PT3439665T - Tratamento de sintomas cognitivos e de humor em distúrbios neurodegenerativos e neuropsiquiátricos com gaba contendo agonistas de recetores de gabaa contendo alfa5 - Google Patents
Tratamento de sintomas cognitivos e de humor em distúrbios neurodegenerativos e neuropsiquiátricos com gaba contendo agonistas de recetores de gabaa contendo alfa5Info
- Publication number
- PT3439665T PT3439665T PT177677010T PT17767701T PT3439665T PT 3439665 T PT3439665 T PT 3439665T PT 177677010 T PT177677010 T PT 177677010T PT 17767701 T PT17767701 T PT 17767701T PT 3439665 T PT3439665 T PT 3439665T
- Authority
- PT
- Portugal
- Prior art keywords
- alpha5
- neurodegenerative
- cognitive
- treatment
- receptor agonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662310409P | 2016-03-18 | 2016-03-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3439665T true PT3439665T (pt) | 2022-09-27 |
Family
ID=59851645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT177677010T PT3439665T (pt) | 2016-03-18 | 2017-03-20 | Tratamento de sintomas cognitivos e de humor em distúrbios neurodegenerativos e neuropsiquiátricos com gaba contendo agonistas de recetores de gabaa contendo alfa5 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10906909B2 (pt) |
| EP (2) | EP4129297A1 (pt) |
| JP (2) | JP7023876B2 (pt) |
| AU (2) | AU2017235665B2 (pt) |
| CA (1) | CA3016491A1 (pt) |
| DK (1) | DK3439665T3 (pt) |
| ES (1) | ES2926918T3 (pt) |
| HR (1) | HRP20221098T1 (pt) |
| HU (1) | HUE059774T2 (pt) |
| LT (1) | LT3439665T (pt) |
| PL (1) | PL3439665T3 (pt) |
| PT (1) | PT3439665T (pt) |
| RS (1) | RS63674B1 (pt) |
| SI (1) | SI3439665T1 (pt) |
| WO (1) | WO2017161370A1 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017313753B2 (en) | 2016-08-16 | 2022-01-27 | The Trustees Of Columbia University In The City Of New York | GABA(A) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma |
| CA3129749A1 (en) * | 2019-02-13 | 2020-08-20 | Centre For Addiction And Mental Health | Compositions and methods relating to use of agonists of alpha5-containing gabaa receptors |
| CN113840610A (zh) * | 2019-03-18 | 2021-12-24 | 纽罗塞克医疗公司 | Gabaａ受体调节剂用于治疗疼痛的用途 |
| TW202202495A (zh) | 2020-03-26 | 2022-01-16 | 匈牙利商羅特格登公司 | 作為ｇａｍｍａ－胺基丁酸Ａ受體次單元ａｌｐｈａ ５受體調節劑之㖠啶及吡啶并〔３，４－ｃ〕嗒𠯤衍生物 |
| WO2023039018A1 (en) * | 2021-09-08 | 2023-03-16 | Uwm Research Foundation, Inc. | Imidazobenzodiazepines for treatment of cognitive and mood symptoms |
| HUP2100338A1 (hu) | 2021-09-29 | 2023-04-28 | Richter Gedeon Nyrt | GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok |
| CA3233966A1 (en) * | 2021-10-07 | 2023-04-13 | Douglas C. Stafford | Methods and compounds for treating inflammation |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA755418B (en) * | 1974-09-11 | 1977-06-29 | Hoffmann La Roche | Diazepine derivatives |
| US4226768A (en) | 1979-05-29 | 1980-10-07 | Hoffmann-La Roche Inc. | Process for the preparation of imidazobenzodiazepines |
| US20030176456A1 (en) | 2001-12-21 | 2003-09-18 | June Harry L. | Methods for reducing alcohol cravings in chronic alcoholics |
| AU2003230754B2 (en) | 2002-03-28 | 2007-10-25 | Wisys Technology Foundation, Inc. | Anxiolytic agents with reduced sedative and ataxic effects |
| USRE47475E1 (en) | 2002-03-28 | 2019-07-02 | Wisys Technology Foundation, Inc. | Selective agents for pain suppression |
