JP2019526257A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019526257A5 JP2019526257A5 JP2019511456A JP2019511456A JP2019526257A5 JP 2019526257 A5 JP2019526257 A5 JP 2019526257A5 JP 2019511456 A JP2019511456 A JP 2019511456A JP 2019511456 A JP2019511456 A JP 2019511456A JP 2019526257 A5 JP2019526257 A5 JP 2019526257A5
- Authority
- JP
- Japan
- Prior art keywords
- region
- sample
- genomic dna
- adapters
- adapter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000523 sample Substances 0.000 claims description 258
- 108020004414 DNA Proteins 0.000 claims description 229
- 238000000034 method Methods 0.000 claims description 148
- 239000002773 nucleotide Substances 0.000 claims description 111
- 125000003729 nucleotide group Chemical group 0.000 claims description 111
- 239000012634 fragment Substances 0.000 claims description 88
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 52
- 238000012360 testing method Methods 0.000 claims description 34
- 230000003321 amplification Effects 0.000 claims description 25
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 25
- 108090000623 proteins and genes Proteins 0.000 claims description 21
- 108091033319 polynucleotide Proteins 0.000 claims description 18
- 102000040430 polynucleotide Human genes 0.000 claims description 18
- 239000002157 polynucleotide Substances 0.000 claims description 18
- 238000012163 sequencing technique Methods 0.000 claims description 14
- 108091092356 cellular DNA Proteins 0.000 claims description 12
- 238000012252 genetic analysis Methods 0.000 claims description 12
- 201000010099 disease Diseases 0.000 claims description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
- 108091034117 Oligonucleotide Proteins 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 9
- 208000037051 Chromosomal Instability Diseases 0.000 claims description 8
- 150000007523 nucleic acids Chemical group 0.000 claims description 8
- 238000001712 DNA sequencing Methods 0.000 claims description 6
- 238000012408 PCR amplification Methods 0.000 claims description 6
- 238000004458 analytical method Methods 0.000 claims description 6
- 239000013610 patient sample Substances 0.000 claims description 6
- 238000000746 purification Methods 0.000 claims description 6
- 208000026350 Inborn Genetic disease Diseases 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- 238000012935 Averaging Methods 0.000 claims description 4
- 238000001574 biopsy Methods 0.000 claims description 4
- 208000016361 genetic disease Diseases 0.000 claims description 4
- 230000002068 genetic effect Effects 0.000 claims description 4
- 238000010606 normalization Methods 0.000 claims description 4
- 230000008685 targeting Effects 0.000 claims description 4
- 230000004077 genetic alteration Effects 0.000 claims description 3
- 231100000118 genetic alteration Toxicity 0.000 claims description 3
- 102000000872 ATM Human genes 0.000 claims description 2
- 108010004586 Ataxia Telangiectasia Mutated Proteins Proteins 0.000 claims description 2
- 108700020463 BRCA1 Proteins 0.000 claims description 2
- 102000036365 BRCA1 Human genes 0.000 claims description 2
- 101150072950 BRCA1 gene Proteins 0.000 claims description 2
- 108700020462 BRCA2 Proteins 0.000 claims description 2
- 102000052609 BRCA2 Human genes 0.000 claims description 2
- 101150008921 Brca2 gene Proteins 0.000 claims description 2
