JP2019531055A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019531055A5 JP2019531055A5 JP2019505354A JP2019505354A JP2019531055A5 JP 2019531055 A5 JP2019531055 A5 JP 2019531055A5 JP 2019505354 A JP2019505354 A JP 2019505354A JP 2019505354 A JP2019505354 A JP 2019505354A JP 2019531055 A5 JP2019531055 A5 JP 2019531055A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- binding protein
- isoleucine
- binding
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000014914 Carrier Proteins Human genes 0.000 claims 21
- 108091008324 binding proteins Proteins 0.000 claims 21
- 150000001413 amino acids Chemical group 0.000 claims 20
- 229940024606 amino acid Drugs 0.000 claims 17
- 235000001014 amino acid Nutrition 0.000 claims 17
- 229960000310 isoleucine Drugs 0.000 claims 12
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 12
- 235000014705 isoleucine Nutrition 0.000 claims 12
- 239000011159 matrix material Substances 0.000 claims 9
- 108060003951 Immunoglobulin Proteins 0.000 claims 8
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 8
- 102000018358 immunoglobulin Human genes 0.000 claims 8
- 238000000926 separation method Methods 0.000 claims 7
- 238000000034 method Methods 0.000 claims 5
- 239000004475 Arginine Substances 0.000 claims 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 4
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 4
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 4
- 235000004279 alanine Nutrition 0.000 claims 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 4
- 235000013922 glutamic acid Nutrition 0.000 claims 4
- 239000004220 glutamic acid Substances 0.000 claims 4
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 4
- 238000001261 affinity purification Methods 0.000 claims 3
- 229940072221 immunoglobulins Drugs 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 229940099472 immunoglobulin a Drugs 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022112299A JP2022160444A (ja) | 2016-08-11 | 2022-07-13 | アルカリ安定性免疫グロブリン結合タンパク質 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16183710 | 2016-08-11 | ||
| EP16183710.9 | 2016-08-11 | ||
| EP16205707.9 | 2016-12-21 | ||
| EP16205707 | 2016-12-21 | ||
| PCT/EP2017/069976 WO2018029157A1 (en) | 2016-08-11 | 2017-08-07 | Novel alkaline stable immunoglobulin-binding proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022112299A Division JP2022160444A (ja) | 2016-08-11 | 2022-07-13 | アルカリ安定性免疫グロブリン結合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019531055A JP2019531055A (ja) | 2019-10-31 |
| JP2019531055A5 true JP2019531055A5 (OSRAM) | 2020-08-13 |
| JP7181612B2 JP7181612B2 (ja) | 2022-12-01 |
Family
ID=59631752
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019507171A Active JP6951417B2 (ja) | 2016-08-11 | 2017-08-07 | アフィニティークロマトグラフィーのためのＦＣ−結合タンパク質、並びにＦｃ−結合タンパク質を含むアフィニティー分離マトリックスおよびその使用 |
| JP2019505354A Active JP7181612B2 (ja) | 2016-08-11 | 2017-08-07 | アルカリ安定性免疫グロブリン結合タンパク質 |
| JP2022112299A Pending JP2022160444A (ja) | 2016-08-11 | 2022-07-13 | アルカリ安定性免疫グロブリン結合タンパク質 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019507171A Active JP6951417B2 (ja) | 2016-08-11 | 2017-08-07 | アフィニティークロマトグラフィーのためのＦＣ−結合タンパク質、並びにＦｃ−結合タンパク質を含むアフィニティー分離マトリックスおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022112299A Pending JP2022160444A (ja) | 2016-08-11 | 2022-07-13 | アルカリ安定性免疫グロブリン結合タンパク質 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US11014967B2 (OSRAM) |
| EP (4) | EP3497117B1 (OSRAM) |
| JP (3) | JP6951417B2 (OSRAM) |
| KR (3) | KR102578256B1 (OSRAM) |
| CN (4) | CN117736281A (OSRAM) |
| AU (2) | AU2017311541B2 (OSRAM) |
| CA (2) | CA3030208A1 (OSRAM) |
