JP2018526970A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018526970A5 JP2018526970A5 JP2017563328A JP2017563328A JP2018526970A5 JP 2018526970 A5 JP2018526970 A5 JP 2018526970A5 JP 2017563328 A JP2017563328 A JP 2017563328A JP 2017563328 A JP2017563328 A JP 2017563328A JP 2018526970 A5 JP2018526970 A5 JP 2018526970A5
- Authority
- JP
- Japan
- Prior art keywords
- hla
- amino acid
- antibody
- binding
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 29
- 125000000539 amino acid group Chemical group 0.000 claims 18
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 14
- 239000000427 antigen Substances 0.000 claims 14
- 108091007433 antigens Proteins 0.000 claims 14
- 102000036639 antigens Human genes 0.000 claims 14
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 14
- 238000006467 substitution reaction Methods 0.000 claims 13
- 235000004279 alanine Nutrition 0.000 claims 6
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 4
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 3
- 230000001363 autoimmune Effects 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims 1
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims 1
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 claims 1
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims 1
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562172264P | 2015-06-08 | 2015-06-08 | |
| US62/172,264 | 2015-06-08 | ||
| NL2014935 | 2015-06-08 | ||
| NL2014935A NL2014935B1 (en) | 2015-06-08 | 2015-06-08 | T cell receptor like antibodies having fine specificity. |
| PCT/IL2016/050599 WO2016199140A1 (en) | 2015-06-08 | 2016-06-08 | T cell receptor like antibodies having fine specificity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018526970A JP2018526970A (ja) | 2018-09-20 |
| JP2018526970A5 true JP2018526970A5 (OSRAM) | 2019-07-11 |
| JP7013243B2 JP7013243B2 (ja) | 2022-01-31 |
Family
ID=54325627
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017563331A Active JP6912392B2 (ja) | 2015-06-08 | 2016-06-08 | 高親和性および微細特異性を有するｔｃｒ様抗体結合ドメインを含む親和性結合体ならびにその使用 |
| JP2017563328A Active JP7013243B2 (ja) | 2015-06-08 | 2016-06-08 | 微細特異性を有する親和性結合体 |
| JP2021113633A Active JP7147018B2 (ja) | 2015-06-08 | 2021-07-08 | 高親和性および微細特異性を有するｔｃｒ様抗体結合ドメインを含む親和性結合体ならびにその使用 |
| JP2022150286A Active JP7376655B2 (ja) | 2015-06-08 | 2022-09-21 | 高親和性および微細特異性を有するｔｃｒ様抗体結合ドメインを含む親和性結合体ならびにその使用 |
| JP2023183842A Ceased JP2024016092A (ja) | 2015-06-08 | 2023-10-26 | 高親和性および微細特異性を有するｔｃｒ様抗体結合ドメインを含む親和性結合体ならびにその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017563331A Active JP6912392B2 (ja) | 2015-06-08 | 2016-06-08 | 高親和性および微細特異性を有するｔｃｒ様抗体結合ドメインを含む親和性結合体ならびにその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021113633A Active JP7147018B2 (ja) | 2015-06-08 | 2021-07-08 | 高親和性および微細特異性を有するｔｃｒ様抗体結合ドメインを含む親和性結合体ならびにその使用 |
| JP2022150286A Active JP7376655B2 (ja) | 2015-06-08 | 2022-09-21 | 高親和性および微細特異性を有するｔｃｒ様抗体結合ドメインを含む親和性結合体ならびにその使用 |
| JP2023183842A Ceased JP2024016092A (ja) | 2015-06-08 | 2023-10-26 | 高親和性および微細特異性を有するｔｃｒ様抗体結合ドメインを含む親和性結合体ならびにその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11001642B2 (OSRAM) |