- 102000012410 DNA Ligases Human genes 0.000 claims description 2
- 108010061982 DNA Ligases Proteins 0.000 claims description 2
- 239000003298 DNA probe Substances 0.000 claims description 2
- 102000009095 Fanconi Anemia Complementation Group A protein Human genes 0.000 claims description 2
- 108010087740 Fanconi Anemia Complementation Group A protein Proteins 0.000 claims description 2
- 108010067741 Fanconi Anemia Complementation Group N protein Proteins 0.000 claims description 2
- 102000016627 Fanconi Anemia Complementation Group N protein Human genes 0.000 claims description 2
- 102100034553 Fanconi anemia group J protein Human genes 0.000 claims description 2
- 208000031448 Genomic Instability Diseases 0.000 claims description 2
- 208000028782 Hereditary disease Diseases 0.000 claims description 2
- 102100039999 Histone deacetylase 2 Human genes 0.000 claims description 2
- 101000848171 Homo sapiens Fanconi anemia group J protein Proteins 0.000 claims description 2
- 101001035011 Homo sapiens Histone deacetylase 2 Proteins 0.000 claims description 2
- 101000777277 Homo sapiens Serine/threonine-protein kinase Chk2 Proteins 0.000 claims description 2
- 208000024556 Mendelian disease Diseases 0.000 claims description 2
- 101100015391 Mus musculus Ralgds gene Proteins 0.000 claims description 2
- 239000012661 PARP inhibitor Substances 0.000 claims description 2
- 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 claims description 2
- 108010021757 Polynucleotide 5'-Hydroxyl-Kinase Proteins 0.000 claims description 2
- 102000008422 Polynucleotide 5'-hydroxyl-kinase Human genes 0.000 claims description 2
- 102100031075 Serine/threonine-protein kinase Chk2 Human genes 0.000 claims description 2
- 210000004381 amniotic fluid Anatomy 0.000 claims description 2
- 239000012472 biological sample Substances 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 2
- 238000007385 chemical modification Methods 0.000 claims description 2
- 230000002759 chromosomal effect Effects 0.000 claims description 2
- 230000003247 decreasing effect Effects 0.000 claims description 2
- 238000012217 deletion Methods 0.000 claims description 2
- 230000037430 deletion Effects 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims description 2
- 102000038379 digestive enzymes Human genes 0.000 claims description 2
- 108091007734 digestive enzymes Proteins 0.000 claims description 2
- 238000002474 experimental method Methods 0.000 claims description 2
- 210000001508 eye Anatomy 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 238000011331 genomic analysis Methods 0.000 claims description 2
- 210000003917 human chromosome Anatomy 0.000 claims description 2
- 238000003780 insertion Methods 0.000 claims description 2
- 230000037431 insertion Effects 0.000 claims description 2
- 210000002751 lymph Anatomy 0.000 claims description 2
- 210000003097 mucus Anatomy 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 claims description 2
- 210000003296 saliva Anatomy 0.000 claims description 2
- 210000000582 semen Anatomy 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 210000004243 sweat Anatomy 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 22
- 230000004075 alteration Effects 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 238000000151 deposition Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021180899A JP7304393B2 (ja) | 2016-08-25 | 2021-11-05 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
