JP2019525772A5 - - Google Patents

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Publication number

JP2019525772A5

JP2019525772A5 JP2019521522A JP2019521522A JP2019525772A5 JP 2019525772 A5 JP2019525772 A5 JP 2019525772A5 JP 2019521522 A JP2019521522 A JP 2019521522A JP 2019521522 A JP2019521522 A JP 2019521522A JP 2019525772 A5 JP2019525772 A5 JP 2019525772A5

Authority

JP

Japan

Prior art keywords

seq

antibody

chain variable

subject

variable region

Prior art date

2017-07-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 125000003275 alpha amino acid group Chemical group 0.000 claims 11
• 150000001413 amino acids Chemical group 0.000 claims 10
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 7
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
• 239000008280 blood Substances 0.000 claims 5
• 210000004369 blood Anatomy 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 3
• 108010062497 VLDL Lipoproteins Proteins 0.000 claims 3
• 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 3
• 102000018616 Apolipoproteins B Human genes 0.000 claims 2
• 108010027006 Apolipoproteins B Proteins 0.000 claims 2
• 108010004103 Chylomicrons Proteins 0.000 claims 2
• 229940127355 PCSK9 Inhibitors Drugs 0.000 claims 2
• 239000003524 antilipemic agent Substances 0.000 claims 2
• 230000027455 binding Effects 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
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• 229960000815 ezetimibe Drugs 0.000 claims 2
• OLNTVTPDXPETLC-XPWALMASSA-N ezetimibe Chemical compound N1([C@@H]([C@H](C1=O)CC[C@H](O)C=1C=CC(F)=CC=1)C=1C=CC(O)=CC=1)C1=CC=C(F)C=C1 OLNTVTPDXPETLC-XPWALMASSA-N 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 claims 2
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• 230000000291 postprandial effect Effects 0.000 claims 2
• FJLGEFLZQAZZCD-MCBHFWOFSA-N (3R,5S)-fluvastatin Chemical compound C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 FJLGEFLZQAZZCD-MCBHFWOFSA-N 0.000 claims 1
• 206010002383 Angina Pectoris Diseases 0.000 claims 1
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• XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 1
• XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims 1
• 208000024172 Cardiovascular disease Diseases 0.000 claims 1
• 102100022119 Lipoprotein lipase Human genes 0.000 claims 1
• PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims 1
• TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims 1
• RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims 1
• 208000006011 Stroke Diseases 0.000 claims 1
• 229960004539 alirocumab Drugs 0.000 claims 1
• 229960005370 atorvastatin Drugs 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
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• 229960002027 evolocumab Drugs 0.000 claims 1
• 229960003765 fluvastatin Drugs 0.000 claims 1
• 210000003494 hepatocyte Anatomy 0.000 claims 1
• 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 230000004576 lipid-binding Effects 0.000 claims 1
• 230000004130 lipolysis Effects 0.000 claims 1
• 229960004844 lovastatin Drugs 0.000 claims 1
• PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims 1
• QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims 1
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• 229960002797 pitavastatin Drugs 0.000 claims 1
• VGYFMXBACGZSIL-MCBHFWOFSA-N pitavastatin Chemical compound OC(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 VGYFMXBACGZSIL-MCBHFWOFSA-N 0.000 claims 1
• 229960002965 pravastatin Drugs 0.000 claims 1
• TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims 1
• 229960000672 rosuvastatin Drugs 0.000 claims 1
• BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 claims 1
• 229960002855 simvastatin Drugs 0.000 claims 1
• RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims 1
• UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1