 2020-12-22 | 2024-12-18 | Chroma Medicine, Inc. | Compositions and methods for epigenetic editing |
| CA3222023A1 (en) | 2021-06-01 | 2022-12-08 | Arbor Biotechnologies, Inc. | Gene editing systems comprising a crispr nuclease and uses thereof |
| WO2022261150A2 (en) | 2021-06-09 | 2022-12-15 | Scribe Therapeutics Inc. | Particle delivery systems |
| US20240392271A1 (en) * | 2021-09-21 | 2024-11-28 | Scribe Therapeutics Inc. | Engineered casx repressor systems |
| CN113969281B (zh) * | 2021-12-24 | 2022-04-01 | 汕头大学 | 经修饰的CrRNA片段及非洲猪瘟病毒试剂盒 |
| AU2024220323A1 (en) | 2023-02-15 | 2025-08-14 | Arbor Biotechnologies, Inc. | Gene editing method for inhibiting aberrant splicing in stathmin 2 (stmn2) transcript |
| TW202444914A (zh) * | 2023-03-29 | 2024-11-16 | 美商斯奎柏治療公司 | 抑制子融合蛋白系統 |
| CN116926043B (zh) * | 2023-04-28 | 2024-09-06 | 新乡医学院第三附属医院 | 一种dCasX蛋白核酸酶、重组载体及其应用 |
| WO2024233366A2 (en) * | 2023-05-05 | 2024-11-14 | Aera Therapeutics, Inc. | Modified cas9-iid nucleases and uses thereof |
| WO2025171210A1 (en) | 2024-02-09 | 2025-08-14 | Arbor Biotechnologies, Inc. | Compositions and methods for gene editing via homology-mediated end joining |
| CN119709771B (zh) * | 2024-10-24 | 2025-11-25 | 四川轻化工大学 | 马铃薯drm3基因及其在马铃薯保鲜中的应用 |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| CA2410072C (en) | 2000-05-24 | 2011-07-19 | Third Wave Technologies, Inc. | Polymerase cleavage agents and detection of rna |
| US6773885B1 (en) | 2000-09-29 | 2004-08-10 | Integrated Dna Technologies, Inc. | Compositions and methods for visual ribonuclease detection assays |
| CN1886512A (zh) * | 2002-04-23 | 2006-12-27 | 斯克里普斯研究所 | 多肽在叶绿体中的表达以及用于表达多肽的组合物和方法 |
| EP1580273A1 (en) | 2004-03-26 | 2005-09-28 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Peptide-based method for monitoring gene expression in a host cell |
| CN101283089A (zh) | 2005-10-07 | 2008-10-08 | 加利福尼亚大学董事会 | 修饰细胞色素p450酶的编码核酸和其应用方法 |
| US9689031B2 (en) | 2007-07-14 | 2017-06-27 | Ionian Technologies, Inc. | Nicking and extension amplification reaction for the exponential amplification of nucleic acids |
| WO2010075303A1 (en) | 2008-12-23 | 2010-07-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Splicing factors with a puf protein rna-binding domain and a splicing effector domain and uses of same |
| US8597886B2 (en) | 2010-02-15 | 2013-12-03 | Cascade Biosystems, Inc. | Methods and materials for detecting viral or microbial infections |
| SG186987A1 (en) | 2010-06-11 | 2013-02-28 | Pathogenica Inc | Nucleic acids for multiplex organism detection and methods of use and making the same |
| WO2012027675A2 (en) | 2010-08-26 | 2012-03-01 | Massachusetts Institute Of Technology | Poly(beta-amino alcohols), their preparation, and uses thereof |
| US9580714B2 (en) | 2010-11-24 | 2017-02-28 | The University Of Western Australia | Peptides for the specific binding of RNA targets |
| US9730967B2 (en) | 2011-02-04 | 2017-08-15 | Katherine Rose Kovarik | Method and system for treating cancer cachexia |
| US8815782B2 (en) | 2011-11-11 | 2014-08-26 | Agilent Technologies, Inc. | Use of DNAzymes for analysis of an RNA sample |
| CA2873073A1 (en) | 2012-04-16 | 2013-10-24 | The University Of Western Australia | Peptides for the binding of nucleotide targets |
| GB2537000C (en) * | 2012-05-25 | 2019-10-09 | Univ California | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| CA2891347C (en) | 2012-12-06 | 2018-02-27 | Sigma-Aldrich Co. Llc | Crispr-based genome modification and regulation |
| EP2931899A1 (en) | 2012-12-12 | 2015-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
| PL2771468T3 (pl) | 2012-12-12 | 2015-07-31 | Broad Inst Inc | Inżynieria systemów, metod i zoptymalizowanych kompozycji kierujących dla manipulacji sekwencjami |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| KR20150105635A (ko) | 2012-12-12 | 2015-09-17 | 더 브로드 인스티튜트, 인코퍼레이티드 | 서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물 |
