JP2019527361A5 - - Google Patents
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- Publication number
- JP2019527361A5 JP2019527361A5 JP2019503672A JP2019503672A JP2019527361A5 JP 2019527361 A5 JP2019527361 A5 JP 2019527361A5 JP 2019503672 A JP2019503672 A JP 2019503672A JP 2019503672 A JP2019503672 A JP 2019503672A JP 2019527361 A5 JP2019527361 A5 JP 2019527361A5
- Authority
- JP
- Japan
- Prior art keywords
- patient
- moieties
- blood
- free nucleosomes
- extracellular free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 206010009944 Colon cancer Diseases 0.000 description 4
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 108010047956 Nucleosomes Proteins 0.000 description 4
- 210000001623 nucleosome Anatomy 0.000 description 4
- 230000002550 fecal effect Effects 0.000 description 3
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 description 2
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 239000000090 biomarker Substances 0.000 description 2
- 238000002052 colonoscopy Methods 0.000 description 2
- 201000002758 colorectal adenoma Diseases 0.000 description 2
- 230000001973 epigenetic effect Effects 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 208000022131 polyp of large intestine Diseases 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000012216 screening Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1612815.9A GB201612815D0 (en) | 2016-07-25 | 2016-07-25 | Novel combination test |
| GB1612815.9 | 2016-07-25 | ||
| PCT/EP2017/068754 WO2018019827A1 (en) | 2016-07-25 | 2017-07-25 | Combination test for colorectal cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019527361A JP2019527361A (ja) | 2019-09-26 |
| JP2019527361A5 true JP2019527361A5 (https=) | 2020-08-20 |
| JP6983221B2 JP6983221B2 (ja) | 2021-12-17 |
Family
ID=56894403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503672A Active JP6983221B2 (ja) | 2016-07-25 | 2017-07-25 | 大腸癌の併用検査 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20200182875A1 (https=) |
| EP (1) | EP3488238B1 (https=) |
| JP (1) | JP6983221B2 (https=) |
| KR (1) | KR102442803B1 (https=) |
| CN (1) | CN109791154A (https=) |
| AU (1) | AU2017301970B2 (https=) |
| BR (1) | BR112019001384A2 (https=) |
| CA (1) | CA3031580A1 (https=) |
| GB (1) | GB201612815D0 (https=) |
| IL (1) | IL264359B2 (https=) |
| MY (1) | MY193895A (https=) |
| RU (1) | RU2019104870A (https=) |
| SG (2) | SG10202100630SA (https=) |
| TW (1) | TWI776816B (https=) |
| WO (1) | WO2018019827A1 (https=) |
| ZA (1) | ZA201808601B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201906199D0 (en) * | 2019-05-02 | 2019-06-19 | Belgian Volition Sprl | Method for the detection of cancer |
| WO2021024009A1 (en) * | 2019-08-02 | 2021-02-11 | Shanghai Yunxiang Medical Technology Co., Ltd. | Methods and compositions for providing colon cancer assessment using protein biomarkers |
| CN112345766B (zh) * | 2020-10-22 | 2024-02-02 | 中国工程物理研究院核物理与化学研究所 | 一种荧光-放射性联用的体外靶向筛选方法 |
| TW202242146A (zh) * | 2021-01-13 | 2022-11-01 | 比利時商比利時意志有限公司 | 肺癌的檢測方法 |
| EP4291899A1 (en) * | 2021-02-11 | 2023-12-20 | EDP Biotech Corporation | Kits and methods for detecting markers and determining the presence or risk of cancer |
| WO2024223947A1 (en) * | 2023-04-28 | 2024-10-31 | Belgian Volition Srl | Use of cell free nucleosomes as biomarkers of carcinomas |
| CN116973572B (zh) * | 2023-06-02 | 2025-03-07 | 东南大学附属中大医院 | 基于血、粪便铁蛋白检测评估肠屏障损伤严重程度的方法 |
| CN116718775B (zh) * | 2023-08-04 | 2023-10-27 | 天津迈基生物科技有限公司 | 一种检测结直肠癌的组合物、试纸及方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2541178T3 (es) * | 2009-02-03 | 2015-07-16 | Mdxhealth Sa | Método de detección de cáncer colorrectal |
| WO2010120942A2 (en) * | 2009-04-14 | 2010-10-21 | The Regents Of The University Of California | Histone modification patterns for clinical diagnosis and prognosis of cancer |
| US8568984B2 (en) * | 2010-02-19 | 2013-10-29 | Philadelphia Health & Education Corporation | Methods of diagnosing non-urinary tract diseases by detecting aberrant methylation |
| JP2012018119A (ja) * | 2010-07-09 | 2012-01-26 | Toray Ind Inc | 大腸癌検出用マーカーおよびそれを用いた大腸癌検出方法 |
| CN103328500B (zh) * | 2010-08-04 | 2018-01-26 | 西兹尔生物技术有限公司 | 用于癌症的诊断和治疗的方法和化合物 |
| GB201115098D0 (en) * | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes containing histone variants |
| PT2788767T (pt) * | 2011-12-07 | 2017-12-06 | Belgian Volition Sprl | Método de detecção de adutos de nucleosoma |
| EP4001436B1 (en) * | 2012-05-11 | 2024-03-13 | Clinical Genomics Pty. Ltd. | Diagnostic gene marker panel |
-
2016
- 2016-07-25 GB GBGB1612815.9A patent/GB201612815D0/en not_active Ceased
-
2017
- 2017-07-25 RU RU2019104870A patent/RU2019104870A/ru unknown
- 2017-07-25 MY MYPI2019000398A patent/MY193895A/en unknown
- 2017-07-25 WO PCT/EP2017/068754 patent/WO2018019827A1/en not_active Ceased
- 2017-07-25 BR BR112019001384-9A patent/BR112019001384A2/pt not_active Application Discontinuation
- 2017-07-25 IL IL264359A patent/IL264359B2/en unknown
- 2017-07-25 TW TW106124811A patent/TWI776816B/zh active
- 2017-07-25 SG SG10202100630SA patent/SG10202100630SA/en unknown
- 2017-07-25 JP JP2019503672A patent/JP6983221B2/ja active Active
- 2017-07-25 SG SG11201900329XA patent/SG11201900329XA/en unknown
- 2017-07-25 CN CN201780045694.2A patent/CN109791154A/zh active Pending
- 2017-07-25 KR KR1020197002048A patent/KR102442803B1/ko active Active
- 2017-07-25 CA CA3031580A patent/CA3031580A1/en active Pending
- 2017-07-25 US US16/320,440 patent/US20200182875A1/en not_active Abandoned
- 2017-07-25 AU AU2017301970A patent/AU2017301970B2/en not_active Ceased
- 2017-07-25 EP EP17743043.6A patent/EP3488238B1/en active Active
-
2018
- 2018-12-20 ZA ZA2018/08601A patent/ZA201808601B/en unknown
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