CA3025247A1 - Non-integrating viral delivery system and methods related thereto - Google Patents

Non-integrating viral delivery system and methods related thereto Download PDF

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Publication number
CA3025247A1
CA3025247A1 CA3025247A CA3025247A CA3025247A1 CA 3025247 A1 CA3025247 A1 CA 3025247A1 CA 3025247 A CA3025247 A CA 3025247A CA 3025247 A CA3025247 A CA 3025247A CA 3025247 A1 CA3025247 A1 CA 3025247A1
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Prior art keywords
seq
viral
gene
delivery system
expression
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CA3025247A
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English (en)
French (fr)
Inventor
Charles David PAUZA
Tyler LAHUSEN
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American Gene Technologies International Inc
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American Gene Technologies International Inc
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    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
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    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
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    • C07K14/475—Growth factors; Growth regulators
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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CA3025247A 2016-06-08 2017-06-07 Non-integrating viral delivery system and methods related thereto Pending CA3025247A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662347552P 2016-06-08 2016-06-08
US62/347,552 2016-06-08
US201662431760P 2016-12-08 2016-12-08
US62/431,760 2016-12-08
USPCT/US2016/066185 2016-12-12
PCT/US2016/066185 WO2017213697A1 (en) 2016-06-08 2016-12-12 Non-integrating viral delivery system and methods related thereto
PCT/US2017/036433 WO2017214327A2 (en) 2016-06-08 2017-06-07 Non-integrating viral delivery system and methods related thereto

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CA3025247A1 true CA3025247A1 (en) 2017-12-14

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CA3025247A Pending CA3025247A1 (en) 2016-06-08 2017-06-07 Non-integrating viral delivery system and methods related thereto

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US (4) US11976292B2 (enExample)
EP (2) EP3468617A4 (enExample)
JP (5) JP7173548B2 (enExample)
KR (2) KR102762623B1 (enExample)
CN (1) CN109641064A (enExample)
AU (2) AU2017279542A1 (enExample)
BR (1) BR112018075399A2 (enExample)
CA (1) CA3025247A1 (enExample)
IL (1) IL263402A (enExample)
WO (2) WO2017213697A1 (enExample)

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US11980663B2 (en) 2015-07-08 2024-05-14 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
US10137144B2 (en) 2016-01-15 2018-11-27 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells
IL297238B2 (en) 2016-01-15 2024-08-01 American Gene Tech Int Inc Methods and preparations for gamma-delta T-cell activation
JP7153332B2 (ja) 2016-02-08 2022-10-14 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド Ｈｉｖワクチン接種および免疫療法
ES2911448T3 (es) 2016-03-09 2022-05-19 American Gene Tech Int Inc Vectores combinados y métodos para el tratamiento del cáncer
WO2017213697A1 (en) * 2016-06-08 2017-12-14 American Gene Technologies International Inc. Non-integrating viral delivery system and methods related thereto
CA3028982A1 (en) 2016-07-08 2018-01-11 American Gene Technologies International Inc. Hiv pre-immunization and immunotherapy
WO2018017882A1 (en) 2016-07-21 2018-01-25 American Gene Technologies International Inc. Viral vectors for treating parkinson's disease
US11820999B2 (en) 2017-04-03 2023-11-21 American Gene Technologies International Inc. Compositions and methods for treating phenylketonuria
US12559769B2 (en) 2017-06-16 2026-02-24 American Gene Technologies International Inc. Methods and compositions for the activation of tumor cytotoxicity via human gamma-delta t-cells
AU2021232603A1 (en) * 2020-03-03 2022-10-20 American Gene Technologies International Inc. On demand expression of exogenous factors in lymphocytes to treat HIV
CN112029803A (zh) * 2020-09-21 2020-12-04 西人马联合测控（泉州）科技有限公司 一种慢病毒过表达病毒载体及其制备方法、用途
CN113046330B (zh) * 2021-03-23 2023-03-21 中吉智药(南京)生物技术有限公司 携带红系基因编辑系统的慢病毒及药物
CN114395586A (zh) * 2022-01-12 2022-04-26 中国科学院天津工业生物技术研究所 非整合慢病毒载体系统在基因编辑器递送中的应用
CN114317610B (zh) * 2022-01-27 2024-07-02 上海本导基因技术有限公司 一种适用于帕金森疾病基因治疗的慢病毒载体

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