JP2019518073A5 - - Google Patents
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- Publication number
- JP2019518073A5 JP2019518073A5 JP2019508309A JP2019508309A JP2019518073A5 JP 2019518073 A5 JP2019518073 A5 JP 2019518073A5 JP 2019508309 A JP2019508309 A JP 2019508309A JP 2019508309 A JP2019508309 A JP 2019508309A JP 2019518073 A5 JP2019518073 A5 JP 2019518073A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- composition
- chrimson
- fused
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 26
- 102000004169 proteins and genes Human genes 0.000 claims 21
- 108090000623 proteins and genes Proteins 0.000 claims 21
- 239000013598 vector Substances 0.000 claims 14
- 108091006047 fluorescent proteins Proteins 0.000 claims 13
- 102000034287 fluorescent proteins Human genes 0.000 claims 13
- 210000003994 retinal ganglion cell Anatomy 0.000 claims 5
- 239000013607 AAV vector Substances 0.000 claims 2
- 102000004144 Green Fluorescent Proteins Human genes 0.000 claims 2
- 108010043121 Green Fluorescent Proteins Proteins 0.000 claims 2
- 201000007737 Retinal degeneration Diseases 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000007812 deficiency Effects 0.000 claims 2
- 230000006870 function Effects 0.000 claims 2
- 239000005090 green fluorescent protein Substances 0.000 claims 2
- 230000008447 perception Effects 0.000 claims 2
- 108091008695 photoreceptors Proteins 0.000 claims 2
- 230000004258 retinal degeneration Effects 0.000 claims 2
- 241000702423 Adeno-associated virus - 2 Species 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 230000002999 depolarising effect Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000000620 electrically active cell Anatomy 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 230000032258 transport Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662329692P | 2016-04-29 | 2016-04-29 | |
| US62/329,692 | 2016-04-29 | ||
| PCT/IB2017/000663 WO2017187272A1 (en) | 2016-04-29 | 2017-04-28 | Optogenetic visual restoration using chrimson |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019518073A JP2019518073A (ja) | 2019-06-27 |
| JP2019518073A5 true JP2019518073A5 (enExample) | 2020-05-07 |
| JP6942789B2 JP6942789B2 (ja) | 2021-09-29 |
Family
ID=59253830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508309A Active JP6942789B2 (ja) | 2016-04-29 | 2017-04-28 | Ｃｈｒｉｍｓｏｎを用いた光遺伝学的視覚回復 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20190269755A1 (enExample) |
| EP (1) | EP3448411A1 (enExample) |
| JP (1) | JP6942789B2 (enExample) |
| KR (1) | KR102466887B1 (enExample) |
| CN (1) | CN110267673B (enExample) |
| AU (2) | AU2017256910B2 (enExample) |
| CA (1) | CA3025975A1 (enExample) |
| WO (1) | WO2017187272A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190126043A1 (en) | 2016-04-14 | 2019-05-02 | The Trustees Of The University Of Pennsylvania | Implantable living electrodes and methods for use thereof |
| EP3693061A1 (en) | 2019-02-05 | 2020-08-12 | Gensight Biologics | Method for controlling an optogenetic device using filtering and associated devices |
| EP3693060A1 (en) | 2019-02-05 | 2020-08-12 | Gensight Biologics | Method for controlling an optogenetic device using a command law for the radiant power of a light source and associated devices |
| EP3733139A1 (en) | 2019-05-02 | 2020-11-04 | Gensight Biologics | Viewing apparatus and method for projecting a light signal |
| US20220249864A1 (en) * | 2019-12-26 | 2022-08-11 | Korea University Research And Business Foundation | Method by which brain with alzheimer's disease recovers from brain wave damage by using optogenetics |
| US20250235585A1 (en) * | 2022-02-18 | 2025-07-24 | The Trustees Of The University Of Pennsylvania | Tissue Engineered Spinal Tracts For Functional Regeneration After Spinal Cord Injury |
| WO2024033837A1 (en) | 2022-08-11 | 2024-02-15 | Institute Of Molecular And Clinical Ophthalmology Basel (Iob) | Human cone photoreceptor optogenetic constructs |
| CN119827471B (zh) * | 2025-02-14 | 2025-10-03 | 中山大学中山眼科中心 | 一种体内追踪外段蛋白运输的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10216005A1 (de) | 2002-04-11 | 2003-10-30 | Max Planck Gesellschaft | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
| US20070053996A1 (en) | 2005-07-22 | 2007-03-08 | Boyden Edward S | Light-activated cation channel and uses thereof |
| US8470790B2 (en) * | 2006-05-04 | 2013-06-25 | Wayne State University | Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids |
| EP1891976A1 (en) | 2006-08-23 | 2008-02-27 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research | Use of light sensitive genes |
| AU2009212309B2 (en) * | 2008-02-07 | 2014-04-03 | Ceregene, Inc. | Rescue of photoreceptors by intravitreal administration of an expression vector encoding a therapeutic protein |
| JP2011516091A (ja) | 2008-04-18 | 2011-05-26 | ノバルティス・フォルシュングスシュティフトゥング・ツヴァイクニーダーラッスング・フリードリッヒ・ミーシェー・インスティトゥート・フォー・バイオメディカル・リサーチ | 失明の治療のための新規な治療用ツールおよび方法 |
| RS66184B1 (sr) | 2011-04-22 | 2024-12-31 | Univ California | Adeno-povezani virioni virusa sa varijantama kapsida i postupci za njihovu primenu |
| KR102084803B1 (ko) * | 2011-11-12 | 2020-03-05 | 메사추세츠 인스티튜트 오브 테크놀로지 | 세포의 광학 조절을 위한 채널로돕신 |
| WO2015161308A1 (en) * | 2014-04-18 | 2015-10-22 | Massachusetts Institute Of Technology | Mutant channelrhodopsins with altered ion selectivity |
| US10882892B2 (en) * | 2014-08-05 | 2021-01-05 | Massachusetts Institute Of Technology | Channelrhodopsin variants and uses thereof |
| US11390866B2 (en) * | 2015-12-04 | 2022-07-19 | Sorbonne Université | Promoters and uses thereof |
-
2017
- 2017-04-28 EP EP17734136.9A patent/EP3448411A1/en active Pending
- 2017-04-28 AU AU2017256910A patent/AU2017256910B2/en active Active
- 2017-04-28 CA CA3025975A patent/CA3025975A1/en active Pending
- 2017-04-28 KR KR1020187034650A patent/KR102466887B1/ko active Active
- 2017-04-28 CN CN201780041321.8A patent/CN110267673B/zh active Active
- 2017-04-28 US US16/097,204 patent/US20190269755A1/en not_active Abandoned
- 2017-04-28 JP JP2019508309A patent/JP6942789B2/ja active Active
- 2017-04-28 WO PCT/IB2017/000663 patent/WO2017187272A1/en not_active Ceased
-
2022
- 2022-07-07 AU AU2022204884A patent/AU2022204884A1/en not_active Abandoned
-
2023
- 2023-09-05 US US18/461,035 patent/US20240165198A1/en active Pending
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