JP2019519208A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019519208A5 JP2019519208A5 JP2018559329A JP2018559329A JP2019519208A5 JP 2019519208 A5 JP2019519208 A5 JP 2019519208A5 JP 2018559329 A JP2018559329 A JP 2018559329A JP 2018559329 A JP2018559329 A JP 2018559329A JP 2019519208 A5 JP2019519208 A5 JP 2019519208A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- binding fragment
- antibody
- cell
- ctla
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims description 77
- 102000036639 antigens Human genes 0.000 claims description 77
- 108091007433 antigens Proteins 0.000 claims description 77
- 239000012634 fragment Substances 0.000 claims description 77
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 42
- 210000004027 cell Anatomy 0.000 claims description 39
- 229920001184 polypeptide Polymers 0.000 claims description 32
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 32
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 32
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims description 23
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 23
- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 23
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 23
- 239000000203 mixture Substances 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 16
- -1 ICOS Proteins 0.000 claims description 10
- 238000000338 in vitro Methods 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 201000011510 cancer Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 230000004064 dysfunction Effects 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 208000035473 Communicable disease Diseases 0.000 claims description 5
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 5
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims description 5
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 5
- 208000015181 infectious disease Diseases 0.000 claims description 5
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 230000003915 cell function Effects 0.000 claims description 4
- 102000043321 human CTLA4 Human genes 0.000 claims description 4
- 230000003993 interaction Effects 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims description 3
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims description 2
- 102100021501 ATP-binding cassette sub-family B member 5 Human genes 0.000 claims description 2
- 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 claims description 2
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims description 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims description 2
- 108010074708 B7-H1 Antigen Proteins 0.000 claims description 2
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims description 2
- 102100027207 CD27 antigen Human genes 0.000 claims description 2
- 102100038078 CD276 antigen Human genes 0.000 claims description 2
- 101710185679 CD276 antigen Proteins 0.000 claims description 2
- 101150013553 CD40 gene Proteins 0.000 claims description 2
- 102100032912 CD44 antigen Human genes 0.000 claims description 2
- 108010065524 CD52 Antigen Proteins 0.000 claims description 2
- 102000024905 CD99 Human genes 0.000 claims description 2
- 108060001253 CD99 Proteins 0.000 claims description 2
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 claims description 2
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims description 2
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims description 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 2
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims description 2
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims description 2
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims description 2
- 101000677872 Homo sapiens ATP-binding cassette sub-family B member 5 Proteins 0.000 claims description 2
- 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 claims description 2
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims description 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims description 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 2
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 2
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims description 2
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims description 2
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims description 2
- 101000610551 Homo sapiens Prominin-1 Proteins 0.000 claims description 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 2
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims description 2
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims description 2