| EP2931898B1 (en) | 2012-12-12 | 2016-03-09 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| EP2896697B1 (en) | 2012-12-12 | 2015-09-02 | The Broad Institute, Inc. | Engineering of systems, methods and optimized guide compositions for sequence manipulation |
| US20140186919A1 (en) | 2012-12-12 | 2014-07-03 | Feng Zhang | Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation |
| IL239317B (en) | 2012-12-12 | 2022-07-01 | Broad Inst Inc | Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications |
| US20140310830A1 (en) | 2012-12-12 | 2014-10-16 | Feng Zhang | CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes |
| CA2893579A1 (en) | 2012-12-13 | 2014-06-19 | Dow Agrosciences Llc | Dna detection methods for site specific nuclease activity |
| US9970024B2 (en) | 2012-12-17 | 2018-05-15 | President And Fellows Of Harvard College | RNA-guided human genome engineering |
| WO2014118272A1 (en) | 2013-01-30 | 2014-08-07 | Santaris Pharma A/S | Antimir-122 oligonucleotide carbohydrate conjugates |
| JP6491113B2 (ja) | 2013-02-25 | 2019-03-27 | サンガモ セラピューティクス， インコーポレイテッド | ヌクレアーゼ媒介性遺伝子破壊を増強するための方法および組成物 |
| AU2014235794A1 (en) | 2013-03-14 | 2015-10-22 | Caribou Biosciences, Inc. | Compositions and methods of nucleic acid-targeting nucleic acids |
| KR102874079B1 (ko) | 2013-03-15 | 2025-10-22 | 더 제너럴 하스피탈 코포레이션 | Rna-안내 게놈 편집을 위해 특이성을 증가시키기 위한 절단된 안내 rna(tru-grnas)의 이용 |
| US9234213B2 (en) | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
| US20140364333A1 (en) | 2013-03-15 | 2014-12-11 | President And Fellows Of Harvard College | Methods for Live Imaging of Cells |
| US10760064B2 (en) | 2013-03-15 | 2020-09-01 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
| US20140273230A1 (en) | 2013-03-15 | 2014-09-18 | Sigma-Aldrich Co., Llc | Crispr-based genome modification and regulation |
| US20140349400A1 (en) | 2013-03-15 | 2014-11-27 | Massachusetts Institute Of Technology | Programmable Modification of DNA |
| MX376838B (es) | 2013-03-15 | 2025-03-07 | Univ Minnesota | Ingenieria genomica de plantas utilizando sistemas crispr/cas. |
| US11332719B2 (en) | 2013-03-15 | 2022-05-17 | The Broad Institute, Inc. | Recombinant virus and preparations thereof |
| EP3679785A3 (en) | 2013-04-05 | 2020-09-16 | Dow AgroSciences LLC | Methods and compositions for integration of an exogenous sequence within the genome of plants |
| KR20200136508A (ko) | 2013-04-16 | 2020-12-07 | 리제너론 파마슈티칼스 인코포레이티드 | 랫트 게놈의 표적화된 변형 |
| AU2014262867B2 (en) | 2013-05-10 | 2019-12-05 | Sangamo Therapeutics, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering |
| US20140349405A1 (en) | 2013-05-22 | 2014-11-27 | Wisconsin Alumni Research Foundation | Rna-directed dna cleavage and gene editing by cas9 enzyme from neisseria meningitidis |
| US11414695B2 (en) | 2013-05-29 | 2022-08-16 | Agilent Technologies, Inc. | Nucleic acid enrichment using Cas9 |
| US20140356956A1 (en) | 2013-06-04 | 2014-12-04 | President And Fellows Of Harvard College | RNA-Guided Transcriptional Regulation |
| EP3071695A2 (en) * | 2013-11-18 | 2016-09-28 | Crispr Therapeutics AG | Crispr-cas system materials and methods |
| EP3080266B1 (en) | 2013-12-12 | 2021-02-03 | The Regents of The University of California | Methods and compositions for modifying a single stranded target nucleic acid |
| WO2015116686A1 (en) | 2014-01-29 | 2015-08-06 | Agilent Technologies, Inc. | Cas9-based isothermal method of detection of specific dna sequence |
| JP2017514513A (ja) | 2014-03-20 | 2017-06-08 | ユニベルシテ ラバル | フラタキシンレベルを増加させるためのｃｒｉｓｐｒ系の方法及び生成物、ならびにそれらの使用 |