| JP2023044421A JP2023078336A (ja) | 2016-08-25 | 2023-03-20 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
| JP2024094503A JP2024107320A (ja) | 2016-08-25 | 2024-06-11 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662379593P | 2016-08-25 | 2016-08-25 | |
| US62/379,593 | 2016-08-25 | ||
| US201762481538P | 2017-04-04 | 2017-04-04 | |
| US62/481,538 | 2017-04-04 | ||
| PCT/US2017/048434 WO2018039463A1 (en) | 2016-08-25 | 2017-08-24 | Methods for the detection of genomic copy changes in dna samples |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021180899A Division JP7304393B2 (ja) | 2016-08-25 | 2021-11-05 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019526257A JP2019526257A (ja) | 2019-09-19 |
| JP2019526257A5 true JP2019526257A5 (cg-RX-API-DMAC7.html) | 2020-08-20 |
| JP7217224B2 JP7217224B2 (ja) | 2023-02-02 |
Family
ID=61245331
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511456A Active JP7217224B2 (ja) | 2016-08-25 | 2017-08-24 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
| JP2021180899A Active JP7304393B2 (ja) | 2016-08-25 | 2021-11-05 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
| JP2023044421A Pending JP2023078336A (ja) | 2016-08-25 | 2023-03-20 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
| JP2024094503A Pending JP2024107320A (ja) | 2016-08-25 | 2024-06-11 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021180899A Active JP7304393B2 (ja) | 2016-08-25 | 2021-11-05 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
| JP2023044421A Pending JP2023078336A (ja) | 2016-08-25 | 2023-03-20 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
| JP2024094503A Pending JP2024107320A (ja) | 2016-08-25 | 2024-06-11 | Ｄｎａ試料中のゲノムコピー変化の検出方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11319594B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP4667584A2 (cg-RX-API-DMAC7.html) |
| JP (4) | JP7217224B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR102850460B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN109804080B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2017315769B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3034649A1 (cg-RX-API-DMAC7.html) |
| IL (2) | IL264971B2 (cg-RX-API-DMAC7.html) |
| MX (2) | MX2019002093A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ750902A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2019108294A (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201901371XA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018039463A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3561072A1 (en) | 2012-12-10 | 2019-10-30 | Resolution Bioscience, Inc. | Methods for targeted genomic analysis |
| US20160053301A1 (en) | 2014-08-22 | 2016-02-25 | Clearfork Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
| CA3004435A1 (en) | 2015-11-11 | 2017-05-18 | Resolution Bioscience, Inc. | High efficiency construction of dna libraries |
| SG11201901371XA (en) | 2016-08-25 | 2019-03-28 | Resolution Bioscience Inc | Methods for the detection of genomic copy changes in dna samples |
| EP3762513A1 (en) * | 2018-03-08 | 2021-01-13 | St. Johns University | Circulating serum cell-free dna biomarkers and methods |
| GB2587939B (en) | 2018-04-02 | 2023-06-14 | Grail Llc | Methylation markers and targeted methylation probe panels |