| EP (4) | EP3302538B1 (OSRAM) |
| JP (5) | JP6912392B2 (OSRAM) |
| KR (2) | KR20180012851A (OSRAM) |
| CN (4) | CN114605547B (OSRAM) |
| AU (3) | AU2016276555B2 (OSRAM) |
| CA (3) | CA2988270A1 (OSRAM) |
| ES (1) | ES2922236T3 (OSRAM) |
| IL (3) | IL256178B2 (OSRAM) |
| MX (3) | MX2017015928A (OSRAM) |
| NL (1) | NL2014935B1 (OSRAM) |
| SG (1) | SG10202007398PA (OSRAM) |
| WO (2) | WO2016199141A2 (OSRAM) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA49157A (fr) | 2014-12-23 | 2021-06-02 | Immatics Biotechnologies Gmbh | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers |
| GB201501017D0 (en) | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| EP3359565A1 (en) * | 2015-10-09 | 2018-08-15 | Immatics Biotechnologies GmbH | Anti-wt1/hla-specific antibodies |
| IL295398B2 (en) | 2015-10-23 | 2025-01-01 | Eureka Therapeutics Inc | Antibody/T-cell receptor chimeric constructs and their uses |
| JP7303750B2 (ja) * | 2017-01-24 | 2023-07-05 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 癌における非古典的ｈｌａ－ｉおよびネオ抗原を含む複合体を標的とするための方法および組成物 |
| CN110741016A (zh) | 2017-04-26 | 2020-01-31 | 优瑞科生物技术公司 | 嵌合抗体/t-细胞受体构筑体及其用途 |
| US11807662B2 (en) | 2017-05-16 | 2023-11-07 | The Johns Hopkins University | MANAbodies and methods of using |
| KR102412805B1 (ko) * | 2017-05-31 | 2022-06-27 | 크라제 메디컬 씨오 리미티드 | 세포 면역 요법을 위한 조성물 및 방법 |
| WO2018225732A1 (ja) * | 2017-06-05 | 2018-12-13 | 国立大学法人三重大学 | Ｍａｇｅ－ａ４由来ペプチドを認識する抗原結合性タンパク質 |
| CN111032076A (zh) * | 2017-06-14 | 2020-04-17 | 阿迪塞特生物公司 | 能够以hla限制性方式结合hla-a2/tyrd的抗体及其用途 |
| CN109776671B (zh) * | 2017-11-14 | 2022-05-27 | 杭州康万达医药科技有限公司 | 分离的t细胞受体、其修饰的细胞、编码核酸、表达载体、制备方法、药物组合物和应用 |
| MA51302A (fr) * | 2017-12-21 | 2021-03-31 | Hoffmann La Roche | Anticorps se liant à hla-a2/wt1 |
| EP3755371A4 (en) * | 2018-02-23 | 2021-11-24 | Abexxa Biologics, Inc. | ANTI-CANCER TREATMENT COMBINED WITH ANTI-CANCER AGENTS AND ANTIBODIES TARGETING A COMPLEX INCLUDING A NON-CLASSIC HLA-I AND A NEO-ANTIGEN |
| GB201803750D0 (en) | 2018-03-08 | 2018-04-25 | Immunocore Ltd | Method |
| WO2019192972A1 (en) * | 2018-04-04 | 2019-10-10 | F. Hoffmann-La Roche Ag | Diagnostic assays to detect tumor antigens in cancer patients |
| EP3802614A1 (en) * | 2018-06-04 | 2021-04-14 | Apo-T B.V. | Methods and means for attracting immune effector cells to tumor cells |
| JP7090204B2 (ja) * | 2018-07-19 | 2022-06-23 | イーライ リリー アンド カンパニー | 免疫チェックポイントを標的とする二重特異性抗体 |
| CN112638947B (zh) * | 2018-08-30 | 2022-09-30 | 上海斯丹赛生物技术有限公司 | 用于治疗实体瘤的嵌合抗原受体细胞 |
| AU2019354395A1 (en) | 2018-10-01 | 2021-05-06 | Adicet Therapeutics, Inc. | Compositions and methods regarding engineered and non-engineered γδ -T cells for treatment of solid tumors |
| SG11202103235PA (en) | 2018-10-01 | 2021-04-29 | Adicet Bio Inc | COMPOSITIONS AND METHODS REGARDING ENGINEERED AND NON- ENGINEERED γδ-Τ CELLS FOR TREATMENT OF HEMATOLOGICAL TUMORS |
| JP2022523708A (ja) * | 2019-01-29 | 2022-04-26 | グリットストーン バイオ インコーポレイテッド | 多重特異性結合タンパク質 |
