JP2019531121A - 生体成分採取用カセット、生体成分採取回路セット及び生体成分採取システム - Google Patents
生体成分採取用カセット、生体成分採取回路セット及び生体成分採取システム Download PDFInfo
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Abstract
Description
複数の流路が形成されたカセット本体を備え、少なくとも1の生体成分を含有する液体から生体成分を分離する分離装置に装着可能に構成された生体成分採取用カセットと、前記生体成分採取用カセットにチューブを介して接続され、前記分離装置の作動により前記液体を複数の生体成分に分離する処理室を有する分離処理部と、前記生体成分採取用カセットにチューブを介して接続されたバッグと、を備えた生体成分採取回路セットであって、前記カセット本体は、熱滅菌が適用可能な軟質素材で形成されており、前記複数の流路は、前記液体を導入する導入ラインと、前記液体を分離処理することによって得られた生体成分を採取容器へ向けて移送する生体成分移送ラインと、前記分離処理によって得られた生体成分以外の液体を移送する返還ラインと、を含み、前記返還ラインには、返還される液体を一時的に貯留するリザーバが設けられ、前記リザーバは、拡張及び収縮可能に構成されるとともに、前記分離装置に設けられた返還ポンプにより押圧されることで前記リザーバ内の前記液体を排出することを特徴とする。
図1において、血液成分採取システム10Aは、供血者から血液(全血)を連続的に取り出して体外で遠心分離することにより、特定の血液成分(本実施形態では、血小板、赤血球、血漿)を採取し、未採取の血液成分を供血者に戻す血液アフェレーシスシステムとして構成されている。
次に、図15に示す本発明の第2実施形態に係る血液成分採取システム10Bについて、第1実施形態に係る血液成分採取システム10Aと異なる部分を中心に説明する。この血液成分採取システム10Bは、血液成分採取用カセット22a(以下、「カセット22a」という)を有する採血回路セット12aと、採血回路セット12aが装着される遠心分離装置14a(図16参照)とを備える。
前記種々の実施形態においては、生体成分として血液を挙げているが、これに限定されるものではなく、例えば、患者やドナーから採取、または培養された各種細胞や、患者などに投与される薬剤を含む医療用液体なども適用可能である。
14、14a…遠心分離装置 22、22a…カセット
23、23a…カセット本体 38…第1シート
39…第2シート 42…導入ライン
43…血液成分移送ライン 44…返血ライン
47…リザーバ 49…返血ポンプ
57…リザーバ圧力センサ 61…センサ押圧部
71…制御部
Claims (13)
- 複数の流路が形成されたカセット本体を備え、少なくとも1の生体成分を含有する液体から生体成分を分離する分離装置に装着可能に構成された生体成分採取用カセットであって、
前記カセット本体は、熱滅菌が適用可能な軟質素材で形成されており、
前記複数の流路は、
前記液体を導入する導入ラインと、
前記液体を分離処理することによって得られた生体成分を採取容器へ向けて移送する生体成分移送ラインと、
前記分離処理によって得られた生体成分以外の液体を移送する返還ラインと、を含み、
前記返還ラインには、返還される液体を一時的に貯留するリザーバが設けられ、
前記リザーバは、拡張及び収縮可能に構成されるとともに、前記分離装置に設けられた返還ポンプにより押圧されることで前記リザーバ内の前記液体を排出する、
ことを特徴とする生体成分採取用カセット。 - 請求項1記載の生体成分採取用カセットにおいて、
前記カセット本体は、前記リザーバ内の圧力を検出するために前記分離装置に搭載されたリザーバ圧力センサを押圧するセンサ押圧部を有する、
ことを特徴とする生体成分採取用カセット。 - 請求項2記載の生体成分採取用カセットにおいて、
前記センサ押圧部は、前記返還ラインに設けられている、
ことを特徴とする生体成分採取用カセット。 - 請求項1〜3のいずれか1項に記載の生体成分採取用カセットにおいて、
前記リザーバは、自然状態で膨らんでいる、
ことを特徴とする生体成分採取用カセット。 - 請求項4記載の生体成分採取用カセットにおいて、
前記少なくとも1の生体成分が、血液、培養または採取した細胞であることを特徴とする生体成分採取用カセット。 - 複数の流路が形成されたカセット本体を備え、少なくとも1の生体成分を含有する液体から生体成分を分離する分離装置に装着可能に構成された生体成分採取用カセットと、
前記生体成分採取用カセットにチューブを介して接続され、前記分離装置の作動により前記液体を複数の生体成分に分離する処理室を有する分離処理部と、
前記生体成分採取用カセットにチューブを介して接続されたバッグと、を備えた生体成分採取回路セットであって、
前記カセット本体は、熱滅菌が適用可能な軟質素材で形成されており、
前記複数の流路は、
前記液体を導入する導入ラインと、
前記液体を分離処理することによって得られた生体成分を採取容器へ向けて移送する生体成分移送ラインと、
前記分離処理によって得られた生体成分以外の液体を移送する返還ラインと、を含み、
前記返還ラインには、返還される液体を一時的に貯留するリザーバが設けられ、
前記リザーバは、拡張及び収縮可能に構成されるとともに、前記分離装置に設けられた返還ポンプにより押圧されることで前記リザーバ内の前記液体を排出する、
ことを特徴とする生体成分採取回路セット。 - 請求項6記載の生体成分採取回路セットにおいて、
前記少なくとも1の生体成分が、血液、培養または採取した細胞であることを特徴とする生体成分採取回路セット。 - 少なくとも1の生体成分を含有する液体から生体成分を分離する分離装置と、前記分離装置に装着可能に構成された生体成分採取用カセットとを備えた生体成分採取システムであって、
前記生体成分採取用カセットは、複数の流路が形成されたカセット本体を備え、
前記カセット本体は、熱滅菌が適用可能な軟質素材で形成されており、
前記複数の流路は、
前記液体を導入する導入ラインと、
前記液体を分離処理することによって得られた生体成分を採取容器へ向けて移送する生体成分移送ラインと、
前記分離処理によって得られた生体成分以外の液体を移送する返還ラインと、を含み、
前記返還ラインには、前記返還する液体を一時的に貯留するリザーバが設けられ、
前記リザーバは、拡張及び収縮可能に構成されるとともに、前記分離装置に設けられた返還ポンプにより押圧されることで前記リザーバ内の前記液体を排出する、
ことを特徴とする生体成分採取システム。 - 請求項8記載の生体成分採取システムにおいて、
前記分離装置に搭載された前記返還ポンプは、前記リザーバを厚さ方向に押圧可能な押圧プレートを有する、
ことを特徴とする生体成分採取システム。 - 請求項9記載の生体成分採取システムにおいて、
前記分離装置は、
前記リザーバ内の圧力を検出するリザーバ圧力検出機構と、
前記リザーバ圧力検出機構により検出された圧力に基づいて前記返還ポンプの動作を制御する制御部と、を有する、
ことを特徴とする生体成分採取システム。 - 請求項10記載の生体成分採取システムにおいて、
前記制御部は、前記リザーバ内の圧力が所定の目標圧力になるように前記返還ポンプの動作を制御する、
ことを特徴とする生体成分採取システム。 - 請求項10又は11記載の生体成分採取システムにおいて、
前記カセット本体は、前記リザーバ圧力検出機構を押圧するセンサ押圧部を有する、
ことを特徴とする生体成分採取システム。 - 請求項12記載の生体成分採取システムにおいて、
前記少なくとも1の生体成分が、血液、培養または採取した細胞であることを特徴とする生体成分採取システム。
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