| CN113286881A (zh) | 2018-09-27 | 2021-08-20 | 格里尔公司 | 甲基化标记和标靶甲基化探针板 |
| CN111118610A (zh) * | 2018-10-31 | 2020-05-08 | 深圳华大基因股份有限公司 | 用于基因突变高深度测序的基因芯片及其制备方法和应用 |
| US20210355546A1 (en) * | 2018-11-02 | 2021-11-18 | The Regents Of The University Of California | Methods to Diagnose and Treat Cancer Using Non-Human Nucleic Acids |
| DK3884071T3 (da) * | 2019-01-03 | 2025-06-10 | Ncan Genomics Inc | Sammenkædet måloptagelse |
| US20210310067A1 (en) * | 2019-01-24 | 2021-10-07 | Illumina, Inc. | Methods and systems for monitoring organ health and disease |
| KR20220021909A (ko) * | 2019-05-17 | 2022-02-22 | 더 존스 홉킨스 유니버시티 | 신속한 이수성 검출 |
| CA3147613A1 (en) * | 2019-08-19 | 2021-02-25 | Chang-Seok Ki | Method for detecting chromosomal abnormality by using information about distance between nucleic acid fragments |
| KR102452413B1 (ko) * | 2019-08-19 | 2022-10-11 | 주식회사 지씨지놈 | 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법 |
| KR102184277B1 (ko) * | 2020-01-16 | 2020-11-30 | 성균관대학교산학협력단 | 초음파 진단 및 dna 검사 일체형 ai 자가 건강 관리 장치 및 이를 이용한 원격 의료 진단 방법 |
| WO2021159184A1 (en) * | 2020-02-13 | 2021-08-19 | Garvan Institute Of Medical Research | Reference ladders and adaptors |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| CN113496760B (zh) * | 2020-04-01 | 2024-01-12 | 深圳华大基因科技服务有限公司 | 基于第三代测序的多倍体基因组组装方法和装置 |
| CN113113085B (zh) * | 2021-03-15 | 2022-08-19 | 杭州杰毅生物技术有限公司 | 基于智能宏基因组测序数据肿瘤检测的分析系统及方法 |
| GB202108237D0 (en) * | 2021-06-09 | 2021-07-21 | Univ London | Cancer methods |
| CN114649094B (zh) * | 2022-03-30 | 2022-11-15 | 广东省人民医院 | 一种基于核磁共振的乳腺癌多参数临床决策辅助装置 |
| WO2024029814A1 (ko) | 2022-08-04 | 2024-02-08 | 주식회사 엘지에너지솔루션 | 배터리 팩 |
Family Cites Families (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5591582A (en) | 1985-07-23 | 1997-01-07 | The Board Of Rijks Universiteit Leiden | Methods for detecting activated RAS oncogenes |
| US5888731A (en) | 1995-08-30 | 1999-03-30 | Visible Genetics Inc. | Method for identification of mutations using ligation of multiple oligonucleotide probes |
| US5972618A (en) | 1997-08-28 | 1999-10-26 | Bloch; Will | Detection of mutations in nucleic acids by chemical cleavage |
| US6480791B1 (en) | 1998-10-28 | 2002-11-12 | Michael P. Strathmann | Parallel methods for genomic analysis |
| US6812341B1 (en) | 2001-05-11 | 2004-11-02 | Ambion, Inc. | High efficiency mRNA isolation methods and compositions |
| WO2003052116A2 (en) | 2001-07-17 | 2003-06-26 | Stratagene | Methods for detection of a target nucleic acid using multi-subunit probes |
| AU2002322518A1 (en) | 2001-08-31 | 2003-03-18 | Rosetta Inpharmactis Llc | Methods for preparing nucleic acid samples |
| US7361821B2 (en) | 2002-09-20 | 2008-04-22 | Intel Corporation | Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading |
| JP4441623B2 (ja) | 2002-12-11 | 2010-03-31 | 学校法人慶應義塾 | 対応付け分子およびその構成要素のライブラリーの製造方法および利用方法 |
| TW200506052A (en) | 2003-05-07 | 2005-02-16 | Takara Bio Inc | Method of analyzing DNA region |
| US7393665B2 (en) | 2005-02-10 | 2008-07-01 | Population Genetics Technologies Ltd | Methods and compositions for tagging and identifying polynucleotides |
| NZ564923A (en) | 2005-07-07 | 2012-02-24 | Athlomics Pty Ltd | Polynucleotide marker genes and their expression, for diagnosis of endotoxemia |
| GB0522310D0 (en) | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