| SG11202109701SA (en) * | 2019-03-25 | 2021-10-28 | Univ Health Network | T cell receptors and methods of use thereof |
| GB201904328D0 (en) * | 2019-03-28 | 2019-05-15 | Immunocore Ltd | Specific binding molecules |
| EP3986938A4 (en) * | 2019-06-18 | 2023-06-28 | Regeneron Pharmaceuticals, Inc. | Mage-a4 t cell receptors and methods of use thereof |
| BR112022001194A2 (pt) * | 2019-07-24 | 2022-06-07 | Regeneron Pharma | Receptores de antígeno quimérico com especificidade de mage a4 e usos dos mesmos |
| US12480958B2 (en) | 2019-08-13 | 2025-11-25 | Immatics Biotechnologies Gmbh | Method for the characterization of peptide:MHC binding polypeptides |
| CN112442119B (zh) * | 2019-09-05 | 2023-02-24 | 香雪生命科学技术（广东）有限公司 | 一种识别ssx2的高亲和力t细胞受体 |
| CN110563804A (zh) * | 2019-09-19 | 2019-12-13 | 河南省农业科学院 | 基于天然免疫库筛选识别氧氟沙星单链抗体的多肽序列及应用 |
| NL2024375B1 (en) * | 2019-12-04 | 2021-08-31 | Apo T B V | Methods and means for attracting immune effector cells to tumor cells. |
| EP4076666A1 (en) * | 2019-12-18 | 2022-10-26 | F. Hoffmann-La Roche AG | Antibodies binding to hla-a2/mage-a4 |
| WO2021226063A1 (en) | 2020-05-05 | 2021-11-11 | Regeneron Pharmaceuticals, Inc. | Car comprising cd28 zeta and cd3 zeta |
| MX2022014636A (es) * | 2020-05-19 | 2023-02-23 | Amgen Inc | Construcciones de unión a mageb2. |
| IL276599A (en) | 2020-08-09 | 2022-03-01 | Yeda Res & Dev | T cell receptor unique to mage-a1 and its uses |
| AU2022233285A1 (en) | 2021-03-09 | 2023-10-19 | Cdr-Life Ag | Mage-a4 peptide-mhc antigen binding proteins |
| US12435444B2 (en) | 2021-03-09 | 2025-10-07 | Cdr-Life Ag | Rabbit-derived antigen binding protein nucleic acid libraries and methods of making the same |
| KR20240005854A (ko) * | 2021-05-04 | 2024-01-12 | 리제너론 파아마슈티컬스, 인크. | Mage-a4 특이성을 갖는 키메라 항원 수용체 및 이들의 용도 |
| CN118541382A (zh) * | 2021-12-14 | 2024-08-23 | 豪夫迈·罗氏有限公司 | 使用HLA-A2/MAGE-A4 x CD3双特异性抗体和4-1BB(CD137)激动剂治疗癌症 |
| CN120202015A (zh) * | 2022-09-14 | 2025-06-24 | Cdr-生物科技股份有限公司 | Mage-a4肽双重t细胞衔接子 |
| AR133120A1 (es) * | 2023-09-22 | 2025-08-27 | Regeneron Pharma | Métodos para obtener moléculas de anticuerpos que se unen a una interfaz péptido-mhc |
| GB202315181D0 (en) * | 2023-10-03 | 2023-11-15 | Immunocore Ltd | Peptide-HLA binding molecules |
Family Cites Families (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| US8258260B2 (en) | 1970-02-11 | 2012-09-04 | Immatics Biotechnologies Gmbh | Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules |
| US3940475A (en) | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4036945A (en) | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4289747A (en) | 1978-12-26 | 1981-09-15 | E-Y Laboratories, Inc. | Immunological determination using lectin |
| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| DE122007000007I2 (de) | 1986-04-09 | 2010-12-30 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| US20020150914A1 (en) | 1995-06-30 | 2002-10-17 | Kobenhavns Universitet | Recombinant antibodies from a phage display library, directed against a peptide-MHC complex |
