JP2019516754A5 - - Google Patents
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- JP2019516754A5 JP2019516754A5 JP2018561512A JP2018561512A JP2019516754A5 JP 2019516754 A5 JP2019516754 A5 JP 2019516754A5 JP 2018561512 A JP2018561512 A JP 2018561512A JP 2018561512 A JP2018561512 A JP 2018561512A JP 2019516754 A5 JP2019516754 A5 JP 2019516754A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- cells
- population
- pluripotent cells
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 29
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 11
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 11
- 239000003795 chemical substances by application Substances 0.000 claims 9
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 5
- 230000014509 gene expression Effects 0.000 claims 5
- 239000003968 dna methyltransferase inhibitor Substances 0.000 claims 4
- 229960000604 valproic acid Drugs 0.000 claims 4
- 108090000695 Cytokines Proteins 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 3
- 108010016918 Histone-Lysine N-Methyltransferase Proteins 0.000 claims 3
- 102000000581 Histone-lysine N-methyltransferase Human genes 0.000 claims 3
- 230000003750 conditioning effect Effects 0.000 claims 3
- 239000002532 enzyme inhibitor Substances 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- MAUCONCHVWBMHK-UHFFFAOYSA-N 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)-oxomethyl]phenoxy]ethyl]-2-benzofurancarboxamide Chemical compound O1C2=CC=CC=C2C(CN(C)C)=C1C(=O)NCCOC1=CC=C(C(=O)NO)C=C1 MAUCONCHVWBMHK-UHFFFAOYSA-N 0.000 claims 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 206010055008 Gastric sarcoma Diseases 0.000 claims 2
- 208000032612 Glial tumor Diseases 0.000 claims 2
- 206010018338 Glioma Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 229950008805 abexinostat Drugs 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 230000000735 allogeneic effect Effects 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims 2
- INVTYAOGFAGBOE-UHFFFAOYSA-N entinostat Chemical compound NC1=CC=CC=C1NC(=O)C(C=C1)=CC=C1CNC(=O)OCC1=CC=CN=C1 INVTYAOGFAGBOE-UHFFFAOYSA-N 0.000 claims 2
- 229950005837 entinostat Drugs 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000000415 inactivating effect Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 239000003471 mutagenic agent Substances 0.000 claims 2
- 208000025113 myeloid leukemia Diseases 0.000 claims 2
- 201000008968 osteosarcoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- FWZRWHZDXBDTFK-ZHACJKMWSA-N panobinostat Chemical compound CC1=NC2=CC=C[CH]C2=C1CCNCC1=CC=C(\C=C\C(=O)NO)C=C1 FWZRWHZDXBDTFK-ZHACJKMWSA-N 0.000 claims 2
- 229960005184 panobinostat Drugs 0.000 claims 2
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 claims 2
- 229960000237 vorinostat Drugs 0.000 claims 2
- NMUSYJAQQFHJEW-UHFFFAOYSA-N 5-Azacytidine Natural products O=C1N=C(N)N=CN1C1C(O)C(O)C(CO)O1 NMUSYJAQQFHJEW-UHFFFAOYSA-N 0.000 claims 1
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 claims 1
- 229940126190 DNA methyltransferase inhibitor Drugs 0.000 claims 1
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 1
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 1
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 1
- 229960002756 azacitidine Drugs 0.000 claims 1
- 229940022399 cancer vaccine Drugs 0.000 claims 1
- 238000009566 cancer vaccine Methods 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 1
- 231100000636 lethal dose Toxicity 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022110028A JP7622006B2 (ja) | 2016-05-25 | 2022-07-07 | 癌を処置するための方法及び組成物 |
| JP2024168499A JP2025000812A (ja) | 2016-05-25 | 2024-09-27 | 癌を処置するための方法及び組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16305607 | 2016-05-25 | ||
| EP16305607.0 | 2016-05-25 | ||
| PCT/EP2017/062604 WO2017202949A1 (en) | 2016-05-25 | 2017-05-24 | Methods and compositions for treating cancers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022110028A Division JP7622006B2 (ja) | 2016-05-25 | 2022-07-07 | 癌を処置するための方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019516754A JP2019516754A (ja) | 2019-06-20 |
| JP2019516754A5 true JP2019516754A5 (enExample) | 2020-07-09 |
| JP7563872B2 JP7563872B2 (ja) | 2024-10-08 |
Family
ID=56131478
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561512A Active JP7563872B2 (ja) | 2016-05-25 | 2017-05-24 | 癌を処置するための方法及び組成物 |
| JP2022110028A Active JP7622006B2 (ja) | 2016-05-25 | 2022-07-07 | 癌を処置するための方法及び組成物 |