| WO2007081841A2 (en) | 2006-01-06 | 2007-07-19 | Stratagene California | Reaction buffer composition for nucleic acid replication with packed dna polymerases |
| WO2007087312A2 (en) | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Molecular counting |
| US8383338B2 (en) | 2006-04-24 | 2013-02-26 | Roche Nimblegen, Inc. | Methods and systems for uniform enrichment of genomic regions |
| US7754429B2 (en) | 2006-10-06 | 2010-07-13 | Illumina Cambridge Limited | Method for pair-wise sequencing a plurity of target polynucleotides |
| US8568979B2 (en) | 2006-10-10 | 2013-10-29 | Illumina, Inc. | Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| WO2009023676A1 (en) | 2007-08-12 | 2009-02-19 | Integrated Dna Technologies, Inc. | Microarray system with improved sequence specificity |
| US9388457B2 (en) | 2007-09-14 | 2016-07-12 | Affymetrix, Inc. | Locus specific amplification using array probes |
| JP5362738B2 (ja) | 2007-12-05 | 2013-12-11 | コンプリート・ジェノミックス・インコーポレイテッド | シーケンシング反応における効率のよい塩基決定 |
| WO2009091798A1 (en) | 2008-01-16 | 2009-07-23 | Helicos Biosciences Corporation | Quantitative genetic analysis |
| US8202691B2 (en) | 2008-01-25 | 2012-06-19 | Illumina, Inc. | Uniform fragmentation of DNA using binding proteins |
| US8383345B2 (en) | 2008-09-12 | 2013-02-26 | University Of Washington | Sequence tag directed subassembly of short sequencing reads into long sequencing reads |
| US8728764B2 (en) | 2008-10-02 | 2014-05-20 | Illumina Cambridge Limited | Nucleic acid sample enrichment for sequencing applications |
| WO2010068856A1 (en) | 2008-12-11 | 2010-06-17 | Trustees Of Boston University | Isolation of rna |
| EP2789694A1 (en) | 2009-04-02 | 2014-10-15 | Fluidigm Corporation | Microfluidic device with reaction product recovery system |
| US9085798B2 (en) | 2009-04-30 | 2015-07-21 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| WO2010129937A2 (en) | 2009-05-08 | 2010-11-11 | Life Technologies Corporation | Methods for detecting genetic variations in dna samples |
| CA2770389C (en) | 2009-08-25 | 2015-12-29 | Illumina, Inc. | Methods for selecting and amplifying polynucleotides |
| US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US10388403B2 (en) | 2010-01-19 | 2019-08-20 | Verinata Health, Inc. | Analyzing copy number variation in the detection of cancer |
| US10378064B1 (en) | 2010-04-16 | 2019-08-13 | Chronix Biomedical | Analyzing circulating nucleic acids to identify a biomarker representative of cancer presented by a patient population |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US8828688B2 (en) | 2010-05-27 | 2014-09-09 | Affymetrix, Inc. | Multiplex amplification methods |
| EP2580378A4 (en) | 2010-06-08 | 2014-01-01 | Nugen Technologies Inc | MULTIPLEX SEQUENCING METHODS AND COMPOSITION |
| EP2426217A1 (en) | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| KR20130113447A (ko) | 2010-09-24 | 2013-10-15 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 고정된 프라이머들을 이용하여 표적 dna의 직접적인 캡쳐, 증폭 및 서열화 |
| EP2646579B1 (en) | 2010-11-30 | 2017-06-14 | The Chinese University Of Hong Kong | Detection of genetic or molecular aberrations associated with cancer |
| KR20210131432A (ko) | 2010-12-30 | 2021-11-02 | 파운데이션 메디신 인코포레이티드 | 종양 샘플의 다유전자 분석의 최적화 |
| RU2671980C2 (ru) | 2011-02-09 | 2018-11-08 | Натера, Инк. | Способы неинвазивного пренатального установления плоидности |
| US9260753B2 (en) | 2011-03-24 | 2016-02-16 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
