JP2019528242A5 - - Google Patents
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- JP2019528242A5 JP2019528242A5 JP2018565888A JP2018565888A JP2019528242A5 JP 2019528242 A5 JP2019528242 A5 JP 2019528242A5 JP 2018565888 A JP2018565888 A JP 2018565888A JP 2018565888 A JP2018565888 A JP 2018565888A JP 2019528242 A5 JP2019528242 A5 JP 2019528242A5
- Authority
- JP
- Japan
- Prior art keywords
- acid sequence
- seq
- amino acid
- polypeptide
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021165271A JP7273918B2 (ja) | 2016-06-17 | 2021-10-07 | 第ｘａ因子誘導体の調製 |
| JP2023074627A JP2023086970A (ja) | 2016-06-17 | 2023-04-28 | 第ｘａ因子誘導体の調製 |
| JP2025166337A JP2026010692A (ja) | 2016-06-17 | 2025-10-02 | 第ｘａ因子誘導体の調製 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662351841P | 2016-06-17 | 2016-06-17 | |
| US62/351,841 | 2016-06-17 | ||
| PCT/US2017/038169 WO2017219034A2 (en) | 2016-06-17 | 2017-06-19 | Preparation of factor xa derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021165271A Division JP7273918B2 (ja) | 2016-06-17 | 2021-10-07 | 第ｘａ因子誘導体の調製 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528242A JP2019528242A (ja) | 2019-10-10 |
| JP2019528242A5 true JP2019528242A5 (enExample) | 2020-06-11 |
| JP6959268B2 JP6959268B2 (ja) | 2021-11-02 |
Family
ID=60663351
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018565888A Active JP6959268B2 (ja) | 2016-06-17 | 2017-06-19 | 第ｘａ因子誘導体の調製 |
| JP2021165271A Active JP7273918B2 (ja) | 2016-06-17 | 2021-10-07 | 第ｘａ因子誘導体の調製 |
| JP2023074627A Pending JP2023086970A (ja) | 2016-06-17 | 2023-04-28 | 第ｘａ因子誘導体の調製 |
| JP2025166337A Pending JP2026010692A (ja) | 2016-06-17 | 2025-10-02 | 第ｘａ因子誘導体の調製 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021165271A Active JP7273918B2 (ja) | 2016-06-17 | 2021-10-07 | 第ｘａ因子誘導体の調製 |
| JP2023074627A Pending JP2023086970A (ja) | 2016-06-17 | 2023-04-28 | 第ｘａ因子誘導体の調製 |
| JP2025166337A Pending JP2026010692A (ja) | 2016-06-17 | 2025-10-02 | 第ｘａ因子誘導体の調製 |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US10604748B2 (enExample) |
| EP (3) | EP3926044B1 (enExample) |
| JP (4) | JP6959268B2 (enExample) |
| KR (1) | KR102373215B1 (enExample) |
| CN (3) | CN110167575B (enExample) |
| AU (3) | AU2017283720C1 (enExample) |
| CL (2) | CL2018003654A1 (enExample) |
| CO (1) | CO2019000120A2 (enExample) |
| DK (1) | DK3472314T3 (enExample) |
| EA (1) | EA037815B1 (enExample) |
| ES (2) | ES2875538T3 (enExample) |
| HU (1) | HUE054597T2 (enExample) |
| IL (1) | IL263591B2 (enExample) |
| MX (1) | MX2018015873A (enExample) |
| PE (1) | PE20190661A1 (enExample) |
| PH (1) | PH12018502614A1 (enExample) |
| PL (1) | PL3472314T3 (enExample) |
| PT (1) | PT3472314T (enExample) |
| SG (1) | SG11201810915QA (enExample) |
| SI (1) | SI3472314T1 (enExample) |
| WO (1) | WO2017219034A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3604510T3 (pl) * | 2009-03-30 | 2025-07-28 | Alexion Pharmaceuticals, Inc. | Antidota na inhibitory czynnika xa i sposoby ich stosowania |
| EP2948168B1 (en) * | 2013-01-24 | 2018-07-18 | Portola Pharmaceuticals, Inc. | Inhibition of tissue factor pathway inhibitor with factor xa derivatives |
| EP3926044B1 (en) * | 2016-06-17 | 2025-06-04 | Alexion Pharmaceuticals, Inc. | Preparation of factor xa derivatives |
| US12195774B2 (en) | 2018-06-19 | 2025-01-14 | Alexion Pharmaceuticals, Inc. | Antidotes to factor XA inhibitors |
| KR102337683B1 (ko) * | 2018-09-21 | 2021-12-13 | 주식회사 녹십자 | 고효율 항-tfpi 항체 조성물 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5189019A (en) | 1990-04-23 | 1993-02-23 | Merck & Co., Inc. | Antistasin derived anticoagulant protein |
| US5589571A (en) | 1994-10-28 | 1996-12-31 | Cor Therapeutics, Inc. | Process for production of inhibited forms of activated blood factors |
| JPH1066572A (ja) * | 1996-08-29 | 1998-03-10 | Showa Sangyo Co Ltd | 高純度の大豆トリプシンインヒビターの製造方法 |
