JP2019519492A5 - - Google Patents
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- JP2019519492A5 JP2019519492A5 JP2018558733A JP2018558733A JP2019519492A5 JP 2019519492 A5 JP2019519492 A5 JP 2019519492A5 JP 2018558733 A JP2018558733 A JP 2018558733A JP 2018558733 A JP2018558733 A JP 2018558733A JP 2019519492 A5 JP2019519492 A5 JP 2019519492A5
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- 239000012634 fragment Substances 0.000 claims description 113
- 239000000427 antigen Substances 0.000 claims description 112
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- 108091007433 antigens Proteins 0.000 claims description 112
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- 101000840258 Homo sapiens Immunoglobulin J chain Proteins 0.000 claims description 10
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- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 6
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 6
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 5
- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 5
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- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims description 5
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- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 3
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- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 description 3
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- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 3
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662333643P | 2016-05-09 | 2016-05-09 | |
| US62/333,643 | 2016-05-09 | ||
| PCT/US2017/031791 WO2017196867A1 (en) | 2016-05-09 | 2017-05-09 | Anti-pd-l1 antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019519492A JP2019519492A (ja) | 2019-07-11 |
| JP2019519492A5 true JP2019519492A5 (enExample) | 2020-06-18 |
| JP6979971B2 JP6979971B2 (ja) | 2021-12-15 |
Family
ID=58710168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018558733A Active JP6979971B2 (ja) | 2016-05-09 | 2017-05-09 | 抗ｐｄ−ｌ１抗体 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10954302B2 (enExample) |
| EP (1) | EP3455257B1 (enExample) |
| JP (1) | JP6979971B2 (enExample) |
| KR (1) | KR102343742B1 (enExample) |
| CN (1) | CN109311985B (enExample) |
| AU (1) | AU2017264683B2 (enExample) |
| CA (1) | CA3021669A1 (enExample) |
| DK (1) | DK3455257T3 (enExample) |
| ES (1) | ES2899361T3 (enExample) |
| HU (1) | HUE055972T2 (enExample) |
| IL (1) | IL262295B2 (enExample) |
| PL (1) | PL3455257T3 (enExample) |
| PT (1) | PT3455257T (enExample) |
| SG (1) | SG11201809336QA (enExample) |
| WO (1) | WO2017196867A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250091304A (ko) | 2013-03-15 | 2025-06-20 | 제넨테크, 인크. | Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법 |
| CA2922830A1 (en) | 2013-09-05 | 2015-04-16 | Igm Biosciences, Inc. | Constant chain modified bispecific, penta- and hexavalent ig-m antibodies |
| AU2015213593B2 (en) | 2014-02-10 | 2020-09-03 | Igm Biosciences, Inc. | IgA multi-specific binding molecules |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| KR102380402B1 (ko) | 2014-04-03 | 2022-03-31 | 아이쥐엠 바이오사이언스 인코포레이티드 | 변형된 j-사슬 |
| EP3750918A1 (en) | 2015-01-20 | 2020-12-16 | IGM Biosciences, Inc. | Tumor necrosis factor (tnf) superfamily receptor binding molecules and uses thereof |
| CN115093479A (zh) | 2015-03-04 | 2022-09-23 | Igm生物科学股份有限公司 | Cd20结合分子及其用途 |
| AU2016233495B2 (en) | 2015-03-13 | 2022-02-24 | Cytomx Therapeutics, Inc | Anti-PDL1 antibodies, activatable anti-PDL1 antibodies, and methods of use thereof |
| JP6882184B2 (ja) | 2015-03-25 | 2021-06-02 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多価ｂ型肝炎ウイルス抗原結合分子およびその使用 |
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| MX2020007406A (es) * | 2018-01-10 | 2020-09-14 | Jiangsu Hengrui Medicine Co | Anticuerpo pd-l1, fragmento de union al antigeno del mismo y uso farmaceutico del mismo. |
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| CN114269785A (zh) * | 2019-08-15 | 2022-04-01 | Igm生物科学股份有限公司 | 免疫刺激性多聚体结合分子 |
| CN110746493A (zh) * | 2019-09-06 | 2020-02-04 | 中国药科大学 | 一种pd-l1拮抗剂多肽及其应用 |
