CN110225750A - 细菌性阴道病的治疗和预防方法 - Google Patents

细菌性阴道病的治疗和预防方法 Download PDF

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Publication number
CN110225750A
CN110225750A CN201780070201.0A CN201780070201A CN110225750A CN 110225750 A CN110225750 A CN 110225750A CN 201780070201 A CN201780070201 A CN 201780070201A CN 110225750 A CN110225750 A CN 110225750A
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CN
China
Prior art keywords
treatment
weeks
subject
vaginal
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780070201.0A
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English (en)
Chinese (zh)
Inventor
D·R·弗兰德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evofem Inc
Original Assignee
Evofem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evofem Inc filed Critical Evofem Inc
Publication of CN110225750A publication Critical patent/CN110225750A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201780070201.0A 2016-10-04 2017-10-03 细菌性阴道病的治疗和预防方法 Pending CN110225750A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662404061P 2016-10-04 2016-10-04
US62/404,061 2016-10-04
PCT/US2017/054943 WO2018067568A1 (en) 2016-10-04 2017-10-03 Method of treatment and prevention of bacterial vaginosis

Publications (1)

Publication Number Publication Date
CN110225750A true CN110225750A (zh) 2019-09-10

Family

ID=61831547

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780070201.0A Pending CN110225750A (zh) 2016-10-04 2017-10-03 细菌性阴道病的治疗和预防方法

Country Status (6)

Country Link
US (2) US11419835B2 (enExample)
EP (1) EP3522879A4 (enExample)
JP (4) JP2019529572A (enExample)
CN (1) CN110225750A (enExample)
AU (1) AU2017338748A1 (enExample)
WO (1) WO2018067568A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013187984A1 (en) 2012-06-13 2013-12-19 Evofem, Inc. Compositions and methods for enhancing the efficacy of contraceptive microbicides
US20230346724A1 (en) * 2018-10-09 2023-11-02 Crapaud Bio Inc. Methods of Making and Using pH Modulating Compositions in the Reproductive System
JP7706226B2 (ja) * 2020-06-26 2025-07-11 小林製薬株式会社 粘膜洗浄用組成物

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US20130005787A1 (en) * 2011-06-28 2013-01-03 Medicis Pharmaceutical Corporation High dosage mucoadhesive metronidazole aqueous-based gel formulations and their use to treat bacterial vaginosis
WO2014041378A2 (en) * 2012-09-14 2014-03-20 Cipla Limited Topical pharmaceutical composition
WO2015070072A1 (en) * 2013-11-07 2015-05-14 Evofem, Inc. Methods for manufacturing contraceptive microbicides with antiviral properties
WO2015095793A1 (en) * 2013-12-19 2015-06-25 Evofem, Inc. Compositions and methods for inhibiting inflammation and diseases using an alginic acid-based antimicrobial compound
US20160008276A1 (en) * 2012-06-13 2016-01-14 Evofem, Inc. Compositions and methods for enhancing the efficacy of contraceptive microbicides
US20160136193A1 (en) * 2003-06-13 2016-05-19 Idh Holding Aps Treatment of symptoms associated with bacterial vaginosis

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IT1213323B (it) 1986-08-07 1989-12-20 Crinos Industria Farmaco Composizione per uso locale ad atti vita' spermicida virulicida ,disinfettante e/o battericida
US4999342A (en) 1988-08-16 1991-03-12 Ortho Pharmaceutical Corporation Long lasting contraceptive suppository composition and methods of use
JP3202365B2 (ja) 1992-12-04 2001-08-27 株式会社紀文フードケミファ オリゴマンヌロン酸を重合度によって分離する方法
US5592949A (en) 1994-06-29 1997-01-14 Moench; Thomas R. Device for acidic buffering and method for inactivation of pathogens
US5667492A (en) 1994-10-07 1997-09-16 Columbia Laboratories, Inc. Use and composition of an anti-sexually transmitted diseases formulation
FR2728464B1 (fr) 1994-12-22 1997-04-30 Innothera Lab Sa Forme galenique unitaire, son procede d'obtention et ses utilisations
US6093394A (en) 1997-04-11 2000-07-25 Gynelogix, Inc. Vaginal lactobacillus medicant
DK0956858T3 (da) * 1998-04-30 2002-01-28 Vesely Renata Maria Cavaliere Farmaceutiske præparater indeholdende lactobacilli til behandling af vaginale infektioner
WO2001038284A1 (en) 1999-11-24 2001-05-31 Cargill Dow Llc Improved lactic acid processing; methods; arrangements; and, products
PL202918B1 (pl) 2000-03-07 2009-08-31 Rush Presbyterian St Luke Przeciwbakteryjna i antykoncepcyjna kompozycja oraz jej zastosowanie
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US20020177624A1 (en) 2001-03-16 2002-11-28 Calvin Hanna Acetate-lactate buffering vaginal gel and for method of making same and treating bacterial vaginosis
ITMI20010913A1 (it) 2001-05-04 2002-11-04 Univ Pavia Composizioni a rilascio controllato di acido lattico a livello vaginale
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* Cited by examiner, † Cited by third party
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US20060105008A1 (en) * 2002-03-28 2006-05-18 Nawaz Ahmad Compositions and methods for reducing vaginal pH
US20160136193A1 (en) * 2003-06-13 2016-05-19 Idh Holding Aps Treatment of symptoms associated with bacterial vaginosis
US20130005787A1 (en) * 2011-06-28 2013-01-03 Medicis Pharmaceutical Corporation High dosage mucoadhesive metronidazole aqueous-based gel formulations and their use to treat bacterial vaginosis
US20160008276A1 (en) * 2012-06-13 2016-01-14 Evofem, Inc. Compositions and methods for enhancing the efficacy of contraceptive microbicides
WO2014041378A2 (en) * 2012-09-14 2014-03-20 Cipla Limited Topical pharmaceutical composition
WO2015070072A1 (en) * 2013-11-07 2015-05-14 Evofem, Inc. Methods for manufacturing contraceptive microbicides with antiviral properties
WO2015095793A1 (en) * 2013-12-19 2015-06-25 Evofem, Inc. Compositions and methods for inhibiting inflammation and diseases using an alginic acid-based antimicrobial compound

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MARLA J. KELLER等: "Phase I Randomized Safety Study of Twice Daily Dosing of Acidform Vaginal Gel: Candidate Antimicrobial Contraceptive", 《PLOS ONE》 *

Also Published As

Publication number Publication date
JP2022169581A (ja) 2022-11-09
AU2017338748A1 (en) 2019-05-02
EP3522879A1 (en) 2019-08-14
US20190224150A1 (en) 2019-07-25
JP2024133639A (ja) 2024-10-02
JP2019529572A (ja) 2019-10-17
EP3522879A4 (en) 2020-06-03
US20230081059A1 (en) 2023-03-16
WO2018067568A1 (en) 2018-04-12
JP2024138259A (ja) 2024-10-08
US11419835B2 (en) 2022-08-23

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