| DK (1) | DK3497117T5 (OSRAM) |
| LT (1) | LT3497117T (OSRAM) |
| SG (1) | SG11201901066UA (OSRAM) |
| WO (2) | WO2018029157A1 (OSRAM) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6738340B2 (ja) | 2015-02-06 | 2020-08-12 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | 新規なｅｇｆｒ結合タンパク質 |
| ES2916101T3 (es) | 2015-07-16 | 2022-06-28 | Navigo Proteins Gmbh | Nuevas proteínas de unión a inmunoglobulina y su uso en la purificación por afinidad |
| JP2018520675A (ja) | 2015-07-20 | 2018-08-02 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ジユビキチン変異タンパク質をベースとした新規結合タンパク質及びその生成方法 |
| JP2019526526A (ja) | 2016-05-04 | 2019-09-19 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ペプチドリンカーを含む化学的部分の部位特異的カップリングのための標的化合物 |
| DK3497117T5 (da) * | 2016-08-11 | 2024-09-02 | Navigo Proteins Gmbh | Nye alkalisk stabile immunglobulin-bindende proteiner |
| EP3521304B9 (en) * | 2018-02-01 | 2023-10-04 | Repligen Corporation | Fc binding proteins with cysteine in the c-terminal helical region |
| CN111132994B (zh) * | 2017-08-07 | 2024-05-31 | 瑞普利金公司 | 在c末端螺旋区中具有半胱氨酸的fc结合蛋白 |
| EP3546476A1 (en) * | 2018-03-26 | 2019-10-02 | Repligen Corporation | Fc binding proteins with cysteine in the c-terminal helical region |
| EP3706804B1 (en) | 2017-11-07 | 2022-02-23 | Navigo Proteins GmbH | Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer |
| EP4349853A3 (en) * | 2018-11-12 | 2024-07-03 | Navigo Proteins Gmbh | Novel triple-helical polypeptides lacking binding affinity for the fc domain of immunoglobulin and uses thereof |
| EP3650465A1 (en) * | 2018-11-12 | 2020-05-13 | Navigo Proteins Gmbh | Novel populations of polypeptides having a triple-helical structure |
| BR112021013026A2 (pt) * | 2019-02-01 | 2021-10-13 | Navigo Proteins Gmbh | Proteínas de ligação à imunoglobulina, matriz de separação por afinidade, uso da proteína de ligação à imunoglobulina, e método de purificação por afinidade de uma proteína compreendendo uma sequência de imunoglobulina |
| GB201904125D0 (en) | 2019-03-26 | 2019-05-08 | Ge Healthcare Bio Sciences Ab | Method for sanitization of a chromatography column |
| JP7432813B2 (ja) * | 2019-09-10 | 2024-02-19 | 東ソー株式会社 | 免疫グロブリン結合性タンパク質 |
| WO2021122943A1 (en) * | 2019-12-17 | 2021-06-24 | Navigo Proteins Gmbh | Binding proteins for the enzyme acid alpha glucosidase (gaa) and uses thereof |
| US20230093429A1 (en) * | 2020-02-21 | 2023-03-23 | Navigo Proteins Gmbh | AFFINITY LIGAND FOR THE SOLUBLE PART OF FIBROBLAST GROWTH FACTOR RECEPTOR 3 (sFGFR3) |
| EP3875472A1 (en) * | 2020-03-06 | 2021-09-08 | Navigo Proteins Gmbh | Novel immunoglobulin binding polypeptides |
| EP4168439B1 (en) * | 2020-06-23 | 2024-07-31 | Navigo Proteins Gmbh | Binding protein specific for the spike protein of severe acute respiratory syndrome corona virus 2 (sars-cov-2) |
| CA3184992A1 (en) * | 2020-07-15 | 2022-01-20 | Paul KNICK | Immunoglobulin binding proteins for affinity purification |
| WO2022096738A1 (en) * | 2020-11-09 | 2022-05-12 | Navigo Proteins Gmbh | Novel type ii collagen binding proteins |
| EP4001301A1 (en) * | 2020-11-13 | 2022-05-25 | Navigo Proteins Gmbh | Binding protein for complement factor h (cfh) |
| EP4380955A1 (en) * | 2021-08-06 | 2024-06-12 | Roche Diagnostics GmbH | Chimeric igg-fc-binding ligand polypeptide and uses thereof for igg affinity purification |
| GB202113626D0 (en) | 2021-09-24 | 2021-11-10 | Cytiva Bioprocess R & D Ab | FC binding polypeptides |
| CN116925197A (zh) * | 2021-12-21 | 2023-10-24 | 百林科(兰州)新材料有限公司 | 耐碱蛋白A变体在纯化IgG抗体中的应用 |
| CN113999294B (zh) * | 2021-12-30 | 2022-03-29 | 苏州纳微科技股份有限公司 | 免疫球蛋白结合蛋白及其应用 |
