JP2019528771A5 - - Google Patents
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- JP2019528771A5 JP2019528771A5 JP2019518229A JP2019518229A JP2019528771A5 JP 2019528771 A5 JP2019528771 A5 JP 2019528771A5 JP 2019518229 A JP2019518229 A JP 2019518229A JP 2019518229 A JP2019518229 A JP 2019518229A JP 2019528771 A5 JP2019528771 A5 JP 2019528771A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- hla
- hpc
- ipsc
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 25
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 7
- 238000012258 culturing Methods 0.000 claims 7
- 210000002865 immune cell Anatomy 0.000 claims 7
- 101000608935 Homo sapiens Leukosialin Proteins 0.000 claims 5
- 102100039564 Leukosialin Human genes 0.000 claims 5
- 210000000601 blood cell Anatomy 0.000 claims 5
- 210000000066 myeloid cell Anatomy 0.000 claims 5
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 4
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 4
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 4
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 4
- 230000004069 differentiation Effects 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 210000004698 lymphocyte Anatomy 0.000 claims 4
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 claims 3
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 3
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 102000001267 GSK3 Human genes 0.000 claims 2
- 108060006662 GSK3 Proteins 0.000 claims 2
- 108010002386 Interleukin-3 Proteins 0.000 claims 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 230000024245 cell differentiation Effects 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical compound CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 1
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 1
- -1 CD31 Proteins 0.000 claims 1
- AQGNHMOJWBZFQQ-UHFFFAOYSA-N CT 99021 Chemical group CC1=CNC(C=2C(=NC(NCCNC=3N=CC(=CC=3)C#N)=NC=2)C=2C(=CC(Cl)=CC=2)Cl)=N1 AQGNHMOJWBZFQQ-UHFFFAOYSA-N 0.000 claims 1
- 102100029761 Cadherin-5 Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 102100033553 Delta-like protein 4 Human genes 0.000 claims 1
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
- 102100020715 Fms-related tyrosine kinase 3 ligand protein Human genes 0.000 claims 1
- 101710162577 Fms-related tyrosine kinase 3 ligand protein Proteins 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims 1
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 claims 1
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 claims 1
- 108010075704 HLA-A Antigens Proteins 0.000 claims 1
- 108010058607 HLA-B Antigens Proteins 0.000 claims 1
- 108010052199 HLA-C Antigens Proteins 0.000 claims 1
- 108010010378 HLA-DP Antigens Proteins 0.000 claims 1
- 102000015789 HLA-DP Antigens Human genes 0.000 claims 1
- 108010062347 HLA-DQ Antigens Proteins 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 claims 1
- 101000794587 Homo sapiens Cadherin-5 Proteins 0.000 claims 1
- 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 claims 1
- 101001078143 Homo sapiens Integrin alpha-IIb Proteins 0.000 claims 1
- 101000914496 Homo sapiens T-cell antigen CD7 Proteins 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 102100025306 Integrin alpha-IIb Human genes 0.000 claims 1
- 102000000646 Interleukin-3 Human genes 0.000 claims 1
