JP2019528769A5 - - Google Patents
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- JP2019528769A5 JP2019528769A5 JP2019518049A JP2019518049A JP2019528769A5 JP 2019528769 A5 JP2019528769 A5 JP 2019528769A5 JP 2019518049 A JP2019518049 A JP 2019518049A JP 2019518049 A JP2019518049 A JP 2019518049A JP 2019528769 A5 JP2019528769 A5 JP 2019528769A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecule
- human
- cell
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020004707 nucleic acids Proteins 0.000 claims 19
- 150000007523 nucleic acids Chemical class 0.000 claims 19
- 102000039446 nucleic acids Human genes 0.000 claims 19
- 210000001744 T-lymphocyte Anatomy 0.000 claims 13
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 9
- 239000013603 viral vector Substances 0.000 claims 8
- 101710163270 Nuclease Proteins 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 108020004511 Recombinant DNA Proteins 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 238000003776 cleavage reaction Methods 0.000 claims 4
- 230000007017 scission Effects 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 3
- 239000013607 AAV vector Substances 0.000 claims 2
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 108091033409 CRISPR Proteins 0.000 claims 1
- 238000010354 CRISPR gene editing Methods 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 201000000053 blastoma Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000000139 costimulatory effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 201000008184 embryoma Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000006801 homologous recombination Effects 0.000 claims 1
- 238000002744 homologous recombination Methods 0.000 claims 1
- 230000001024 immunotherapeutic effect Effects 0.000 claims 1
- 230000004068 intracellular signaling Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 108091006106 transcriptional activators Proteins 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021083808A JP7106715B2 (ja) | 2016-10-04 | 2021-05-18 | 遺伝子改変細胞で使用するための共刺激ドメイン |
| JP2022112159A JP2022160443A (ja) | 2016-10-04 | 2022-07-13 | 遺伝子改変細胞で使用するための共刺激ドメイン |
| JP2024013162A JP2024059633A (ja) | 2016-10-04 | 2024-01-31 | 遺伝子改変細胞で使用するための共刺激ドメイン |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662403880P | 2016-10-04 | 2016-10-04 | |
| US62/403,880 | 2016-10-04 | ||
| US201762501475P | 2017-05-04 | 2017-05-04 | |
| US62/501,475 | 2017-05-04 | ||
| US201762556199P | 2017-09-08 | 2017-09-08 | |
| US62/556,199 | 2017-09-08 | ||
| PCT/US2017/055133 WO2018067697A1 (en) | 2016-10-04 | 2017-10-04 | Co-stimulatory domains for use in genetically-modified cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021083808A Division JP7106715B2 (ja) | 2016-10-04 | 2021-05-18 | 遺伝子改変細胞で使用するための共刺激ドメイン |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2019528769A JP2019528769A (ja) | 2019-10-17 |
| JP2019528769A5 true JP2019528769A5 (OSRAM) | 2020-11-12 |
| JP6887492B2 JP6887492B2 (ja) | 2021-06-16 |
| JP6887492B6 JP6887492B6 (ja) | 2021-07-14 |
Family
ID=60382586
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019518049A Active JP6887492B6 (ja) | 2016-10-04 | 2017-10-04 | 遺伝子改変細胞で使用するための共刺激ドメイン |
| JP2021083808A Active JP7106715B2 (ja) | 2016-10-04 | 2021-05-18 | 遺伝子改変細胞で使用するための共刺激ドメイン |
| JP2022112159A Pending JP2022160443A (ja) | 2016-10-04 | 2022-07-13 | 遺伝子改変細胞で使用するための共刺激ドメイン |
| JP2024013162A Pending JP2024059633A (ja) | 2016-10-04 | 2024-01-31 | 遺伝子改変細胞で使用するための共刺激ドメイン |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021083808A Active JP7106715B2 (ja) | 2016-10-04 | 2021-05-18 | 遺伝子改変細胞で使用するための共刺激ドメイン |