| ES2806728T3 (es) | 2011-04-12 | 2021-02-18 | Verinata Health Inc | Resolución de fracciones de genoma usando recuentos de polimorfismos |
| PL3246416T3 (pl) | 2011-04-15 | 2024-09-30 | The Johns Hopkins University | Bezpieczny system sekwencjonowania |
| US9809904B2 (en) * | 2011-04-21 | 2017-11-07 | University Of Washington Through Its Center For Commercialization | Methods for retrieval of sequence-verified DNA constructs |
| WO2013056178A2 (en) | 2011-10-14 | 2013-04-18 | Foundation Medicine, Inc. | Novel estrogen receptor mutations and uses thereof |
| CN103103624B (zh) | 2011-11-15 | 2014-12-31 | 深圳华大基因科技服务有限公司 | 高通量测序文库的构建方法及其应用 |
| US10227587B2 (en) | 2012-01-10 | 2019-03-12 | Berry Genomics Co., Ltd. | Method for constructing a plasma DNA sequencing library |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| US9752188B2 (en) | 2012-03-20 | 2017-09-05 | University Of Washington Through Its Center For Commercialization | Methods of lowering the error rate of massively parallel DNA sequencing using duplex consensus sequencing |
| US20130288915A1 (en) | 2012-04-27 | 2013-10-31 | Htg Molecular Diagnostics, Inc. | Compositions and methods for alk molecular testing |
| CA2872141C (en) | 2012-05-31 | 2016-01-19 | Board Of Regents, The University Of Texas System | Method for accurate sequencing of dna |
| AU2013286635B2 (en) | 2012-07-03 | 2018-11-08 | Foundation Medicine, Inc. | Tm-enhanced blocking oligonucleotides and baits for improved target enrichment and reduced off-target selection |
| JP2015526078A (ja) | 2012-07-31 | 2015-09-10 | ノバルティス アーゲー | ヒト二重微小染色体２阻害剤と関連するマーカー |
| EP4119676A1 (en) | 2012-08-03 | 2023-01-18 | Foundation Medicine, Inc. | Human papilloma virus as predictor of cancer prognosis |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| SG10202000486VA (en) | 2012-09-04 | 2020-03-30 | Guardant Health Inc | Systems and methods to detect rare mutations and copy number variation |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| JP2015530113A (ja) | 2012-09-28 | 2015-10-15 | セファイド | マイクロｒｎａ多重アッセイのための２プライマーｐｃｒ |
| EP2904534B1 (en) | 2012-10-04 | 2021-12-15 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US20150291953A1 (en) | 2012-11-02 | 2015-10-15 | Enzymatics Inc. | Methods and kits for nucleic acid sample preparation for sequencing |
| EP2914621B1 (en) | 2012-11-05 | 2023-06-07 | Foundation Medicine, Inc. | Novel ntrk1 fusion molecules and uses thereof |
| EP3561072A1 (en) | 2012-12-10 | 2019-10-30 | Resolution Bioscience, Inc. | Methods for targeted genomic analysis |
| US9909186B2 (en) | 2012-12-14 | 2018-03-06 | Chronix Biomedical | Personalized biomarkers for cancer |
| US11158425B2 (en) | 2013-01-05 | 2021-10-26 | Foundation Medicine, Inc. | System and method for managing genomic information |
| US20140242581A1 (en) | 2013-01-23 | 2014-08-28 | Reproductive Genetics And Technology Solutions, Llc | Compositions and methods for genetic analysis of embryos |
| US10745686B2 (en) | 2013-02-08 | 2020-08-18 | Qiagen Gmbh | Method for separating DNA by size |
| CA2906818C (en) | 2013-03-15 | 2022-08-16 | Verinata Health, Inc. | Generating cell-free dna libraries directly from blood |
| EP4253558B1 (en) | 2013-03-15 | 2025-07-02 | The Board of Trustees of the Leland Stanford Junior University | Identification and use of circulating nucleic acid tumor markers |