- 102100027208 T-cell antigen CD7 Human genes 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 210000003071 memory t lymphocyte Anatomy 0.000 claims 1
- 210000000581 natural killer T-cell Anatomy 0.000 claims 1
- 229960003966 nicotinamide Drugs 0.000 claims 1
- 235000005152 nicotinamide Nutrition 0.000 claims 1
- 239000011570 nicotinamide Substances 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 230000008672 reprogramming Effects 0.000 claims 1
- 108010056030 retronectin Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022034065A JP7560502B2 (ja) | 2016-10-05 | 2022-03-07 | 多能性幹細胞からｈｌａホモ接合免疫細胞への指向分化方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662404470P | 2016-10-05 | 2016-10-05 | |
| US62/404,470 | 2016-10-05 | ||
| US201762486895P | 2017-04-18 | 2017-04-18 | |
| US62/486,895 | 2017-04-18 | ||
| PCT/US2017/055369 WO2018067836A1 (en) | 2016-10-05 | 2017-10-05 | Methods for directed differentiation of pluripotent stem cells to hla homozygous immune cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022034065A Division JP7560502B2 (ja) | 2016-10-05 | 2022-03-07 | 多能性幹細胞からｈｌａホモ接合免疫細胞への指向分化方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528771A JP2019528771A (ja) | 2019-10-17 |
| JP2019528771A5 true JP2019528771A5 (enExample) | 2020-11-12 |
| JP7212615B2 JP7212615B2 (ja) | 2023-01-25 |
Family
ID=60302439
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019518229A Active JP7212615B2 (ja) | 2016-10-05 | 2017-10-05 | 多能性幹細胞からｈｌａホモ接合免疫細胞への指向分化方法 |
| JP2022034065A Active JP7560502B2 (ja) | 2016-10-05 | 2022-03-07 | 多能性幹細胞からｈｌａホモ接合免疫細胞への指向分化方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022034065A Active JP7560502B2 (ja) | 2016-10-05 | 2022-03-07 | 多能性幹細胞からｈｌａホモ接合免疫細胞への指向分化方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20200263139A1 (enExample) |
| EP (1) | EP3523423B1 (enExample) |
| JP (2) | JP7212615B2 (enExample) |
| KR (1) | KR102598351B1 (enExample) |
| CN (1) | CN110023491B (enExample) |
| AU (1) | AU2017340644B2 (enExample) |
| BR (1) | BR112019006910A2 (enExample) |
| CA (1) | CA3038701A1 (enExample) |
| DK (1) | DK3523423T3 (enExample) |
| ES (1) | ES2989469T3 (enExample) |
| IL (1) | IL265810B2 (enExample) |
| MX (1) | MX2019003689A (enExample) |
| WO (1) | WO2018067836A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114558032B (zh) | 2012-12-21 | 2025-07-29 | 安斯泰来再生医药协会 | 由多能干细胞制备血小板的方法及其组合物 |
| ES2862676T3 (es) | 2015-10-20 | 2021-10-07 | Fujifilm Cellular Dynamics Inc | Producción de células precursoras hematopoyéticas multilinaje mediante programación genética |
| KR102598351B1 (ko) * | 2016-10-05 | 2023-11-08 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 만능 줄기 세포를 hla 동형 접합 면역 세포로 직접 분화시키기 위한 방법 |
| AU2018254442B2 (en) | 2017-04-18 | 2024-03-28 | FUJIFILM Cellular Dynamics, Inc. | Antigen-specific immune effector cells |
| US12037607B2 (en) | 2017-11-08 | 2024-07-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of preparing hematopoietic progenitor cells in vitro |
| AU2020225597A1 (en) * | 2019-02-24 | 2021-10-07 | Gamida-Cell Ltd. | Method of homing and retention of gammadelta T cells for generating cell compositions for use in therapy |
| CN110106144B (zh) * | 2019-05-17 | 2021-10-08 | 苏州大学 | 一种诱导造血干细胞向前t系细胞分化的方法和试剂盒 |
