JP2017501728A5 - - Google Patents
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- Publication number
- JP2017501728A5 JP2017501728A5 JP2016543004A JP2016543004A JP2017501728A5 JP 2017501728 A5 JP2017501728 A5 JP 2017501728A5 JP 2016543004 A JP2016543004 A JP 2016543004A JP 2016543004 A JP2016543004 A JP 2016543004A JP 2017501728 A5 JP2017501728 A5 JP 2017501728A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- amino acid
- binding fragment
- terminal amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361920425P | 2013-12-23 | 2013-12-23 | |
| US61/920,425 | 2013-12-23 | ||
| PCT/CA2014/051263 WO2015095972A1 (en) | 2013-12-23 | 2014-12-23 | Antibodies comprising c-terminal light chain polypeptide extensions and conjugates and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501728A JP2017501728A (ja) | 2017-01-19 |
| JP2017501728A5 true JP2017501728A5 (OSRAM) | 2018-02-01 |
| JP6585600B2 JP6585600B2 (ja) | 2019-10-02 |
Family
ID=53477259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016543004A Active JP6585600B2 (ja) | 2013-12-23 | 2014-12-23 | Ｃ末端軽鎖ポリペプチド伸長を含有する抗体、ならびにその複合体及びその使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11208497B2 (OSRAM) |
| EP (1) | EP3087185A4 (OSRAM) |
| JP (1) | JP6585600B2 (OSRAM) |
| KR (1) | KR20160122127A (OSRAM) |
| CN (1) | CN106459981A (OSRAM) |
| AU (1) | AU2014373593B2 (OSRAM) |
| BR (1) | BR112016014913A8 (OSRAM) |
| CA (1) | CA2934818C (OSRAM) |
| IL (1) | IL246371A0 (OSRAM) |
| MX (1) | MX2016008355A (OSRAM) |
| RU (1) | RU2016129724A (OSRAM) |
| SG (1) | SG11201605093VA (OSRAM) |
| WO (1) | WO2015095972A1 (OSRAM) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6983511B2 (ja) | 2014-04-25 | 2021-12-17 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 脳中の転移乳癌および他の癌を処置するための方法および組成物 |
| WO2018071913A2 (en) * | 2016-10-14 | 2018-04-19 | Dana-Farber Cancer Institute, Inc. | Modular tetrameric bispecific antibody platform |
| IL268554B2 (en) | 2017-02-08 | 2025-03-01 | Dragonfly Therapeutics Inc | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| CA3235295C (en) | 2017-02-20 | 2024-11-19 | Dragonfly Therapeutics, Inc. | Proteins binding her2, nkg2d and cd16 |
| JP7295838B2 (ja) * | 2017-07-13 | 2023-06-21 | シティ・オブ・ホープ | ホスホロチオエートコンジュゲートペプチド及びその使用方法 |
| US11607457B2 (en) | 2017-07-13 | 2023-03-21 | City Of Hope | Anti-cancer phosphorothioate-coupled peptide conjugates and methods of using the same |
| MX420258B (es) * | 2017-09-07 | 2025-02-10 | Dragonfly Therapeutics Inc | Proteínas de unión a nkg2d, cd16 y nectina 4. |
| US12384847B2 (en) | 2018-02-08 | 2025-08-12 | Dragonfly Therapeutics, Inc. | Cancer therapy involving an anti-PD1 antibody and a multi-specific binding protein that binds NKG2D, CD16, and a tumor-associated antigen |
| US11884733B2 (en) | 2018-02-08 | 2024-01-30 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting the NKG2D receptor |
| US12215157B2 (en) | 2018-02-20 | 2025-02-04 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind CD33, NKG2D, and CD16, and methods of use |
| WO2019213331A1 (en) | 2018-05-01 | 2019-11-07 | Ambrx, Inc. | A method for optimizing antibody expression |
| MA53284A (fr) | 2018-08-08 | 2022-01-26 | Dragonfly Therapeutics Inc | Protéines de liaison à nkg2d, à cd16 et à un antigène associé à une tumeur |
| EP3833392A4 (en) | 2018-08-08 | 2022-05-18 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| WO2020112588A1 (en) | 2018-11-30 | 2020-06-04 | Bristol-Myers Squibb Company | Antibody comprising a glutamine-containing light chain c-terminal extension, conjugates thereof, and methods and uses |
| TW202208428A (zh) | 2020-05-06 | 2022-03-01 | 美商蜻蜓醫療公司 | 結合ｎｋｇ２ｄ、ｃｄ１６及ｃｌｅｃ１２ａ之蛋白質 |
| EP4301774A4 (en) | 2021-03-03 | 2025-08-13 | Dragonfly Therapeutics Inc | METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN |
| CN117164701A (zh) * | 2022-12-27 | 2023-12-05 | 优洛生物(上海)有限公司 | 一种经改造的抗体、其制备方法及其用途 |
| EP4548936A1 (en) | 2023-10-30 | 2025-05-07 | BioNTech SE | Antibody-drug conjugates having a tailor-made drug-to-antibody ratio |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2170589C2 (ru) | 1992-10-28 | 2001-07-20 | Генентек Инк. | Композиция для ингибирования ангиогенеза, моноклональное антитело, полипептид, способ ингибирования роста опухоли (варианты) |
