JP2019516378A5 - - Google Patents

Download PDF

Info

Publication number
JP2019516378A5
JP2019516378A5 JP2018560571A JP2018560571A JP2019516378A5 JP 2019516378 A5 JP2019516378 A5 JP 2019516378A5 JP 2018560571 A JP2018560571 A JP 2018560571A JP 2018560571 A JP2018560571 A JP 2018560571A JP 2019516378 A5 JP2019516378 A5 JP 2019516378A5
Authority
JP
Japan
Prior art keywords
sequence
host cell
component
exogenous
landing pad
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018560571A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019516378A (ja
JP7093310B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/033369 external-priority patent/WO2017201311A2/en
Publication of JP2019516378A publication Critical patent/JP2019516378A/ja
Publication of JP2019516378A5 publication Critical patent/JP2019516378A5/ja
Application granted granted Critical
Publication of JP7093310B2 publication Critical patent/JP7093310B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018560571A 2016-05-18 2017-05-18 外因性ランディングパッドへの核酸のゲノム組込みのための組成物および方法 Active JP7093310B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662338412P 2016-05-18 2016-05-18
US62/338,412 2016-05-18
PCT/US2017/033369 WO2017201311A2 (en) 2016-05-18 2017-05-18 Compositions and methods for genomic integration of nucleic acids into exogenous landing pads

Publications (3)

Publication Number Publication Date
JP2019516378A JP2019516378A (ja) 2019-06-20
JP2019516378A5 true JP2019516378A5 (cg-RX-API-DMAC7.html) 2020-06-18
JP7093310B2 JP7093310B2 (ja) 2022-06-29

Family

ID=59014740

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018560571A Active JP7093310B2 (ja) 2016-05-18 2017-05-18 外因性ランディングパッドへの核酸のゲノム組込みのための組成物および方法

Country Status (4)

Country Link
US (2) US11293033B2 (cg-RX-API-DMAC7.html)
EP (2) EP4219731A3 (cg-RX-API-DMAC7.html)
JP (1) JP7093310B2 (cg-RX-API-DMAC7.html)
WO (1) WO2017201311A2 (cg-RX-API-DMAC7.html)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3204496A1 (en) 2014-10-10 2017-08-16 Editas Medicine, Inc. Compositions and methods for promoting homology directed repair
WO2016073990A2 (en) 2014-11-07 2016-05-12 Editas Medicine, Inc. Methods for improving crispr/cas-mediated genome-editing
US11667911B2 (en) 2015-09-24 2023-06-06 Editas Medicine, Inc. Use of exonucleases to improve CRISPR/CAS-mediated genome editing
WO2017165826A1 (en) 2016-03-25 2017-09-28 Editas Medicine, Inc. Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
EP4047092B1 (en) 2016-04-13 2025-07-30 Editas Medicine, Inc. Cas9 fusion molecules, gene editing systems, and methods of use thereof
KR101839109B1 (ko) * 2016-09-22 2018-03-15 ㈜프론트바이오 퍼플콘 추출물을 함유하는 피부 질환의 예방 또는 치료용 약제학적 조성물
US11866726B2 (en) 2017-07-14 2024-01-09 Editas Medicine, Inc. Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
AU2020309602B2 (en) 2019-07-11 2025-05-15 Clara Foods Co. Protein compositions and consumable products thereof
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
US20230048847A1 (en) * 2020-01-07 2023-02-16 Limmatech Biologics Ag Engineered leishmania cells
US11739359B2 (en) * 2020-05-01 2023-08-29 Microsoft Technology Licensing, Llc Universal template strands for enzymatic polynucleotide synthesis
CN115715323A (zh) * 2020-06-19 2023-02-24 深圳华大智造科技股份有限公司 一种高兼容性的PCR-free建库和测序方法
CN116323940A (zh) * 2020-09-25 2023-06-23 邦迪生物私人有限公司 标准化蓝细菌菌株工程
US20250129362A1 (en) * 2021-08-25 2025-04-24 Iontas Limited Preparation of libraries of protein variants expressed in eukaryotic cells
CN114134091B (zh) * 2021-11-08 2024-04-12 中国科学院武汉病毒研究所 细菌基因组绝缘位点的鉴定方法及应用
WO2024050054A1 (en) * 2022-08-31 2024-03-07 The Regents Of The University Of California High throughput characterization of bacterial promoters from their host environments
WO2024076688A2 (en) * 2022-10-05 2024-04-11 The Regents Of The University Of California Synthetic genomic safe harbors and methods thereof
WO2024218234A1 (en) * 2023-04-21 2024-10-24 Novozymes A/S Generation of multi-copy host cells
WO2025119959A1 (en) * 2023-12-05 2025-06-12 F. Hoffmann-La Roche Ag Monitoring populations of cells producing biomolecules

