JP2019529572A - 細菌性膣炎の治療および予防方法 - Google Patents

細菌性膣炎の治療および予防方法 Download PDF

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JP2019529572A
JP2019529572A JP2019538583A JP2019538583A JP2019529572A JP 2019529572 A JP2019529572 A JP 2019529572A JP 2019538583 A JP2019538583 A JP 2019538583A JP 2019538583 A JP2019538583 A JP 2019538583A JP 2019529572 A JP2019529572 A JP 2019529572A
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JP2019529572A5 (enExample
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フレンド,デイビッド・アール
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エボフェム・インコーポレイテッド
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Publication of JP2019529572A5 publication Critical patent/JP2019529572A5/ja
Priority to JP2022124559A priority Critical patent/JP2022169581A/ja
Priority to JP2024094902A priority patent/JP2024138259A/ja
Priority to JP2024109033A priority patent/JP2024133639A/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2019538583A 2016-10-04 2017-10-03 細菌性膣炎の治療および予防方法 Pending JP2019529572A (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2022124559A JP2022169581A (ja) 2016-10-04 2022-08-04 細菌性膣炎の治療および予防方法
JP2024094902A JP2024138259A (ja) 2016-10-04 2024-06-12 細菌性膣炎の治療および予防方法
JP2024109033A JP2024133639A (ja) 2016-10-04 2024-07-05 細菌性膣炎の治療および予防方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662404061P 2016-10-04 2016-10-04
US62/404,061 2016-10-04
PCT/US2017/054943 WO2018067568A1 (en) 2016-10-04 2017-10-03 Method of treatment and prevention of bacterial vaginosis

Related Child Applications (2)

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JP2022124559A Division JP2022169581A (ja) 2016-10-04 2022-08-04 細菌性膣炎の治療および予防方法
JP2024094902A Division JP2024138259A (ja) 2016-10-04 2024-06-12 細菌性膣炎の治療および予防方法

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JP2019529572A true JP2019529572A (ja) 2019-10-17
JP2019529572A5 JP2019529572A5 (enExample) 2020-11-05

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JP2019538583A Pending JP2019529572A (ja) 2016-10-04 2017-10-03 細菌性膣炎の治療および予防方法
JP2022124559A Pending JP2022169581A (ja) 2016-10-04 2022-08-04 細菌性膣炎の治療および予防方法
JP2024094902A Pending JP2024138259A (ja) 2016-10-04 2024-06-12 細菌性膣炎の治療および予防方法
JP2024109033A Pending JP2024133639A (ja) 2016-10-04 2024-07-05 細菌性膣炎の治療および予防方法

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JP2022124559A Pending JP2022169581A (ja) 2016-10-04 2022-08-04 細菌性膣炎の治療および予防方法
JP2024094902A Pending JP2024138259A (ja) 2016-10-04 2024-06-12 細菌性膣炎の治療および予防方法
JP2024109033A Pending JP2024133639A (ja) 2016-10-04 2024-07-05 細菌性膣炎の治療および予防方法

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US (2) US11419835B2 (enExample)
EP (1) EP3522879A4 (enExample)
JP (4) JP2019529572A (enExample)
CN (1) CN110225750A (enExample)
AU (1) AU2017338748A1 (enExample)
WO (1) WO2018067568A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022007544A (ja) * 2020-06-26 2022-01-13 小林製薬株式会社 粘膜洗浄用組成物

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013187984A1 (en) 2012-06-13 2013-12-19 Evofem, Inc. Compositions and methods for enhancing the efficacy of contraceptive microbicides
US20230346724A1 (en) * 2018-10-09 2023-11-02 Crapaud Bio Inc. Methods of Making and Using pH Modulating Compositions in the Reproductive System