| JP2022112159A Pending JP2022160443A (ja) | 2016-10-04 | 2022-07-13 | 遺伝子改変細胞で使用するための共刺激ドメイン |
| JP2024013162A Pending JP2024059633A (ja) | 2016-10-04 | 2024-01-31 | 遺伝子改変細胞で使用するための共刺激ドメイン |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US11286291B2 (OSRAM) |
| EP (3) | EP3757120B8 (OSRAM) |
| JP (4) | JP6887492B6 (OSRAM) |
| AU (4) | AU2017338846B2 (OSRAM) |
| CA (1) | CA3039014A1 (OSRAM) |
| DK (2) | DK3757120T3 (OSRAM) |
| ES (2) | ES2811500T3 (OSRAM) |
| WO (1) | WO2018067697A1 (OSRAM) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102463529B1 (ko) | 2014-04-10 | 2022-11-07 | 시애틀 칠드런즈 호스피탈 디/비/에이 시애틀 칠드런즈 리서치 인스티튜트 | 약물 관련 트랜스진 발현 |
| JP7162530B2 (ja) | 2015-08-07 | 2022-10-28 | シアトル チルドレンズ ホスピタル （ディービーエイ シアトル チルドレンズ リサーチ インスティテュート） | 固形腫瘍を標的とする二重特異性ｃａｒ ｔ細胞 |
| EP3757120B8 (en) * | 2016-10-04 | 2022-06-15 | Precision Biosciences, Inc. | Co-stimulatory domains for use in genetically-modified cells |
| CN110545826A (zh) | 2016-12-03 | 2019-12-06 | 朱诺治疗学股份有限公司 | 用于与激酶抑制剂组合使用治疗性t细胞的方法和组合物 |
| EP3615662A1 (en) * | 2017-04-28 | 2020-03-04 | Precision Biosciences, Inc. | Methods for reducing dna-induced cytotoxicity and enhancing gene editing in primary cells |
| WO2018223101A1 (en) | 2017-06-02 | 2018-12-06 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| US11434290B2 (en) * | 2017-06-08 | 2022-09-06 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Chimeric antigen receptors with enhanced NFκB signaling |
| US10869888B2 (en) | 2018-04-17 | 2020-12-22 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| US12240915B2 (en) | 2018-08-30 | 2025-03-04 | Innovative Cellular Therapeutics Holdings, Ltd. | Chimeric antigen receptor cells for treating solid tumor |
| US10918667B2 (en) | 2018-11-20 | 2021-02-16 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expressing therapeutic agent and uses thereof |
| IL316764A (en) | 2019-04-03 | 2025-01-01 | Prec Biosciences Inc | Genetically modified immune cells containing shRNA-targeted microRNA (shRNAmir) |
| CA3136265A1 (en) | 2019-04-05 | 2020-10-08 | Precision Biosciences, Inc. | Methods of preparing populations of genetically-modified immune cells |
| EP4004216A1 (en) | 2019-07-25 | 2022-06-01 | Precision BioSciences, Inc. | Compositions and methods for sequential stacking of nucleic acid sequences into a genomic locus |
| WO2021035054A1 (en) | 2019-08-20 | 2021-02-25 | Precision Biosciences, Inc. | Lymphodepletion dosing regimens for cellular immunotherapies |
| WO2021087305A1 (en) | 2019-10-30 | 2021-05-06 | Precision Biosciences, Inc. | Cd20 chimeric antigen receptors and methods of use for immunotherapy |
| WO2021113543A1 (en) | 2019-12-06 | 2021-06-10 | Precision Biosciences, Inc. | Methods for cancer immunotherapy, using lymphodepletion regimens and cd19, cd20 or bcma allogeneic car t cells |
| WO2021160120A1 (zh) * | 2020-02-13 | 2021-08-19 | 北京艺妙神州医药科技有限公司 | 嵌合抗原受体的优化 |
| US12076343B2 (en) | 2020-02-19 | 2024-09-03 | Innovative Cellular Therapeutics Holdings, Ltd. | Engineered safety in cell therapy |
| WO2021231959A1 (en) * | 2020-05-15 | 2021-11-18 | Precision Biosciences, Inc. | Methods for immunotherapy |
| US20230190780A1 (en) * | 2020-05-15 | 2023-06-22 | Precision Biosciences, Inc. | Methods for immunotherapy |
| US12043654B2 (en) | 2020-06-02 | 2024-07-23 | Innovative Cellular Therapeutics Holdings, Ltd. | Anti-GCC antibody and CAR thereof for treating digestive system cancer |
| IL299414A (en) * | 2020-06-30 | 2023-02-01 | Univ Court Univ Of Edinburgh | Transgene expression system |
