|
US4443340A
(en)
|
1981-10-09 |
1984-04-17 |
Betz Laboratories, Inc. |
Control of iron induced fouling in water systems
|
|
US5100899A
(en)
|
1989-06-06 |
1992-03-31 |
Roy Calne |
Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
|
|
JPH04230389A
(ja)
|
1990-07-16 |
1992-08-19 |
American Home Prod Corp |
ラパマイシン誘導体
|
|
US5023262A
(en)
|
1990-08-14 |
1991-06-11 |
American Home Products Corporation |
Hydrogenated rapamycin derivatives
|
|
PT98990A
(pt)
|
1990-09-19 |
1992-08-31 |
American Home Prod |
Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
|
|
US5145684A
(en)
|
1991-01-25 |
1992-09-08 |
Sterling Drug Inc. |
Surface modified drug nanoparticles
|
|
US5120842A
(en)
|
1991-04-01 |
1992-06-09 |
American Home Products Corporation |
Silyl ethers of rapamycin
|
|
US5120725A
(en)
|
1991-05-29 |
1992-06-09 |
American Home Products Corporation |
Bicyclic rapamycins
|
|
US5120727A
(en)
|
1991-05-29 |
1992-06-09 |
American Home Products Corporation |
Rapamycin dimers
|
|
ZA924953B
(en)
|
1991-07-25 |
1993-04-28 |
Univ Louisville Res Found |
Method of treating ocular inflammation
|
|
KR970007322B1
(ko)
|
1991-12-19 |
1997-05-07 |
미쓰이도오아쓰 가가쿠 가부시키가이샤 |
폴리히드록시 카르복실산 및 그 제조방법
|
|
US5177203A
(en)
|
1992-03-05 |
1993-01-05 |
American Home Products Corporation |
Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents
|
|
US5242910A
(en)
|
1992-10-13 |
1993-09-07 |
The Procter & Gamble Company |
Sustained release compositions for treating periodontal disease
|
|
US5536729A
(en)
|
1993-09-30 |
1996-07-16 |
American Home Products Corporation |
Rapamycin formulations for oral administration
|
|
US5527907A
(en)
|
1993-11-19 |
1996-06-18 |
Abbott Laboratories |
Macrolide immunomodulators
|
|
US5968542A
(en)
|
1995-06-07 |
1999-10-19 |
Southern Biosystems, Inc. |
High viscosity liquid controlled delivery system as a device
|
|
US7833543B2
(en)
*
|
1995-06-07 |
2010-11-16 |
Durect Corporation |
High viscosity liquid controlled delivery system and medical or surgical device
|
|
US5747058A
(en)
|
1995-06-07 |
1998-05-05 |
Southern Biosystems, Inc. |
High viscosity liquid controlled delivery system
|
|
PT1006935E
(pt)
*
|
1995-06-07 |
2005-06-30 |
Durect Corp |
Sistema de entrega controlada liquido de alta viscosidade
|
|
US5989591A
(en)
|
1997-03-14 |
1999-11-23 |
American Home Products Corporation |
Rapamycin formulations for oral administration
|
|
US6015815A
(en)
|
1997-09-26 |
2000-01-18 |
Abbott Laboratories |
Tetrazole-containing rapamycin analogs with shortened half-lives
|
|
US6890546B2
(en)
|
1998-09-24 |
2005-05-10 |
Abbott Laboratories |
Medical devices containing rapamycin analogs
|
|
US6376517B1
(en)
|
1998-08-14 |
2002-04-23 |
Gpi Nil Holdings, Inc. |
Pipecolic acid derivatives for vision and memory disorders
|
|
DK1372729T3
(da)
|
2001-02-23 |
2009-06-22 |
Genentech Inc |
Nedbrydelige polymere til injektion
|
|
DE60325742D1
(de)
|
2002-07-31 |
2009-02-26 |
Alza Corp |
Injizierbare multimodale polymere depotzusammensetzungen und ihre verwendungen
|
|
US8163726B2
(en)
|
2002-09-18 |
2012-04-24 |
University Of Pennsylvania |
Method of inhibiting choroidal neovascularization
|
|
ATE418323T1
(de)
|
2002-11-06 |
2009-01-15 |
Alza Corp |
Depot-formulierungen mit verzögerter freisetzung
|
|
ATE482695T1
(de)
|
2002-12-13 |
2010-10-15 |
Durect Corp |
Orale darreichungsform mit flüssigen hochviskosen trägersystemen
|
|
AU2004219595A1
(en)
|
2003-03-11 |
2004-09-23 |
Qlt Usa Inc. |
Formulations for cell- schedule dependent anticancer agents
|
|
CA2539324A1
(en)
|
2003-09-18 |
2005-03-31 |
Macusight, Inc. |
Transscleral delivery
|
|
US7087237B2
(en)
|
2003-09-19 |
2006-08-08 |
Advanced Ocular Systems Limited |
Ocular solutions
|
|
SI2415484T1
