PT3472314T - Preparação de derivados do fator xa - Google Patents

Preparação de derivados do fator xa

Info

Publication number
PT3472314T
PT3472314T PT178142675T PT17814267T PT3472314T PT 3472314 T PT3472314 T PT 3472314T PT 178142675 T PT178142675 T PT 178142675T PT 17814267 T PT17814267 T PT 17814267T PT 3472314 T PT3472314 T PT 3472314T
Authority
PT
Portugal
Prior art keywords
derivatives
factor
preparation
Prior art date
Application number
PT178142675T
Other languages
English (en)
Original Assignee
Alexion Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60663351&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3472314(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alexion Pharma Inc filed Critical Alexion Pharma Inc
Publication of PT3472314T publication Critical patent/PT3472314T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6432Coagulation factor Xa (3.4.21.6)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/4846Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/18Ion-exchange chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/20Partition-, reverse-phase or hydrophobic interaction chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/22Affinity chromatography or related techniques based upon selective absorption processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
PT178142675T 2016-06-17 2017-06-19 Preparação de derivados do fator xa PT3472314T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662351841P 2016-06-17 2016-06-17

Publications (1)

Publication Number Publication Date
PT3472314T true PT3472314T (pt) 2021-06-18

Family

ID=60663351

Family Applications (1)

Application Number Title Priority Date Filing Date
PT178142675T PT3472314T (pt) 2016-06-17 2017-06-19 Preparação de derivados do fator xa

Country Status (23)

Country Link
US (4) US10604748B2 (pt)
EP (2) EP3926044A1 (pt)
JP (3) JP6959268B2 (pt)
KR (1) KR102373215B1 (pt)
CN (2) CN116425860A (pt)
AU (2) AU2017283720B2 (pt)
BR (1) BR112018075964A2 (pt)
CA (1) CA3027457A1 (pt)
CL (2) CL2018003654A1 (pt)
CO (1) CO2019000120A2 (pt)
DK (1) DK3472314T3 (pt)
EA (1) EA037815B1 (pt)
ES (1) ES2875538T3 (pt)
HU (1) HUE054597T2 (pt)
IL (1) IL263591B2 (pt)
MX (1) MX2018015873A (pt)
PE (1) PE20190661A1 (pt)
PH (1) PH12018502614A1 (pt)
PL (1) PL3472314T3 (pt)
PT (1) PT3472314T (pt)
SG (1) SG11201810915QA (pt)
SI (1) SI3472314T1 (pt)
WO (1) WO2017219034A2 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3604510A1 (en) * 2009-03-30 2020-02-05 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same
EP2948168B1 (en) * 2013-01-24 2018-07-18 Portola Pharmaceuticals, Inc. Inhibition of tissue factor pathway inhibitor with factor xa derivatives
DK3472314T3 (da) * 2016-06-17 2021-07-26 Alexion Pharma Inc Fremstilling af faktor-xa-derivater
EP3810187A4 (en) * 2018-06-19 2022-08-31 Alexion Pharmaceuticals, Inc. ANTIDOTES FOR FACTOR XA INHIBITORS
KR102337683B1 (ko) * 2018-09-21 2021-12-13 주식회사 녹십자 고효율 항-tfpi 항체 조성물

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189019A (en) * 1990-04-23 1993-02-23 Merck & Co., Inc. Antistasin derived anticoagulant protein
US5589571A (en) * 1994-10-28 1996-12-31 Cor Therapeutics, Inc. Process for production of inhibited forms of activated blood factors
JPH1066572A (ja) * 1996-08-29 1998-03-10 Showa Sangyo Co Ltd 高純度の大豆トリプシンインヒビターの製造方法
DK1259485T3 (da) 2000-02-29 2006-04-10 Millennium Pharm Inc Benzamider og beslægtede inhibitorer for faktor Xa
PE20070717A1 (es) 2005-11-08 2007-08-17 Millennium Pharm Inc Sal de maleato y polimorfo de [2-({4-[(dimetilamino)iminometil]fenil}carbonilamino)-5-metoxifenil]-n-(5-cloro-(2-piridil))carboxamida
EP2915564B1 (en) 2007-09-28 2020-11-04 Portola Pharmaceuticals, Inc. Antidotes for factor XA inhibitors and methods of using the same
EP2364165B1 (en) 2008-11-14 2018-01-03 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same in combination with blood coagulating agents
EP3604510A1 (en) 2009-03-30 2020-02-05 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same
JP6163304B2 (ja) * 2009-07-15 2017-07-12 ポートラ ファーマシューティカルズ, インコーポレイテッド 第Xa因子インヒビターの解毒剤の単位用量処方物およびその使用方法
KR102100629B1 (ko) * 2012-06-14 2020-04-16 포톨라 파마슈티컬스, 인코포레이티드 재조합 인자 Xa 유도체의 정제방법
US20140346397A1 (en) * 2012-12-27 2014-11-27 Portola Pharmaceuticals, Inc. Compounds and methods for purification of serine proteases
EP2948168B1 (en) * 2013-01-24 2018-07-18 Portola Pharmaceuticals, Inc. Inhibition of tissue factor pathway inhibitor with factor xa derivatives
MY173548A (en) * 2013-09-24 2020-02-04 Pfizer Fxa variant compositions
CN107073082B (zh) * 2014-08-20 2021-04-30 博尔托拉制药公司 Xa因子解毒剂的冻干制剂
DK3472314T3 (da) * 2016-06-17 2021-07-26 Alexion Pharma Inc Fremstilling af faktor-xa-derivater