| WO1997015597A1 (en) | 1995-10-25 | 1997-05-01 | Centocor B.V. | HUMAN EPITHELIAL ANTIGEN Ep-CAM DERIVED PEPTIDES AND THEIR USE |
| US6710172B1 (en) | 1998-10-02 | 2004-03-23 | Ludwig Institute For Cancer Research | Tumor antigens and CTL clones isolated by a novel procedure |
| US7157091B1 (en) * | 1999-06-18 | 2007-01-02 | Ludwig Institute For Cancer Research | MAGE-A1 peptides presented by HLA class II molecules |
| US7521202B2 (en) | 1999-12-17 | 2009-04-21 | The Board Of Regents Of The University Of Oklahoma | Method and apparatus for the production of soluble MHC antigens and uses thereof |
| US20040191260A1 (en) | 2003-03-26 | 2004-09-30 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
| US20070099182A1 (en) | 2000-10-10 | 2007-05-03 | Hildebrand William H | Comparative ligand mapping from MHC class I positive cells |
| US20090062512A1 (en) | 2000-10-10 | 2009-03-05 | Hildebrand William H | Comparative ligand mapping from MHC class I positive cells |
| US20070026433A1 (en) | 2001-03-09 | 2007-02-01 | Hildebrand William H | Epitope testing using soluble HLA |
| US6867283B2 (en) | 2001-05-16 | 2005-03-15 | Technion Research & Development Foundation Ltd. | Peptides capable of binding to MHC molecules, cells presenting such peptides, and pharmaceutical compositions comprising such peptides and/or cells |
| US6992176B2 (en) | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
| CA2476625A1 (en) | 2002-02-20 | 2003-08-28 | Dyax Corp. | Mhc-peptide complex binding ligands |
| DE10225144A1 (de) | 2002-05-29 | 2003-12-18 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
| DE10313819A1 (de) | 2003-03-24 | 2004-10-07 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
| US7488793B2 (en) | 2003-09-22 | 2009-02-10 | Ludwig Institute For Cancer Research | Isolated peptide which binds to HLA-Cw*07 and uses thereof |
| WO2005113595A2 (en) | 2004-05-19 | 2005-12-01 | Avidex Ltd | High affinity ny-eso t cell receptor |
| DE102004026135A1 (de) | 2004-05-25 | 2006-01-05 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
| GB0411773D0 (en) | 2004-05-26 | 2004-06-30 | Avidex Ltd | Method for the identification of polypeptides which bind to a given peptide mhc complex or cd 1-antigen complex |
| ATE430164T1 (de) | 2004-05-26 | 2009-05-15 | Immunocore Ltd | Hochaffine telomerase-t-zellen-rezeptoren |
| US20090226474A1 (en) | 2004-05-27 | 2009-09-10 | Weidanz Jon A | Antibodies as T cell receptor mimics, methods of production and uses thereof |
| ES2319286T3 (es) | 2004-10-02 | 2009-05-06 | Immatics Biotechnologies Gmbh | Epitopos inmunogenos de linfocitos t colaboradores de antigenos de tumor humanos y utilizacion de dichos epitopos en metodos inmunoterapeuticos. |
| TW200636064A (en) | 2004-10-28 | 2006-10-16 | Centocor Inc | Anti-respiratory syncytial virus antibodies, antigens and uses thereof |
| WO2006103429A2 (en) | 2005-04-01 | 2006-10-05 | Medigene Limited | High affinity hiv t cell receptors |