(sl)
|
2004-09-17 |
2014-10-30 |
Durect Corporation |
Pripravek, ki vsebuje lokalni anestetik SAIB, s podaljšanim sproščanjem
|
|
EP2452670A1
(en)
|
2004-10-01 |
2012-05-16 |
Ramscor, Inc. |
Conveniently implantable sustained release drug compositions
|
|
US20080038316A1
(en)
|
2004-10-01 |
2008-02-14 |
Wong Vernon G |
Conveniently implantable sustained release drug compositions
|
|
US8313763B2
(en)
*
|
2004-10-04 |
2012-11-20 |
Tolmar Therapeutics, Inc. |
Sustained delivery formulations of rapamycin compounds
|
|
JP4974903B2
(ja)
|
2005-02-09 |
2012-07-11 |
参天製薬株式会社 |
疾患または状態を処置するための液体処方物
|
|
US8663639B2
(en)
*
|
2005-02-09 |
2014-03-04 |
Santen Pharmaceutical Co., Ltd. |
Formulations for treating ocular diseases and conditions
|
|
KR20070121754A
(ko)
*
|
2005-03-21 |
2007-12-27 |
마커사이트, 인코포레이티드 |
질환 또는 상태의 치료를 위한 약물 송달 시스템
|
|
US20070027105A1
(en)
|
2005-07-26 |
2007-02-01 |
Alza Corporation |
Peroxide removal from drug delivery vehicle
|
|
US8852638B2
(en)
|
2005-09-30 |
2014-10-07 |
Durect Corporation |
Sustained release small molecule drug formulation
|
|
WO2007092620A2
(en)
|
2006-02-09 |
2007-08-16 |
Macusight, Inc. |
Stable formulations, and methods of their preparation and use
|
|
PL2001466T3
(pl)
|
2006-03-23 |
2016-06-30 |
Santen Pharmaceutical Co Ltd |
Rapamycyna w małej dawce do leczenia chorób związanych z przepuszczalnością naczyń
|
|
CN1973822A
(zh)
|
2006-12-20 |
2007-06-06 |
山东蓝金生物工程有限公司 |
一种含雷帕霉素的抗癌组合物
|
|
CA2671925A1
(en)
|
2006-12-21 |
2008-07-10 |
Stryker Corporation |
Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents
|
|
DK2167039T3
(en)
|
2007-05-18 |
2017-01-09 |
Durect Corp |
Improved depot formulations
|
|
WO2009023877A2
(en)
|
2007-08-16 |
2009-02-19 |
Macusight, Inc. |
Formulations for treatment of ocular diseases or conditions
|
|
JP2011506319A
(ja)
|
2007-12-06 |
2011-03-03 |
デュレクト コーポレーション |
疼痛、関節炎症状、または慢性疾患に伴う炎症の治療に有用な方法
|
|
WO2009100222A1
(en)
|
2008-02-08 |
2009-08-13 |
Qps Llc |
Non-polymeric compositions for controlled drug delivery
|
|
US20120114637A1
(en)
|
2009-05-04 |
2012-05-10 |
Santen Pharmaceutical Co., Ltd. |
Mtor pathway inhibitors for treating ocular disorders
|
|
JP2013543898A
(ja)
|
2010-11-24 |
2013-12-09 |
デュレクト コーポレイション |
生体分解性薬物送達組成物
|
|
US20140294977A1
(en)
|
2011-11-23 |
2014-10-02 |
Durect Corporation |
Radiation-Sterilized Biodegradable Drug Delivery Composition
|
|
RU2672596C2
(ru)
|
2012-01-23 |
2018-11-16 |
Аллерган, Инк. |
Биологически разлагаемые или биологически разрушаемые микросферы или микрочастицы длительного высвобождения, суспендированные в затвердевающем депообразующем инъекцируемом лекарственном составе
|
|
HK1220628A1
(zh)
|
2013-03-11 |
2017-05-12 |
Durect Corporation |
包含高粘度液体载体的可注射控制释放组合物
|
|
AU2014233453A1
(en)
|
2013-03-15 |
2015-10-01 |
Durect Corporation |
Compositions with a rheological modifier to reduce dissolution variability
|
|
JP2016514692A
(ja)
|
2013-03-15 |
2016-05-23 |
デュレクト コーポレーション |
チキソトロピーならびに強化された溶解再現性及び安定性を有する組成物
|
|
ES2902951T3
(es)
|
2013-05-24 |
2022-03-30 |
Icon Bioscience Inc |
Uso de dexametasona de liberación sostenida en la inflamación después de cirugía de cataratas
|
|
EP3220887A1
(en)
|
2014-11-21 |
2017-09-27 |
Technical University of Denmark |
Gel formulations for local drug release
|
|
TWI731853B
(zh)
|
2015-03-18 |
2021-07-01 |
日商參天製藥股份有限公司 |
徐放性醫藥組成物及其安定化方法
|
|
EP3318280A4
(en)
|
2015-07-01 |
2018-08-22 |
Santen Pharmaceutical Co., Ltd |
Depot preparation containing citric acid ester
|
|
KR20190025635A
(ko)
|
2016-06-30 |
2019-03-11 |
듀렉트 코퍼레이션 |
데포 제형
|
|
EP3565553B1
(en)
|
2017-01-06 |
2023-04-26 |
Santen Pharmaceutical Co., Ltd. |
Intratumoral administration of sirolimus for treatment of prostate cancer
|