| CN110564691A (zh) * | 2019-07-19 | 2019-12-13 | 青岛华赛伯曼医学细胞生物有限公司 | Hla纯合子来源的通用型car-t细胞的制备方法 |
| IL299625A (en) * | 2020-07-02 | 2023-03-01 | Accellta Ltd | Mammalian pluripotent stem cells from late embryos |
| CN111808812B (zh) * | 2020-08-31 | 2020-12-15 | 首都医科大学附属北京友谊医院 | 一种用于多能干细胞向造血干细胞分化的材料和方法 |
| CA3214045A1 (en) | 2021-04-07 | 2022-10-13 | Century Therapeutics, Inc. | Compositions and methods for generating gamma-delta t cells from induced pluripotent stem cells |
| US20220333074A1 (en) | 2021-04-07 | 2022-10-20 | Century Therapeutics, Inc. | Compositions and Methods for Generating Alpha-Beta T Cells from Induced Pluripotent Stem Cells |
| CN117957313A (zh) * | 2021-07-19 | 2024-04-30 | 修复免疫股份有限公司 | 从多能干细胞生产免疫细胞群的方法 |
| CN114324126B (zh) * | 2022-01-07 | 2024-03-19 | 南京鼓楼医院 | 一种改变早期b细胞分化的方法 |
| CN115896016B (zh) * | 2022-09-07 | 2023-09-12 | 普华赛尔生物医疗科技有限公司 | 培养组合物及其在培养免疫细胞中的应用 |
| US20250368954A1 (en) * | 2022-10-05 | 2025-12-04 | Stratus Therapeutics, Inc. | Myeloid lineages derived from pluripotent cells |
| IL320085A (en) * | 2022-10-05 | 2025-06-01 | Garuda Therapeutics Inc | B cell lineages derived from pluripotent cells |
| KR20240069648A (ko) * | 2022-11-10 | 2024-05-20 | 의료법인 성광의료재단 | 전분화능 줄기세포에서 자연살해세포로의 분화 유도용 배지 조성물 및 이를 이용한 분화 방법 |
| AU2022489605A1 (en) * | 2022-12-02 | 2025-07-17 | Nuwacell Biotechnologies Co., Ltd. | Culture medium, coating matrix and method for expanding midbrain dopaminergic progenitor cells |
| EP4698636A2 (en) * | 2023-04-21 | 2026-02-25 | New York Blood Center, Inc. | Patrolling monocyte cellular therapy |
| CN117050941B (zh) * | 2023-10-11 | 2024-01-26 | 苏州艾凯利元生物科技有限公司 | 一种制备自然杀伤细胞的方法 |
| KR102921286B1 (ko) * | 2024-02-23 | 2026-02-04 | ㈜바이오솔빅스 | Op9 세포의 분비단백질을 이용한 cd34 양성 조혈모세포의 제조방법 |
| WO2025237762A1 (en) * | 2024-05-14 | 2025-11-20 | Englmeier Ludwig | Matched t-cells and myeloid cells from cell culture |
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| JP6641299B2 (ja) * | 2014-06-04 | 2020-02-05 | フレッド ハッチンソン キャンサー リサーチ センター | Ｎｏｔｃｈ １および／またはＮｏｔｃｈ ２アゴニストを用いた幹細胞の増殖および生着 |
| KR102598351B1 (ko) | 2016-10-05 | 2023-11-08 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 만능 줄기 세포를 hla 동형 접합 면역 세포로 직접 분화시키기 위한 방법 |
| AU2018254442B2 (en) * | 2017-04-18 | 2024-03-28 | FUJIFILM Cellular Dynamics, Inc. | Antigen-specific immune effector cells |
-
2017
- 2017-10-05 KR KR1020197013026A patent/KR102598351B1/ko active Active
- 2017-10-05 US US16/339,676 patent/US20200263139A1/en active Pending
- 2017-10-05 MX MX2019003689A patent/MX2019003689A/es unknown
- 2017-10-05 BR BR112019006910-0A patent/BR112019006910A2/pt active Search and Examination
- 2017-10-05 CN CN201780071847.0A patent/CN110023491B/zh active Active
- 2017-10-05 AU AU2017340644A patent/AU2017340644B2/en active Active
- 2017-10-05 JP JP2019518229A patent/JP7212615B2/ja active Active
- 2017-10-05 EP EP17797460.7A patent/EP3523423B1/en active Active
- 2017-10-05 DK DK17797460.7T patent/DK3523423T3/da active
- 2017-10-05 ES ES17797460T patent/ES2989469T3/es active Active
- 2017-10-05 IL IL265810A patent/IL265810B2/en unknown
- 2017-10-05 CA CA3038701A patent/CA3038701A1/en active Pending
- 2017-10-05 WO PCT/US2017/055369 patent/WO2018067836A1/en not_active Ceased
-
2022
- 2022-03-07 JP JP2022034065A patent/JP7560502B2/ja active Active
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