| ATE512160T1 (de) | 2005-04-26 | 2011-06-15 | Immatics Biotechnologies Gmbh | T-cell-epitope aus dem unreifen lamininrezeptorprotein (oncofoetal antigen) und deren medizinische verwendungen |
| GB0524477D0 (en) | 2005-11-30 | 2006-01-11 | Avidex Ltd | Isolated T cell receptors which specifically bind to vygfvracl-hla-24 |
| GB0511124D0 (en) | 2005-06-01 | 2005-07-06 | Avidex Ltd | High affinity melan-a t cell receptors |
| ATE461215T1 (de) | 2005-09-05 | 2010-04-15 | Immatics Biotechnologies Gmbh | Tumor-assoziierte peptide, welche an unterschiedliche menschliche leukozytenantigene der klasse ii binden |
| CA2630023A1 (en) * | 2005-11-14 | 2007-05-18 | Universite Laval | Cancer antigen mage-a9 and uses thereof |
| AU2007254859A1 (en) * | 2006-06-01 | 2007-12-13 | Receptor Logic, Ltd | Antibodies as T cell receptor mimics, methods of production and uses thereof |
| DE102007001370A1 (de) * | 2007-01-09 | 2008-07-10 | Curevac Gmbh | RNA-kodierte Antikörper |
| US20100158927A1 (en) * | 2007-03-29 | 2010-06-24 | Technion Research & Development Foundation Ltd. | Antibodies, methods and kits for diagnosing and treating melanoma |
| JP5352586B2 (ja) | 2007-07-27 | 2013-11-27 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 腫瘍関連ペプチドおよび関連抗癌ワクチンの組成物 |
| HUE027057T2 (en) | 2007-07-27 | 2016-08-29 | Immatics Biotechnologies Gmbh | New immunogenic epitope for immunotherapy |
| CN103911358B (zh) | 2007-07-27 | 2017-03-01 | 伊玛提克斯生物技术有限公司 | 神经元和脑肿瘤的新型免疫疗法 |
| US20110105724A1 (en) | 2007-08-16 | 2011-05-05 | Stephanie Jane Clegg | Novel compounds |
| WO2009090651A2 (en) | 2008-01-15 | 2009-07-23 | Technion Research And Development Foundation Ltd. | Major histocompatibility complex hla-b2705 ligands useful for therapy and diagnosis |
| PL2113253T3 (pl) | 2008-04-30 | 2010-09-30 | Immatics Biotechnologies Gmbh | Nowa postać leku - preparat zawierający peptydy nowotworowe wiążące się z antygenami ludzkich leukocytów klasy I i II, zastosowany w szczepionce |
| HUE024541T2 (hu) | 2008-05-14 | 2016-01-28 | Immatics Biotechnologies Gmbh | Szurvivinbõl és neurocanból származó új és hatásos II-es osztályú MHC peptidek |
| PL2172211T3 (pl) | 2008-10-01 | 2015-05-29 | Immatics Biotechnologies Gmbh | Kompozycja związanych z guzem peptydów i związana z tym szczepionka przeciwrakowa do leczenia glejaka (GBM) i innych rodzajów raka |
| US20120077696A1 (en) | 2009-03-15 | 2012-03-29 | Technion Research And Development Foundation Ltd. | Soluble hla complexes for use in disease diagnosis |
| US8933198B2 (en) | 2009-03-25 | 2015-01-13 | Altor Bioscience Corporation | HIV VPR-specific T cell receptors |
| GB0911566D0 (en) | 2009-07-03 | 2009-08-12 | Immunocore Ltd | T cell receptors |
| EP2501722A4 (en) * | 2009-11-19 | 2013-05-01 | Univ Singapore | METHOD FOR PRODUCING T-CELL-RECEPTOR-SIMILAR MONOCLONAL ANTIBODIES AND APPLICATIONS THEREOF |
| US9023802B2 (en) | 2009-12-14 | 2015-05-05 | Immatics Biotechnologies Gmbh | HLA-binding peptides derived from prostate-associated antigenic molecules and methods of use thereof |
| GB201004551D0 (en) | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