- 101000946850 Homo sapiens T-lymphocyte activation antigen CD86 Proteins 0.000 claims description 2
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims description 2
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 2
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 2
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims description 2
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims description 2
- 102000017578 LAG3 Human genes 0.000 claims description 2
- 101150030213 Lag3 gene Proteins 0.000 claims description 2
- 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 claims description 2
- 102100034256 Mucin-1 Human genes 0.000 claims description 2
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims description 2
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims description 2
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims description 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 2
- 102100040120 Prominin-1 Human genes 0.000 claims description 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 2
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims description 2
- 102100038081 Signal transducer CD24 Human genes 0.000 claims description 2
- 101100215487 Sus scrofa ADRA2A gene Proteins 0.000 claims description 2
- 230000017274 T cell anergy Effects 0.000 claims description 2
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims description 2
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims description 2
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 2
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 2
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 2
- 108010079206 V-Set Domain-Containing T-Cell Activation Inhibitor 1 Proteins 0.000 claims description 2
- 102100038929 V-set domain-containing T-cell activation inhibitor 1 Human genes 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims description 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims description 2
- 230000001747 exhibiting effect Effects 0.000 claims description 2
- 102000054189 human CD80 Human genes 0.000 claims description 2
- 102000049849 human CD86 Human genes 0.000 claims description 2
- 238000013160 medical therapy Methods 0.000 claims description 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims 1
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 1
- 102000002698 KIR Receptors Human genes 0.000 claims 1
- 108010043610 KIR Receptors Proteins 0.000 claims 1
- 102100023123 Mucin-16 Human genes 0.000 claims 1
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 1
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 102100023990 60S ribosomal protein L17 Human genes 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG10201603721T | 2016-05-10 | ||
| SG10201603721TA SG10201603721TA (en) | 2016-05-10 | 2016-05-10 | Anti-CTLA-4 Antibodies |
| PCT/EP2017/058956 WO2017194265A1 (en) | 2016-05-10 | 2017-04-13 | Anti-CTLA-4 Antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019519208A JP2019519208A (ja) | 2019-07-11 |
| JP2019519208A5 true JP2019519208A5 (cg-RX-API-DMAC7.html) | 2019-08-22 |
| JP6650537B2 JP6650537B2 (ja) | 2020-02-19 |
Family
ID=58609383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018559329A Active JP6650537B2 (ja) | 2016-05-10 | 2017-04-13 | 抗ｃｔｌａ−４抗体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9758583B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3455255B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6650537B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20190015715A (cg-RX-API-DMAC7.html) |
| CN (1) | CN109563165B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017262448A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3023787A1 (cg-RX-API-DMAC7.html) |
| SG (2) | SG10201603721TA (cg-RX-API-DMAC7.html) |
| TW (1) | TW201739763A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017194265A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102000770B1 (ko) | 2011-12-01 | 2019-07-16 | 케모센트릭스, 인크. | Ｃｃｒ(4) 길항제로서의 치환된 아닐린 |
| EP3907285A1 (en) | 2015-05-06 | 2021-11-10 | Snipr Technologies Limited | Altering microbial populations & modifying microbiota |
| HRP20201031T1 (hr) | 2015-05-29 | 2020-10-16 | Agenus Inc. | Anti-ctla-4 protutijela i postupci njihove upotrebe |
| US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
| SG10201603721TA (en) * | 2016-05-10 | 2017-12-28 | Agency Science Tech & Res | Anti-CTLA-4 Antibodies |
| GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
| US11013802B2 (en) | 2016-12-07 | 2021-05-25 | Agenus Inc. | Anti-CTLA-4 antibodies and methods of use thereof |
| CN111511762B (zh) | 2017-08-21 | 2025-05-06 | 天演药业公司 | 抗cd137分子及其用途 |