| AU5610194A (en) * | 1992-11-16 | 1994-06-08 | Centocor Inc. | Compounds having reduced immunogenicity and a method of reducing the immunogenicity of compounds |
| US6165476A (en) * | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
| US20050159343A1 (en) | 1999-03-26 | 2005-07-21 | Board Of Regents, University Of Texas System | Inhibitors of glycosaminoglycans |
| IL155204A0 (en) | 2000-10-02 | 2003-11-23 | Arizeke Pharmaceuticals Inc | Compositions and methods for the transport of biologically active agents across cellular barriers |
| US7834258B2 (en) | 2003-06-30 | 2010-11-16 | Mu-Hyeon Choe | Dimer of chimeric recombinant binding domain-functional group fusion formed via disulfide-bond-bridge and the processes for producing the same |
| WO2007103288A2 (en) * | 2006-03-02 | 2007-09-13 | Seattle Genetics, Inc. | Engineered antibody drug conjugates |
| EP2418223A3 (en) * | 2006-06-12 | 2013-01-16 | Emergent Product Development Seattle, LLC | Single-chain multivalent binding proteins with effector function |
| EP2641618A3 (en) * | 2007-07-16 | 2013-10-23 | Genentech, Inc. | Humanized anti-CD79B antibodies and immunoconjugates and methods of use |
| CN101952312A (zh) | 2007-07-31 | 2011-01-19 | 米迪缪尼有限公司 | 多特异性表位结合蛋白及其应用 |
| US8865875B2 (en) * | 2007-08-22 | 2014-10-21 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions |
| UY31504A1 (es) * | 2007-11-30 | 2009-07-17 | Construcciones de union de antigenos | |
| NZ586701A (en) | 2008-01-03 | 2013-07-26 | Scripps Research Inst | Antibody targeting through a modular recognition domain (MRD) wherein the MRD targets angiopoietin-2 (ANG-2) |
| US8454960B2 (en) * | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
| CN105218673A (zh) * | 2008-10-10 | 2016-01-06 | 新兴产品开发西雅图有限公司 | Tcr复合物免疫治疗剂 |
| CA2755133A1 (en) * | 2009-03-20 | 2010-09-23 | Amgen Inc. | Selective and potent peptide inhibitors of kv1.3 |
| US9676871B2 (en) * | 2010-11-05 | 2017-06-13 | Pfizer Inc. | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| PT2707031T (pt) * | 2011-05-08 | 2019-09-05 | Legochem Biosciences Inc | Conjugados de proteína e agente ativo e processo para a sua preparação |
| DK2714738T3 (en) | 2011-05-24 | 2019-01-28 | Zyngenia Inc | MULTIVALENT AND MONOVALENT MULTISPECIFIC COMPLEXES AND THEIR APPLICATIONS |
| BR112013029746B1 (pt) * | 2011-06-22 | 2021-02-02 | F. Hoffmann-La Roche Ag | método para a produção recombinante de um complexo, complexo, formulação farmacêutica e uso do complexo |
| AU2012336069A1 (en) * | 2011-11-07 | 2014-05-22 | Medimmune, Llc | Multispecific and multivalent binding proteins and uses thereof |
| WO2013096829A2 (en) | 2011-12-22 | 2013-06-27 | Arizona Biomedical Research Commission | Activation of cellular assault processes in the treatment of glioblastoma multiforme |
| EP2820043B1 (en) * | 2012-03-02 | 2020-01-15 | Ablynx N.V. | Biparatopic pseudomonas aeruginosa pcrv binding single variable domain antibodies |
| WO2014099997A1 (en) | 2012-12-18 | 2014-06-26 | Novartis Ag | Compositions and methods that utilize a peptide tag that binds to hyaluronan |
-
2014
- 2014-12-23 SG SG11201605093VA patent/SG11201605093VA/en unknown
- 2014-12-23 BR BR112016014913A patent/BR112016014913A8/pt not_active Application Discontinuation
- 2014-12-23 AU AU2014373593A patent/AU2014373593B2/en active Active
- 2014-12-23 KR KR1020167019769A patent/KR20160122127A/ko not_active Withdrawn
- 2014-12-23 MX MX2016008355A patent/MX2016008355A/es unknown
- 2014-12-23 EP EP14874786.8A patent/EP3087185A4/en not_active Withdrawn
- 2014-12-23 CA CA2934818A patent/CA2934818C/en active Active
- 2014-12-23 WO PCT/CA2014/051263 patent/WO2015095972A1/en not_active Ceased
- 2014-12-23 US US15/107,884 patent/US11208497B2/en active Active
- 2014-12-23 RU RU2016129724A patent/RU2016129724A/ru unknown
- 2014-12-23 JP JP2016543004A patent/JP6585600B2/ja active Active
- 2014-12-23 CN CN201480075958.5A patent/CN106459981A/zh active Pending
-
2016
- 2016-06-21 IL IL246371A patent/IL246371A0/en unknown
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