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11322621A (ja) * 1998-04-30 1999-11-24 Ved Vesely Renata Maria Anna Cavaliere 乳酸杆菌属の菌類を含有する膣感染症を治療するための薬学的組成物
WO2001066084A2 (en) * 2000-03-07 2001-09-13 Rush-Presbyterian-St. Luke's Medical Center Compositions and methods for trapping and inactivating pathogenic microbes and spermatozoa
JP2005521888A (ja) * 2002-03-30 2005-07-21 ゼノトープ・ダイアグノスティクス,インコーポレイテッド トリコモナスを検出するための方法および装置
JP2007077152A (ja) * 2005-09-12 2007-03-29 Mcneil Ppc Inc 膣のpHを低下させるための組成物および方法
WO2015070072A1 (en) * 2013-11-07 2015-05-14 Evofem, Inc. Methods for manufacturing contraceptive microbicides with antiviral properties
WO2015095793A1 (en) * 2013-12-19 2015-06-25 Evofem, Inc. Compositions and methods for inhibiting inflammation and diseases using an alginic acid-based antimicrobial compound
JP2015528490A (ja) * 2012-09-14 2015-09-28 シプラ・リミテッド テノホビル、抗菌剤、及び任意にシクロピロックスを含む局所医薬組成物
JP2016520076A (ja) * 2013-05-14 2016-07-11 プロバイオティカル・ソシエタ・ペル・アチオニProbiotical S.P.A. 細菌性腟症の予防的および/または治療的処置に使用するための乳酸菌含有組成物

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213323B (it) 1986-08-07 1989-12-20 Crinos Industria Farmaco Composizione per uso locale ad atti vita' spermicida virulicida ,disinfettante e/o battericida
US4999342A (en) 1988-08-16 1991-03-12 Ortho Pharmaceutical Corporation Long lasting contraceptive suppository composition and methods of use
JP3202365B2 (ja) 1992-12-04 2001-08-27 株式会社紀文フードケミファ オリゴマンヌロン酸を重合度によって分離する方法
US5592949A (en) 1994-06-29 1997-01-14 Moench; Thomas R. Device for acidic buffering and method for inactivation of pathogens
US5667492A (en) 1994-10-07 1997-09-16 Columbia Laboratories, Inc. Use and composition of an anti-sexually transmitted diseases formulation
FR2728464B1 (fr) 1994-12-22 1997-04-30 Innothera Lab Sa Forme galenique unitaire, son procede d'obtention et ses utilisations
US6093394A (en) 1997-04-11 2000-07-25 Gynelogix, Inc. Vaginal lactobacillus medicant
WO2001038284A1 (en) 1999-11-24 2001-05-31 Cargill Dow Llc Improved lactic acid processing; methods; arrangements; and, products
JP2009102407A (ja) 2001-03-08 2009-05-14 Rohto Pharmaceut Co Ltd Gリッチなアルギン酸含有組成物
US20020177624A1 (en) 2001-03-16 2002-11-28 Calvin Hanna Acetate-lactate buffering vaginal gel and for method of making same and treating bacterial vaginosis
ITMI20010913A1 (it) 2001-05-04 2002-11-04 Univ Pavia Composizioni a rilascio controllato di acido lattico a livello vaginale
EP1399151A4 (en) 2001-06-11 2004-08-04 Merck & Co Inc METHOD FOR TREATING INFLAMMABLE DISEASES BY ADMINISTRATING A PPAR DELTA AGONIST
US20130150810A1 (en) 2002-04-30 2013-06-13 The Population Council, Inc. Intravaginal ring for the delivery of unique combinations of antimicrobial compositions
WO2004011032A1 (ja) 2002-07-26 2004-02-05 Mikasa Seiyaku Co., Ltd. 外用剤
US7820145B2 (en) 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
DK1635847T3 (da) * 2003-06-13 2019-10-28 Idh Holding Aps Behandling af symptomer forbundet med bakteriel vaginose
US20050272700A1 (en) 2004-05-10 2005-12-08 Servet Buyuktimkin Topical treatment and prevention of human papilloma virus (HPV) infection
RU2257197C1 (ru) 2004-05-12 2005-07-27 Дулькис Мария Дмитриевна Вагинальные суппозитории, обладающие контрацептивным действием
UA93354C2 (ru) 2004-07-09 2011-02-10 Гилиад Сайенсиз, Инк. Местный противовирусный препарат
WO2008056786A1 (fr) 2006-11-10 2008-05-15 Rohto Pharmaceutical Co., Ltd. Composition pour application cutanée ou par voie muqueuse
US7659259B2 (en) 2006-12-21 2010-02-09 Bausch & Lomb Incorporated Method of treating inflammation of the eye
RU2459620C2 (ru) 2007-03-30 2012-08-27 Лаккуре Аб Применение олигомеров молочной кислоты в лечении гинекологических расстройств
EP2146698A2 (en) 2007-05-24 2010-01-27 New York Blood Center, Inc. Rapidly dispersible vaginal tablet that provides a bioadhesive gel
TW200927141A (en) 2007-11-22 2009-07-01 Bayer Schering Pharma Oy Vaginal delivery system
MX2010011244A (es) 2008-04-16 2010-11-09 Cipla Ltd Combinaciones topicas las cuales comprenden una agente antimicotico y un agente antiviral.
WO2009155118A1 (en) 2008-05-30 2009-12-23 Reprotect, Inc. Compositions and methods for inactivation of pathogens at genital tract surfaces
EP2130531A1 (en) 2008-06-04 2009-12-09 Rolf Kullgren AB Vaginal suppository comprising lactic acid
US20120070476A1 (en) * 2009-05-29 2012-03-22 Moench Thomas R Compositions and Methods for Inactivation of Pathogens at Genital Tract Surfaces
WO2010142761A1 (en) 2009-06-10 2010-12-16 Ultimorphix Technologies B.V. The succinate of tenofovir disoproxil
MX2013012745A (es) 2011-05-02 2014-12-05 Aptalis Pharmatech Inc Composiciones en forma de comprmido de disolución rápida para administración vaginal.
BR112013033759B1 (pt) 2011-06-28 2021-05-25 Chemo Research Sl forma de dosagem unitária de um gel de base aquosa de metronidazol mucoadesivo e uso relacionado ao gel de base aquosa de metronidazol
MX2014011218A (es) * 2012-03-19 2015-04-10 Wolff August Gmbh & Co Kg Arzneimittel Dr Uso de agentes tensoactivos anfotericos para la prevencion y tratamiento de biopeliculas vaginales patogenas en infecciones vaginales.
WO2013187984A1 (en) * 2012-06-13 2013-12-19 Evofem, Inc. Compositions and methods for enhancing the efficacy of contraceptive microbicides
WO2015027071A1 (en) 2013-08-21 2015-02-26 Georgia Regents Research Institute, Inc. Gpr81 agonists and methods thereof for promoting production of secretory iga
US9801839B2 (en) 2014-02-28 2017-10-31 Macfarlane Burnet Institute For Medical Research And Public Health Pty Ltd Therapeutic method
US20190209502A1 (en) 2016-09-12 2019-07-11 Evofem, Inc. Combination gel for sexually transmitted infections