| WO2001064642A2 (en) | 2000-02-29 | 2001-09-07 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| CN101304971B (zh) | 2005-11-08 | 2011-09-07 | 米伦纽姆医药公司 | Xa因子抑制剂n-(5-氯-2-吡啶基)-2-[[4-[(二甲氨基)亚氨基甲基]苯甲酰基]氨基]-5-甲氧基-苯甲酰胺的医药盐和多晶型 |
| KR102069498B1 (ko) | 2007-09-28 | 2020-01-23 | 포톨라 파마슈티컬스, 인코포레이티드 | 인자 Ｘａ 저해제에 대한 안티도트 및 그것을 사용하는 방법 |
| CA2743496C (en) | 2008-11-14 | 2018-03-27 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same in combination with blood coagulating agents |
| PL3604510T3 (pl) * | 2009-03-30 | 2025-07-28 | Alexion Pharmaceuticals, Inc. | Antidota na inhibitory czynnika xa i sposoby ich stosowania |
| EP2453910B1 (en) | 2009-07-15 | 2016-08-31 | Portola Pharmaceuticals, Inc. | Unit dose formulation of antidote for factor xa inhibitors for use in preventing bleeding |
| EP2861614B1 (en) * | 2012-06-14 | 2016-11-30 | Portola Pharmaceuticals, Inc. | METHOD FOR PURIFICATION OF RECOMBINANT FACTOR Xa DERIVATIVES |
| US20140346397A1 (en) * | 2012-12-27 | 2014-11-27 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
| EP2948168B1 (en) * | 2013-01-24 | 2018-07-18 | Portola Pharmaceuticals, Inc. | Inhibition of tissue factor pathway inhibitor with factor xa derivatives |
| CN112195169A (zh) * | 2013-09-24 | 2021-01-08 | 辉瑞大药厂 | 包含重组人凝血因子Xa蛋白的异质性群体的组合物 |
| KR20250150675A (ko) * | 2014-08-20 | 2025-10-20 | 포톨라 파마슈티컬스, 인코포레이티드 | 인자 xa 해독제용 동결건조된 제형 |
| EP3926044B1 (en) * | 2016-06-17 | 2025-06-04 | Alexion Pharmaceuticals, Inc. | Preparation of factor xa derivatives |
-
2017
- 2017-06-19 EP EP21164923.1A patent/EP3926044B1/en active Active
- 2017-06-19 ES ES17814267T patent/ES2875538T3/es active Active
- 2017-06-19 PL PL17814267T patent/PL3472314T3/pl unknown
- 2017-06-19 EP EP25172582.6A patent/EP4588932A3/en active Pending
- 2017-06-19 SI SI201730865T patent/SI3472314T1/sl unknown
- 2017-06-19 SG SG11201810915QA patent/SG11201810915QA/en unknown
- 2017-06-19 WO PCT/US2017/038169 patent/WO2017219034A2/en not_active Ceased
- 2017-06-19 JP JP2018565888A patent/JP6959268B2/ja active Active
- 2017-06-19 PE PE2018003241A patent/PE20190661A1/es unknown
- 2017-06-19 CN CN201780041530.2A patent/CN110167575B/zh active Active
- 2017-06-19 KR KR1020197000840A patent/KR102373215B1/ko active Active
- 2017-06-19 HU HUE17814267A patent/HUE054597T2/hu unknown
- 2017-06-19 PT PT178142675T patent/PT3472314T/pt unknown
- 2017-06-19 EA EA201990052A patent/EA037815B1/ru not_active IP Right Cessation
- 2017-06-19 ES ES21164923T patent/ES3038834T3/es active Active
- 2017-06-19 CN CN202310427500.2A patent/CN116425860B/zh active Active
- 2017-06-19 US US15/626,813 patent/US10604748B2/en active Active
- 2017-06-19 EP EP17814267.5A patent/EP3472314B1/en active Active
- 2017-06-19 IL IL263591A patent/IL263591B2/en unknown
- 2017-06-19 CN CN202410192888.7A patent/CN118271391A/zh active Pending
- 2017-06-19 DK DK17814267.5T patent/DK3472314T3/da active
- 2017-06-19 MX MX2018015873A patent/MX2018015873A/es unknown
- 2017-06-19 AU AU2017283720A patent/AU2017283720C1/en active Active
-
2018
- 2018-12-11 PH PH12018502614A patent/PH12018502614A1/en unknown
- 2018-12-17 CL CL2018003654A patent/CL2018003654A1/es unknown
-
2019
- 2019-01-09 CO CONC2019/0000120A patent/CO2019000120A2/es unknown
-
2020
- 2020-01-10 US US16/740,001 patent/US10954504B2/en active Active
- 2020-06-25 CL CL2020001733A patent/CL2020001733A1/es unknown
-
2021
- 2021-03-09 US US17/196,172 patent/US11845966B2/en active Active
- 2021-10-07 JP JP2021165271A patent/JP7273918B2/ja active Active
-
2023
- 2023-02-14 AU AU2023200825A patent/AU2023200825B2/en active Active
- 2023-04-28 JP JP2023074627A patent/JP2023086970A/ja active Pending
- 2023-11-08 US US18/505,022 patent/US20240076642A1/en active Pending
-
2025
- 2025-10-02 JP JP2025166337A patent/JP2026010692A/ja active Pending
-
2026
- 2026-07-20 AU AU2026206233A patent/AU2026206233A1/en active Pending
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