| US8835424B2 (en) | 2002-03-28 | 2014-09-16 | Wisconsin Alumni Research Foundation | Selective agents for pain suppression |
| US7618958B2 (en) | 2004-06-30 | 2009-11-17 | Wisys Technology Foundation, Inc. | Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects |
| AU2006276998A1 (en) * | 2005-05-16 | 2007-02-15 | Wisys Technology Foundation, Inc. | Gabaergic agents to treat memory deficits |
| US20100130479A1 (en) | 2005-05-16 | 2010-05-27 | Cook James M | Gabaergic Agents to Treat Memory Deficits |
| US7858649B2 (en) | 2005-10-14 | 2010-12-28 | Neurosearch A/S | Imidazole derivatives and their use for modulating the GABAA receptor complex |
| DE102006023554A1 (de) | 2006-05-19 | 2007-11-22 | Zf Friedrichshafen Ag | Ermittlung der Drehzahl einer Getriebewelle |
| US8119629B2 (en) * | 2007-10-03 | 2012-02-21 | Bristol-Meyers Squibb Company | Carboxamide GABAA α2 modulators |
| EP2364571B1 (en) | 2008-10-02 | 2012-08-22 | Telefonaktiebolaget L M Ericsson (PUBL) | Wireless communication system and method for assigning a channel in said wireless communication system |
| US20100261711A1 (en) | 2009-03-20 | 2010-10-14 | Wisys Technology Foundation | Selective anticonvulsant agents and their uses |
| US9006233B2 (en) | 2011-04-28 | 2015-04-14 | Uwm Research Foundation, Inc. | Gabaergic receptor subtype selective ligands and their uses |
| WO2014047413A1 (en) | 2012-09-21 | 2014-03-27 | Uwm Research Foundation, Inc. | Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma |
| US10259815B2 (en) | 2015-03-20 | 2019-04-16 | Uwm Research Foundation, Inc. | Gabaergic ligands and their uses |
-
2017
- 2017-03-20 PT PT177677010T patent/PT3439665T/pt unknown
- 2017-03-20 SI SI201731230T patent/SI3439665T1/sl unknown
- 2017-03-20 LT LTEPPCT/US2017/023206T patent/LT3439665T/lt unknown
- 2017-03-20 JP JP2018568186A patent/JP7023876B2/ja active Active
- 2017-03-20 EP EP22181243.1A patent/EP4129297A1/en active Pending
- 2017-03-20 WO PCT/US2017/023206 patent/WO2017161370A1/en active Application Filing
- 2017-03-20 CA CA3016491A patent/CA3016491A1/en active Pending
- 2017-03-20 EP EP17767701.0A patent/EP3439665B1/en active Active
- 2017-03-20 DK DK17767701.0T patent/DK3439665T3/da active
- 2017-03-20 RS RS20220892A patent/RS63674B1/sr unknown
- 2017-03-20 ES ES17767701T patent/ES2926918T3/es active Active
- 2017-03-20 PL PL17767701.0T patent/PL3439665T3/pl unknown
- 2017-03-20 AU AU2017235665A patent/AU2017235665B2/en active Active
- 2017-03-20 HU HUE17767701A patent/HUE059774T2/hu unknown
- 2017-03-20 HR HRP20221098TT patent/HRP20221098T1/hr unknown
- 2017-03-20 US US16/086,053 patent/US10906909B2/en active Active
-
2020
- 2020-12-15 US US17/122,745 patent/US11753412B2/en active Active
-
2022
- 2022-02-08 JP JP2022017827A patent/JP2022065035A/ja active Pending
- 2022-11-23 AU AU2022275446A patent/AU2022275446A1/en active Pending
-
2023
- 2023-08-02 US US18/363,933 patent/US20240083905A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2926918T3 (es) | 2022-10-31 |
| LT3439665T (lt) | 2022-10-10 |
| EP3439665A1 (en) | 2019-02-13 |
| AU2017235665B2 (en) | 2022-12-08 |
| US20210309662A1 (en) | 2021-10-07 |
| AU2017235665A1 (en) | 2018-09-27 |
| US20200181146A1 (en) | 2020-06-11 |
