JP2019520396A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019520396A5 JP2019520396A5 JP2019500372A JP2019500372A JP2019520396A5 JP 2019520396 A5 JP2019520396 A5 JP 2019520396A5 JP 2019500372 A JP2019500372 A JP 2019500372A JP 2019500372 A JP2019500372 A JP 2019500372A JP 2019520396 A5 JP2019520396 A5 JP 2019520396A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- independently
- heterocyclyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 143
- 125000000623 heterocyclic group Chemical group 0.000 claims 65
- 229910052739 hydrogen Inorganic materials 0.000 claims 65
- 229910052799 carbon Inorganic materials 0.000 claims 56
- 229910052757 nitrogen Inorganic materials 0.000 claims 27
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 24
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 21
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 13
- -1 CN Inorganic materials 0.000 claims 13
- 125000004452 carbocyclyl group Chemical group 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 239000011780 sodium chloride Substances 0.000 claims 12
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 10
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 125000006706 (C3-C6) carbocyclyl group Chemical group 0.000 claims 5
- 125000005418 aryl aryl group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 125000004432 carbon atoms Chemical group C* 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000005842 heteroatoms Chemical group 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 208000008787 Cardiovascular Disease Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 2
- 206010002383 Angina pectoris Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 206010003816 Autoimmune disease Diseases 0.000 claims 1
- 206010007554 Cardiac failure Diseases 0.000 claims 1
- 206010019280 Heart failure Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 210000002464 Muscle, Smooth, Vascular Anatomy 0.000 claims 1
- 208000010125 Myocardial Infarction Diseases 0.000 claims 1
- 208000009025 Nervous System Disease Diseases 0.000 claims 1
- 206010029305 Neurological disorder Diseases 0.000 claims 1
- 206010034636 Peripheral vascular disease Diseases 0.000 claims 1
- 208000002815 Pulmonary Hypertension Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010047163 Vasospasm Diseases 0.000 claims 1
- 230000001594 aberrant Effects 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 201000001320 atherosclerosis Diseases 0.000 claims 1
- 201000001084 cerebrovascular disease Diseases 0.000 claims 1
- 201000008739 coronary artery disease Diseases 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000003176 fibrotic Effects 0.000 claims 1
- 200000000018 inflammatory disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001613 neoplastic Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 102000000568 rho-Associated Kinases Human genes 0.000 claims 1
- 108010041788 rho-Associated Kinases Proteins 0.000 claims 1
- 200000000009 stenosis Diseases 0.000 claims 1
- 230000036262 stenosis Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662359363P | 2016-07-07 | 2016-07-07 | |
| US62/359,363 | 2016-07-07 | ||
| PCT/US2017/040852 WO2018009627A1 (en) | 2016-07-07 | 2017-07-06 | Spiro-fused cyclic ureas as inhibitors of rock |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019520396A JP2019520396A (ja) | 2019-07-18 |
| JP2019520396A5 true JP2019520396A5 (US07585860-20090908-C00112.png) | 2020-08-13 |
| JP7155102B2 JP7155102B2 (ja) | 2022-10-18 |
Family
ID=59337924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019500372A Active JP7155102B2 (ja) | 2016-07-07 | 2017-07-06 | Ｒｏｃｋ阻害剤としてのスピロ縮合環尿素 |
Country Status (7)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR107354A1 (es) | 2016-01-13 | 2018-04-18 | Bristol Myers Squibb Co | Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock |
| WO2017205709A1 (en) | 2016-05-27 | 2017-11-30 | Bristol-Myers Squibb Company | Triazolones and tetrazolones as inhibitors of rock |
| JP7155102B2 (ja) | 2016-07-07 | 2022-10-18 | ブリストル－マイヤーズ スクイブ カンパニー | Ｒｏｃｋ阻害剤としてのスピロ縮合環尿素 |
| EP3481816B1 (en) | 2016-07-07 | 2020-06-24 | Bristol-Myers Squibb Company | Lactam, cyclic urea and carbamate, and triazolone derivatives as potent and selective rock inhibitors |
| ES2821877T3 (es) | 2016-07-07 | 2021-04-28 | Bristol Myers Squibb Co | Espirolactamas como inhibidores de ROCK |