| CN114409748A (zh) * | 2022-01-28 | 2022-04-29 | 博格隆(浙江)生物技术有限公司 | 蛋白a的b结构域和z结构域突变体及其应用 |
| GB202203478D0 (en) | 2022-03-14 | 2022-04-27 | Cytiva Bioprocess R & D Ab | Vh3 binding polypeptides |
| EP4634208A1 (en) * | 2022-12-16 | 2025-10-22 | Navigo Proteins Gmbh | New ligands for affinity chromatography |
| WO2025059162A1 (en) | 2023-09-11 | 2025-03-20 | Dana-Farber Cancer Institute, Inc. | Car-engager containing il-2 variants to enhance the functionality of car t cells |
| EP4541444A1 (en) * | 2023-10-20 | 2025-04-23 | Cytiva BioProcess R&D AB | Fusion protein for affinity capture |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| SE9103701D0 (sv) | 1991-12-13 | 1991-12-13 | Kabi Pharmacia Ab | Apolipoprotein |
| US5629167A (en) * | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
| EP0729513B1 (en) * | 1994-07-21 | 2004-06-02 | Aventis Pasteur Limited | Analog of haemophilus hin47 with reduced protease activity |
| WO1997012992A2 (en) | 1995-10-02 | 1997-04-10 | Royal Netherlands Academy Of Arts And Sciences | Diagnosis method for a disease caused by a frameshift mutation in a gene and reagents therefore |
| WO1997016556A1 (en) | 1995-10-30 | 1997-05-09 | Massachusetts Institute Of Technology | Rationally designed polysaccharide lyases derived from heparinase i |
| US5789166A (en) | 1995-12-08 | 1998-08-04 | Stratagene | Circular site-directed mutagenesis |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| FR2761689B1 (fr) | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
| ES2209145T5 (es) | 1997-05-28 | 2009-10-30 | Crescendo Biologics Ltd. | Complejos de ribosomas como particulas de seleccion para el desarrollo in vitro y evolucion de proteinas. |
| EP0985039B1 (en) | 1997-06-12 | 2008-02-20 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| US20030045681A1 (en) | 1998-05-11 | 2003-03-06 | Anthony J. Zelano | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| TWI259837B (en) | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| CA2399866C (en) | 2000-02-24 | 2011-05-10 | Philogen S.R.L. | Compositions and methods for treatment of angiogenesis in pathological lesions |
| EP1259548A1 (en) | 2000-02-24 | 2002-11-27 | Eidgenössische Technische Hochschule Zürich | Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis |
| US6799121B2 (en) | 2000-03-30 | 2004-09-28 | York University | Sequencing of peptides by mass spectrometry |
| US20110179531A1 (en) | 2000-05-09 | 2011-07-21 | Kovalic David K | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| US20030073623A1 (en) | 2001-07-30 | 2003-04-17 | Drmanac Radoje T. | Novel nucleic acid sequences obtained from various cDNA libraries |
| JP4460302B2 (ja) | 2002-02-05 | 2010-05-12 | ジェネンテック インコーポレイテッド | タンパク質精製法 |
| SE0200943D0 (sv) * | 2002-03-25 | 2002-03-25 | Amersham Biosciences Ab | Mutant protein |
| US20040043386A1 (en) | 2002-08-30 | 2004-03-04 | Todd Pray | Methods and compositions for functional ubiquitin assays |
| EP1591527B1 (en) | 2003-01-23 | 2015-08-26 | Ono Pharmaceutical Co., Ltd. | Substance specific to human pd-1 |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| WO2005044845A2 (en) | 2003-11-04 | 2005-05-19 | Yale University | Protein binding miniature proteins |
| US7393918B2 (en) | 2003-12-11 | 2008-07-01 | Yale University | Protein binding miniature proteins and uses thereof |
| DE10360483B4 (de) | 2003-12-22 | 2007-11-15 | Scil Proteins Gmbh | Expressionsvektor und dessen Verwendung |
| DE102004014983A1 (de) | 2004-03-26 | 2005-10-20 | Univ Stuttgart | Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung |
| DE102004049479A1 (de) | 2004-10-11 | 2006-04-13 | Scil Proteins Gmbh | Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie |
| JP2006304633A (ja) * | 2005-04-26 | 2006-11-09 | Apro Life Science Institute Inc | イムノグロブリン結合タンパク質 |
| CA2607954A1 (en) | 2005-05-11 | 2006-11-16 | Philogen S.P.A. | Conjugate for targeting of drug |
| MY185597A (en) * | 2005-09-20 | 2021-05-24 | Avantor Performance Mat Inc | Vegetarian protein a preparation and methods thereof |
| BRPI0520677A2 (pt) | 2005-11-09 | 2009-05-19 | Bayer Schering Pharma Ag | identificação e caracterização de anticorpos de função de bloqueio anti-ed-b-fibronectina |
| EP1842553A1 (en) | 2006-04-07 | 2007-10-10 | Bayer Schering Pharma Aktiengesellschaft | Combination of an anti-EDb fibronectin domain antibody/IL2 fusion protein and a further small molecule |
| JP2009536170A (ja) | 2006-05-08 | 2009-10-08 | フィロジェン・エッセペア | 治療用の抗体標的指向サイトカイン |
| EP1892248A1 (en) | 2006-08-21 | 2008-02-27 | Eidgenössische Technische Hochschule Zürich | Specific and high affinity binding proteins comprising modified SH3 domains of FYN kinase |
| JP5345539B2 (ja) * | 2006-09-29 | 2013-11-20 | ジーイー・ヘルスケア・バイオ−サイエンシズ・アーベー | 抗体単離のためのスタフィロコッカスアウレウス由来のドメインｃを含むクロマトグラフィーリガンド |
| EP1925664A1 (en) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
| EP1955712A1 (en) | 2007-02-09 | 2008-08-13 | Scil proteins GmbH | Multimeric conjugate |
| PL2310509T3 (pl) | 2008-07-21 | 2015-08-31 | Apogenix Ag | Jednołańcuchowe cząsteczki TNFSF |
| US8592555B2 (en) * | 2008-08-11 | 2013-11-26 | Emd Millipore Corporation | Immunoglobulin-binding proteins with improved specificity |
| BR112012014194A2 (pt) | 2009-12-14 | 2017-01-10 | Scil Proteins Gmbh | um método para identificar proteínas ubiquitinas modificadas hetero-multiméricas com capacidade de ligação a ligandos |
| JP5952185B2 (ja) * | 2010-03-24 | 2016-07-13 | 株式会社カネカ | 免疫グロブリンに特異的に結合するタンパク質および免疫グロブリン結合性アフィニティーリガンド |
| US10065995B2 (en) * | 2011-03-25 | 2018-09-04 | Kaneka Corporation | Protein for affinity-separation matrix |
| SG10201604554WA (en) | 2011-06-08 | 2016-07-28 | Emd Millipore Corp | Chromatography matrices including novel staphylococcus aureus protein a based ligands |
| EP2721152B1 (en) | 2011-06-15 | 2019-03-27 | Navigo Proteins GmbH | Dimeric binding proteins based on modified ubiquitins |
| WO2012171541A1 (en) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins |
| US20150183846A1 (en) | 2012-06-13 | 2015-07-02 | Scil Proteins Gmbh | Human fusion proteins comprising single chain tnfalpha and targeting domains |
| US9920098B2 (en) | 2012-09-21 | 2018-03-20 | Kaneka Corporation | Protein ligand for affinity isolation matrix |
| EP2727942A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Bispecific antibodies against human EGFR, HER2, and HER3 |
| EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| WO2014094799A1 (en) | 2012-12-19 | 2014-06-26 | Scil-Proteins-Gmbh | Ubiquitin moieties as a means for prolonging serum half-life |
| US9896486B2 (en) * | 2013-07-10 | 2018-02-20 | Ge Healthcare Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| KR102236367B1 (ko) | 2013-07-26 | 2021-04-05 | 삼성전자주식회사 | DARPin을 포함하는 이중 특이 키메라 단백질 |
| US11566082B2 (en) * | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| EP3253795B1 (en) | 2015-02-06 | 2019-04-17 | Navigo Proteins Gmbh | Novel binding proteins comprising a ubiquitin mutein and antibodies or antibody fragments |
| JP6738340B2 (ja) | 2015-02-06 | 2020-08-12 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | 新規なｅｇｆｒ結合タンパク質 |
| ES2916101T3 (es) | 2015-07-16 | 2022-06-28 | Navigo Proteins Gmbh | Nuevas proteínas de unión a inmunoglobulina y su uso en la purificación por afinidad |
