AU2017305239C1 - Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide - Google Patents

Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide Download PDF

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Publication number
AU2017305239C1
AU2017305239C1 AU2017305239A AU2017305239A AU2017305239C1 AU 2017305239 C1 AU2017305239 C1 AU 2017305239C1 AU 2017305239 A AU2017305239 A AU 2017305239A AU 2017305239 A AU2017305239 A AU 2017305239A AU 2017305239 C1 AU2017305239 C1 AU 2017305239C1
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Australia
Prior art keywords
25hc3s
composition
aspects
cyclodextrin
pharmaceutically acceptable
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AU2017305239A
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English (en)
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AU2017305239A1 (en
AU2017305239B2 (en
Inventor
Jin Koung Kim
Mee Jean KIM
Min L. Lee
Weiqi Lin
Andrew R. Miksztal
Yanxia NING
Shunlin Ren
Wilma Tamraz
Hongwei WU
Leyuan XU
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Virginia Commonwealth University
Medicis Pharmaceutical Corp
United States Department of Veterans Affairs
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Virginia Commonwealth University
Medicis Pharmaceutical Corp
United States Department of Veterans Affairs
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Publication of AU2017305239A1 publication Critical patent/AU2017305239A1/en
Assigned to VIRGINIA COMMONWEALTH UNIVERSITY, DURECT CORPORATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS reassignment VIRGINIA COMMONWEALTH UNIVERSITY Amend patent request/document other than specification (104) Assignors: DURECT CORPORATION, VIRGINIA COMMONWEALTH UNIVERSITY
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Publication of AU2017305239B2 publication Critical patent/AU2017305239B2/en
Priority to AU2022204217A priority Critical patent/AU2022204217B2/en
Publication of AU2017305239C1 publication Critical patent/AU2017305239C1/en
Assigned to VIRGINIA COMMONWEALTH UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, MEDICIS PHARMACEUTICAL CORPORATION reassignment VIRGINIA COMMONWEALTH UNIVERSITY Request to Amend Deed and Register Assignors: THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, DURECT CORPORATION, VIRGINIA COMMONWEALTH UNIVERSITY
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/738—Cyclodextrins
    • A—HUMAN NECESSITIES
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    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61K31/716—Glucans
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical Kinetics & Catalysis (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
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  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
AU2017305239A 2016-08-02 2017-08-01 Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide Active AU2017305239C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022204217A AU2022204217B2 (en) 2016-08-02 2022-06-16 Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662370024P 2016-08-02 2016-08-02
US62/370,024 2016-08-02
US201762470578P 2017-03-13 2017-03-13
US62/470,578 2017-03-13
PCT/US2017/044840 WO2018026781A1 (en) 2016-08-02 2017-08-01 Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022204217A Division AU2022204217B2 (en) 2016-08-02 2022-06-16 Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide

Publications (3)

Publication Number Publication Date
AU2017305239A1 AU2017305239A1 (en) 2019-02-21
AU2017305239B2 AU2017305239B2 (en) 2022-03-17
AU2017305239C1 true AU2017305239C1 (en) 2022-08-18

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AU2017305239A Active AU2017305239C1 (en) 2016-08-02 2017-08-01 Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide
AU2022204217A Active AU2022204217B2 (en) 2016-08-02 2022-06-16 Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide

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AU2022204217A Active AU2022204217B2 (en) 2016-08-02 2022-06-16 Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide

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US (4) US20190269695A1 (enExample)
EP (2) EP3494125B1 (enExample)
JP (3) JP2019524772A (enExample)
KR (3) KR102465046B1 (enExample)
CN (2) CN116747233A (enExample)
AU (2) AU2017305239C1 (enExample)
CA (1) CA3031224A1 (enExample)
CY (1) CY1125567T1 (enExample)
DK (1) DK3494125T3 (enExample)
EA (1) EA201990438A1 (enExample)
ES (1) ES2922933T3 (enExample)
HR (1) HRP20220932T1 (enExample)
HU (1) HUE059768T2 (enExample)
IL (2) IL298681A (enExample)
LT (1) LT3494125T (enExample)
MX (2) MX2019001323A (enExample)
PL (1) PL3494125T3 (enExample)
PT (1) PT3494125T (enExample)
RS (1) RS63529B1 (enExample)
SI (1) SI3494125T1 (enExample)
SM (1) SMT202200330T1 (enExample)
TW (2) TWI920454B (enExample)
WO (1) WO2018026781A1 (enExample)

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WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
EA201990684A1 (ru) 2013-12-24 2020-12-30 Вирджиния Коммонвелт Юниверсити Способы применения оксигенированных холестеролсульфатов (ocs)
IL298681A (en) * 2016-08-02 2023-01-01 Univ Virginia Commonwealth Preparations
JP7830313B2 (ja) * 2019-09-30 2026-03-16 デュレクト コーポレーション アルコール性肝炎の処置
CN115103591B (zh) * 2019-12-27 2026-06-19 度勒科特公司 结晶性和液体结晶性25-羟基-胆甾-5-烯-3-硫酸钠及其制备方法
CA3170320A1 (en) * 2020-02-11 2021-08-19 Durect Corporation Treatment of infectious diseases
US12478603B2 (en) 2020-03-31 2025-11-25 The Regents Of The University Of Michigan Serum metabolites as biomarkers for carnitine treatment of sepsis
JP2023527153A (ja) * 2020-05-22 2023-06-27 デュレクト コーポレーション 非アルコール性脂肪性肝炎（ｎａｓｈ）の処置
CA3187310A1 (en) 2020-06-26 2021-12-30 Durect Corporation Use of oxygenated cholesterol sulfates for treating autoimmune conditions
CN112967234B (zh) * 2021-02-09 2022-12-09 复旦大学附属中山医院 冠状动脉功能生理学病变模式定量评价方法
US20240425545A1 (en) * 2021-06-25 2024-12-26 Durect Corporation 25-Hydroxy-Cholest-5-En-3-Sulfate Choline and Methods for Preparing, and Uses of, Same
CN113750039B (zh) * 2021-10-26 2023-08-18 浙江中医药大学 一种黄芩苷-海藻酸钙温敏纳米凝胶、制备方法及其应用
WO2023196412A1 (en) * 2022-04-06 2023-10-12 Nobias Therapeutics, Inc. Liquid formulations comprising mitogen-activated protein kinase kinase (mek) inhibitors and methods using same
CN119896674A (zh) * 2023-10-27 2025-04-29 上海交通大学医学院附属新华医院 胆固醇硫酸酯在制备治疗特应性皮炎的药物中的应用

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WO2015100312A1 (en) * 2013-12-24 2015-07-02 Virginia Commonwealth University Uses of oxygenated cholesterol sulfates (ocs)

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