JP2019520814A5 - - Google Patents

Info

Publication number

JP2019520814A5

JP2019520814A5 JP2018563822A JP2018563822A JP2019520814A5 JP 2019520814 A5 JP2019520814 A5 JP 2019520814A5 JP 2018563822 A JP2018563822 A JP 2018563822A JP 2018563822 A JP2018563822 A JP 2018563822A JP 2019520814 A5 JP2019520814 A5 JP 2019520814A5

Authority

JP

Japan

Prior art keywords

lcr

truncated

delivery system

outcome

viral delivery

Prior art date

2017-06-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 108090000623 proteins and genes Proteins 0.000 claims description 54
• 238000000034 method Methods 0.000 claims description 40
• 102000004169 proteins and genes Human genes 0.000 claims description 24
• 239000003999 initiator Substances 0.000 claims description 21
• 239000012634 fragment Substances 0.000 claims description 9
• 239000003102 growth factor Substances 0.000 claims description 3
• 102000015936 AP-1 transcription factor Human genes 0.000 claims 4
• 108050004195 AP-1 transcription factor Proteins 0.000 claims 4
• 230000004069 differentiation Effects 0.000 claims 1
• 230000002068 genetic effect Effects 0.000 claims 1
• 238000010362 genome editing Methods 0.000 claims 1
• 230000005746 immune checkpoint blockade Effects 0.000 claims 1
• 230000003053 immunization Effects 0.000 claims 1
• 238000002649 immunization Methods 0.000 claims 1
• 230000003308 immunostimulating effect Effects 0.000 claims 1
• 229940068196 placebo Drugs 0.000 claims 1
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• 230000008672 reprogramming Effects 0.000 claims 1
• 230000035897 transcription Effects 0.000 claims 1
• 238000013518 transcription Methods 0.000 claims 1
• 230000010076 replication Effects 0.000 description 26
• 108091070501 miRNA Proteins 0.000 description 15
• 239000002679 microRNA Substances 0.000 description 15
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 13
• 108091027967 Small hairpin RNA Proteins 0.000 description 13
• 108020004459 Small interfering RNA Proteins 0.000 description 13
• 239000000047 product Substances 0.000 description 13
• 239000002924 silencing RNA Substances 0.000 description 13
• 239000004055 small Interfering RNA Substances 0.000 description 13
• 241000341655 Human papillomavirus type 16 Species 0.000 description 10
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• 239000013612 plasmid Substances 0.000 description 6
• 101150052131 Pgap2 gene Proteins 0.000 description 5
• 230000004543 DNA replication Effects 0.000 description 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
• 108010061833 Integrases Proteins 0.000 description 3
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• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 2
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• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 2
• 230000001939 inductive effect Effects 0.000 description 2
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• 241000701822 Bovine papillomavirus Species 0.000 description 1
• 102100035875 C-C chemokine receptor type 5 Human genes 0.000 description 1
• 101710149870 C-C chemokine receptor type 5 Proteins 0.000 description 1
• 108010031111 EBV-encoded nuclear antigen 1 Proteins 0.000 description 1
• 241000701806 Human papillomavirus Species 0.000 description 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
• 241000713666 Lentivirus Species 0.000 description 1
• 241001631646 Papillomaviridae Species 0.000 description 1
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