JP2019516352A5 - - Google Patents

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Publication number
JP2019516352A5
JP2019516352A5 JP2018551409A JP2018551409A JP2019516352A5 JP 2019516352 A5 JP2019516352 A5 JP 2019516352A5 JP 2018551409 A JP2018551409 A JP 2018551409A JP 2018551409 A JP2018551409 A JP 2018551409A JP 2019516352 A5 JP2019516352 A5 JP 2019516352A5
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JP
Japan
Prior art keywords
clone
seq
amino acid
receptor
cell
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Pending
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JP2018551409A
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English (en)
Japanese (ja)
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JP2019516352A (ja
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Priority claimed from PCT/US2017/025613 external-priority patent/WO2017173410A1/en
Publication of JP2019516352A publication Critical patent/JP2019516352A/ja
Publication of JP2019516352A5 publication Critical patent/JP2019516352A5/ja
Priority to JP2022035975A priority Critical patent/JP7561155B2/ja
Priority to JP2024070373A priority patent/JP2024105337A/ja
Pending legal-status Critical Current

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JP2018551409A 2016-04-01 2017-03-31 Flt3に対するキメラ受容体及びその使用方法 Pending JP2019516352A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022035975A JP7561155B2 (ja) 2016-04-01 2022-03-09 Flt3に対するキメラ受容体及びその使用方法
JP2024070373A JP2024105337A (ja) 2016-04-01 2024-04-24 Flt3に対するキメラ受容体及びその使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662317219P 2016-04-01 2016-04-01
US62/317,219 2016-04-01
PCT/US2017/025613 WO2017173410A1 (en) 2016-04-01 2017-03-31 Chimeric receptors to flt3 and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022035975A Division JP7561155B2 (ja) 2016-04-01 2022-03-09 Flt3に対するキメラ受容体及びその使用方法

Publications (2)

Publication Number Publication Date
JP2019516352A JP2019516352A (ja) 2019-06-20
JP2019516352A5 true JP2019516352A5 (OSRAM) 2020-05-07

Family

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JP2018551409A Pending JP2019516352A (ja) 2016-04-01 2017-03-31 Flt3に対するキメラ受容体及びその使用方法
JP2022035975A Active JP7561155B2 (ja) 2016-04-01 2022-03-09 Flt3に対するキメラ受容体及びその使用方法
JP2024070373A Pending JP2024105337A (ja) 2016-04-01 2024-04-24 Flt3に対するキメラ受容体及びその使用方法

Family Applications After (2)

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JP2022035975A Active JP7561155B2 (ja) 2016-04-01 2022-03-09 Flt3に対するキメラ受容体及びその使用方法
JP2024070373A Pending JP2024105337A (ja) 2016-04-01 2024-04-24 Flt3に対するキメラ受容体及びその使用方法

Country Status (26)