| WO2015157534A1 (en) | 2014-04-10 | 2015-10-15 | The Regents Of The University Of California | Methods and compositions for using argonaute to modify a single stranded target nucleic acid |
| CA2951707A1 (en) | 2014-06-10 | 2015-12-17 | Massachusetts Institute Of Technology | Method for gene editing |
| JP6806668B2 (ja) | 2014-08-19 | 2021-01-06 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 核酸をプロービングおよびマッピングするためのｒｎａ誘導型システム |
| EP3889260A1 (en) | 2014-12-12 | 2021-10-06 | The Broad Institute, Inc. | Protected guide rnas (pgrnas) |
| EP3230452B1 (en) | 2014-12-12 | 2025-06-11 | The Broad Institute, Inc. | Dead guides for crispr transcription factors |
| WO2016106236A1 (en) | 2014-12-23 | 2016-06-30 | The Broad Institute Inc. | Rna-targeting system |
| EP3250689B1 (en) * | 2015-01-28 | 2020-11-04 | The Regents of The University of California | Methods and compositions for labeling a single-stranded target nucleic acid |
| WO2016205613A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Crispr enzyme mutations reducing off-target effects |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| CA3012631A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| WO2016205749A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| US9580727B1 (en) | 2015-08-07 | 2017-02-28 | Caribou Biosciences, Inc. | Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides |
| CN109153980B (zh) | 2015-10-22 | 2023-04-14 | 布罗德研究所有限公司 | Vi-b型crispr酶和系统 |
| EP3400299B1 (en) | 2016-01-08 | 2020-11-11 | University of Georgia Research Foundation, Inc. | Methods for cleaving dna and rna molecules |
| US11441146B2 (en) | 2016-01-11 | 2022-09-13 | Christiana Care Health Services, Inc. | Compositions and methods for improving homogeneity of DNA generated using a CRISPR/Cas9 cleavage system |
| US9896696B2 (en) | 2016-02-15 | 2018-02-20 | Benson Hill Biosystems, Inc. | Compositions and methods for modifying genomes |
| AU2017223821B2 (en) | 2016-02-23 | 2023-07-27 | Arc Bio, Llc | Methods and compositions for target detection |
| US20190093091A1 (en) | 2016-04-06 | 2019-03-28 | Temple University - Of The Commonwealth System Of Higher Education | Compositions for eradicating flavivirus infections in subjects |
| US11371081B2 (en) | 2016-05-25 | 2022-06-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Portable, low-cost pathogen detection and strain identification platform |
| US10337051B2 (en) | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
| CN109642231A (zh) | 2016-06-17 | 2019-04-16 | 博德研究所 | Vi型crispr直向同源物和系统 |
| US10017760B2 (en) * | 2016-06-24 | 2018-07-10 | Inscripta, Inc. | Methods for generating barcoded combinatorial libraries |
| US12431216B2 (en) | 2016-08-17 | 2025-09-30 | Broad Institute, Inc. | Methods for identifying class 2 crispr-cas systems |
| KR20230170126A (ko) | 2016-09-30 | 2023-12-18 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Rna-가이드된 핵산 변형 효소 및 이의 사용 방법 |
| EA201990860A1 (ru) | 2016-09-30 | 2019-10-31 | Рнк-направляемые модифицирующие нуклеиновые кислоты ферменты и способы их применения | |
| CN106701830B (zh) | 2016-12-07 | 2020-01-03 | 湖南人文科技学院 | 一种敲除猪胚胎p66shc基因的方法 |
| AU2017371324B2 (en) | 2016-12-09 | 2024-06-13 | Massachusetts Institute Of Technology | CRISPR effector system based diagnostics |
| JP2020513824A (ja) | 2017-03-24 | 2020-05-21 | キュアバック アーゲー | Ｃｒｉｓｐｒ関連タンパク質をコードする核酸、及びその使用 |
| WO2018195545A2 (en) | 2017-04-21 | 2018-10-25 | The General Hospital Corporation | Variants of cpf1 (cas12a) with altered pam specificity |
| WO2019030695A1 (en) | 2017-08-09 | 2019-02-14 | Benson Hill Biosystems, Inc. | Compositions and methods for modifying genomes |
| MX2020004578A (es) | 2017-11-01 | 2020-12-03 | Univ California | Composiciones de casz y metodos de uso. |
| US11970719B2 (en) | 2017-11-01 | 2024-04-30 | The Regents Of The University Of California | Class 2 CRISPR/Cas compositions and methods of use |