| CN113121686B (zh) * | 2019-12-31 | 2025-12-02 | 迈威(上海)生物科技股份有限公司 | 抗pd-l1抗体及其应用 |
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| US20230212293A1 (en) | 2020-04-22 | 2023-07-06 | Igm Biosciences, Inc. | Pd-1 agonist multimeric binding molecules |
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| CA3187008A1 (en) * | 2020-07-27 | 2022-02-03 | Paul R. Hinton | Multimeric coronavirus binding molecules and uses thereof |
| CN116437944A (zh) * | 2020-08-03 | 2023-07-14 | 南特细胞公司 | Il-15超级激动剂的药物特异性药代动力学测定 |
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| CN113943371B (zh) * | 2021-11-01 | 2023-05-05 | 达石药业(广东)有限公司 | 一种抗her2/抗pd-l1双功能抗体及其应用 |
| WO2023178253A2 (en) * | 2022-03-18 | 2023-09-21 | Igm Biosciences, Inc. | Use of a multimeric anti-pd-l1 binding molecule in combination with a monoclonal antibody therapy |
| IL317449A (en) | 2022-06-07 | 2025-02-01 | Genentech Inc | Method for determining the efficacy of a lung cancer treatment comprising an anti-PD-L1 antagonist and an anti-TIGIT antibody-antagonist |
| EP4652201A1 (en) * | 2023-01-18 | 2025-11-26 | Elpiscience (Suzhou) Biopharma, Ltd. | Anti-pdl1 single domain antibody, fusion protein and use thereof |
| JP2026504180A (ja) | 2023-01-30 | 2026-02-03 | カイマブ・リミテッド | 抗体 |
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| JP6882184B2 (ja) | 2015-03-25 | 2021-06-02 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多価ｂ型肝炎ウイルス抗原結合分子およびその使用 |
| WO2016168758A1 (en) | 2015-04-17 | 2016-10-20 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| US11639389B2 (en) | 2015-09-30 | 2023-05-02 | Igm Biosciences, Inc. | Binding molecules with modified J-chain |
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| PL3455257T3 (pl) * | 2016-05-09 | 2022-01-17 | Igm Biosciences Inc. | Przeciwciała anty-pd-l1 |
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| US20190330360A1 (en) | 2016-07-20 | 2019-10-31 | Igm Biosciences, Inc. | Multimeric gitr binding molecules and uses thereof |
| US20190338040A1 (en) | 2016-07-20 | 2019-11-07 | Igm Biosciences, Inc. | Multimeric cd137/4-1bb binding molecules and uses thereof |
| US11401337B2 (en) | 2017-04-07 | 2022-08-02 | Igm Biosciences, Inc. | Modified human IgM constant regions for modulation of complement-dependent cytolysis effector function |
| US20200392239A1 (en) | 2018-02-26 | 2020-12-17 | Igm Biosciences, Inc. | Use of a multimeric anti-dr5 binding molecule in combination with a chemotherapeutic agent for treating cancer |
| WO2019169314A1 (en) | 2018-03-01 | 2019-09-06 | Igm Biosciences, Inc. | IgM Fc AND J-CHAIN MUTATIONS THAT AFFECT IgM SERUM HALF-LIFE |
| KR20210083260A (ko) | 2018-10-23 | 2021-07-06 | 아이쥐엠 바이오사이언스 인코포레이티드 | 다가 IgM- 및 IgA-Fc 기반 결합 분자 |
| US20220106398A1 (en) | 2019-02-08 | 2022-04-07 | Igm Biosciences, Inc. | Anti-gitr antigen-binding domains and uses thereof |
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2017
- 2017-05-09 PL PL17724263T patent/PL3455257T3/pl unknown
- 2017-05-09 HU HUE17724263A patent/HUE055972T2/hu unknown
- 2017-05-09 ES ES17724263T patent/ES2899361T3/es active Active
- 2017-05-09 IL IL262295A patent/IL262295B2/en unknown
- 2017-05-09 KR KR1020187035104A patent/KR102343742B1/ko active Active
- 2017-05-09 CA CA3021669A patent/CA3021669A1/en active Pending
- 2017-05-09 JP JP2018558733A patent/JP6979971B2/ja active Active
- 2017-05-09 EP EP17724263.3A patent/EP3455257B1/en active Active
- 2017-05-09 DK DK17724263.3T patent/DK3455257T3/da active
- 2017-05-09 WO PCT/US2017/031791 patent/WO2017196867A1/en not_active Ceased
- 2017-05-09 AU AU2017264683A patent/AU2017264683B2/en not_active Ceased
- 2017-05-09 SG SG11201809336QA patent/SG11201809336QA/en unknown
- 2017-05-09 US US16/098,479 patent/US10954302B2/en active Active
- 2017-05-09 CN CN201780027997.1A patent/CN109311985B/zh active Active
- 2017-05-09 PT PT177242633T patent/PT3455257T/pt unknown
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2021
- 2021-02-10 US US17/172,790 patent/US20210163600A1/en not_active Abandoned
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2023
- 2023-09-07 US US18/463,194 patent/US20240002514A1/en active Pending
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