| EP4192875A1 (en) | 2020-08-10 | 2023-06-14 | Precision BioSciences, Inc. | Antibodies and fragments specific for b-cell maturation antigen and uses thereof |
| US20230365995A1 (en) | 2020-10-07 | 2023-11-16 | Precision Biosciences, Inc. | Lipid nanoparticle compositions |
| EP4284823A1 (en) | 2021-01-28 | 2023-12-06 | Precision BioSciences, Inc. | Modulation of tgf beta signaling in genetically-modified eukaryotic cells |
| TW202306997A (zh) * | 2021-06-16 | 2023-02-16 | 英商英斯特生物科技有限公司 | 用於在過繼細胞療法中提供標靶共刺激之受體 |
| WO2023064872A1 (en) | 2021-10-14 | 2023-04-20 | Precision Biosciences, Inc. | Combinations of anti-bcma car t cells and gamma secretase inhibitors |
| WO2023081767A1 (en) | 2021-11-05 | 2023-05-11 | Precision Biosciences, Inc. | Methods for immunotherapy |
| US20250009800A1 (en) | 2021-11-16 | 2025-01-09 | Precision Biosciences, Inc. | Methods for cancer immunotherapy |
| US20250041417A1 (en) | 2021-12-10 | 2025-02-06 | Precision Biosciences, Inc. | Methods for cancer immunotherapy |
| IL313935A (en) | 2021-12-30 | 2024-08-01 | Tr1X Inc | CD4+ T cells expressing IL-10 chimeric antigen receptors and uses thereof |
| EP4646223A1 (en) | 2023-01-05 | 2025-11-12 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for the human t cell receptor alpha constant region gene |
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| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
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| EP3757120B8 (en) * | 2016-10-04 | 2022-06-15 | Precision Biosciences, Inc. | Co-stimulatory domains for use in genetically-modified cells |
| IL316764A (en) * | 2019-04-03 | 2025-01-01 | Prec Biosciences Inc | Genetically modified immune cells containing shRNA-targeted microRNA (shRNAmir) |
| WO2021087305A1 (en) * | 2019-10-30 | 2021-05-06 | Precision Biosciences, Inc. | Cd20 chimeric antigen receptors and methods of use for immunotherapy |
| WO2021113543A1 (en) * | 2019-12-06 | 2021-06-10 | Precision Biosciences, Inc. | Methods for cancer immunotherapy, using lymphodepletion regimens and cd19, cd20 or bcma allogeneic car t cells |
-
2017
- 2017-10-04 EP EP20176441.2A patent/EP3757120B8/en active Active
- 2017-10-04 WO PCT/US2017/055133 patent/WO2018067697A1/en not_active Ceased
- 2017-10-04 DK DK20176441.2T patent/DK3757120T3/da active
- 2017-10-04 US US16/339,699 patent/US11286291B2/en active Active
- 2017-10-04 ES ES17800638T patent/ES2811500T3/es active Active
- 2017-10-04 EP EP22172338.0A patent/EP4115951A1/en active Pending
- 2017-10-04 JP JP2019518049A patent/JP6887492B6/ja active Active
- 2017-10-04 ES ES20176441T patent/ES2925644T3/es active Active
- 2017-10-04 AU AU2017338846A patent/AU2017338846B2/en active Active
- 2017-10-04 CA CA3039014A patent/CA3039014A1/en active Pending
- 2017-10-04 DK DK17800638.3T patent/DK3523326T3/da active
- 2017-10-04 EP EP17800638.3A patent/EP3523326B1/en active Active
-
2019
- 2019-10-11 US US16/600,074 patent/US10800833B2/en active Active
-
2020
- 2020-09-09 US US17/016,016 patent/US20200399346A1/en not_active Abandoned
- 2020-12-11 AU AU2020286323A patent/AU2020286323B2/en active Active
-
2021
- 2021-05-18 JP JP2021083808A patent/JP7106715B2/ja active Active
-
2022
- 2022-07-13 JP JP2022112159A patent/JP2022160443A/ja active Pending
-
2023
- 2023-05-10 AU AU2023202905A patent/AU2023202905A1/en not_active Abandoned
- 2023-08-21 US US18/453,022 patent/US20240018215A1/en active Pending
-
2024
- 2024-01-31 JP JP2024013162A patent/JP2024059633A/ja active Pending
-
2025
- 2025-02-03 AU AU2025200717A patent/AU2025200717A1/en active Pending
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