| US20200339967A1 (en) | 2017-11-01 | 2020-10-29 | The Regents Of The University Of California | Cas12c compositions and methods of use |
| US12227753B2 (en) | 2017-11-01 | 2025-02-18 | The Regents Of The University Of California | CasY compositions and methods of use |
| US10253365B1 (en) | 2017-11-22 | 2019-04-09 | The Regents Of The University Of California | Type V CRISPR/Cas effector proteins for cleaving ssDNAs and detecting target DNAs |
| RU2020124203A (ru) | 2017-12-22 | 2022-01-24 | Зе Броад Институт, Инк. | Мультиплексная диагностика на основе эффекторной системы crispr |
-
2017
- 2017-09-28 KR KR1020237041555A patent/KR20230170126A/ko not_active Ceased
- 2017-09-28 NZ NZ751946A patent/NZ751946A/en unknown
- 2017-09-28 US US16/335,516 patent/US11873504B2/en active Active
- 2017-09-28 MX MX2019003674A patent/MX2019003674A/es unknown
- 2017-09-28 KR KR1020197012244A patent/KR20190071725A/ko not_active Ceased
- 2017-09-28 EA EA201990861A patent/EA201990861A1/ru unknown
- 2017-09-28 WO PCT/US2017/054081 patent/WO2018064371A1/en not_active Ceased
- 2017-09-28 CN CN201780074116.1A patent/CN110023494A/zh active Pending
- 2017-09-28 JP JP2019517305A patent/JP2019532644A/ja active Pending
- 2017-09-28 BR BR112019006384-6A patent/BR112019006384A2/pt not_active Application Discontinuation
- 2017-09-28 CA CA3038960A patent/CA3038960A1/en active Pending
- 2017-09-28 EP EP17857442.2A patent/EP3523426A4/en active Pending
- 2017-09-28 GB GB1905575.5A patent/GB2569733B/en active Active
- 2017-09-28 AU AU2017335890A patent/AU2017335890B2/en active Active
-
2018
- 2018-08-03 US US16/054,513 patent/US10570415B2/en active Active
-
2019
- 2019-03-25 IL IL265598A patent/IL265598A/en unknown
- 2019-05-24 US US16/422,824 patent/US11795472B2/en active Active
-
2022
- 2022-12-14 JP JP2022199477A patent/JP2023027277A/ja active Pending
-
2023
- 2023-11-17 US US18/513,347 patent/US20240167052A1/en active Pending
-
2025
- 2025-08-08 JP JP2025133612A patent/JP2025166123A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019532644A5 (cg-RX-API-DMAC7.html) | ||
| JP2019534695A5 (cg-RX-API-DMAC7.html) | ||
| JP2021121205A5 (cg-RX-API-DMAC7.html) | ||
| JP7154248B2 (ja) | 標的遺伝子座を修飾するための方法及び組成物 | |
| JP7095066B2 (ja) | 単一ステップの複数標的化を通じた標的化された遺伝子修飾のための方法及び組成物 | |
| US12173339B2 (en) | Variants of Cpf1 (Cas12a) with altered PAM specificity | |
| CN111328343B (zh) | Rna靶向方法和组合物 | |
| JP2024095765A (ja) | Ｓ．ピオゲネスｃａｓ９変異遺伝子及びこれによってコードされるポリペプチド | |
| JP2015503535A5 (cg-RX-API-DMAC7.html) | ||
| US9567603B2 (en) | Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing | |
| US9840699B2 (en) | Methods for nucleic acid editing | |
| KR20190025565A (ko) | 프로그램가능한 dna 결합 단백질을 사용한, 표적화된 게놈 변형의 개선 | |
| AU2016297167A1 (en) | Editing mitochondrial DNA | |
| Delacôte et al. | High frequency targeted mutagenesis using engineered endonucleases and DNA-end processing enzymes | |
| US11970720B2 (en) | RNA targeting methods and compositions | |
| WO2020077138A2 (en) | Selective curbing of unwanted rna editing (secure) dna base editor variants | |
| Zhang et al. | MTV, an ssDNA protecting complex essential for transposon-based telomere maintenance in Drosophila | |
| WO2024198961A1 (zh) | 一种Cas蛋白及其突变体、其相应的基因编辑系统及应用 | |
| US9771402B2 (en) | Fluorescent and colored proteins and methods for using them | |
| CN112930398A (zh) | 新的核酸酶结构域及其利用 | |
| KR20210141536A (ko) | 타우 응집과 관련된 유전적 취약성을 식별하기 위한 CRISPR/Cas 드랍아웃 스크리닝 플랫폼 | |
| Wei et al. | Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals | |
| JPWO2020181102A5 (cg-RX-API-DMAC7.html) | ||
| Zhou et al. | Optical Control of Base Editing and Transcription through Light‐Activated Guide RNA | |
| WO2024240053A1 (zh) | 一种基因编辑蛋白、其相应的基因编辑系统及应用 |