| SG11202001604UA (en) * | 2017-09-21 | 2020-04-29 | Eucure Beijing Biopharma Co Ltd | Anti-ctla4 antibodies and uses thereof |
| JP7269249B2 (ja) | 2017-11-10 | 2023-05-08 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | Ｉｌ２ｒベータ／共通ガンマ鎖抗体 |
| WO2019148444A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Anti-ctla4 antibodies and methods of making and using the same |
| WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
| JP2021512635A (ja) * | 2018-02-12 | 2021-05-20 | ザ ジェネラル ホスピタル コーポレイション | 腫瘍微小環境を標的とするキメラ抗原受容体 |
| US10760075B2 (en) | 2018-04-30 | 2020-09-01 | Snipr Biome Aps | Treating and preventing microbial infections |
| AU2019269628A1 (en) * | 2018-05-17 | 2020-12-03 | The Board Of Trustees Of The Leland Stanford Junior University | Receptor inhibition by phosphatase recruitment |
| WO2020047030A1 (en) | 2018-08-29 | 2020-03-05 | Chemocentryx, Inc. | Combination therapy using c-c chemokine receptor 4 (ccr4) antagonists and one or more immune checkpoint inhibitors |
| TW202039557A (zh) | 2018-11-09 | 2020-11-01 | 新加坡商優其洛伊生物私人有限公司 | 介白素2受體β(IL2Rβ)/共同γ鏈抗體 |
| TW202031683A (zh) | 2018-11-09 | 2020-09-01 | 新加坡商優其洛伊生物私人有限公司 | 介白素2受體β(IL2Rβ)/共同γ鏈抗體 |
| US20230071889A1 (en) | 2018-12-21 | 2023-03-09 | Ose Immunotherapeutics | Bifunctional anti-pd-1/il-7 molecule |
| CN114008071B (zh) | 2018-12-27 | 2025-01-21 | 吉加根公司 | 抗ctla-4结合蛋白及其使用方法 |
| WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
| CN110343180B (zh) * | 2019-07-25 | 2021-03-30 | 北京免疫方舟医药科技有限公司 | 抗ctla-4抗体及其应用 |
| TW202136287A (zh) | 2019-12-17 | 2021-10-01 | 法商Ｏｓｅ免疫治療公司 | 包含il-7變體之雙官能分子 |
| JP7695272B2 (ja) * | 2020-06-11 | 2025-06-18 | ナントバイオ，インコーポレイテッド | 抗ｃｔｌａ４モノクローナル抗体及びキメラ抗原受容体 |
| AU2021299338A1 (en) * | 2020-07-02 | 2023-02-23 | Gigagen, Inc. | Anti-CTLA-4 binding proteins and methods of use thereof |
| WO2022112198A1 (en) | 2020-11-24 | 2022-06-02 | Worldwide Innovative Network | Method to select the optimal immune checkpoint therapies |
| KR20220112208A (ko) * | 2021-02-03 | 2022-08-10 | 주식회사 유틸렉스 | 항 ctla-4 항체 및 이의 용도 |
| RU2757418C1 (ru) * | 2021-03-04 | 2021-10-15 | федеральное государственное бюджетное образовательное учреждение высшего образования "Алтайский государственный университет" | Тетрадекапептидный антагонист взаимодействия CTLA-4 c B7-1 |
| US20240182572A1 (en) | 2021-04-09 | 2024-06-06 | Ose Immunotherapeutics | Scaffold for bifunctional molecules comprising pd-1 or cd28 and sirp binding domains |
| JP2024515263A (ja) | 2021-04-09 | 2024-04-08 | オーエスイー・イミュノセラピューティクス | 改善された特性を有する二機能性分子のための新規足場構造 |
| GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
| WO2024003360A1 (en) | 2022-07-01 | 2024-01-04 | Institut Curie | Biomarkers and uses thereof for the treatment of neuroblastoma |
| CN119907811A (zh) | 2022-08-02 | 2025-04-29 | Ose免疫疗法公司 | 针对cd28的多功能分子 |
| WO2024200823A1 (en) | 2023-03-30 | 2024-10-03 | Ose Immunotherapeutics | Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell enhancing molecule and use thereof |
| WO2024200820A1 (en) | 2023-03-30 | 2024-10-03 | Ose Immunotherapeutics | Method of synthesis of targeted lipid nanoparticle and uses thereof |
| WO2025137321A1 (en) * | 2023-12-21 | 2025-06-26 | Fenwal, Inc. | System and method for affinity cell selection |
| EP4599843A1 (en) | 2024-02-09 | 2025-08-13 | Fundació Institut de recerca de l'Hospital de la Santa Creu i Sant Pau | Car and modified cd200r combination |
| WO2025242835A1 (en) | 2024-05-22 | 2025-11-27 | Ose Immunotherapeutics | Molecules comprising masking linkers and uses thereof for the treatment of cancer |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2252732T3 (es) | 1992-05-26 | 2006-05-16 | Immunex Corporation | Nueva citoquina que une cd30. |
| WO2001014424A2 (en) | 1999-08-24 | 2001-03-01 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
| ITRM20010408A1 (it) | 2001-07-10 | 2003-01-10 | Univ Napoli Federico Ii | Mini-anticorpo umano citotossico per cellule tumorali che esprimono il recettore erbb2. |
| KR100829283B1 (ko) | 2002-01-09 | 2008-05-13 | 메다렉스, 인코포레이티드 | Ｃｄ３０에 대한 인간 모노클로날 항체 |
| US8263746B2 (en) | 2004-02-06 | 2012-09-11 | Morphosys Ag | Anti-CD38 human antibodies and uses thereof |
| SI2287195T1 (sl) | 2004-07-01 | 2019-08-30 | Novo Nordisk A/S | Pan-kir2dl nk-receptor protitelesa in njihova uporaba pri diagnostiki in terapiji |
| NZ586780A (en) | 2005-03-23 | 2012-02-24 | Genmab As | Antibodies against CD38 for treatment of multiple myeloma |
| EP1896582A4 (en) | 2005-05-09 | 2009-04-08 | Ono Pharmaceutical Co | HUMAN MONOCLONAL ANTIBODIES AGAINST PROGRAMMED CELL DEATH 1 (PD-1) AND METHOD FOR CREATING TREATMENT WITH ANTI-PD-1 ANTIBODIES ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTICS |
| TWI461436B (zh) | 2005-11-25 | 2014-11-21 | Kyowa Hakko Kirin Co Ltd | 人類ｃｄ１３４（ｏｘ４０）之人類單株抗體及其製造及使用方法 |
| LT2511301T (lt) | 2006-08-04 | 2018-04-10 | Medimmune Limited | Žmogaus antikūnas prieš erbb2 |
| WO2008059491A1 (en) | 2006-11-13 | 2008-05-22 | The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center | Methods of treating cancer using sirna molecules directed against cd24 |
| KR101598229B1 (ko) | 2007-02-16 | 2016-02-26 | 메리맥 파마슈티컬즈, 인크. | Ｅｒｂｂ3에 대한 항체 및 이의 용도 |
| AR069747A1 (es) | 2007-11-30 | 2010-02-17 | Medarex Inc | Conjugado anticuerpo monoclonal anti-b7h4- farmaco y metodos de utilizacion |
| TW202442680A (zh) | 2008-12-09 | 2024-11-01 | 美商建南德克公司 | 抗pd-l1抗體及其於增進t細胞功能之用途 |
| EP3009455A1 (en) | 2009-09-16 | 2016-04-20 | Immunomedics Inc. | Class i anti-cea antibodies and uses thereof |
| EP2982380B1 (en) | 2010-03-04 | 2021-09-01 | MacroGenics, Inc. | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| WO2011149493A1 (en) | 2010-05-26 | 2011-12-01 | Regents Of The Unviversity Of Minnesota | Single -chain variable fragment anti-cd133 antibodies and uses thereof |
| ES2630328T3 (es) | 2010-08-23 | 2017-08-21 | Board Of Regents, The University Of Texas System | Anticuerpos anti-OX40 y procedimientos de uso de los mismos |
| ES2667568T3 (es) | 2011-04-25 | 2018-05-11 | Daiichi Sankyo Company, Limited | Anticuerpo anti-B7-H3 |
| GB201116092D0 (en) | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
| HK1200468A1 (en) | 2011-09-30 | 2015-08-07 | Regeneron Pharmaceuticals, Inc. | Anti-erbb3 antibodies and uses thereof |
| WO2013067492A1 (en) | 2011-11-03 | 2013-05-10 | The Trustees Of The University Of Pennsylvania | Isolated b7-h4 specific compositions and methods of use thereof |
| CA2884704C (en) | 2012-09-07 | 2023-04-04 | Randolph J. Noelle | Vista modulators for diagnosis and treatment of cancer |
| EP2912063A1 (en) | 2012-10-23 | 2015-09-02 | Bristol-Myers Squibb Company | Combination of anti-kir and anti-ctla-4 antibodies to treat cancer |
| AU2013361231A1 (en) | 2012-12-19 | 2015-06-04 | Amplimmune, Inc. | B7-H4 specific antibodies, and compositions and methods of use thereof |
| EP2958942B1 (en) | 2013-02-20 | 2020-06-03 | Novartis AG | Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells |
| WO2014160627A1 (en) | 2013-03-25 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-cd276 polypeptides, proteins, and chimeric antigen receptors |
| US10081681B2 (en) | 2013-09-20 | 2018-09-25 | Bristol-Myers Squibb Company | Combination of anti-LAG-3 antibodies and anti-PD-1 antibodies to treat tumors |
| IL301714A (en) | 2013-12-24 | 2023-05-01 | Janssen Pharmaceutica Nv | Antibodies and anti-VISTA fragments |
| CN104974253A (zh) * | 2014-04-01 | 2015-10-14 | 上海中信国健药业股份有限公司 | 抗ctla-4/pd-1双特异性抗体、其制备方法及应用 |
| SG10201603721TA (en) * | 2016-05-10 | 2017-12-28 | Agency Science Tech & Res | Anti-CTLA-4 Antibodies |
-
2016
- 2016-05-10 SG SG10201603721TA patent/SG10201603721TA/en unknown
-
2017
- 2017-04-13 TW TW106112375A patent/TW201739763A/zh unknown
- 2017-04-13 US US15/486,468 patent/US9758583B2/en active Active
- 2017-04-13 CA CA3023787A patent/CA3023787A1/en not_active Abandoned
- 2017-04-13 JP JP2018559329A patent/JP6650537B2/ja active Active
- 2017-04-13 SG SG11201809857TA patent/SG11201809857TA/en unknown
- 2017-04-13 US US16/099,652 patent/US11267887B2/en active Active
- 2017-04-13 WO PCT/EP2017/058956 patent/WO2017194265A1/en not_active Ceased
- 2017-04-13 AU AU2017262448A patent/AU2017262448A1/en not_active Abandoned
- 2017-04-13 KR KR1020187035791A patent/KR20190015715A/ko not_active Ceased
- 2017-04-13 CN CN201780029330.5A patent/CN109563165B/zh active Active
- 2017-04-13 EP EP17718870.3A patent/EP3455255B1/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019519208A5 (cg-RX-API-DMAC7.html) | ||
| JP2018508475A5 (cg-RX-API-DMAC7.html) | ||
| US11690908B2 (en) | Use of endogenous viral vaccine in chimeric antigen receptor T cell therapy | |
| AU2021200091B2 (en) | Chimeric antigen receptor compositions | |
| JP2018500924A5 (cg-RX-API-DMAC7.html) | ||
| JP2017536111A5 (cg-RX-API-DMAC7.html) | ||
| JP2017538441A5 (cg-RX-API-DMAC7.html) | ||
| JP2018527912A5 (cg-RX-API-DMAC7.html) | ||
| JP2020533960A (ja) | 抗ｉｌ１ｒａｐ抗体 | |
| RU2017116847A (ru) | Антитела к pd-1 | |
| US20190358262A1 (en) | Methods for modulation of car-t cells | |
| FI3250592T3 (fi) | Transtyretiinin vastaisia vasta-aineita | |
| CN112955179A (zh) | 拮抗性抗肿瘤坏死因子受体超家族多肽 | |
| JP2023073965A (ja) | 癌関連免疫抑制阻害剤 | |
| WO2024182541A1 (en) | Molecules that bind to b-cell activating factor receptor polypeptides | |
| TW202545991A (zh) | 抗ｃｄ２８抗體及其用途 | |
| RU2024115283A (ru) | Композиции vcar и способы применения |