Country Link
US (2) US20190183931A1 (OSRAM)
EP (1) EP3436479A1 (OSRAM)
JP (3) JP2019516352A (OSRAM)
KR (2) KR102389096B1 (OSRAM)
CN (1) CN109641956A (OSRAM)
AR (2) AR109626A1 (OSRAM)
AU (3) AU2017240801A1 (OSRAM)
BR (1) BR112018070187A8 (OSRAM)
CA (1) CA3019655A1 (OSRAM)
CL (1) CL2018002792A1 (OSRAM)
CO (1) CO2018011804A2 (OSRAM)
CR (2) CR20180518A (OSRAM)
EA (1) EA201892193A1 (OSRAM)
IL (2) IL262061B2 (OSRAM)
MA (1) MA44507A (OSRAM)
MX (1) MX2023013729A (OSRAM)
MY (2) MY210545A (OSRAM)
NZ (1) NZ746925A (OSRAM)
PE (2) PE20241061A1 (OSRAM)
PH (1) PH12018502118B1 (OSRAM)
SA (1) SA518400154B1 (OSRAM)
SG (2) SG10201911963VA (OSRAM)
TN (1) TN2018000337A1 (OSRAM)
TW (2) TWI776807B (OSRAM)
UA (1) UA128326C2 (OSRAM)
WO (1) WO2017173410A1 (OSRAM)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9725710B2 (en) 2014-01-08 2017-08-08 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
KR102359735B1 (ko) 2016-03-31 2022-02-08 얀센 파마슈티칼즈, 인코포레이티드 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체
KR102359743B1 (ko) 2016-03-31 2022-02-07 얀센 파마슈티칼즈, 인코포레이티드 뎅기 바이러스 복제 억제제로서의 치환 인돌 유도체
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
SG11201808237UA (en) 2016-04-01 2018-10-30 Janssen Pharmaceuticals Inc Substituted indole compound derivatives as dengue viral replication inhibitors
TWI761831B (zh) 2016-04-01 2022-04-21 美商凱特製藥公司 嵌合抗原受體(car)和t細胞受體(tcr)及彼等之用途
US10603380B2 (en) * 2016-04-01 2020-03-31 Kite Pharma, Inc. Chimeric antigen and T cell receptors and methods of use
DK3436030T3 (da) 2016-04-01 2022-11-21 Kite Pharma Inc Kimæriske receptorer og fremgangsmåder til anvendelse deraf
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
EP3559038B1 (en) 2016-12-21 2022-12-14 The United States of America as represented by The Secretary Department of Health and Human Services Human monoclonal antibodies specific for flt3 and uses thereof
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
US11407715B2 (en) 2017-05-22 2022-08-09 Janssen Pharmaceuticals, Inc. Substituted indoline derivatives as dengue viral replication inhibitors
BR112019024311A2 (pt) 2017-05-22 2020-07-28 Janssen Pharmaceuticals, Inc. derivados de indolina substituídos como inibidores da replicação viral do dengue
US12296012B2 (en) * 2017-06-02 2025-05-13 Pfizer Inc. Chimeric antigen receptors targeting FLT3
TN2020000015A1 (en) 2017-08-03 2021-10-04 Amgen Inc Interleukin-21 muteins and methods of treatment
EP4403175A3 (en) 2017-09-08 2024-10-02 Amgen Inc. Inhibitors of kras g12c and methods of using the same
SG11202005605SA (en) 2018-01-12 2020-07-29 Amgen Inc Anti-pd-1 antibodies and methods of treatment
CA3094927A1 (en) * 2018-03-23 2019-09-26 Gavish-Galilee Bio Applications Ltd. Genetically reprogrammed tregs expressing membrane-bound il-10
TWI842703B (zh) * 2018-04-10 2024-05-21 美商安進公司 Dll3 的嵌合受體及其使用方法
JP7447014B2 (ja) * 2018-04-13 2024-03-11 サンガモ セラピューティクス フランス インターロイキン23受容体に特異的なキメラ抗原受容体
EA202191650A1 (ru) 2018-12-18 2021-10-22 Бёрингер Ингельхайм Ио Канада Инк. Flt3 агонистические антитела и их применения
US20220160771A1 (en) * 2019-04-10 2022-05-26 Iulia Diaconu Flt3-specific chimeric antigen receptors and methods of using the same
AU2020265679A1 (en) 2019-04-30 2021-12-23 Senti Biosciences, Inc. Chimeric receptors and methods of use thereof
CN115066248A (zh) * 2019-12-16 2022-09-16 华盛顿大学 嵌合抗原受体树突状细胞(car-dc)及其制备和使用方法
JP2023522330A (ja) * 2020-04-17 2023-05-30 シティ・オブ・ホープ Flt3陽性悪性腫瘍を処置するためのflt3標的化キメラ抗原受容体改変細胞
CN111808821B (zh) * 2020-06-24 2022-06-14 南方医科大学珠江医院 Flt3-nkg2d双靶点car-t的构建与制备
US12404315B2 (en) 2020-12-21 2025-09-02 Allogene Therapeutics, Inc. Protease-activating CD45-gate CAR
KR20230135593A (ko) * 2021-01-28 2023-09-25 알로젠 테라퓨틱스 인코포레이티드 면역 세포를 형질도입하는 방법
EP4284918A1 (en) 2021-01-29 2023-12-06 Allogene Therapeutics, Inc. Knockdown or knockout of one or more of tap2, nlrc5, beta2m, trac, rfx5, rfxap and rfxank to mitigate t cell recognition of allogeneic cell products
CN116410315A (zh) * 2021-12-31 2023-07-11 博生吉医药科技(苏州)有限公司 一种新型靶向人flt3的嵌合抗原受体修饰的t细胞的构建及应用
WO2024026445A1 (en) 2022-07-29 2024-02-01 Allogene Therapeutics Inc. Engineered cells with reduced gene expression to mitigate immune cell recognition
WO2025096560A1 (en) 2023-10-30 2025-05-08 Allogene Therapeutics, Inc. Engineered cells
CN120157768A (zh) * 2023-12-15 2025-06-17 博生吉安科细胞技术有限公司 一种识别flt3-car分子的单克隆抗体及其应用