| GB201019331D0 (en) | 2010-03-19 | 2010-12-29 | Immatics Biotechnologies Gmbh | Methods for the diagnosis and treatment of cancer based on AVL9 |
| EA201291133A1 (ru) * | 2010-04-30 | 2013-04-30 | Алексион Фармасьютикалз, Инк. | Антитела, обладающие пониженной иммуногенностью в организме человека |
| US9821073B2 (en) | 2010-12-27 | 2017-11-21 | Apo-T B.V. | Polypeptide that binds aberrant cells and induces apoptosis |
| SG193023A1 (en) | 2011-02-11 | 2013-10-30 | Sloan Kettering Inst Cancer | Hla-restricted, peptide-specific antigen binding proteins |
| GB201103955D0 (en) * | 2011-03-09 | 2011-04-20 | Antitope Ltd | Antibodies |
| WO2015070061A1 (en) | 2013-11-07 | 2015-05-14 | Memorial Sloan-Kettering Cancer Center | Anti-wt1/hla bi-specific antibody |
| EA201391449A1 (ru) * | 2011-04-01 | 2014-03-31 | Мемориал Слоан-Кеттеринг Кэнсер Сентер | Антитела против пептидов цитозоля |
| US10946104B2 (en) | 2012-01-13 | 2021-03-16 | Apo-Tb.V. | Aberrant cell-restricted immunoglobulins provided with a toxic moiety |
| UA114108C2 (uk) | 2012-07-10 | 2017-04-25 | Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем | Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання |
| GB201223172D0 (en) | 2012-12-21 | 2013-02-06 | Immunocore Ltd | Method |
| CA2934033A1 (en) | 2013-11-07 | 2015-05-14 | Memorial Sloan-Kettering Cancer Center | Fc-enhanced anti-wt1/hla antibody |
| HK1249048A1 (zh) | 2015-04-03 | 2018-10-26 | Eureka Therapeutics, Inc. | 靶向afp肽/mhc复合体的构建体及其用途 |
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| US20180179283A1 (en) | 2015-06-08 | 2018-06-28 | Adicet Bio Inc. | T cell receptor like antibodies having fine specificity |
| CN111032076A (zh) | 2017-06-14 | 2020-04-17 | 阿迪塞特生物公司 | 能够以hla限制性方式结合hla-a2/tyrd的抗体及其用途 |
-
2015
- 2015-06-08 NL NL2014935A patent/NL2014935B1/en active
-
2016
- 2016-06-08 AU AU2016276555A patent/AU2016276555B2/en not_active Ceased
- 2016-06-08 AU AU2016276556A patent/AU2016276556C1/en not_active Ceased
- 2016-06-08 EP EP16739266.1A patent/EP3302538B1/en active Active
- 2016-06-08 JP JP2017563331A patent/JP6912392B2/ja active Active
- 2016-06-08 CN CN202210349590.3A patent/CN114605547B/zh active Active
- 2016-06-08 CA CA2988270A patent/CA2988270A1/en active Pending
- 2016-06-08 CN CN201680039192.4A patent/CN107847569A/zh active Pending
- 2016-06-08 WO PCT/IL2016/050600 patent/WO2016199141A2/en not_active Ceased
- 2016-06-08 KR KR1020187000504A patent/KR20180012851A/ko not_active Ceased
- 2016-06-08 CN CN201680040163.XA patent/CN108025045B/zh active Active
- 2016-06-08 SG SG10202007398PA patent/SG10202007398PA/en unknown
- 2016-06-08 CN CN202210030010.4A patent/CN114437217B/zh active Active
- 2016-06-08 WO PCT/IL2016/050599 patent/WO2016199140A1/en not_active Ceased
- 2016-06-08 MX MX2017015928A patent/MX2017015928A/es unknown
- 2016-06-08 JP JP2017563328A patent/JP7013243B2/ja active Active
- 2016-06-08 IL IL256178A patent/IL256178B2/en unknown
- 2016-06-08 US US15/579,616 patent/US11001642B2/en active Active
- 2016-06-08 EP EP22154188.1A patent/EP4039270A1/en active Pending