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272065A (en) 1983-10-20 1993-12-21 Research Foundation Of State University Of New York Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
US4873192A (en) 1987-02-17 1989-10-10 The United States Of America As Represented By The Department Of Health And Human Services Process for site specific mutagenesis without phenotypic selection
US6140466A (en) 1994-01-18 2000-10-31 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
ATE222289T1 (de) 1995-06-07 2002-08-15 Invitrogen Corp Rekombinatorische klonierung in vitro unter verwendung genmanipulierter rekombinationsorte
JP4206154B2 (ja) 1997-11-13 2009-01-07 大日本住友製薬株式会社 変異型loxP配列とその応用
AU760113C (en) 1997-11-18 2004-04-22 Pioneer Hi-Bred International, Inc. Compositions and methods for genetic modification of plants
US5929301A (en) 1997-11-18 1999-07-27 Pioneer Hi-Bred International Nucleic acid sequence encoding FLP recombinase
PT1032680E (pt) 1997-11-18 2006-05-31 Pioneer Hi Bred Int Um novo metodo para a integracao de adn estranho em genomas eucarioticos
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US6794136B1 (en) 2000-11-20 2004-09-21 Sangamo Biosciences, Inc. Iterative optimization in the design of binding proteins
EP1234022B1 (en) 1999-07-23 2010-04-07 The Regents Of The University Of California Dna recombination in eukaryotic cells by the bacteriophage phic31 recombination system
WO2001011058A1 (en) 1999-08-09 2001-02-15 Monsanto Technology Llc Novel cloning methods and vectors
WO2001023545A1 (fr) 1999-09-30 2001-04-05 Sumitomo Pharmaceuticals Company, Limited Adn contenant des sequences frt allelomorphes
US6511808B2 (en) 2000-04-28 2003-01-28 Sangamo Biosciences, Inc. Methods for designing exogenous regulatory molecules
US20030082561A1 (en) 2000-07-21 2003-05-01 Takashi Sera Zinc finger domain recognition code and uses thereof
EP1353941B1 (en) 2001-01-22 2013-03-13 Sangamo BioSciences, Inc. Modified zinc finger binding proteins
GB0108491D0 (en) 2001-04-04 2001-05-23 Gendaq Ltd Engineering zinc fingers
AT5356U1 (de) 2001-07-16 2002-06-25 Uv & P Umweltman Verfahrenstec Verfahren zur immobilisierung von verbrennungsrückständen
ATE375388T1 (de) 2001-07-27 2007-10-15 Us Gov Health & Human Serv Systeme zur stellengerichteten in-vivo-mutagenese mit oligonukleotiden
WO2009095742A1 (en) 2008-01-31 2009-08-06 Cellectis New i-crei derived single-chain meganuclease and uses thereof
WO2003078619A1 (en) 2002-03-15 2003-09-25 Cellectis Hybrid and single chain meganucleases and use thereof
EP2368982A3 (en) 2002-03-21 2011-10-12 Sangamo BioSciences, Inc. Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
AU2003290518A1 (en) 2002-09-06 2004-04-23 Fred Hutchinson Cancer Research Center Methods and compositions concerning designed highly-specific nucleic acid binding proteins
US20060153826A1 (en) 2003-01-28 2006-07-13 Sylvain Arnould Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
CA2534296C (en) 2003-08-08 2013-03-26 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
EP1591521A1 (en) 2004-04-30 2005-11-02 Cellectis I-Dmo I derivatives with enhanced activity at 37 degrees C and use thereof
WO2006097784A1 (en) 2005-03-15 2006-09-21 Cellectis I-crei meganuclease variants with modified specificity, method of preparation and uses thereof
EP2325307A1 (en) 2005-03-15 2011-05-25 Cellectis I-crel meganuclease variants with modified specificity, method of preparation and uses thereof
WO2007034262A1 (en) 2005-09-19 2007-03-29 Cellectis Heterodimeric meganucleases and use thereof
WO2007049095A1 (en) 2005-10-25 2007-05-03 Cellectis Laglidadg homing endonuclease variants having mutations in two functional subdomains and use thereof
WO2007060495A1 (en) 2005-10-25 2007-05-31 Cellectis I-crei homing endonuclease variants having novel cleavage specificity and use thereof
EP2049663B1 (en) 2006-08-11 2015-02-25 Dow AgroSciences LLC Zinc finger nuclease-mediated homologous recombination
WO2009001159A1 (en) 2007-06-25 2008-12-31 Cellectis Method for enhancing the cleavage activity of i-crei derived meganucleases
WO2008152524A2 (en) 2007-06-06 2008-12-18 Cellectis Method for enhancing the cleavage activity of i-crei derived meganucleases
CA2700170A1 (en) 2007-09-27 2009-04-02 Sangamo Biosciences, Inc. Genomic editing in zebrafish using zinc finger nucleases
AU2008317354B2 (en) 2007-10-25 2014-04-10 Ospedale San Raffaele S.R.L. Methods and compositions for targeted integration
WO2010001189A1 (en) 2008-07-03 2010-01-07 Cellectis The crystal structure of i-dmoi in complex with its dna target, improved chimeric meganucleases and uses thereof
EP2329017A2 (en) 2008-08-04 2011-06-08 Cellectis Novel method to generate meganucleases with altered characteristics
EP2180058A1 (en) 2008-10-23 2010-04-28 Cellectis Meganuclease recombination system
JP2012509084A (ja) 2008-11-19 2012-04-19 アムイリス, インコーポレイテッド ポリヌクレオチドアセンブリに関する組成物及び方法
WO2010065123A1 (en) 2008-12-04 2010-06-10 Sangamo Biosciences, Inc. Genome editing in rats using zinc-finger nucleases
EP2206723A1 (en) 2009-01-12 2010-07-14 Bonas, Ulla Modular DNA-binding domains
WO2011072246A2 (en) 2009-12-10 2011-06-16 Regents Of The University Of Minnesota Tal effector-mediated dna modification
CN105671073B (zh) * 2010-01-22 2020-03-27 陶氏益农公司 供植物中基因靶向用的工程化降落场
US7919605B1 (en) 2010-08-30 2011-04-05 Amyris, Inc. Nucleic acids, compositions and methods for the excision of target nucleic acids
EP3320910A1 (en) 2011-04-05 2018-05-16 Cellectis Method for the generation of compact tale-nucleases and uses thereof
SG194089A1 (en) 2011-04-27 2013-11-29 Amyris Inc Methods for genomic modification
GB201122458D0 (en) 2011-12-30 2012-02-08 Univ Wageningen Modified cascade ribonucleoproteins and uses thereof
US9637739B2 (en) 2012-03-20 2017-05-02 Vilnius University RNA-directed DNA cleavage by the Cas9-crRNA complex
AU2013282323B2 (en) * 2012-06-29 2018-05-10 Massachusetts Institute Of Technology Massively parallel combinatorial genetics
JP2016523084A (ja) * 2013-06-19 2016-08-08 シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニーSigma−Aldrich Co., LLC 標的組込み
MX2016007797A (es) * 2013-12-19 2016-09-07 Amyris Inc Metodos para integracion genomica.
WO2017075529A1 (en) 2015-10-29 2017-05-04 The Research Foundation For The State University Of New York Genomic combinatorial screening platform