Also Published As

Publication number Publication date
US20240076642A1 (en) 2024-03-07
BR112018075964A2 (pt) 2019-04-02
PH12018502614A1 (en) 2019-09-30
US11845966B2 (en) 2023-12-19
PL3472314T3 (pl) 2021-11-22
ES2875538T3 (es) 2021-11-10
HUE054597T2 (hu) 2021-09-28
CN110167575B (zh) 2024-03-15
JP2022000477A (ja) 2022-01-04
EA201990052A1 (ru) 2019-05-31
CL2020001733A1 (es) 2020-09-25
WO2017219034A3 (en) 2019-03-14
EP3472314B1 (en) 2021-05-05
IL263591B2 (en) 2023-03-01
JP6959268B2 (ja) 2021-11-02
SG11201810915QA (en) 2019-01-30
IL263591A (en) 2019-02-03
EA037815B1 (ru) 2021-05-25
WO2017219034A2 (en) 2017-12-21
MX2018015873A (es) 2019-08-12
KR20190019134A (ko) 2019-02-26
PE20190661A1 (es) 2019-05-08
EP3472314A2 (en) 2019-04-24
US20170369862A1 (en) 2017-12-28
US10604748B2 (en) 2020-03-31
AU2017283720A1 (en) 2019-01-03
CN116425860A (zh) 2023-07-14
US20200208131A1 (en) 2020-07-02
IL263591B (en) 2022-11-01
KR102373215B1 (ko) 2022-03-10
EP3926044A1 (en) 2021-12-22
EP3472314A4 (en) 2020-01-22
JP2023086970A (ja) 2023-06-22
US20210348149A1 (en) 2021-11-11
US10954504B2 (en) 2021-03-23
SI3472314T1 (sl) 2021-11-30
JP7273918B2 (ja) 2023-05-15
AU2017283720B2 (en) 2022-11-17
CO2019000120A2 (es) 2019-03-29
CN110167575A (zh) 2019-08-23
CA3027457A1 (en) 2017-12-21
AU2023200825A1 (en) 2023-03-16
JP2019528242A (ja) 2019-10-10
CL2018003654A1 (es) 2019-01-25
DK3472314T3 (da) 2021-07-26

Similar Documents

Publication Publication Date Title
HK1255045A1 (zh) 取代的氧代吡啶衍生物
SG11201706729SA (en) Derivatives of sobetirome
IL272888A (en) Uses of piperidinyl-indole derivatives
IL263050B (en) History of Subtirum
IL263591A (en) Preparation of xa factor history
HK1245258A1 (zh) 新的二氟酮酰胺衍生物
ZA201602198B (en) Preparation of hydroxy-benzylbenzene derivatives
HK1257800A1 (zh) L-4-氯喹寧的治療用途
HK1250719A1 (zh) 脫氧糖胺的合成
EP3384921A4 (en) NEW USE OF THIOPEPTIN
HK1231387A1 (zh) 蔷薇色素化合物的新型用途
GB201502813D0 (en) Mesoporous materials
SG11201609739UA (en) Derivatives of dolaproine-dolaisoleuine peptides
IL255182A0 (en) History of korormicim with antibiotic use
IL249130B (en) Preparation of piperidine-4-carbothioamide
GB2564185B (en) Process for the preparation of derivatives of benzodioxole
EP3338775A4 (en) USES OF BUTYLIDENEPHTHALIDE
TH1601002304A (th) สารผสมเคลือบผง
GB201403170D0 (en) Preparation of antibacterial bisbenzimidazoles
TWM489614U (en) Structure of bathroom accessory