JP2019528267A5 - - Google Patents

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Publication number
JP2019528267A5
JP2019528267A5 JP2019508255A JP2019508255A JP2019528267A5 JP 2019528267 A5 JP2019528267 A5 JP 2019528267A5 JP 2019508255 A JP2019508255 A JP 2019508255A JP 2019508255 A JP2019508255 A JP 2019508255A JP 2019528267 A5 JP2019528267 A5 JP 2019528267A5
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JP
Japan
Prior art keywords
pharmaceutical composition
reducing
pneumonia
disease
onset
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019508255A
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English (en)
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JP2019528267A (ja
JP7013446B2 (ja
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Priority claimed from PCT/US2017/047185 external-priority patent/WO2018035246A1/en
Publication of JP2019528267A publication Critical patent/JP2019528267A/ja
Publication of JP2019528267A5 publication Critical patent/JP2019528267A5/ja
Application granted granted Critical
Publication of JP7013446B2 publication Critical patent/JP7013446B2/ja
Active legal-status Critical Current
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Claims (4)

  1. 気道狭窄を低減するための、請求項２９に記載の医薬組成物。
  2. 肺炎症を低減するための、請求項２９に記載の医薬組成物。
  3. 肺炎症に関連するリスク因子を有する対象における疾患の発症を低減するための、請求項２９に記載の医薬組成物。
  4. 肺疾患を治療するための、請求項２９に記載の医薬組成物。
JP2019508255A 2016-08-16 2017-08-16 Ｇａｂａ（ａ）受容体モジュレーター、及び、喘息における気道過敏及び炎症を抑制するための方法 Active JP7013446B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662375694P 2016-08-16 2016-08-16
US62/375,694 2016-08-16
US201662427771P 2016-11-29 2016-11-29
US62/427,771 2016-11-29
PCT/US2017/047185 WO2018035246A1 (en) 2016-08-16 2017-08-16 Gaba(a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma

Publications (3)

Publication Number Publication Date
JP2019528267A JP2019528267A (ja) 2019-10-10
JP2019528267A5 true JP2019528267A5 (ja) 2020-09-24
JP7013446B2 JP7013446B2 (ja) 2022-02-15

Family

ID=59714151

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019508255A Active JP7013446B2 (ja) 2016-08-16 2017-08-16 Ｇａｂａ（ａ）受容体モジュレーター、及び、喘息における気道過敏及び炎症を抑制するための方法

Country Status (9)

Country Link
US (2) US11447495B2 (ja)
EP (1) EP3500573B1 (ja)
JP (1) JP7013446B2 (ja)
CN (1) CN109790170B (ja)
AU (1) AU2017313753B2 (ja)
BR (1) BR112019003065A2 (ja)
CA (1) CA3033964A1 (ja)
ES (1) ES2895965T3 (ja)
WO (1) WO2018035246A1 (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20230440A1 (es) 2020-03-31 2023-03-08 Hoffmann La Roche Derivados de benzodiazepinas como pam de gaba a gamma1
EP3901155A1 (en) * 2020-04-20 2021-10-27 F. Hoffmann-La Roche AG New benzodiazepine derivatives as gaba a gamma1 pam

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ZA755418B (en) 1974-09-11 1977-06-29 Hoffmann La Roche Diazepine derivatives
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ZA845757B (en) 1983-08-25 1985-04-24 Hoffmann La Roche Benzodiazepine derivatives
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TW349100B (en) 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
CA2184802C (en) 1995-10-10 2007-07-31 Karl-Heinz Bender Process for manufacture of imidazo benzodiazepine derivatives
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US20010014738A1 (en) 1999-06-30 2001-08-16 Madhup K. Dhaon Process for the preparation of imidazodiazepine intermediates
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MXPA04009332A (es) 2002-03-28 2005-12-12 Wisys Technology Found Inc Agentes ansioliticos con efectos sedantes y ataxicos.
US20060009487A1 (en) 2004-06-09 2006-01-12 Sircar Jagadish C Heterocyclic derivatives for treatment of hyperlipidemia and related diseases
AU2005260650A1 (en) 2004-06-30 2006-01-12 Wisys Technology Foundation, Inc. Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects
EP1888594A2 (en) 2005-05-16 2008-02-20 Wisys Technology Foundation, Inc. Gabaergic agents to treat memory deficits
US8119629B2 (en) 2007-10-03 2012-02-21 Bristol-Meyers Squibb Company Carboxamide GABAA α2 modulators
US20100261711A1 (en) 2009-03-20 2010-10-14 Wisys Technology Foundation Selective anticonvulsant agents and their uses
IT1399764B1 (it) 2010-05-04 2013-05-03 F S I Fabbrica Italiana Sint Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam.
US9006233B2 (en) 2011-04-28 2015-04-14 Uwm Research Foundation, Inc. Gabaergic receptor subtype selective ligands and their uses
EP2726465A1 (en) * 2011-05-23 2014-05-07 Elan Pharmaceuticals Inc. Inhibitors of lrrk2 kinase activity
EP2592077A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
CN103204838B (zh) * 2012-01-13 2017-06-09 北京盛诺基医药科技有限公司 多羟基苯并吡喃酮类化合物的合成及其抗肿瘤作用
CN103319486B (zh) 2012-03-22 2017-10-10 徐州市心血管病研究所 合成4H‑咪唑并[1,5‑a][1,4]苯二氮卓,特别是咪达唑仑的方法
JP2015529254A (ja) * 2012-09-21 2015-10-05 ユーダブリューエム・リサーチ・ファウンデーション，インコーポレーテッド 喘息における気道の過敏症及び炎症を制御するための新規なｇａｂａａアゴニスト及び使用方法
PT3439665T (pt) 2016-03-18 2022-09-27 Uwm Res Foundation Inc Tratamento de sintomas cognitivos e de humor em distúrbios neurodegenerativos e neuropsiquiátricos com gaba contendo agonistas de recetores de gabaa contendo alfa5

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