JP2018506995A5 - - Google Patents
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- Publication number
- JP2018506995A5 JP2018506995A5 JP2017562971A JP2017562971A JP2018506995A5 JP 2018506995 A5 JP2018506995 A5 JP 2018506995A5 JP 2017562971 A JP2017562971 A JP 2017562971A JP 2017562971 A JP2017562971 A JP 2017562971A JP 2018506995 A5 JP2018506995 A5 JP 2018506995A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- transgene
- cell
- sequence encoding
- dhfr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562120329P | 2015-02-24 | 2015-02-24 | |
| US62/120,329 | 2015-02-24 | ||
| US201562120790P | 2015-02-25 | 2015-02-25 | |
| US62/120,790 | 2015-02-25 | ||
| US201562175794P | 2015-06-15 | 2015-06-15 | |
| US62/175,794 | 2015-06-15 | ||
| PCT/US2016/019288 WO2016138091A2 (en) | 2015-02-24 | 2016-02-24 | Selection methods for genetically-modified t cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018506995A JP2018506995A (ja) | 2018-03-15 |
| JP2018506995A5 true JP2018506995A5 (enExample) | 2019-03-14 |
| JP6947647B2 JP6947647B2 (ja) | 2021-10-13 |
Family
ID=56464271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562971A Active JP6947647B2 (ja) | 2015-02-24 | 2016-02-24 | 遺伝子改変ｔ細胞の選択方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10808230B2 (enExample) |
| EP (2) | EP3261656B1 (enExample) |
| JP (1) | JP6947647B2 (enExample) |
| KR (1) | KR20170117095A (enExample) |
| CN (1) | CN107667169B (enExample) |
| AU (2) | AU2016222850B2 (enExample) |
| CA (1) | CA2976126A1 (enExample) |
| WO (1) | WO2016138091A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3783098A1 (en) | 2013-05-14 | 2021-02-24 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| KR102375998B1 (ko) | 2014-02-14 | 2022-03-21 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 키메라 항원 수용체 및 제조방법 |
| CA2964783C (en) | 2014-11-05 | 2024-01-23 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (car) to selectively target protein complexes |
| KR102615825B1 (ko) | 2015-03-11 | 2023-12-21 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 전위효소 폴리펩타이드 및 이의 용도 |
| HK1258218A1 (zh) | 2015-09-15 | 2019-11-08 | Board Of Regents, The University Of Texas System | T细胞受体(tcr)结合抗体及其应用 |
| EP3368075B1 (en) | 2015-10-27 | 2020-01-29 | Board of Regents, The University of Texas System | Chimeric antigen receptor molecules and uses thereof |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| CA3064000A1 (en) | 2017-05-24 | 2018-11-29 | Effector Therapeutics, Inc. | Methods and compositions for cellular immunotherapy |
| CN109136282A (zh) * | 2018-09-30 | 2019-01-04 | 北京鼎成肽源生物技术有限公司 | 一种hafft1细胞的构建方法 |
| AU2019379604B2 (en) | 2018-11-16 | 2026-04-23 | Rapa Therapeutics, Llc | Als treatment using induced regulatory T (iTREG) cells |
| WO2020102726A1 (en) * | 2018-11-16 | 2020-05-22 | Rapa Therapeutics, Llc | Method for manufacturing of human hybrid regulatory t/th2 cells (hybrid treg/th2 cells) from de-differentiated t cells |
| KR102594009B1 (ko) | 2021-02-01 | 2023-10-24 | 서울대학교산학협력단 | 형질전환 생식세포의 제조 방법 및 이를 이용한 형질전환 동물의 제조 방법 |
| EP4408169A4 (en) * | 2021-09-30 | 2025-10-29 | Univ Southern California | Human hepatocyte culture medium and conditioned medium of in vitro cultured human hepatocyte cells and their uses |
| CN114740196B (zh) * | 2022-04-08 | 2023-04-18 | 中南大学湘雅二医院 | 标志物及其在制备评价机体免疫功能的产品中的应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2573912C2 (ru) * | 2008-10-08 | 2016-01-27 | Интрексон Корпорейшн | Сконструированные клетки, экспрессирующие множественные иммуномодуляторы, и их применения |
| DK3246042T3 (da) * | 2009-11-02 | 2019-10-14 | Univ Emory | Lægemiddelresistent immunterapi til behandling af cancer |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| US8809017B2 (en) * | 2011-05-24 | 2014-08-19 | Agency For Science, Technology And Research | IRES mediated multicistronic vectors |
| US10391126B2 (en) | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
| CA2861491C (en) * | 2012-02-13 | 2020-08-25 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| EP3783098A1 (en) | 2013-05-14 | 2021-02-24 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| CA2913052A1 (en) | 2013-05-24 | 2014-11-27 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor-targeting monoclonal antibodies |
| EP3060059A4 (en) | 2013-10-25 | 2017-11-01 | Board of Regents, The University of Texas System | Polyclonal gamma delta t cells for immunotherapy |
| WO2015075195A1 (en) | 2013-11-22 | 2015-05-28 | Cellectis | Method of engineering chemotherapy drug resistant t-cells for immunotherapy |
| KR102375998B1 (ko) | 2014-02-14 | 2022-03-21 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 키메라 항원 수용체 및 제조방법 |
| US10611837B2 (en) | 2014-04-10 | 2020-04-07 | Seattle Children's Hospital | Transgene genetic tags and methods of use |
| CA2945388A1 (en) | 2014-04-23 | 2015-10-29 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (car) for use in therapy and methods for making the same |
| KR20200138445A (ko) | 2014-04-24 | 2020-12-09 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 입양 세포 요법 생성물을 생성하기 위한 유도 만능 줄기 세포의 응용 |
| US20170333480A1 (en) | 2014-11-05 | 2017-11-23 | Board Of Regents, The University Of Texas System | Gene modified immune effector cells and engineered cells for expansion of immune effector cells |
| CA2964783C (en) | 2014-11-05 | 2024-01-23 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (car) to selectively target protein complexes |
| KR102615825B1 (ko) | 2015-03-11 | 2023-12-21 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 전위효소 폴리펩타이드 및 이의 용도 |
| HK1258218A1 (zh) | 2015-09-15 | 2019-11-08 | Board Of Regents, The University Of Texas System | T细胞受体(tcr)结合抗体及其应用 |
| EP3368075B1 (en) | 2015-10-27 | 2020-01-29 | Board of Regents, The University of Texas System | Chimeric antigen receptor molecules and uses thereof |
-
2016
- 2016-02-24 US US15/552,821 patent/US10808230B2/en active Active
- 2016-02-24 CN CN201680011714.XA patent/CN107667169B/zh not_active Expired - Fee Related
- 2016-02-24 EP EP16741163.6A patent/EP3261656B1/en active Active
- 2016-02-24 AU AU2016222850A patent/AU2016222850B2/en not_active Ceased
- 2016-02-24 KR KR1020177024195A patent/KR20170117095A/ko not_active Withdrawn
- 2016-02-24 WO PCT/US2016/019288 patent/WO2016138091A2/en not_active Ceased
- 2016-02-24 JP JP2017562971A patent/JP6947647B2/ja active Active
- 2016-02-24 EP EP20191615.2A patent/EP3804741A3/en not_active Withdrawn
- 2016-02-24 CA CA2976126A patent/CA2976126A1/en active Pending
-
2020
- 2020-09-04 US US17/013,195 patent/US20210054346A1/en not_active Abandoned
-
2021
- 2021-06-02 AU AU2021203606A patent/AU2021203606A1/en not_active Abandoned
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