| EP3548468B1 (en) | 2016-11-30 | 2020-09-16 | Bristol-Myers Squibb Company | Tricyclic rho kinase inhibitors |
| US11186544B2 (en) * | 2017-06-09 | 2021-11-30 | Bristol-Myers Squibb Company | Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists |
| CN110914257B (zh) | 2017-07-12 | 2023-05-26 | 百时美施贵宝公司 | 作为rock抑制剂的螺庚基乙内酰脲 |
| WO2019014303A1 (en) | 2017-07-12 | 2019-01-17 | Bristol-Myers Squibb Company | 5-OR 6,6-CHANNEL BICYCLIC CHAINS AND AMINOHETEROCYCLIC AMINOHETEROCYCLIC INHIBITORS FOR THE TREATMENT OF CARDIAC INSUFFICIENCY |
| ES2951212T3 (es) | 2017-07-12 | 2023-10-18 | Bristol Myers Squibb Co | Fenilacetamidas como inhibidores de ROCK |
| TW201908293A (zh) | 2017-07-12 | 2019-03-01 | 美商必治妥美雅史谷比公司 | 作為rock抑制劑之5員及雙環雜環醯胺 |
| EP3704121B1 (en) | 2017-11-03 | 2022-12-21 | Bristol-Myers Squibb Company | Diazaspiro rock inhibitors |
| BR112021008883A2 (pt) | 2018-11-06 | 2021-08-10 | Cervello Therapeutics, Llc | inibidores de rock quinase |
| US11248004B2 (en) | 2018-11-06 | 2022-02-15 | Cervello Therapeutics, Llc. | Substituted isoquinolines as rock kinase inhibitors |
| AU2022385051A1 (en) | 2021-11-11 | 2024-06-20 | Actualeyes Inc. | Cryopreservation preparation for corneal endothelial cells and method for producing said cryopreservation preparation |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004050039A2 (en) * | 2002-12-04 | 2004-06-17 | Merck & Co., Inc. | Spirocyclic ureas, compositions containing such compounds and methods of use |
| JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
| CA2664335C (en) | 2006-09-20 | 2014-12-02 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| CL2007003874A1 (es) | 2007-01-03 | 2008-05-16 | Boehringer Ingelheim Int | Compuestos derivados de benzamida; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades cardiovasculares, hipertension, aterosclerosis, reestenosis, ictus, insuficiencia cardiaca, lesion isquemica, hipertensio |
| BR112013012078A2 (pt) | 2010-11-15 | 2019-09-24 | Abbvie Inc | inibidores de nampt e rock |
| JP2014040374A (ja) * | 2010-12-15 | 2014-03-06 | Taisho Pharmaceutical Co Ltd | グリシントランスポーター阻害物質 |
| WO2014113620A2 (en) * | 2013-01-18 | 2014-07-24 | Bristol-Myers Squibb Company | Phthalazinones and isoquinolinones as rock inhibitors |
| JP6423372B2 (ja) * | 2013-02-28 | 2018-11-14 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 強力なｒｏｃｋ１およびｒｏｃｋ２阻害剤としてのフェニルピラゾール誘導体 |
| AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
| ES2634628T3 (es) * | 2013-07-02 | 2017-09-28 | Bristol-Myers Squibb Company | Derivados tricíclicos de pirido-carboxamida como inhibidores ROCK |
| EP3016951B1 (en) | 2013-07-02 | 2017-05-31 | Bristol-Myers Squibb Company | Tricyclic pyrido-carboxamide derivatives as rock inhibitors |
| US9902702B2 (en) | 2014-07-15 | 2018-02-27 | Bristol-Myers Squibb Company | Spirocycloheptanes as inhibitors of rock |
| CN107108581B (zh) | 2014-08-21 | 2020-06-23 | 百时美施贵宝公司 | 作为强效rock抑制剂的回接苯甲酰胺衍生物 |
| ES2815681T3 (es) * | 2015-01-09 | 2021-03-30 | Bristol Myers Squibb Co | Ureas cíclicas como inhibidores de ROCK |
| TW201706265A (zh) | 2015-03-09 | 2017-02-16 | 必治妥美雅史谷比公司 | 做為Ｒｈｏ激酶（ＲＯＣＫ）抑制劑之內醯胺 |
| AR107354A1 (es) | 2016-01-13 | 2018-04-18 | Bristol Myers Squibb Co | Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock |
| WO2017205709A1 (en) | 2016-05-27 | 2017-11-30 | Bristol-Myers Squibb Company | Triazolones and tetrazolones as inhibitors of rock |
| ES2821877T3 (es) | 2016-07-07 | 2021-04-28 | Bristol Myers Squibb Co | Espirolactamas como inhibidores de ROCK |
| JP7155102B2 (ja) | 2016-07-07 | 2022-10-18 | ブリストル－マイヤーズ スクイブ カンパニー | Ｒｏｃｋ阻害剤としてのスピロ縮合環尿素 |
| EP3481816B1 (en) | 2016-07-07 | 2020-06-24 | Bristol-Myers Squibb Company | Lactam, cyclic urea and carbamate, and triazolone derivatives as potent and selective rock inhibitors |
| EP3548468B1 (en) | 2016-11-30 | 2020-09-16 | Bristol-Myers Squibb Company | Tricyclic rho kinase inhibitors |
-
2017
- 2017-07-06 JP JP2019500372A patent/JP7155102B2/ja active Active
- 2017-07-06 CN CN201780054590.8A patent/CN109661396B/zh active Active
- 2017-07-06 WO PCT/US2017/040852 patent/WO2018009627A1/en unknown
- 2017-07-06 EP EP17739834.4A patent/EP3481828B1/en active Active
- 2017-07-06 KR KR1020197003129A patent/KR102449652B1/ko active IP Right Grant
- 2017-07-06 ES ES17739834T patent/ES2829550T3/es active Active
- 2017-07-06 US US16/315,679 patent/US10787450B2/en active Active