Similar Documents

Publication Publication Date Title
JP2019516378A5 (cg-RX-API-DMAC7.html)
JP2021500072A5 (cg-RX-API-DMAC7.html)
Stull et al. A targeted enrichment strategy for massively parallel sequencing of angiosperm plastid genomes
JP2017510293A5 (cg-RX-API-DMAC7.html)
JP2017532042A5 (cg-RX-API-DMAC7.html)
JP2020524998A5 (cg-RX-API-DMAC7.html)
EP4372091A3 (en) Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides
JP6430631B2 (ja) リンカー要素、及び、それを使用してシーケンシングライブラリーを構築する方法
JP2019536425A5 (cg-RX-API-DMAC7.html)
JP2017512767A5 (cg-RX-API-DMAC7.html)
RU2018124657A (ru) Способы редактирования генов и композиции для устранения риска активации вируса jc и пмл (прогрессирующая мультифокальная лейкоэнцефалопатия) во время иммуносупрессивной терапии
JP2016536991A5 (cg-RX-API-DMAC7.html)
JP2016521993A5 (cg-RX-API-DMAC7.html)
CN112105728A (zh) CRISPR/Cas效应蛋白及系统
JP2018505688A5 (cg-RX-API-DMAC7.html)
JP2017070287A5 (cg-RX-API-DMAC7.html)
JP2016500262A5 (cg-RX-API-DMAC7.html)
JP2019528284A5 (cg-RX-API-DMAC7.html)
JP2019517268A5 (cg-RX-API-DMAC7.html)
JP2017520580A5 (cg-RX-API-DMAC7.html)
WO2017066497A3 (en) Genome engineering with type i crispr systems in eukaryotic cells
JP2016523564A5 (cg-RX-API-DMAC7.html)
RU2016104056A (ru) Мультиплексная геномная инженерия, направляемая рнк
RU2017130143A (ru) Гибридные днк/рнк-полинукдеотиды crispr и способы
EP4245861A3 (en) Single tube bead-based dna co-barcoding for accurate and cost-effective sequencing, haplotyping, and assembly