TWI776816B - 一種偵測和/或篩檢患者之結腸直腸癌、結腸直腸腺瘤、或息肉以及評估患者結腸鏡檢查之適當性之方法 - Google Patents

一種偵測和/或篩檢患者之結腸直腸癌、結腸直腸腺瘤、或息肉以及評估患者結腸鏡檢查之適當性之方法 Download PDF

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TWI776816B
TWI776816B TW106124811A TW106124811A TWI776816B TW I776816 B TWI776816 B TW I776816B TW 106124811 A TW106124811 A TW 106124811A TW 106124811 A TW106124811 A TW 106124811A TW I776816 B TWI776816 B TW I776816B
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patient
crc
colonoscopy
fecal
nucleosomes
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TW106124811A
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TW201804156A (zh
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雅各文森 米考夫
傑森 泰瑞
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比利時意志有限公司
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57535—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
TW106124811A 2016-07-25 2017-07-25 一種偵測和/或篩檢患者之結腸直腸癌、結腸直腸腺瘤、或息肉以及評估患者結腸鏡檢查之適當性之方法 TWI776816B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1612815.9A GB201612815D0 (en) 2016-07-25 2016-07-25 Novel combination test
GB1612815.9 2016-07-25

Publications (2)

Publication Number Publication Date
TW201804156A TW201804156A (zh) 2018-02-01
TWI776816B true TWI776816B (zh) 2022-09-11

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TW106124811A TWI776816B (zh) 2016-07-25 2017-07-25 一種偵測和/或篩檢患者之結腸直腸癌、結腸直腸腺瘤、或息肉以及評估患者結腸鏡檢查之適當性之方法

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US (1) US20200182875A1 (https=)
EP (1) EP3488238B1 (https=)
JP (1) JP6983221B2 (https=)
KR (1) KR102442803B1 (https=)
CN (1) CN109791154A (https=)
AU (1) AU2017301970B2 (https=)
BR (1) BR112019001384A2 (https=)
CA (1) CA3031580A1 (https=)
GB (1) GB201612815D0 (https=)
IL (1) IL264359B2 (https=)
MY (1) MY193895A (https=)
RU (1) RU2019104870A (https=)
SG (2) SG10202100630SA (https=)
TW (1) TWI776816B (https=)
WO (1) WO2018019827A1 (https=)
ZA (1) ZA201808601B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201906199D0 (en) * 2019-05-02 2019-06-19 Belgian Volition Sprl Method for the detection of cancer
WO2021024009A1 (en) * 2019-08-02 2021-02-11 Shanghai Yunxiang Medical Technology Co., Ltd. Methods and compositions for providing colon cancer assessment using protein biomarkers
CN112345766B (zh) * 2020-10-22 2024-02-02 中国工程物理研究院核物理与化学研究所 一种荧光-放射性联用的体外靶向筛选方法
TW202242146A (zh) * 2021-01-13 2022-11-01 比利時商比利時意志有限公司 肺癌的檢測方法
EP4291899A1 (en) * 2021-02-11 2023-12-20 EDP Biotech Corporation Kits and methods for detecting markers and determining the presence or risk of cancer
WO2024223947A1 (en) * 2023-04-28 2024-10-31 Belgian Volition Srl Use of cell free nucleosomes as biomarkers of carcinomas
CN116973572B (zh) * 2023-06-02 2025-03-07 东南大学附属中大医院 基于血、粪便铁蛋白检测评估肠屏障损伤严重程度的方法
CN116718775B (zh) * 2023-08-04 2023-10-27 天津迈基生物科技有限公司 一种检测结直肠癌的组合物、试纸及方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2541178T3 (es) * 2009-02-03 2015-07-16 Mdxhealth Sa Método de detección de cáncer colorrectal
WO2010120942A2 (en) * 2009-04-14 2010-10-21 The Regents Of The University Of California Histone modification patterns for clinical diagnosis and prognosis of cancer
US8568984B2 (en) * 2010-02-19 2013-10-29 Philadelphia Health & Education Corporation Methods of diagnosing non-urinary tract diseases by detecting aberrant methylation
JP2012018119A (ja) * 2010-07-09 2012-01-26 Toray Ind Inc 大腸癌検出用マーカーおよびそれを用いた大腸癌検出方法
CN103328500B (zh) * 2010-08-04 2018-01-26 西兹尔生物技术有限公司 用于癌症的诊断和治疗的方法和化合物
GB201115098D0 (en) * 2011-09-01 2011-10-19 Belgian Volition Sa Method for detecting nucleosomes containing histone variants
PT2788767T (pt) * 2011-12-07 2017-12-06 Belgian Volition Sprl Método de detecção de adutos de nucleosoma
EP4001436B1 (en) * 2012-05-11 2024-03-13 Clinical Genomics Pty. Ltd. Diagnostic gene marker panel

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
網路文獻 Al-Shuneigat, Jehad M., Samir S. Mahgoub, and Fazlul Huq. "Colorectal carcinoma: nucleosomes, carcinoembryonic antigen and CA 19-9 as apoptotic markers; a comparative study." Journal of biomedical science 18.1 (2011),p. 1-5. *
網路文獻 Holdenrieder, Stefan, et al "Novel serum nucleosomics biomarkers for the detection of colorectal cancer." Anticancer research 34. 5 (2014), p. 2357-2362.; *
網路文獻 Karl, Johann, et al. "Improved diagnosis of colorectal cancer using a combination of fecal occult blood and novel fecal protein markers." Clinical Gastroenterology and Hepatology 6. 10 (2008), p. 1122-1128.; *

Also Published As

Publication number Publication date
MY193895A (en) 2022-10-31
IL264359B2 (en) 2024-03-01
EP3488238B1 (en) 2023-06-07
TW201804156A (zh) 2018-02-01
IL264359B1 (en) 2023-11-01
AU2017301970A1 (en) 2019-01-17
KR102442803B1 (ko) 2022-09-15
JP6983221B2 (ja) 2021-12-17
CN109791154A (zh) 2019-05-21
BR112019001384A2 (pt) 2019-04-30
US20200182875A1 (en) 2020-06-11
RU2019104870A (ru) 2020-08-25
IL264359A (en) 2019-02-28
EP3488238A1 (en) 2019-05-29
ZA201808601B (en) 2019-09-25
WO2018019827A1 (en) 2018-02-01
GB201612815D0 (en) 2016-09-07
EP3488238C0 (en) 2023-06-07
JP2019527361A (ja) 2019-09-26
SG11201900329XA (en) 2019-02-27
KR20190039089A (ko) 2019-04-10
AU2017301970B2 (en) 2023-04-27
RU2019104870A3 (https=) 2020-12-01
SG10202100630SA (en) 2021-03-30
CA3031580A1 (en) 2018-02-01

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