JP2019524772A - ５−コレステン−３，２５−ジオール，３−サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物 - Google Patents

５−コレステン−３，２５−ジオール，３−サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物 Download PDF

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JP2019524772A
JP2019524772A JP2019505229A JP2019505229A JP2019524772A JP 2019524772 A JP2019524772 A JP 2019524772A JP 2019505229 A JP2019505229 A JP 2019505229A JP 2019505229 A JP2019505229 A JP 2019505229A JP 2019524772 A JP2019524772 A JP 2019524772A
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25hc3s
composition
cyclodextrin
disease
liver
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JP2019524772A5 (enExample
Inventor
レン，シュンリン
スー，レユアン
ニン，ヤンシア
キム，ジン，コウン
リン，ウェイチー
ジーン キム，ミー
ジーン キム，ミー
ミクスズタル，アンドリュー，アール．
ウー，ホンウェイ
リー，ミン，エル．
タムラズ，ウィルマ
Original Assignee
ヴァージニア コモンウェルス ユニバーシティ
ヴァージニア コモンウェルス ユニバーシティ
デュレクト コーポレーション
デュレクト コーポレーション
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Publication of JP2019524772A publication Critical patent/JP2019524772A/ja
Publication of JP2019524772A5 publication Critical patent/JP2019524772A5/ja
Priority to JP2022122494A priority Critical patent/JP7487264B2/ja
Priority to JP2024075682A priority patent/JP2024105442A/ja
Pending legal-status Critical Current

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    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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JP2019505229A 2016-08-02 2017-08-01 ５−コレステン−３，２５−ジオール，３−サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物 Pending JP2019524772A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022122494A JP7487264B2 (ja) 2016-08-02 2022-08-01 ５－コレステン－３，２５－ジオール，３－サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物
JP2024075682A JP2024105442A (ja) 2016-08-02 2024-05-08 ５－コレステン－３，２５－ジオール，３－サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662370024P 2016-08-02 2016-08-02
US62/370,024 2016-08-02
US201762470578P 2017-03-13 2017-03-13
US62/470,578 2017-03-13
PCT/US2017/044840 WO2018026781A1 (en) 2016-08-02 2017-08-01 Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide

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JP2022122494A Division JP7487264B2 (ja) 2016-08-02 2022-08-01 ５－コレステン－３，２５－ジオール，３－サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物

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JP2019524772A true JP2019524772A (ja) 2019-09-05
JP2019524772A5 JP2019524772A5 (enExample) 2020-08-20

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JP2019505229A Pending JP2019524772A (ja) 2016-08-02 2017-08-01 ５−コレステン−３，２５−ジオール，３−サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物
JP2022122494A Active JP7487264B2 (ja) 2016-08-02 2022-08-01 ５－コレステン－３，２５－ジオール，３－サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物
JP2024075682A Pending JP2024105442A (ja) 2016-08-02 2024-05-08 ５－コレステン－３，２５－ジオール，３－サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物

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JP2022122494A Active JP7487264B2 (ja) 2016-08-02 2022-08-01 ５－コレステン－３，２５－ジオール，３－サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物
JP2024075682A Pending JP2024105442A (ja) 2016-08-02 2024-05-08 ５－コレステン－３，２５－ジオール，３－サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物

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US (4) US20190269695A1 (enExample)
EP (2) EP3494125B1 (enExample)
JP (3) JP2019524772A (enExample)
KR (3) KR102465046B1 (enExample)
CN (2) CN116747233A (enExample)
AU (2) AU2017305239C1 (enExample)
CA (1) CA3031224A1 (enExample)
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IL (2) IL298681A (enExample)
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PL (1) PL3494125T3 (enExample)
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RS (1) RS63529B1 (enExample)
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Families Citing this family (14)

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Publication number Priority date Publication date Assignee Title
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
EA201990684A1 (ru) 2013-12-24 2020-12-30 Вирджиния Коммонвелт Юниверсити Способы применения оксигенированных холестеролсульфатов (ocs)
IL298681A (en) * 2016-08-02 2023-01-01 Univ Virginia Commonwealth Preparations
JP7830313B2 (ja) * 2019-09-30 2026-03-16 デュレクト コーポレーション アルコール性肝炎の処置
CN115103591B (zh) * 2019-12-27 2026-06-19 度勒科特公司 结晶性和液体结晶性25-羟基-胆甾-5-烯-3-硫酸钠及其制备方法
CA3170320A1 (en) * 2020-02-11 2021-08-19 Durect Corporation Treatment of infectious diseases
US12478603B2 (en) 2020-03-31 2025-11-25 The Regents Of The University Of Michigan Serum metabolites as biomarkers for carnitine treatment of sepsis
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