| HK1222466A1 (zh) | 2013-05-10 | 2017-06-30 | Foundation Medicine, Inc | 遗传变异分析 |
| US20150072344A1 (en) * | 2013-09-10 | 2015-03-12 | Imdaptive Incorporated | Barcoded Universal Marker Indicator (BUMI) Tags |
| US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
| EP3068883B1 (en) | 2013-11-13 | 2020-04-29 | Nugen Technologies, Inc. | Compositions and methods for identification of a duplicate sequencing read |
| CN103668471B (zh) | 2013-12-19 | 2015-09-30 | 上海交通大学 | 一种构建dna高通量测序文库的方法及其配套试剂盒 |
| SG10201804519RA (en) | 2013-12-28 | 2018-07-30 | Guardant Health Inc | Methods and systems for detecting genetic variants |
| EP3099796B1 (en) | 2014-01-31 | 2018-08-29 | Swift Biosciences, Inc. | Improved methods for processing dna substrates |
| WO2015134552A1 (en) | 2014-03-03 | 2015-09-11 | Swift Biosciences, Inc. | Enhanced adaptor ligation |
| US10975371B2 (en) | 2014-04-29 | 2021-04-13 | Illumina, Inc. | Nucleic acid sequence analysis from single cells |
| KR20170026383A (ko) | 2014-06-26 | 2017-03-08 | 10엑스 제노믹스, 인크. | 핵산 서열의 분석 |
| CA2957633A1 (en) | 2014-08-06 | 2016-02-11 | Nugen Technologies, Inc. | Digital measurements from targeted sequencing |
| CA2957657A1 (en) | 2014-08-22 | 2016-02-25 | Resolution Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
| US20160053301A1 (en) | 2014-08-22 | 2016-02-25 | Clearfork Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
| CN106661636A (zh) | 2014-09-05 | 2017-05-10 | 凯杰有限公司 | 衔接子连接的扩增子的制备 |
| WO2016037358A1 (zh) | 2014-09-12 | 2016-03-17 | 深圳华大基因科技有限公司 | 分离的寡核苷酸及其在核酸测序中的用途 |
| US11085084B2 (en) | 2014-09-12 | 2021-08-10 | The Board Of Trustees Of The Leland Stanford Junior University | Identification and use of circulating nucleic acids |
| CA2967447C (en) | 2014-12-05 | 2025-07-08 | Foundation Medicine, Inc. | MULTIGEN ANALYSIS OF TUMOR SAMPLES |
| EP3230469B1 (en) | 2014-12-12 | 2019-04-03 | Verinata Health, Inc. | Using cell-free dna fragment size to determine copy number variations |
| EP3240911B1 (en) | 2014-12-31 | 2020-08-26 | Guardant Health, Inc. | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
| DK3256605T3 (da) | 2015-02-10 | 2022-03-14 | Univ Hong Kong Chinese | Påvisning af mutationer til cancerscreening og føtal analyse |
| ES2960201T3 (es) | 2015-07-23 | 2024-03-01 | Univ Hong Kong Chinese | Análisis de los patrones de fragmentación del ADN acelular |
| WO2017062867A1 (en) | 2015-10-09 | 2017-04-13 | Helmy Eltoukhy | Population based treatment recommender using cell free dna |
| WO2017062970A1 (en) | 2015-10-10 | 2017-04-13 | Guardant Health, Inc. | Methods and applications of gene fusion detection in cell-free dna analysis |
| CA3004435A1 (en) | 2015-11-11 | 2017-05-18 | Resolution Bioscience, Inc. | High efficiency construction of dna libraries |
| US10095831B2 (en) | 2016-02-03 | 2018-10-09 | Verinata Health, Inc. | Using cell-free DNA fragment size to determine copy number variations |
| WO2017151524A1 (en) | 2016-02-29 | 2017-09-08 | Foundation Medicine, Inc. | Methods and systems for evaluating tumor mutational burden |
| WO2017214557A1 (en) | 2016-06-10 | 2017-12-14 | Counsyl, Inc. | Nucleic acid sequencing adapters and uses thereof |
| SG11201901371XA (en) * | 2016-08-25 | 2019-03-28 | Resolution Bioscience Inc | Methods for the detection of genomic copy changes in dna samples |