| SI3439665T1 (sl) | 2023-05-31 |
| US20240083905A1 (en) | 2024-03-14 |
| HRP20221098T1 (hr) | 2022-11-25 |
| RS63674B1 (sr) | 2022-11-30 |
| EP3439665A4 (en) | 2019-11-27 |
| WO2017161370A1 (en) | 2017-09-21 |
| EP3439665B1 (en) | 2022-06-29 |
| US11753412B2 (en) | 2023-09-12 |
| JP2019509340A (ja) | 2019-04-04 |
| PL3439665T3 (pl) | 2023-01-16 |
| WO2017161370A8 (en) | 2018-09-27 |
| EP4129297A1 (en) | 2023-02-08 |
| JP7023876B2 (ja) | 2022-02-22 |
| CA3016491A1 (en) | 2017-09-21 |
| DK3439665T3 (da) | 2022-09-26 |
| HUE059774T2 (hu) | 2023-01-28 |
| US10906909B2 (en) | 2021-02-02 |
| JP2022065035A (ja) | 2022-04-26 |
| AU2022275446A1 (en) | 2023-01-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT3439665T (pt) | Tratamento de sintomas cognitivos e de humor em distúrbios neurodegenerativos e neuropsiquiátricos com gaba contendo agonistas de recetores de gabaa contendo alfa5 | |
| ZA201804458B (en) | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases | |
| IL290985A (en) | Methods for diagnosing and treating anxiety disorder | |
| IL259422A (en) | Pharmaceutical contraceptives against stress-induced emotional disorders and their associated symptoms | |
| IL266652A (en) | Subpopulation quantification of exosomes and diagnosis of neurodegenerative disorders | |
| HK1254030A1 (zh) | 治療自身免疫病症和同種免疫病症的方法 | |
| EP2996771A4 (en) | TREATMENT OF HUMILION AND FEAR STROKES | |
| HK1232289A1 (zh) | 分揀蛋白作為針對情感/心境障礙的生物標記的用途 | |
| PT2977056T (pt) | Transferrina para usar no tratamento de distúrbios neurodegenerativos relacionados com o factor induzido por hipoxia (fih) | |
| IL269604A (en) | Pentides for the treatment of autoimmune diseases | |
| PT3250600T (pt) | Tratamento de distúrbios autoimunes com anticorpos anti-cd154 | |
| IL262135A (en) | Methods of treatment with selective cb2 receptor agonists | |
| SG11201708657XA (en) | Short synthetic peptide for treatment and/or prophylaxis of autoimmune and inflammatory disorders | |
| IL249485B (en) | History of o-alkyl-benzylideneguanidine and therapeutic use for the treatment of disorders associated with the accumulation of misfolded proteins | |
| SG10201913129QA (en) | Treatment and diagnosis of inflammatory disorders | |
| ITUA20161679A1 (it) | Composizione per prevenire e trattare patologie neurodegenerative e disturbi cognitivi | |
| GB201411616D0 (en) | Diagnosis and treatment of neurodegenerative disorders | |
| EP3423049C0 (en) | METHODS OF TREATMENT OR RELIEF OF MENTAL DISORDERS AND ASSOCIATED SYMPTOMS | |
| IL252043A0 (en) | A proline-rich polypeptide complex for use in the treatment of brain neurotrophic factor-related disorders | |
| IL248381A0 (en) | A combination of brexpiprazole and nalemapine and its use in the treatment of drug-related disorders | |
| TH1501005802A (th) | องค์ประกอบกาแลคโตโอลิโกแซคคาไรด์สำหรับใช้ในการป้องกัน หรือรักษาความผิดปกติในการรับรู้และความผันแปรทางอารมณ์ในการเจ็บป่วย ทางจิตประสาทหรือความชรา | |
| AU2015905047A0 (en) | Methods of treating or alleviating mental disorders and associated symptoms | |
| MA40969A (fr) | Peptide homodimérique pour le traitement du diabète et des maladies liées | |
| GB201418096D0 (en) | Novel polymorph for use in treatment of inflammatory skin and pruritic disorders | |
| GB201516418D0 (en) | Treatment of acute inflammatory disorders |