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11322621A (ja) * 1998-04-30 1999-11-24 Ved Vesely Renata Maria Anna Cavaliere 乳酸杆菌属の菌類を含有する膣感染症を治療するための薬学的組成物
WO2001066084A2 (en) * 2000-03-07 2001-09-13 Rush-Presbyterian-St. Luke's Medical Center Compositions and methods for trapping and inactivating pathogenic microbes and spermatozoa
JP2005521888A (ja) * 2002-03-30 2005-07-21 ゼノトープ・ダイアグノスティクス,インコーポレイテッド トリコモナスを検出するための方法および装置
JP2007077152A (ja) * 2005-09-12 2007-03-29 Mcneil Ppc Inc 膣のpHを低下させるための組成物および方法
JP2015528490A (ja) * 2012-09-14 2015-09-28 シプラ・リミテッド テノホビル、抗菌剤、及び任意にシクロピロックスを含む局所医薬組成物
JP2016520076A (ja) * 2013-05-14 2016-07-11 プロバイオティカル・ソシエタ・ペル・アチオニProbiotical S.P.A. 細菌性腟症の予防的および/または治療的処置に使用するための乳酸菌含有組成物
WO2015070072A1 (en) * 2013-11-07 2015-05-14 Evofem, Inc. Methods for manufacturing contraceptive microbicides with antiviral properties
WO2015095793A1 (en) * 2013-12-19 2015-06-25 Evofem, Inc. Compositions and methods for inhibiting inflammation and diseases using an alginic acid-based antimicrobial compound

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022007544A (ja) * 2020-06-26 2022-01-13 小林製薬株式会社 粘膜洗浄用組成物
JP7706226B2 (ja) 2020-06-26 2025-07-11 小林製薬株式会社 粘膜洗浄用組成物

Also Published As

Publication number Publication date
JP2022169581A (ja) 2022-11-09
AU2017338748A1 (en) 2019-05-02
EP3522879A1 (en) 2019-08-14
US20190224150A1 (en) 2019-07-25
CN110225750A (zh) 2019-09-10
JP2024133639A (ja) 2024-10-02
EP3522879A4 (en) 2020-06-03
US20230081059A1 (en) 2023-03-16
WO2018067568A1 (en) 2018-04-12
JP2024138259A (ja) 2024-10-08
US11419835B2 (en) 2022-08-23

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