JP6959268B2 - 第ｘａ因子誘導体の調製 - Google Patents
第ｘａ因子誘導体の調製 Download PDFInfo
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- JP6959268B2 JP6959268B2 JP2018565888A JP2018565888A JP6959268B2 JP 6959268 B2 JP6959268 B2 JP 6959268B2 JP 2018565888 A JP2018565888 A JP 2018565888A JP 2018565888 A JP2018565888 A JP 2018565888A JP 6959268 B2 JP6959268 B2 JP 6959268B2
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- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| JP2023074627A JP2023086970A (ja) | 2016-06-17 | 2023-04-28 | 第ｘａ因子誘導体の調製 |
| JP2025166337A JP2026010692A (ja) | 2016-06-17 | 2025-10-02 | 第ｘａ因子誘導体の調製 |
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| PL3604510T3 (pl) * | 2009-03-30 | 2025-07-28 | Alexion Pharmaceuticals, Inc. | Antidota na inhibitory czynnika xa i sposoby ich stosowania |
| EP2948168B1 (en) * | 2013-01-24 | 2018-07-18 | Portola Pharmaceuticals, Inc. | Inhibition of tissue factor pathway inhibitor with factor xa derivatives |
| EP3926044B1 (en) * | 2016-06-17 | 2025-06-04 | Alexion Pharmaceuticals, Inc. | Preparation of factor xa derivatives |
| US12195774B2 (en) | 2018-06-19 | 2025-01-14 | Alexion Pharmaceuticals, Inc. | Antidotes to factor XA inhibitors |
| KR102337683B1 (ko) * | 2018-09-21 | 2021-12-13 | 주식회사 녹십자 | 고효율 항-tfpi 항체 조성물 |
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| US5189019A (en) | 1990-04-23 | 1993-02-23 | Merck & Co., Inc. | Antistasin derived anticoagulant protein |
| US5589571A (en) | 1994-10-28 | 1996-12-31 | Cor Therapeutics, Inc. | Process for production of inhibited forms of activated blood factors |
| JPH1066572A (ja) * | 1996-08-29 | 1998-03-10 | Showa Sangyo Co Ltd | 高純度の大豆トリプシンインヒビターの製造方法 |
| WO2001064642A2 (en) | 2000-02-29 | 2001-09-07 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| CN101304971B (zh) | 2005-11-08 | 2011-09-07 | 米伦纽姆医药公司 | Xa因子抑制剂n-(5-氯-2-吡啶基)-2-[[4-[(二甲氨基)亚氨基甲基]苯甲酰基]氨基]-5-甲氧基-苯甲酰胺的医药盐和多晶型 |
| KR102069498B1 (ko) | 2007-09-28 | 2020-01-23 | 포톨라 파마슈티컬스, 인코포레이티드 | 인자 Ｘａ 저해제에 대한 안티도트 및 그것을 사용하는 방법 |
| CA2743496C (en) | 2008-11-14 | 2018-03-27 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same in combination with blood coagulating agents |
| PL3604510T3 (pl) * | 2009-03-30 | 2025-07-28 | Alexion Pharmaceuticals, Inc. | Antidota na inhibitory czynnika xa i sposoby ich stosowania |
| EP2453910B1 (en) | 2009-07-15 | 2016-08-31 | Portola Pharmaceuticals, Inc. | Unit dose formulation of antidote for factor xa inhibitors for use in preventing bleeding |
| EP2861614B1 (en) * | 2012-06-14 | 2016-11-30 | Portola Pharmaceuticals, Inc. | METHOD FOR PURIFICATION OF RECOMBINANT FACTOR Xa DERIVATIVES |
| US20140346397A1 (en) * | 2012-12-27 | 2014-11-27 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
| EP2948168B1 (en) * | 2013-01-24 | 2018-07-18 | Portola Pharmaceuticals, Inc. | Inhibition of tissue factor pathway inhibitor with factor xa derivatives |
| CN112195169A (zh) * | 2013-09-24 | 2021-01-08 | 辉瑞大药厂 | 包含重组人凝血因子Xa蛋白的异质性群体的组合物 |
| KR20250150675A (ko) * | 2014-08-20 | 2025-10-20 | 포톨라 파마슈티컬스, 인코포레이티드 | 인자 xa 해독제용 동결건조된 제형 |
| EP3926044B1 (en) * | 2016-06-17 | 2025-06-04 | Alexion Pharmaceuticals, Inc. | Preparation of factor xa derivatives |
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