| CA3126055C (en) | 2016-09-30 | 2025-08-12 | Guardant Health, Inc. | MULTIRESOLUTION ANALYSIS METHODS FOR ACELLULAR NUCLEIC ACIDS |
| US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
| ES2980292T3 (es) | 2016-11-17 | 2024-09-30 | Lgc Clinical Diagnostics Inc | Métodos para preparar material de referencia y controles de ADN |
| CA3268717A1 (en) | 2016-12-09 | 2025-11-29 | Ncan Genomics, Inc. | Bound ligature |
| JP7046097B2 (ja) | 2017-04-14 | 2022-04-01 | ガーダント ヘルス， インコーポレイテッド | 試料核酸にアダプターを付着する方法 |
| AU2019384154B2 (en) | 2018-11-21 | 2025-11-20 | Agilent Technologies, Inc. | Methods for targeted nucleic acid library formation |
-
2017
- 2017-08-24 SG SG11201901371XA patent/SG11201901371XA/en unknown
- 2017-08-24 EP EP25208083.3A patent/EP4667584A2/en active Pending
- 2017-08-24 US US15/685,834 patent/US11319594B2/en active Active
- 2017-08-24 CA CA3034649A patent/CA3034649A1/en active Pending
- 2017-08-24 AU AU2017315769A patent/AU2017315769B2/en active Active
- 2017-08-24 EP EP17844424.6A patent/EP3504347B1/en active Active
- 2017-08-24 CN CN201780059053.2A patent/CN109804080B/zh active Active
- 2017-08-24 IL IL264971A patent/IL264971B2/en unknown
- 2017-08-24 IL IL312894A patent/IL312894A/en unknown
- 2017-08-24 CN CN202310805405.1A patent/CN117286217A/zh not_active Withdrawn
- 2017-08-24 MX MX2019002093A patent/MX2019002093A/es unknown
- 2017-08-24 JP JP2019511456A patent/JP7217224B2/ja active Active
- 2017-08-24 RU RU2019108294A patent/RU2019108294A/ru not_active Application Discontinuation
- 2017-08-24 NZ NZ750902A patent/NZ750902A/en unknown
- 2017-08-24 WO PCT/US2017/048434 patent/WO2018039463A1/en not_active Ceased
- 2017-08-24 KR KR1020237006718A patent/KR102850460B1/ko active Active
- 2017-08-24 KR KR1020197008555A patent/KR102505122B1/ko active Active
-
2019
- 2019-02-21 MX MX2024001256A patent/MX2024001256A/es unknown
-
2021
- 2021-11-05 JP JP2021180899A patent/JP7304393B2/ja active Active
-
2022
- 2022-01-27 US US17/586,143 patent/US20220325353A1/en active Pending
-
2023
- 2023-03-20 JP JP2023044421A patent/JP2023078336A/ja active Pending
-
2024
- 2024-04-12 AU AU2024202414A patent/AU2024202414A1/en active Pending
- 2024-06-11 JP JP2024094503A patent/JP2024107320A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019526257A5 (cg-RX-API-DMAC7.html) | ||
| RU2019108294A (ru) | Способы обнаружения изменений количества геномных копий в образцах днк | |
| US20240102101A1 (en) | Systems and methods to detect rare mutations and copy number variation | |
| JP7119014B2 (ja) | まれな変異およびコピー数多型を検出するためのシステムおよび方法 | |
| US11111541B2 (en) | Diagnostic MiRNA markers for Parkinson's disease | |
| RU2018121254A (ru) | Высокоэффективное построение библиотек днк | |
| JP2019504618A5 (cg-RX-API-DMAC7.html) | ||
| RS59073B1 (sr) | Analiza zasnovana na veličini frakcije fetusne dnk u majčinoj plazmi | |
| TWI670495B (zh) | 一種鑑定樣本中腫瘤負荷的方法和系統 | |
| JP2017525371A5 (cg-RX-API-DMAC7.html) | ||
| CN105793438B (zh) | 未知序列的双股线性核酸的全长扩增方法 | |
| US10457988B2 (en) | MiRNAs as diagnostic markers | |
| CN107208153A (zh) | 血浆线粒体dna分析的应用 | |
| JP5789720B2 (ja) | 遺伝子変異分析装置、遺伝子変異分析システム及び遺伝子変異分析方法 | |
| JP6571526B2 (ja) | 鎖を除外することによりマイクロアレイの性能を向上する方法 | |
| KR20150014937A (ko) | Rna 완전성을 결정하는 방법 | |
| CN106591425A (zh) | 基于连接反应的多重靶向检测核酸指标的方法 | |
| EP2733634A1 (en) | Method for obtaining gene signature scores | |
| HK1202135B (en) | Size-based analysis of fetal dna fraction in maternal plasma |