- 2016-06-08 CA CA2987889A patent/CA2987889A1/en active Pending
- 2016-06-08 ES ES16739266T patent/ES2922236T3/es active Active
- 2016-06-08 MX MX2017015801A patent/MX394431B/es unknown
- 2016-06-08 EP EP16734763.2A patent/EP3302537A1/en not_active Withdrawn
- 2016-06-08 KR KR1020177037826A patent/KR20180011275A/ko not_active Ceased
- 2016-06-08 CA CA3220475A patent/CA3220475A1/en active Pending
- 2016-06-08 EP EP24193198.9A patent/EP4488293A3/en active Pending
-
2017
- 2017-12-06 MX MX2022009493A patent/MX2022009493A/es unknown
- 2017-12-07 IL IL256177A patent/IL256177A/en unknown
-
2021
- 2021-05-11 US US17/317,824 patent/US12252547B2/en active Active
- 2021-07-08 JP JP2021113633A patent/JP7147018B2/ja active Active
-
2022
- 2022-09-21 JP JP2022150286A patent/JP7376655B2/ja active Active
- 2022-11-11 AU AU2022268398A patent/AU2022268398A1/en not_active Abandoned
-
2023
- 2023-07-30 IL IL304821A patent/IL304821A/en unknown
- 2023-10-26 JP JP2023183842A patent/JP2024016092A/ja not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018526970A5 (OSRAM) | ||
| MX2022011411A (es) | Proteinas de union a antigeno que se unen especificamente a mage-a. | |
| MY197854A (en) | Antibodies against signal-regulatory protein alpha and methods of use | |
| IL292094B2 (en) | Neoantigens and methods for using them | |
| EA202091710A1 (ru) | Антитела против cd73 и способы их применения | |
| EP4296673A3 (en) | Peptides and methods for the detection of lyme disease antibodies | |
| BR112013004266A8 (pt) | anticorpos anti-ox40 e métodos de uso dos mesmos. | |
| JP2017501728A5 (OSRAM) | ||
| JP2019516665A5 (OSRAM) | ||
| WO2011063003A3 (en) | Peptides and methods for the detection of lyme disease antibodies | |
| WO2018085469A3 (en) | Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3) | |
| EA201990321A1 (ru) | Биспецифические антителоподобные связывающие белки, которые специфически связываются с cd3 и cd123 | |
| JP2017508475A5 (OSRAM) | ||
| WO2016199140A8 (en) | T cell receptor like antibodies having fine specificity | |
| TN2018000325A1 (en) | ANTl-CD3 ANTIBODIES, ANTl-CD123 ANTIBODIES AND BISPECIFIC ANTIBODIES SPECIFICALL Y BINDING TO CD3 AND/OR CD123. | |
| JP2015535816A5 (OSRAM) | ||
| EA202191027A3 (ru) | Новые пептиды и комбинации пептидов для применения в иммунотерапии нескольких видов опухолей | |
| RU2016124179A (ru) | СКОНСТРУИРОВАННЫЕ ВЫСОКОАФФИННЫЕ T-клеточные рецепторы человека | |
| EP4171751A2 (en) | Mhc multimer expression constructs and uses thereof | |
| US20230282304A1 (en) | Off-target prediction method for antigen-recognition molecules binding to mhc-peptide targets | |
| RU2015120601A (ru) | Эритроферрон и erfe-полипептиды и способы регуляции метаболизма железа | |
| WO2021116470A3 (en) | Recombinant peptide-mhc complex binding proteins and their generation and use | |
| JP2017538412A5 (OSRAM) | ||
| EA201790341A1 (ru) | Анти-ск8 антитела для применения в лечении рака | |
| CA3150546A1 (en) | Method for the characterization of peptide:mhc binding polypeptides |