| JP2018520675A (ja) | 2015-07-20 | 2018-08-02 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ジユビキチン変異タンパク質をベースとした新規結合タンパク質及びその生成方法 |
| CA2991814A1 (en) | 2015-07-20 | 2017-01-26 | Navigo Proteins Gmbh | Her2 binding proteins based on di-ubiquitin muteins |
| JP2019526526A (ja) | 2016-05-04 | 2019-09-19 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ペプチドリンカーを含む化学的部分の部位特異的カップリングのための標的化合物 |
| DK3497117T5 (da) | 2016-08-11 | 2024-09-02 | Navigo Proteins Gmbh | Nye alkalisk stabile immunglobulin-bindende proteiner |
| CN111132994B (zh) | 2017-08-07 | 2024-05-31 | 瑞普利金公司 | 在c末端螺旋区中具有半胱氨酸的fc结合蛋白 |
| EP3521304B9 (en) | 2018-02-01 | 2023-10-04 | Repligen Corporation | Fc binding proteins with cysteine in the c-terminal helical region |
| EP3706804B1 (en) | 2017-11-07 | 2022-02-23 | Navigo Proteins GmbH | Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer |
-
2017
- 2017-08-07 DK DK17752349.5T patent/DK3497117T5/da active
- 2017-08-07 CN CN202311795884.XA patent/CN117736281A/zh active Pending
- 2017-08-07 WO PCT/EP2017/069976 patent/WO2018029157A1/en not_active Ceased
- 2017-08-07 EP EP17752349.5A patent/EP3497117B1/en active Active
- 2017-08-07 AU AU2017311541A patent/AU2017311541B2/en active Active
- 2017-08-07 CA CA3030208A patent/CA3030208A1/en active Pending
- 2017-08-07 CN CN202210871980.7A patent/CN116333065A/zh active Pending
- 2017-08-07 EP EP22193930.9A patent/EP4177260A1/en active Pending
- 2017-08-07 AU AU2017311542A patent/AU2017311542B2/en active Active
- 2017-08-07 EP EP23218805.2A patent/EP4324840A3/en active Pending
- 2017-08-07 LT LTEPPCT/EP2017/069976T patent/LT3497117T/lt unknown
- 2017-08-07 SG SG11201901066UA patent/SG11201901066UA/en unknown
- 2017-08-07 WO PCT/EP2017/069979 patent/WO2018029158A1/en not_active Ceased
- 2017-08-07 US US16/324,842 patent/US11014967B2/en active Active
- 2017-08-07 JP JP2019507171A patent/JP6951417B2/ja active Active
- 2017-08-07 EP EP17752350.3A patent/EP3497118B1/en active Active
- 2017-08-07 JP JP2019505354A patent/JP7181612B2/ja active Active
- 2017-08-07 KR KR1020197003790A patent/KR102578256B1/ko active Active
- 2017-08-07 KR KR1020237030862A patent/KR20230133943A/ko not_active Ceased
- 2017-08-07 CN CN201780044905.0A patent/CN109476712B/zh active Active
- 2017-08-07 CA CA3031858A patent/CA3031858A1/en active Pending
- 2017-08-07 US US16/324,651 patent/US11230576B2/en active Active
- 2017-08-07 KR KR1020197003966A patent/KR102573370B1/ko active Active
- 2017-08-07 CN CN201780050413.2A patent/CN109963864B/zh active Active
-
2021
- 2021-03-23 US US17/209,455 patent/US20210206815A1/en not_active Abandoned
-
2022
- 2022-07-13 JP JP2022112299A patent/JP2022160444A/ja active Pending
-
2024
- 2024-09-03 US US18/822,867 patent/US20250051400A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019531055A5 (OSRAM) | ||
| CN105377880B (zh) | 突变的免疫球蛋白结合多肽 | |
| JP2019522490A5 (OSRAM) | ||
| JP6770727B2 (ja) | 変異免疫グロブリン結合ポリペプチド | |
| JP2019033754A5 (OSRAM) | ||
| CN107108700B (zh) | 修饰的κ轻链-结合多肽 | |
| JP2016000731A5 (OSRAM) | ||
| CN109071612B (zh) | 突变的免疫球蛋白结合多肽 | |
| JP2020517287A5 (OSRAM) | ||
| JP2017514522A5 (OSRAM) | ||
| JP2014500311A5 (OSRAM) | ||
| JP2012515160A5 (OSRAM) | ||
| JP2010539921A5 (OSRAM) | ||
| JP2007252368A5 (OSRAM) | ||
| JP2017529067A5 (OSRAM) | ||
| JP2017534296A5 (OSRAM) | ||
| HRP20180937T1 (hr) | Poboljšavanje transporta terapijskih molekula kroz krvno-moždanu barijeru | |
| JP2015511637A5 (OSRAM) | ||
| JP2019513784A5 (OSRAM) | ||
| JP2016508503A5 (OSRAM) | ||
| JP2017501728A5 (OSRAM) | ||
| JP2021505156A5 (OSRAM) | ||
| JP2017113019A5 (OSRAM) | ||
| JP2020526590A5 (OSRAM) | ||
| JP2010534336A5 (OSRAM) |