| JP2024168499A Pending JP2025000812A (ja) | 2016-05-25 | 2024-09-27 | 癌を処置するための方法及び組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022110028A Active JP7622006B2 (ja) | 2016-05-25 | 2022-07-07 | 癌を処置するための方法及び組成物 |
| JP2024168499A Pending JP2025000812A (ja) | 2016-05-25 | 2024-09-27 | 癌を処置するための方法及び組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11458194B2 (enExample) |
| EP (1) | EP3463433A1 (enExample) |
| JP (3) | JP7563872B2 (enExample) |
| KR (3) | KR20190032295A (enExample) |
| CN (2) | CN109689089A (enExample) |
| AU (2) | AU2017270234B2 (enExample) |
| BR (1) | BR112018074192A8 (enExample) |
| CA (1) | CA3025057A1 (enExample) |
| IL (2) | IL263224B2 (enExample) |
| RU (1) | RU2741786C2 (enExample) |
| WO (1) | WO2017202949A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| CA2935960C (en) | 2014-01-08 | 2023-01-10 | Bart Lipkens | Acoustophoresis device with dual acoustophoretic chamber |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| JP7373991B2 (ja) | 2016-07-15 | 2023-11-06 | ビラクタ セラピューティクス，インク． | 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤 |
| US11679148B2 (en) | 2017-11-24 | 2023-06-20 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Methods and compositions for treating cancers |
| KR20220066413A (ko) | 2017-12-14 | 2022-05-24 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
| KR20200140238A (ko) | 2018-01-02 | 2020-12-15 | 클로리스 바이오사이언시스 인코포레이티드 | 암에 대한 예방적 및 치료적 치료로서의 ipsc 기반 백신 |
| JP2021511293A (ja) * | 2018-01-12 | 2021-05-06 | ビラクタ セラピューティクス，インク． | 細胞免疫療法で使用されるエピジェネティック修飾因子 |
| EP3833383A1 (en) | 2018-08-06 | 2021-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating cancers |
| WO2020198145A1 (en) * | 2019-03-22 | 2020-10-01 | The Johns Hopkins University | Gene delivery particles to induce tumor-derived antigen presenting cells |
| WO2020232373A1 (en) * | 2019-05-15 | 2020-11-19 | Board Of Regents, The University Of Texas System | Crispr methods for treating cancers |
| JP7352937B2 (ja) * | 2019-07-19 | 2023-09-29 | 公立大学法人福島県立医科大学 | 乳癌のサブタイプを鑑別又は分類するための鑑別マーカー遺伝子セット、方法およびキット |
| CN111358777A (zh) * | 2020-02-24 | 2020-07-03 | 军事科学院军事医学研究院环境医学与作业医学研究所 | 一种提高外周血单个核细胞线粒体功能的方法和应用 |
| GB202006254D0 (en) * | 2020-04-28 | 2020-06-10 | Institute Of Cancer Res | Anti-cancer vaccines and related therapy |
| EP4149508A4 (en) * | 2020-05-12 | 2024-07-03 | Rush University Medical Center | COMPOSITIONS AND METHODS OF TREATMENT OF CANCER |
| CN112603995B (zh) * | 2020-12-30 | 2022-03-18 | 四川省肿瘤医院 | 靶向CAFs的肿瘤细胞疫苗、其制备方法及其应用 |
| EP4313046A1 (en) * | 2021-03-31 | 2024-02-07 | Celleron Therapeutics Limited | Vaccine adjuvant |
| CA3214527A1 (en) * | 2021-04-05 | 2022-10-13 | Doo-Young Jung | Combined therapy of 4'-thio-5-aza-2'-deoxycytidine and venetoclax |
| WO2023159124A2 (en) * | 2022-02-17 | 2023-08-24 | Memorial Sloan-Kettering Cancer Center | Methods for overcoming tazemetostat-resistance in cancer patients |
| CN115494237B (zh) * | 2022-09-19 | 2025-06-24 | 浙江省人民医院 | Rps6ka2在制备卵巢癌诊断试剂和治疗药物中的应用 |
| CN120936380A (zh) * | 2023-02-27 | 2025-11-11 | 武汉大学 | Pd-1信号调控及疾病治疗 |
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2017
- 2017-05-24 CN CN201780045481.XA patent/CN109689089A/zh active Pending
- 2017-05-24 CN CN202211701185.XA patent/CN116376812A/zh active Pending
- 2017-05-24 BR BR112018074192A patent/BR112018074192A8/pt not_active Application Discontinuation
- 2017-05-24 RU RU2018141200A patent/RU2741786C2/ru active
- 2017-05-24 WO PCT/EP2017/062604 patent/WO2017202949A1/en not_active Ceased
- 2017-05-24 KR KR1020187037459A patent/KR20190032295A/ko not_active Ceased
- 2017-05-24 CA CA3025057A patent/CA3025057A1/en active Pending
- 2017-05-24 JP JP2018561512A patent/JP7563872B2/ja active Active
- 2017-05-24 KR KR1020227044304A patent/KR102677451B1/ko active Active
- 2017-05-24 KR KR1020247020115A patent/KR20240103039A/ko active Pending
- 2017-05-24 US US16/303,705 patent/US11458194B2/en active Active
- 2017-05-24 EP EP17726274.8A patent/EP3463433A1/en active Pending
- 2017-05-24 AU AU2017270234A patent/AU2017270234B2/en active Active
- 2017-05-24 IL IL263224A patent/IL263224B2/en unknown
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2022
- 2022-07-07 JP JP2022110028A patent/JP7622006B2/ja active Active
- 2022-07-28 US US17/815,586 patent/US20220370582A1/en active Pending
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2023
- 2023-09-12 IL IL305882A patent/IL305882B2/en unknown
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2024
- 2024-01-30 AU AU2024200549A patent/AU2024200549A1/en active Pending
- 2024-09-27 JP JP2024168499A patent/JP2025000812A/ja active Pending
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