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0281604B1 (en) 1986-09-02 1993-03-31 Enzon Labs Inc. Single polypeptide chain binding molecules
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US6319494B1 (en) 1990-12-14 2001-11-20 Cell Genesys, Inc. Chimeric chains for receptor-associated signal transduction pathways
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
US5834266A (en) 1993-02-12 1998-11-10 President & Fellows Of Harvard College Regulated apoptosis
US5830462A (en) 1993-02-12 1998-11-03 President & Fellows Of Harvard College Regulated transcription of targeted genes and other biological events
US5869337A (en) 1993-02-12 1999-02-09 President And Fellows Of Harvard College Regulated transcription of targeted genes and other biological events
US20030036654A1 (en) 1994-08-18 2003-02-20 Holt Dennis A. Synthetic multimerizing agents
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
AU4328801A (en) 2000-02-24 2001-09-03 Xcyte Therapies Inc Simultaneous stimulation and concentration of cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US7446190B2 (en) * 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
KR101460932B1 (ko) * 2005-08-26 2014-11-12 로슈 글리카트 아게 변형된 세포 신호 활성을 가진 개질된 항원 결합 분자
WO2007137300A2 (en) 2006-05-23 2007-11-29 Bellicum Pharmaceuticals, Inc. Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods
HRP20160422T1 (hr) * 2009-12-23 2016-05-20 Synimmune Gmbh Protutijela protiv flt3 postupci njihove upotrebe
WO2011146862A1 (en) 2010-05-21 2011-11-24 Bellicum Pharmaceuticals, Inc. Methods for inducing selective apoptosis
US9845362B2 (en) * 2010-10-08 2017-12-19 The University Of North Carolina At Charlotte Compositions comprising chimeric antigen receptors, T cells comprising the same, and methods of using the same
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
WO2012103279A2 (en) 2011-01-26 2012-08-02 Ariad Pharmaceuticals, Incorporated Methods and compositions for the synthesis of multimerizing agents
CN110200997A (zh) 2011-03-23 2019-09-06 弗雷德哈钦森癌症研究中心 用于细胞免疫治疗的方法和组合物
CA3116051C (en) * 2012-03-23 2023-09-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-mesothelin chimeric antigen receptors
DK2956175T3 (da) 2013-02-15 2017-11-27 Univ California Kimærisk antigenreceptor og fremgangsmåder til anvendelse deraf
WO2014151960A2 (en) 2013-03-14 2014-09-25 Bellicum Pharmaceuticals, Inc. Methods for controlling t cell proliferation
US10196444B2 (en) 2013-07-29 2019-02-05 Bluebird Bio, Inc. Multipartite signaling proteins and uses thereof
EP4420663A3 (en) 2013-12-20 2024-10-30 Novartis AG Regulatable chimeric antigen receptor
CA2937750A1 (en) 2014-02-14 2015-08-20 Bellicum Pharmaceuticals, Inc. Methods for activating t cells using an inducible chimeric polypeptide
WO2015142675A2 (en) * 2014-03-15 2015-09-24 Novartis Ag Treatment of cancer using chimeric antigen receptor
AU2015294834B2 (en) * 2014-07-31 2021-04-29 Amgen Research (Munich) Gmbh Optimized cross-species specific bispecific single chain antibody constructs
RU2749922C2 (ru) * 2014-09-19 2021-06-21 Сити Оф Хоуп Т-КЛЕТКИ С КОСТИМУЛИРУЮЩИМ ХИМЕРНЫМ АНТИГЕННЫМ РЕЦЕПТОРОМ, НАЦЕЛЕННЫЕ НА IL13Rα2
TWI829617B (zh) * 2015-07-31 2024-01-21 德商安美基研究(慕尼黑)公司 Flt3及cd3抗體構築體
US10603380B2 (en) * 2016-04-01 2020-03-31 Kite Pharma, Inc. Chimeric antigen and T cell receptors and methods of use

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